scholarly journals Adalimumab Treatment in Biologically Naïve Crohn’s Disease: Relationship with Ectopic MUC5AC Expression and Endoscopic Improvement

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Tsutomu Mizoshita ◽  
Satoshi Tanida ◽  
Hironobu Tsukamoto ◽  
Keiji Ozeki ◽  
Takahito Katano ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Activity Index ◽  
Drug Efficacy ◽  
Predictive Marker ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Before And After ◽  
Adalimumab Treatment ◽  
Positive Groups

Background. Adalimumab (ADA) is effective for patients with Crohn’s disease (CD). However, there have been few reports on ADA therapy with respect to its relationship with pathologic findings and drug efficacy in biologically naïve CD cases.Methods. Fifteen patients with active biologically naïve CD were treated with ADA. We examined them clinically and pathologically with ectopic MUC5AC expression in the lesions before and after 12 and 52 weeks of ADA therapy, retrospectively.Results. Both mean CD activity index scores and serum C-reactive protein values were significantly lower after ADA therapy (P<0.001). In the MUC5AC negative group, all cases exhibited clinical remission (CR) and endoscopic improvement at 52 weeks. In MUC5AC positive groups, loss of MUC5AC expression was detected in cases having CR and endoscopic improvement at 52 weeks, while remnant ectopic MUC5AC expression was observed in those exhibiting no endoscopic improvement and flare up after 52 weeks.Conclusions. ADA leads to CR and endoscopic improvement in biologically naïve CD cases. In addition, ectopic MUC5AC expression may be a predictive marker of flare up and endoscopic improvement in the intestines of CD patients.

scholarly journals Serum C-reactive protein level does not correlate with Crohn’s Disease Activity Index

2010 ◽  
Vol 5 ◽  
pp. 274-278
Author(s):  
Maciej Kohut ◽  
Katarzyna Kozioł ◽  
Emilia Olek ◽  
Anna Koclęga ◽  
Marek Hartleb
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Protein Level ◽  
Activity Index ◽  
Disease Activity Index ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Crohn’S Disease Activity

scholarly journals Postoperative Ratio of C-Reactive Protein to Albumin as a Predictive Marker in Patients with Crohn’s Disease Undergoing Bowel Resection

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Hangfen Zhao ◽  
Huaying Liu ◽  
Weilin Qi ◽  
Wei Liu ◽  
Lingna Ye ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Postoperative Complications ◽  
Crohn's Disease ◽  
Surgical Site Infections ◽  
Predictive Marker ◽  
Roc Curves ◽  
Youden Index ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Independent Risk Factor

Background. The ratio of C-reactive protein (CRP) to albumin (CAR) has a significant correlation with postoperative complications and acts as a predictor in patients with pancreatic cancer and colorectal cancer. However, whether the CAR can be used to predict complications in Crohn’s disease (CD) patients after surgery has not yet been reported. Methods. A total of 534 CD patients undergoing surgery between 2016 and 2020 were enrolled. The risk factors of postoperative complications were assessed by univariate and multivariate analyses. The cutoff values and the accuracy of diagnosis for the CAR and postoperative CRP levels were examined with receiver operating characteristic (ROC) curves. Results. The rate of postoperative complications was 32.2%. The postoperative CAR (OR 13.200; 95% CI 6.501-26.803; P < 0.001 ) was a significant independent risk factor for complications. Compared with the CRP level on postoperative day 3, the CAR more accurately indicated postoperative complications in CD patients (AUC: 0.699 vs. 0.771; Youden index: 0.361 vs. 0.599). ROC curves showed that the cutoff value for the CAR was 3.25. Patients with a CAR ≥ 3.25 had more complications ( P < 0.001 ), a longer postoperative stay ( 15.5 ± 0.6  d vs. 9.0 ± 0.2  d, P < 0.001 ), and more surgical site infections (48.2% vs. 5.7%, P < 0.001 ) than those with a CAR < 3.25 . Conclusions. Compared to the CRP level, the CAR can more accurately predict postoperative complications and can act as a predictive marker in CD patients after surgery.

Non-Invasive Assessment of Inflammation and Treatment Response in Patients with Crohn’s Disease and Ulcerative Colitis using Contrast-Enhanced Ultrasonography Quantification

2015 ◽  
Vol 24 (4) ◽  
pp. 457-465 ◽  
Author(s):  
Mihai Socaciu ◽  
Lidia Ciobanu ◽  
Brindusa Diaconu ◽  
Claudia Hagiu ◽  
Andrada Seicean ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Contrast Enhanced ◽  
Before And After ◽  
Contrast Enhanced Ultrasonography ◽  
The Difference

ackground & Aim: Novel biological therapies in Crohn’s disease (CD) or Ulcerative colitis (UC) require a proper follow-up for the assessment of bowel inflammation. While endoscopy is the standard method, the imaging techniques using contrast, particularly contrast enhanced ultrasonography (CEUS), are better tolerated by the patients and can be used more frequently. Our aim was to find the usefulness of dynamic CEUS quantification as compared to endoscopy in the assessment of disease activity and in the follow-up under therapy of the patients suffering from either CD or UC. Method: We have prospectively evaluated 67 patients with UC and 46 with CD, diagnosed by ileo-colonoscopy and biopsy, comparing the endoscopic scores with clinical scores, C reactive protein (CRP), intestinal wall thickness, layer scores after CEUS and TIC parameters (using SonoLiver® software – Imax, RT, TTP, mTT and AUC). For 25 patients with UC and 13 with CD we performed comparisons of the parameters before and after 3 months of treatment and correlated them with the changes in the endoscopic scores. Results: For UC, time-intensity curves (TIC) volume parameters (AUC) correlated better with endoscopy (ρ=0.64) than the clinical score (ρ =0.62). Other parameters such as CRP and thickness showed significant but less strong correlation, while TIC flow parameters (RT, TTP and mTT) did not show a significant correlation. Results were similar for CD (ρ=0.64 for Imax vs ρ=0.58 for CDAI). The best predictor for endoscopic improvement in both UC and CD was ln(AUC), with a Wilcoxon Z score of 3.76 and 2.61, respectively. There was also a good correlation between the difference of its values and the difference in endoscopic scores before and after the treatment (rho is 0.68 in UC and 0.73 in CD). Abbreviations: CD: Crohn’s disease; CDAI: Crohn‘s disease activity index; CDEIS: Crohn‘s disease endoscopic index of severity; CEUS: Contrast-enhanced ultrasonography; CICDA: Composite index of CD activity; CRP: C-reactive protein; IBD: Inflammatory bowel disease; Imax: Maximum intensity; ln(AUC): Natural logarithm of AUC; MPI: Maximum peak intensity; mTT: Mean transit time; ROI: Region of interest; RT: Rise time; SES-CD: Simple endoscopic score for Crohn‘s disease; TIC:

scholarly journals P578 C-reactive protein levels at first month of adalimumab treatment as predictive of nonresponse in Crohn's disease patients

2013 ◽  
Vol 7 ◽  
pp. S242
Author(s):  
E. Rodrigues-Pinto ◽  
F. Magro ◽  
F. Vilas-Boas ◽  
J. Santos-Antunes ◽  
A. Nunes ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Adalimumab Treatment

C-Reactive Protein as a Predictor of Relapse in Asymptomatic Patients with Crohn's Disease

1983 ◽  
Vol 28 (1) ◽  
pp. 26-29 ◽  
Author(s):  
C. André ◽  
L. Descos ◽  
J. Vignal ◽  
J. Gillon
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Acute Phase Proteins ◽  
Activity Index ◽  
Clinical Status ◽  
Disease Activity Index ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Asymptomatic Patients

Comparison of the Crohn's Disease Activity Index (CDAI) with serum levels of the acute phase proteins during a 4-year study period of 50 patients with Crohn's disease has shown the serum C-reactive protein (CRP) to be a sensitive indicator of clinical status. Five patients are described in whom raised CRP levels reliably predicted relapse at a time when the patients were asymptomatic and the CDAI was normal. Measurement of serum CRP by radial immunodiffusion is cheap and simple, and if performed frequently in the follow-up of patients with Crohn's disease it may permit earlier, and therefore possibly more effective, treatment of relapse.

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