scholarly journals Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Yung-An Tsou ◽  
Hung-Jin Huang ◽  
Tang-Chuan Wang ◽  
Chih-Jaan Tai ◽  
Chuan-Mu Chen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Inverted Papilloma ◽  
Immunohistochemical Method ◽  
Ki 67 ◽  
Sinonasal Inverted Papilloma ◽  
Multiple Recurrences

The recurrent sinonasal inverted papilloma (IP) could be transformed to sinonasal squamous cell carcinoma. We use protein expression patterns by immunohistochemical method to see whether the expression of p53, p16, p21, and p27 belongs to cell-cycle-regulators and PCNA (proliferating cell nuclear antigen) and Ki-67 the proliferation markers in sixty patients with sinonasal inverted papilloma, and 10 of them with squamous cell carcinoma transformation. Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed. No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expression was correlated to sinonasal IP malignant transformation by multivariate survey. However, we found elevated PLUNC expression in IPs with multiple recurrences. Finally, we found that PCNA, p27 may interact with CDK1 which promote IP cell proliferation and correlate to sinonasal squamous cell carcinoma. Ki-67 could work throughout the cell cycles to cause malignant transformation. In conclusion, this is a first study showing the correlation of Ki-67, PCNA interacted with CDK1 might lead to malignant transformation. Elevated PLUNC expression in the sinonasal IPs was related to multiple recurrences in human.

scholarly journals Putative biomarkers of malignant transformation of sinonasal inverted papilloma into squamous cell carcinoma

2019 ◽  
Vol 47 (6) ◽  
pp. 2371-2380 ◽  
Author(s):  
Zheng Yang ◽  
Yang Zhang ◽  
Xiangdong Wang ◽  
Junwei Huang ◽  
Wei Guo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Inverted Papilloma ◽  
Gene Promoters ◽  
Tissue Samples ◽  
Sinonasal Inverted Papilloma ◽  
Genome Wide

Objective To compare genome-wide DNA methylation between samples of sinonasal inverted papilloma (SNIP) and squamous cell carcinoma (SCC) samples in order to identify aberrantly methylated genes that might be involved in malignant transformation. Methods Tissue samples were collected from patients. DNA methylation in C-phosphate-G islands and gene promoters was analysed using a DNA methylation microarray kit. The levels of mRNA or protein from aberrantly methylated genes were measured using real-time polymerase chain reaction or Western blot analysis. Results A total of 27 tissue samples were included in this study; 15 SNIP samples and 12 SCCs arising in SNIPs. A total of 11 201 nominally differentially methylated sites were observed between SNIP and SCC arising in SNIPs. Six sites were significantly different at P < 0.01 and contained three genes ( MIR661, PLEC and OPA3). These three genes were hypermethylated. In addition, the levels of mature miR-661 mRNA and PLEC protein were significantly upregulated in SCC tissues compared with SNIP samples. The levels of OPA3 protein were downregulated in SCC tissues compared with SNIP samples. Conclusions This study demonstrated hypermethylation and abnormal expression of the MIR661, PLEC and OPA3 genes, suggesting a role for their involvement in the malignant transformation of SNIP.

Sinonasal inverted papilloma involving the temporal bone via the eustachian tube: case report

2013 ◽  
Vol 127 (3) ◽  
pp. 318-320 ◽  
Author(s):  
Z W Liu ◽  
A Walden ◽  
C A Lee
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Temporal Bone ◽  
Eustachian Tube ◽  
Squamous Cell ◽  
Inverted Papilloma ◽  
Subsequent Transformation ◽  
Sinonasal Inverted Papilloma ◽  
Pubmed Search ◽  
Inverted Papillomas

AbstractObjective:This study reports a case of a sinonasal inverted papilloma with spread to the temporal bone via the eustachian tube and subsequent transformation to squamous cell carcinoma.Method:An 81-year-old woman presented with sinonasal inverted papilloma which subsequently spread to the ear. A literature review of inverted papilloma was carried out based on a Pubmed search of studies published between 1987 and 2011, using the key words ‘sinonasal inverted papilloma’, ‘temporal bone inverted papilloma’ and ‘squamous cell carcinoma’.Results and conclusion:Sinonasal and temporal bone inverted papillomas may sometimes be linked through direct spread via the eustachian tube. Inverted papillomas have the potential for malignant transformation; careful monitoring of both the nose and ear is therefore required for inverted papillomas found in the nasopharynx.

Clinical value of serum squamous cell carcinoma antigen in the management of sinonasal inverted papilloma

Head & Neck ◽  
2004 ◽  
Vol 27 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Ryuji Yasumatsu ◽  
Torahiko Nakashima ◽  
Muneyuki Masuda ◽  
Yuichiro Kuratomi ◽  
Hideki Shiratsuchi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inverted Papilloma ◽  
Squamous Cell Carcinoma Antigen ◽  
Clinical Value ◽  
Sinonasal Inverted Papilloma

scholarly journals Immunohistochemical Expression of EGFR, NF-kB and Cyclin D1 in Sinonasal Inverted Papilloma and Squamous Cell Carcinoma

2020 ◽  
Vol 12 (3) ◽  
pp. 239-44
Author(s):  
Pudji Rahaju ◽  
Rio Auricknaga Kintono ◽  
Ahmad Dian Wahyudiono ◽  
Arif Satria ◽  
Ferry Sandra
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Neck Surgery ◽  
Cross Sectional Study ◽  
Inverted Papilloma ◽  
Cross Sectional ◽  
Sinonasal Inverted Papilloma

BACKGROUND: Sinonasal inverted papilloma (SIP), a benign epithelial growth in the sinonasal region with epidermoid epithelial transformation, has been known for its invasiveness, recurrency, and its link with malignancy. Meanwhile sinonasal squamous cell carcinoma (SSCC) is an epithelial malignancy on squamous cells from the sinonasal region. Epidermal growth factor receptor (EGFR), Nuclear Factor kB (NF-kB), and Cyclin D1 are factors those might play important role in proliferation of SIP and SSCC. This research was conducted to investigate the expressions of EGFR, NF-kB and Cyclin D1 in SIP and SSCC.METHODS: A cross-sectional study by examining the EGFR, NF-kB, and Cyclin D1 immunohistochemical expressions of SIP and SSCC was conducted. Subjects whose blocks were used in this research, were diagnosed as SIP and SSCC at the Otorhinolaryngology-Head and Neck Surgery Clinic, Dr. Saiful Anwar General Hospital. Samples were selected, processed for inmmunohistochemistry, evaluated and statistical analyzed.RESULTS: Twenty-four SIP and 9 SSCC subjects with their paraffin blocks were selected. Clear immunohistochemical expressions of EGFR, NF-kB, and Cyclin D1 were observed for both SIP and SSCC. Significantly higher immunostaining levels of EGFR (45.6%, p=0.001) and NF-kB (42.2%, p=0.013) were observed in SSCC. Immunostaining levels of EGFR vs. NF-kB were moderately correlated (p=0.03, r=0.437), while the immunostaining levels of NF-kB vs. Cyclin D1 were strongly correlated (p=0.002, r=0.602).CONCLUSION: Expression of EGFR and NF-kB in SSCC were higher than the EGFR and NF-kB expression in SIP, suggesting that EGFR and NF-kB play important role in sinonasal malignancy.KEYWORDS: sinonasal, inverted papilloma, SCC, EGFR, NF-kB, Cyclin D1

scholarly journals Epiphora as a sign of unexpected underlying squamous cell carcinoma within sinonasal inverted papilloma

2020 ◽  
Vol 4 (1) ◽  
pp. 038-040
Author(s):  
Di Maria Alessandra ◽  
Confalonieri Filippo ◽  
Piscopo Raffaele ◽  
Balia Laura ◽  
Malvezzi Luca
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma

scholarly journals Role of p53 and Ki-67 immunomarkers in oral premalignant lesions and squamous cell carcinoma: a hospital based study in BPKIHS

2018 ◽  
Vol 8 (2) ◽  
pp. 1330-1336 ◽  
Author(s):  
Mona Dahal ◽  
Smriti Karki ◽  
Paricha Upadhyaya ◽  
Shyam Thapa Chettri ◽  
Mehul Rajesh Jaisani
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Labelling Index ◽  
Premalignant Lesion ◽  
Premalignant Lesions ◽  
Ki 67

Background: As most of the oral squamous cell carcinoma develop from precursor premalignant lesions, it would be helpful if the malignant transformation is detected early in premalignant state. The objective of the research was to study the role of immunohistochemical expression of p53 and Ki-67 in oral premalignant lesion and squamous cell carcinoma.Materials and Methods: The expression of immunomarkers p53 and Ki67 were studied on formalin fixed paraffin embedded tissue sections from human oral squamous mucosal lesion for duration of 1 year. Results: Of total 36 cases, 80% cases of keratosis without dysplasia showed basal pattern of p53 staining while 47.1% cases of squamous cell carcinoma showed p53 staining in all layers of epithelium. The median p53 Labelling Index of squamous cell carcinoma was more than those of keratosis with and without dysplasia though the result was statistically non-significant. 50.0% cases of keratosis without dysplasia and 83.3% cases of keratosis with dysplasia displayed Ki-67 immunostaining confined to basal and suprabasal layer whereas 94.1% cases of squamous cell carcinoma showed Ki-67 positivity in all layers of epithelium. Median Ki-67 Labelling Index increased from keratosis without dysplasia to keratosis with dysplasia to squamous cell carcinoma, difference being statistically significant. A positive and insignificant correlation was observed between p53 and Ki-67 Labelling Index.Conclusion: Increased expressions of Ki-67 and p53 in oral squamous cell carcinoma compared to premalignant lesion suggest that they may be useful indicator of malignant transformation in dysplastic lesion.

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