scholarly journals A Prospective Study of Soft Tissue Tumors Histocytopathology Correlation

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Priyanka Bhatia Soni ◽  
Anand Kumar Verma ◽  
Raj Kumar Chandoke ◽  
Jitendra Singh Nigam
Keyword(s):  
Soft Tissue ◽  
Predictive Value ◽  
Reticuloendothelial System ◽  
Soft Tissue Tumors ◽  
The Body ◽  
Architectural Patterns ◽  
Cytological Preparation ◽  
Diagnostic Concordance ◽  
Sensitivity Specificity ◽  
A Prospective Study

Background. Soft tissue tumors are defined as nonepithelial extraskeletal tissue of the body exclusive of the reticuloendothelial system, glia, and supporting tissue of various parenchymal organs. The absence of recognizable tissue architectural patterns in cytological preparation makes diagnosis by FNAC more difficult. Aims. To assess the utility of FNAC in diagnosing soft tissue tumors and to determine their patterns compared with with the respective histopathology results. Materials and Methods. 150 cases of soft tissue tumors were included in this study for cytologic and histologic correlation. FNAC air dried smears were stained with Giemsa stain and 95% ethanol fixed smears were stained with Papanicolaou stain. The smears were studied for cytological diagnosis and were categorized as benign, suspicious of malignancy, and malignant along with specific subtyping of the lesion. All diagnostic FNAC results were compared for diagnostic concordance using histology results as the “gold standard.” Results. The sensitivity, specificity, positive predictive value, negative predictive value, and efficiency were 70%, 100%, 97.90%, 100%, and 98%, respectively. P value was <0.0001 which shows statistically extreme significant correlation. Conclusion. FNAC is a very important preliminary diagnostic tool in palpable soft tissue lumps with high degree of correlation with the final histopathology report.

scholarly journals Histopathological study of soft tissue tumours in a tertiary health centre in southern part of Assam

2021 ◽  
Vol 9 (11) ◽  
pp. 3391
Author(s):  
Khadija S. Tapadar ◽  
Manoj K. Deka ◽  
R. N. Chaubey ◽  
Shah A. Sheikh ◽  
Gargi R. Choudhury ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Malignant Tumors ◽  
Soft Tissue Tumors ◽  
The Body ◽  
World Health ◽  
Vascular Tumors ◽  
Benign Tumors ◽  
Peripheral Nerve Sheath Tumors ◽  
Pleomorphic Sarcoma ◽  
Younger Age

Background: Soft tissue tumors are defined as mesenchymal proliferations which occur in the extraskeletal non-epithelial tissues of the body, excluding the viscera, coverings of brain and   lymphoreticular system. The objective of this study was to study the histopathological features of soft tissue tumors and to study the occurrence of soft tissue tumors in relation to age, sex and anatomical site.Methods: This study comprised of 89 cases studied over a period of two years. All soft tissue tumors, their gross features, microscopic findings were analysed in detail. Soft tissue tumors were divided into benign and malignant categories and further sub typing were done according to World Health Organization (WHO) classification. The distribution of soft tissue tumors according to the age, sex and site of occurrence was studied.Results: Out of 89 cases of soft tissue tumors, 76 cases were benign, 4 cases belonged to intermediate category and 9 cases were malignant. Adipocytic tumors formed the largest group constituting 39 cases. Vascular tumors were the second commonest (26 cases) followed by peripheral nerve sheath tumors (11 cases). The benign tumors were seen in younger age as compared to malignant tumors. Malignant soft tissue tumors was seen to be more common in male than female and pleomorphic sarcoma and liposarcoma was commonest (3 cases each).Conclusions: Benign tumors were more common than malignant. The most common benign tumors were lipoma followed by hemangioma and schwannoma. The most common malignant tumor was pleomorphic sarcoma. The benign tumors were seen in younger age as compared to malignant tumors.

scholarly journals Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Cong Yuan ◽  
Xue-Mei Lin ◽  
Yan Ou ◽  
Lin Cai ◽  
Qian Cheng ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Predictive Value ◽  
Underlying Mechanism ◽  
High Definition ◽  
Regular Arrangement ◽  
Gastric Corpus ◽  
H Pylori ◽  
Sensitivity Specificity ◽  
A Prospective Study ◽  
Positive Pattern

Abstract Background The sensitivity of regular arrangement of collecting venules (RAC)-positive pattern for predicting Helicobacter pylori (H. pylori)-negative status greatly altered from 93.8 to 48.0% in recent two decades of various studies, while the reason behind it remained obscure. The aim of this study was to investigate the value of RAC as an endoscopic feature for judging H. pylori status in routine endoscopy and reviewed the underlying mechanism. Methods A prospective study with high-definition non-magnifying endoscopy was performed. RAC-positive and RAC-negative patients were classified according to the collecting venules morphology of the lesser curvature in gastric corpus. Gastric biopsy specimens were obtained from the lesser and greater curvature of corpus with normal RAC-positive or abnormal RAC-negative mucosal patterns. Helicobacter pylori status was established by hematoxylin and eosin staining and immunohistochemistry. Results 41 RAC-positive and 124 RAC-negative patients were enrolled from June 2020 to September 2020. The prevalence of H. pylori infection in patients with RAC-positive pattern and RAC-negative pattern was 7.3% (3/41) and 71.0% (88/124), respectively. Among all 124 RAC-negative patients, 36 (29.0%) patients were H. pylori-negative status. Ten patients (32.3%) demonstrated RAC-positive pattern in 31 H. pylori-eradicated cases. The sensitivity, specificity, positive predictive value, and negative predictive value of RAC-positive pattern for predicting H. pylori-negative status were 51.4% (95% CI, 0.395–0.630), 96.7% (95% CI, 0.900–0.991), 92.7% (95% CI, 0.790–0.981), and 71.0% (95% CI, 0.620–0.786), respectively. Conclusions RAC presence can accurately rule out H. pylori infection of gastric corpus, and H. pylori-positive status cannot be predicted only by RAC absence in routine endoscopy. Trial registration The present study is a non-interventional trial.

scholarly journals Magnetic Resonance Imaging Appearance of Schwannomas from Head to Toe: A Pictorial Review

2017 ◽  
Vol 7 ◽  
pp. 38 ◽  
Author(s):  
Jamie Crist ◽  
Jacob R Hodge ◽  
Matthew Frick ◽  
Fiona P Leung ◽  
Eugene Hsu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
Neurofibromatosis Type ◽  
Soft Tissue Tumors ◽  
The Body ◽  
Resonance Imaging ◽  
Pictorial Review ◽  
Benign Soft Tissue Tumors ◽  
Mri Characteristics

Schwannomas are benign soft-tissue tumors that arise from peripheral nerve sheaths throughout the body and are commonly encountered in patients with neurofibromatosis Type 2. The vast majority of schwannomas are benign, with rare cases of malignant transformation reported. In this pictorial review, we discuss the magnetic resonance imaging (MRI) appearance of schwannomas by demonstrating a collection of tumors from different parts of the body that exhibit similar MRI characteristics. We review strategies to distinguish schwannomas from malignant soft-tissue tumors while exploring the anatomic and histologic origins of these tumors to discuss how this correlates with their imaging findings. Familiarity with the MRI appearance of schwannomas can help aid in the differential diagnosis of soft-tissue masses, especially in unexpected locations.

The Importance of Surgeon-reviewed Computed Tomography for Incisional Hernia Detection: A Prospective Study

2014 ◽  
Vol 80 (7) ◽  
pp. 720-722 ◽  
Author(s):  
Rebeccah B. Baucom ◽  
William C. Beck ◽  
Michael D. Holzman ◽  
Kenneth W. Sharp ◽  
William H. Nealon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Incisional Hernia ◽  
Sensitivity And Specificity ◽  
Predictive Value ◽  
Radiology Report ◽  
Incisional Hernias ◽  
Radiology Reports ◽  
Sensitivity Specificity ◽  
A Prospective Study ◽  
The Cost

Patients with incisional hernias or abdominal pain are frequently referred with abdominal computed tomography (CT) scans. The purpose of this study was to determine the sensitivity and specificity of a CT radiology report for the detection of incisional hernias. General surgery patients with a history of an abdominal operation and a recent viewable abdominal CT scan were enrolled prospectively. Patients with a stoma, fistula, or soft tissue infection were excluded. The results of the radiology reports were compared with blinded, surgeon-interpreted CT for each patient. Testing characteristics including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. One hundred eighty-one patients were enrolled with a mean age of 54 years. Sixty-eight per cent were women. Hernia prevalence was 55 per cent, and mean hernia width was 5.2 cm. The radiology report had a sensitivity and specificity of 79 per cent and 94 per cent, respectively, for hernia diagnosis. The PPV and NPV were 94 and 79 per cent, respectively. Reliance on the CT report alone underestimates the presence of incisional hernia. Referring physicians should not use CT as a screening modality for detection of hernias. Referral to a surgeon for evaluation before imaging may provide more accurate diagnosis and potentially decrease the cost of caring for this population.

scholarly journals Small Subcutaneous Soft Tissue Tumors (<5 cm) Can Be Sarcomas and Contrast-Enhanced Ultrasound (CEUS) Is Useful to Identify Potentially Malignant Masses

2020 ◽  
Vol 17 (23) ◽  
pp. 8868
Author(s):  
Armanda De Marchi ◽  
Simona Pozza ◽  
Lorena Charrier ◽  
Filadelfo Cannone ◽  
Franco Cavallo ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Malignant Tumors ◽  
Univariate Analysis ◽  
Soft Tissue Tumors ◽  
Deep Fascia ◽  
Contrast Enhanced Ultrasound ◽  
Predictive Values ◽  
Contrast Enhanced ◽  
Potentially Malignant ◽  
Sensitivity Specificity

Subcutaneous masses smaller than 5 cm can be malignant, in contrast with the international guidelines. Ultrasound (US) and magnetic resonance imaging (MRI) are useful to distinguish a potentially malignant mass from the numerous benign soft tissue (ST) lesions. Contrast-enhanced ultrasound (CEUS) was applied in ST tumors, without distinguishing the subcutaneous from the deep lesions. We evaluated CEUS and MRI accuracy in comparison to histology in differentiating malignant from nonmalignant superficial ST masses, 50% smaller than 5 cm. Sensitivity, specificity, and positive and negative predictive values (PPV, NPV) with their 95% confidence intervals (CI) were calculated. Of malignant cases, 44.4% measured ≤5 cm. At univariate analysis, no statistically significant differences emerged between benign and malignant tumors in relation with clinical characteristics, except for relationship with the deep fascia (p = 0.048). MRI accuracy: sensitivity 52.8% (CI 37.0, 68.0), specificity 74.1% (CI 55.3, 86.8), PPV 73.1% (CI 53.9, 86.3), and NPV 54.1% (CI 38.4, 69.0). CEUS accuracy: sensitivity 75% (CI 58.9, 86.3), specificity 37% (CI 21.5, 55.8), PPV 61.4% (CI 46.6, 74.3), and NPV 52.6% (CI 31.7, 72.7). CEUS showed a sensitivity higher than MRI, whereas PPV and NPV were comparable. Also, masses measuring less than 5 cm can be malignant and referral criteria for centralization could be revised.

Accuracy of ultrasound in the characterization of superficial soft tissue tumors: a prospective study

2020 ◽  
Vol 49 (6) ◽  
pp. 883-892 ◽  
Author(s):  
Esther H. Y. Hung ◽  
James F. Griffith ◽  
Stefanie W. Y. Yip ◽  
Marina Ivory ◽  
Jeremiah C. H. Lee ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Prospective Study ◽  
Soft Tissue Tumors ◽  
A Prospective Study ◽  
Superficial Soft Tissue

scholarly journals Role of fine needle aspiration cytology in the diagnosis of soft tissue tumors - a prospective study

2019 ◽  
Vol 5 (8) ◽  
pp. 535-541
Author(s):  
Dr. Lakshmi Saraswathi Boni ◽  
◽  
Dr. Sumalatha Kasturi ◽  
Dr. Prasad Uma ◽  
Dr. Bhagyalakshmi Atla ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Prospective Study ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Soft Tissue Tumors ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
A Prospective Study

scholarly journals A young woman with multiple soft tissue tumors in various parts of the body, (Extra Abdominal Fibromatosis and Lymphangioma in both Axillas)

1970 ◽  
Vol 1 (1) ◽  
pp. 29-32
Author(s):  
MD A Kalam ◽  
F Ahmad ◽  
M Hassan ◽  
Md Nasiruddin ◽  
SA Rahman ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Lymphatic System ◽  
Soft Tissue Tumors ◽  
The Body ◽  
Soft Tissue Tumours ◽  
Benign Soft Tissue Tumors ◽  
History Of ◽  
Infiltrative Growth Pattern ◽  
Well Differentiated ◽  
Aggressive Clinical Behavior

The term fibromatosis refers to a group of benign soft tissue tumors (fibromas), which have certain characteristics in common, including absence of cytologic and clinical malignant features, a histology consistent with proliferation of well-differentiated fibroblasts, an infiltrative growth pattern, and aggressive clinical behavior with frequent local recurrence. Lymphangiomas are malformations of the lymphatic system, which is the network of vessels responsible for returning to the venous system of excess fluid from tissues. Here we report a case of 30 years old lady with history of multiple soft tissue tumours in thigh, axilla and abdomen. On physical examination the swelling of the thigh and abdomen were firm and those of axilla were soft. All the tumours were excised surgically and diagnosis of thigh swelling was fibromatosis and that of axilla was lymphangioma, on histopathology.DOI: http://dx.doi.org/10.3329/bdjps.v1i1.6490Bangladesh Journal of Plastic Surgery (2010) Vol. 1 (1) pp.29-32

scholarly journals The First Case Treated with Larotrectinib of a Novel TMTC2-NTRK3 Fusion Undifferentiated High-Grade Pleomorphic Sarcoma of the Chest

2021 ◽  
Author(s):  
Chujie Bai ◽  
Lu Zhang ◽  
Yaohui Wang ◽  
Taiyan Guo ◽  
Xia You ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Clinical Manifestations ◽  
Soft Tissue Tumors ◽  
The Body ◽  
High Grade ◽  
Pleomorphic Sarcoma ◽  
First Case ◽  
Painless Mass ◽  
Almost All ◽  
Next Generation Sequencing Ngs

Abstract Undifferentiated high-grade pleomorphic sarcoma (UPS) is a rare soft tissue sarcoma (STS) of mesenchymal origin, particularly the extremities and retroperitoneum, meanwhile it has been reported in almost all parts of the body. UPS is highly invasive and has a poor prognosis due to its clinical manifestations of painless mass and deep tumor site, which are usually found at an advanced stage. Patients with UPS tend to have a lower 5-year survival rate than patients with other types of STS. Recently, NTRK fusions were detected in many cancer types, such as thyroid cancer, colorectal cancer, non-small cell lung cancer, soft tissue tumors, uterine sarcomas, and melanomas. However, the mutation frequency of NTRK fusion in all cancers is only 0.1-1%. Targeted therapy with NTRK inhibitors, such as Larotrectinib and Entrectinib, leads to a response in most patients with NTRK1/2/3 gene fusion-positive tumors. Herein, we present a 68-years old man diagnosed with stage IIIA (T2N0M0G3) UPS. Next-generation sequencing (NGS) revealed a novel TMTC2-NTRK3 fusion. The NTRK3 positivity was also detected by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). He had a response to Larotrectinib. This report broadens the spectrum of NTRK fusions in UPS and highlights a new target for treatment.

scholarly journals Scope of FNAC in the diagnosis of soft tissue tumors-A study from a tertiary cancer referral center in India

CytoJournal ◽  
2007 ◽  
Vol 4 ◽  
pp. 20 ◽  
Author(s):  
Bharat Rekhi ◽  
Biru D Gorad ◽  
Anagha C Kakade ◽  
RF Chinoy
Keyword(s):  
Soft Tissue ◽  
Predictive Value ◽  
False Positive ◽  
Spindle Cell ◽  
Soft Tissue Tumors ◽  
Diagnostic Tools ◽  
Round Cell ◽  
Cell Type ◽  
Metastatic Lesions ◽  
Spindle Cell Type

Background Fine needle aspiration cytology (FNAC) forms one of the first diagnostic tools in the evaluation of tumors. Its role in diagnosing soft tissue tumors (STT) has been fairly documented, as well as debated. Present study was aimed at evaluating its scope in diagnosing 127 cases of soft tissue tumors. Methods Conventional Pap and MGG staining was available in all the cases. Immunocytochemistry (ICC) was performed in 15 cases. Histopathological details were available in 115 cases. Results 50% cases were referred for a primary diagnosis, while 26.8% & 22.8% cases were evaluated for recurrent and metastatic lesions, respectively. Extremities were the commonest sites. On FNAC, 101 cases (79.5%) were labeled as malignant, whereas 10 cases (7.9%) were labeled as benign. The remaining 16 cases (11%) were not categorized and were labeled as ‘unsure/not specified’. Histopathological confirmation in 115 cases, gave a diagnostic accuracy of 98%, with a positive predictive value of 98% in malignant cases and a negative predictive value of 100% in benign cases. Two cases were false positive. Among the various cytological categories, 60 cases (47.2%) were of spindle cell type, followed by 32 (25.2%) of round cell type and 14 cases (11%) of lipomatous type. Other 12 cases (9.4%) were of pleomorphic type; 7 (5.5%) cases of epithelioid type and remaining 2 cases were of myxoid type. All the round cell, pleomorphic and myxoid type of tumors were sarcomas, whereas 73.3% cases of spindle cell type were labeled as ‘malignant’. Exact cytological sub typing was offered in 58 cases, with rhabdomyosarcoma (RMS) as the most frequently sub typed tumor. The two false positive malignant cases were of fibromatosis and a pigmented schwannoma, on biopsy. Out of 28 metastatic lesions, lymph nodes were the commonest site for metastasis, with epithelioid tumors that formed highest percentage of metastatic cases. Conclusion FNAC is fairly specific and sensitive in STT diagnoses for primary, recurrent and metastatic lesions. The cytological types, especially round cell and pleomorphic sarcomas, can be quickly identified. Clinicopathological correlation with ICC as an adjunct, are valuable in exact sub typing.

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