scholarly journals Major Congenital Malformations in Barbados: The Prevalence, the Pattern, and the Resulting Morbidity and Mortality

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Keerti Singh ◽  
Kandamaran Krishnamurthy ◽  
Camille Greaves ◽  
Latha Kandamaran ◽  
Anders L. Nielsen ◽  
...  
Keyword(s):  
Congenital Malformations ◽  
Circulatory System ◽  
Neonatal Morbidity ◽  
Population Based ◽  
Morbidity And Mortality ◽  
Queen Elizabeth Hospital ◽  
Population Based Study ◽  
Live Births ◽  
Major Congenital Malformations ◽  
The Individual

Objectives. To study the prevalence and the pattern of major congenital malformations and its contribution to the overall perinatal morbidity and mortality. Methods. It is a retrospective population based study. It includes all major congenital malformations in newborns during 1993-2012. The data was collected from the birth register, the neonatal admission register and the individual patient records at the Queen Elizabeth Hospital where over 90% of deliveries take place and it is the only facility for the care of sick newborns in this country. Results. The overall prevalence of major congenital malformations among the live births was 59/10,000 live births and that among the stillbirths was 399/10,000 stillbirths. Circulatory system was the most commonly affected and accounted for 20% of all the major congenital malformations. Individually, Down syndrome (4.1/10, 000 live births) was the commonest major congenital malformation. There was a significant increase in the overall prevalence during the study period. Major congenital malformations were responsible for 14% of all neonatal death. Conclusions. Less than 1% of all live newborns have major congenital malformations with a preponderance of the malformations of the circulatory system. Major congenital malformations contribute significantly to the overall neonatal morbidity and mortality in this country.

Preterm birth in pregnancies complicated by major congenital malformations: a population-based study

2008 ◽  
Vol 199 (3) ◽  
pp. 287.e1-287.e8 ◽  
Author(s):  
Stephanie E. Purisch ◽  
Emily A. DeFranco ◽  
Louis J. Muglia ◽  
Anthony O. Odibo ◽  
David M. Stamilio
Keyword(s):  
Preterm Birth ◽  
Congenital Malformations ◽  
Population Based ◽  
Population Based Study ◽  
Major Congenital Malformations

scholarly journals 984 Population-Based Study to Evaluate the Neonatal Morbidity and Mortality in Maternal Diabetes

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A281-A282
Author(s):  
A. Lange ◽  
R. Spoo ◽  
R. Thyrian ◽  
W. Hoffmann ◽  
H. Lode ◽  
...  
Keyword(s):  
Neonatal Morbidity ◽  
Maternal Diabetes ◽  
Population Based ◽  
Morbidity And Mortality ◽  
Population Based Study

scholarly journals Epidemiology of congenital upper limb anomalies in Korea: A nationwide population-based study

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248105
Author(s):  
Young Ho Shin ◽  
Goo Hyun Baek ◽  
Ye-Jee Kim ◽  
Min-ju Kim ◽  
Jae Kwang Kim
Keyword(s):  
Surgical Treatment ◽  
Upper Limb ◽  
Circulatory System ◽  
Population Based ◽  
Population Based Study ◽  
Live Births ◽  
National Healthcare ◽  
Limb Anomalies ◽  
The Mean ◽  
Limb Deficiency

This study aimed to analyze the epidemiology of congenital upper limb anomalies (CULA) in Korea. We evaluated the incidence of each type of CULA, the presence of coexisting anomalies and the surgical treatment status in CULA patients. We conducted a retrospective cohort study of patients aged < 1 year between 2007 and 2016 who were registered with CULA in the Health Insurance Review and Assessment Service of Korea. In total, 10,704 patients had CULA, including 6,174 boys (57.7%) and 4,530 girls (42.3%). The mean annual incidence of CULA was 23.5 per 10,000 live births; it was significantly higher in boys than in girls (26.3 vs. 20.5, p < 0.001). Among the four categories of CULA—polydactyly, syndactyly, limb deficiency, and other anomalies—polydactyly was the most common. In total, 4,149 patients (38.8%) had other congenital anomalies and coexisting anomalies of the circulatory system (24.9%) were the most common. In total 4,776 patients (44.6%) underwent operative treatment for CULA within minimum three years of the diagnosis. The proportion of patients who underwent surgical treatment was significantly higher for polydactyly (73.4% vs. 16.8%, p < 0.001) and syndactyly (65.3% vs. 41.5%, p < 0.001), but it was significantly lower in limb deficiency (27.6% vs. 45.4%, p < 0.001) and other anomalies (10.0% vs. 69.8%, p < 0.001) than rest of CULA patients. Among the patients who had operations, 21.5% underwent multiple operations. The proportion of patients who underwent multiple operations was significantly higher in syndactyly (35.6% vs. 18.1%, p < 0.001), but it was significantly lower in polydactyly (4.0% vs. 95.5%, p < 0.001) and other anomalies (17.9% vs. 21.9%, p < 0.001) than rest of CULA patients. These results could provide a basis for estimating the national healthcare costs for CULA and the required number of CULA specialists.

Use of Nimesulide During Early Pregnancy and the Risk of Congenital Malformations: A Population-Based Study from Italy

2018 ◽  
Vol 35 (7) ◽  
pp. 981-992 ◽  
Author(s):  
Anna Cantarutti ◽  
Matteo Franchi ◽  
Federico Rea ◽  
Luca Merlino ◽  
Giovanni Corrao
Keyword(s):  
Early Pregnancy ◽  
Congenital Malformations ◽  
Population Based ◽  
Population Based Study

scholarly journals Gastroschisis in Finland 1993 to 2014—Increasing Prevalence, High Rates of Abortion, and Survival: A Population-Based Study

2019 ◽  
Vol 30 (06) ◽  
pp. 536-540
Author(s):  
Arimatias Raitio ◽  
Asta Lahtinen ◽  
Johanna Syvänen ◽  
Teemu Kemppainen ◽  
Eliisa Löyttyniemi ◽  
...  
Keyword(s):  
Infant Mortality ◽  
Live Birth ◽  
Survival Rates ◽  
Population Based ◽  
Good Prognosis ◽  
Associated Anomalies ◽  
Population Based Study ◽  
Birth Prevalence ◽  
Live Births ◽  
Total Prevalence

Abstract Introduction The study aims to assess the changes in prevalence and mortality of gastroschisis, and to identify associated anomalies. Materials and Methods It is a population-based nationwide study. All gastroschisis cases were identified in the Finnish Register of Congenital Malformations and the Care Register for Health Care from 1993 to 2014 including live births, stillbirths, and terminations of pregnancy due to fetal anomalies. Associated anomalies were recorded, and analyzed, and prevalence and infant mortality were calculated. Results There were 320 cases of gastroschisis; 235 (73%) live births, 16 (5%) stillbirths, and 69 (22%) terminations of pregnancy. Live birth prevalence of gastroschisis in Finland was lower than generally reported (1.73 in 10,000). However, due to relatively high rates of abortion, our total prevalence of 2.57/10,000 was similar with other reports. The most common risk factor was young maternal age. Babies with gastroschisis were born prematurely, on average on the 36th week and most are delivered by caesarean section. There was a significant increasing trend in live birth prevalence (p = 0.0018). Overall infant mortality was 7.7% (18/235), 7.2% (16/222) in simple gastroschisis and 15% (2/13) in complex gastroschisis. Associated anomalies were rare both in aborted fetuses and neonates, and there was only one case with a chromosomal abnormality. Conclusion Gastroschisis is usually an isolated anomaly with increasing birth prevalence and excellent survival rates. Regardless of the good prognosis, the abortion rates in Finland are higher than previously reported, and we hypothesize this to be due to lack of appropriate antenatal counselling.

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