scholarly journals Angiogenesis and Proliferation Index in Patients with Acute Leukemia: A Prospective Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Prabhavati Jothilingam ◽  
Debdatta Basu ◽  
Tarun K. Dutta
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Acute Leukemia ◽  
Prospective Study ◽  
Microvessel Density ◽  
Lymphoblastic Leukemia ◽  
Proliferation Index ◽  
Ki 67 ◽  
A Prospective Study ◽  
The Relationship

Angiogenesis and proliferation as measured by microvessel density (MVD) and proliferation index (PI) are essential correlates of malignancy. The aim of our study was to evaluate difference between these values in AML and ALL and also to study the modulation in these parameters following achievement of remission in acute lymphoblastic leukemia. Differences between adult and adolescent cases of acute leukemia in relation to these values were also studied. We also tried to assess the relationship between angiogenesis and proliferation. Fifty-five patients with acute leukemia were included in the study. Trephine biopsies were immunostained with CD34 and factor VIIIrAg to demonstrate angiogenesis measured as MVD. Immunostaining with PCNA and Ki-67 was done to study proliferation. We found a significant increase in MVD and PI in cases when compared with controls (P<0.0001). In addition cases with ALL had a significantly higher MVD compared to those with AML (P<0.01). The patients with ALL who went into remission showed a significant reduction in MVD; PI remained high. The cases which did not achieve remission showed no significant reduction in either MVD or PI. All adolescent cases of ALL were similar to adults with respect to MVD and PI.

scholarly journals A prospective study on drug monitoring of PEGasparaginase and Erwinia asparaginase and asparaginase antibodies in pediatric acute lymphoblastic leukemia

Blood ◽  
2014 ◽  
Vol 123 (13) ◽  
pp. 2026-2033 ◽  
Author(s):  
Wing H. Tong ◽  
Rob Pieters ◽  
Gertjan J. L. Kaspers ◽  
D. Maroeska W. M. te Loo ◽  
Marc B. Bierings ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Prospective Study ◽  
Lymphoblastic Leukemia ◽  
Activity Levels ◽  
Pediatric Acute Lymphoblastic Leukemia ◽  
E Coli ◽  
Key Points ◽  
Asparaginase Activity ◽  
Erwinia Asparaginase ◽  
A Prospective Study

Key Points Use of native E coli asparaginase in induction leads to high hypersensitivity rates to PEGasparaginase in intensification. Switching to Erwinia asparaginase leads to effective asparaginase activity levels in most patients who experienced an allergy to PEGasparaginase.

Immunophenotypic study of acute lymphoblastic leukemia (a prospective study in Brazilian children)

1998 ◽  
Vol 31 (3) ◽  
pp. 185-186 ◽  
Author(s):  
Maria Helena Ornellas de Souza ◽  
Hilda Rachel Diamond ◽  
Marcia P.E. Santos ◽  
Maria Luiza M. Silva ◽  
Alice Maria B. de Azevedo ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Prospective Study ◽  
Lymphoblastic Leukemia ◽  
A Prospective Study ◽  
Brazilian Children

Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: A prospective study

Bone ◽  
2011 ◽  
Vol 48 (3) ◽  
pp. 571-577 ◽  
Author(s):  
M.L. te Winkel ◽  
S.M.P.F. de Muinck Keizer-Schrama ◽  
R. de Jonge ◽  
R.D. van Beek ◽  
I.M. van der Sluis ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Bone Density ◽  
Prospective Study ◽  
Lymphoblastic Leukemia ◽  
Pediatric Acute Lymphoblastic Leukemia ◽  
Germline Variation ◽  
A Prospective Study

scholarly journals Correlation of Serum Lipoproteins with the Activity of Acute Lymphoblastic Leukaemia

2019 ◽  
Vol 13 (2) ◽  
pp. 59-62
Author(s):  
Azher Sebieh Al-Zubaidy
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Acute Leukemia ◽  
Lipid Profile ◽  
Lymphoblastic Leukemia ◽  
Density Lipoprotein ◽  
Inverse Correlation ◽  
Serum Levels ◽  
Serum Lipoproteins ◽  
Serum Triglycerides ◽  
A Prospective Study

Background: the activity of acute lymphoblastic leukemia had been observed to correlate with levels of serum lipoproteins Objective: to evaluate the correlation of serum levels of different types of lipoproteins with activity of the disease in patients with acute lymphoblastic leukemia. Type of the study: A prospective study. Methods: A study included patients diagnosed as acute lymphoblastic leukemia, their serum levels of lipoproteins at time of diagnosis, and on relapse were obtained for comparison. Results: there is significant inverse correlation of activity of acute lymphoblastic leukemia with serum total cholesterol, serum low density cholesterol levels, and serum high density lipoprotein level, but not with serum triglycerides level. Conclusion:. The level of lipid profile is inversely correlated with activity of acute leukemia, and lipid profile assessment is recommended in evaluation of patients with acute leukemia .

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