scholarly journals Primary Burkitt Lymphoma of the Fourth Ventricle in an Immunocompetent Young Patient

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Abdulrahman Alabdulsalam ◽  
Syed Z. A. Zaidi ◽  
Imran Tailor ◽  
Yasser Orz ◽  
Sadeq Al-Dandan
Keyword(s):  
Burkitt Lymphoma ◽  
Cranial Nerves ◽  
High Dose ◽  
Rare Entity ◽  
Diagnostic Challenge ◽  
Dose Methotrexate ◽  
The Central Nervous System ◽  
Blue Cell ◽  
The Brain ◽  
4Th Ventricle

Primary Burkitt lymphoma of the central nervous system (CNS) is rare, with only few cases reported in the literature. An 18 year-old immunocompetent male presented with multiple cranial nerves palsies and was found to have a mass predominantly in the 4th ventricle of the brain. Tumor was surgically removed and showed morphological and immunohistochemical features consistent with Burkitt lymphoma. The patient responded very well to anthracycline based chemotherapy with high dose methotrexate (HD MTX) and intrathecal (IT) chemotherapy delivered by Ommaya reservoir. Primary Burkitt lymphoma of the CNS is a rare entity that poses differential diagnostic challenge with other small round blue cell tumors.

In and Out of the Central Nervous System

2016 ◽  
Author(s):  
Michael J. Aminoff
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Experimental Approach ◽  
Cranial Nerves ◽  
Motor Functions ◽  
System P ◽  
The Central Nervous System ◽  
Experimental Findings ◽  
The Brain

In 1811, Bell had printed privately a monograph titled Idea of a New Anatomy of the Brain. In it, Bell correctly showed that the anterior but not the posterior roots had motor functions. François Magendie subsequently showed that the anterior roots were motor, and the posterior roots were sensory. This led to a dispute about priority during which Bell republished some of his early work with textual alterations to support his claims. Bell was involved in a similar dispute with Herbert Mayo concerning the separate functions of the fifth (sensory) and seventh (motor) cranial nerves, and Mayo today is a forgotten man. In both instances, Bell deserves credit for the concepts and initial experimental approach, and Magendie and Mayo deserve credit for obtaining and correctly interpreting the definitive experimental findings.

Normal computed tomograms of the brain in osteosarcoma patients treated with high-dose methotrexate

Cancer ◽  
1981 ◽  
Vol 47 (7) ◽  
pp. 1762-1765 ◽  
Author(s):  
Debbie Bowles ◽  
Charles Pratt ◽  
William Evans ◽  
Robert A. Price ◽  
Thomas Coburn
Keyword(s):  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate ◽  
The Brain

Addition of Rituximab to High-Dose Methotrexate-Based Chemotherapy Improves Survival of Adults with Burkitt Lymphoma/Leukemia

2012 ◽  
Vol 127 (2) ◽  
pp. 115-117 ◽  
Author(s):  
Dino Dujmovic ◽  
Igor Aurer ◽  
Ivo Radman ◽  
Ranka Serventi-Seiwerth ◽  
Snjezana Dotlic ◽  
...  
Keyword(s):  
Burkitt Lymphoma ◽  
High Dose ◽  
High Dose Methotrexate ◽  
Dose Methotrexate

scholarly journals EPIDEMIOLOGY AND SURVIVAL OF PATIENTS WITH MALIGNANT TUMORS OF THE BRAIN (C71). POPULATION-BASED STUDY

2020 ◽  
Vol 66 (5) ◽  
pp. 489-499
Author(s):  
Vakhtang Merabishvili ◽  
Kalyango Kennet ◽  
M. Valkov ◽  
Andrey Dyachenko
Keyword(s):  
Malignant Tumors ◽  
Cranial Nerves ◽  
Cancer Registries ◽  
Population Based ◽  
Malignant Neoplasms ◽  
Incidence And Mortality ◽  
Icd 10 ◽  
The Central Nervous System ◽  
First Time ◽  
The Brain

Malignant neoplasms of the brain (BMN) in accordance with the international classification of the diseases (ICD-10) belong to the rubric C71. However, in the world and Russia it is customary to understand this term as the entire block of localizations related to the brain - rubrics C70-71. The topographic codes C70 (meninges), C71 (brain) and C72 (spinal cord, cranial nerves and other parts of the central nervous system) make up a small proportion among MN in general. In addition, all the summary data WHO-IARC and Russia as a rule aggregate the CNS tumors under the three heading ICD - 10 (ICDO-3) C70-72. With the developments in Russia of the system of Population cancer registries, it became possible to study the patterns of dynamics of incidence and to calculate the survival rate of patients with malignant necrosis in each ICD-10 section. This study presents the population-based analysis of incidence and mortality from BMN using available sources and, for the first time in Russia, the analysis of the dynamics of the survival among the patients with BMN under the rubric C71 is performed.

scholarly journals Unusual Presentation of Neurocysticercosis: Report of Two Cases

2005 ◽  
Vol 2 (1) ◽  
pp. 85-89 ◽  
Author(s):  
Ghanashyam Gurung ◽  
Bhiva Shrestha ◽  
Tilak C. Shah ◽  
Laxman R. Pokhrel ◽  
Geeta Sayami ◽  
...  
Keyword(s):  
Public Health ◽  
Central Nervous System ◽  
Developing Nations ◽  
Cystic Mass ◽  
Parasitic Infestation ◽  
Imaging Studies ◽  
Frequent Finding ◽  
The Central Nervous System ◽  
The Brain ◽  
4Th Ventricle

Neurocysticercosis (NCC) is the most common parasitic infestation of the central nervous system, and is one of the major public health problems in developing nations like Nepal. On imaging studies, NCC usually demonstrates multiple parenchymal ring enhancing lesions in the gray white matter interface of the brain, though presence of nonenhancing vesicles with scolex or calcified dots is also a frequent finding. Co-existence of brain abscess and neurocysticercosis is a rarity. Presentation of NCC in the form of a large cystic mass in the 4th ventricle is also unusual. Here, we present these unusual cases of neurocysticercosis, which remained in their masks until they were surgically explored and microscopically unveiled! Nepal Journal of Neuroscience, Volume 2, Number 1, 2005, Page: 85-89

scholarly journals A Case of Bing–Neel Syndrome Successfully Treated with Ibrutinib

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Daniel S. O’Neil ◽  
Mark A. Francescone ◽  
Karen Khan ◽  
Alobeid Bachir ◽  
Owen A. O’Connor ◽  
...  
Keyword(s):  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
High Dose ◽  
Lambda Light Chain ◽  
Waldenström Macroglobulinemia ◽  
Dose Methotrexate ◽  
Nerve Sheath ◽  
Waldenstrom Macroglobulinemia ◽  
Rare Manifestation ◽  
The Central Nervous System

Bing–Neel syndrome is a rare manifestation of Waldenström macroglobulinemia characterized by lymphoplasmacytic cells’ infiltration into the central nervous system. We present a case of a 74-year-old patient with a known diagnosis of Waldenström macroglobulinemia and newly depressed consciousness. Flow cytology of his cerebral spinal fluid demonstrated a lambda light chain-restricted population of B-cells consistent with a CD5+ CD10+ B-cell lymphoma. Magnetic resonance imaging suggested involvement of the left optic nerve sheath and the bilateral orbital and parietal parenchyma and leptomeninges. He was diagnosed with Bing–Neel syndrome and treated with intrathecal liposomal cytarabine, intravenous high-dose methotrexate, and rituximab without improvement. Subsequently, he started treatment with ibrutinib 560 mg daily and concurrent rituximab. Within three months, he showed clinical and radiologic improvement. The patient has continued on ibrutinib and has now been stable for over 36 months. This represents the longest reported period of successful treatment of Bing–Neel syndrome with ibrutinib.

scholarly journals An unusual headache: CSF negative APML relapse in the brain

2020 ◽  
Vol 2020 (9) ◽  
Author(s):  
Thomas Quinn ◽  
Manish Jain ◽  
Ming-Te Lee
Keyword(s):  
Diagnostic Delay ◽  
Diagnostic Challenge ◽  
Cerebrospinal Fluid Analysis ◽  
Fluid Analysis ◽  
Diagnostic Difficulties ◽  
The Central Nervous System ◽  
High Degree ◽  
The Brain ◽  
Post Therapy

ABSTRACT Acute Promyelocytic Leukaemia (APML) is a subtype of Acute Myeloid Leukaemia (AML), responsible for around 10% of cases of the disease in adults. Extra medullary disease (EMD) occurs infrequently in APML, but where EMD does occur, the central nervous system is one of the most commonly infiltrated sites. Our case describes a man in his 40s undergoing post-therapy surveillance for APML who presented to follow-up clinic with a headache, which was ultimately found to be caused by a tumour comprised of APML cells. His case presented a diagnostic challenge due to the benign appearances of the lesion on initial computed tomography brain imaging and the non-diagnostic cerebrospinal fluid analysis. The diagnostic difficulties described in our case emphasizes that clinicians working with APML patients must approach new neurological symptoms with a high degree of suspicion to prevent diagnostic delay.

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