scholarly journals Prevalence of Gastroesophageal Reflux Disease in Type II Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Huihui Sun ◽  
Lisha Yi ◽  
Ping Wu ◽  
Yingjie Li ◽  
Bin Luo ◽  
...  

Background/Aims. Patients with type II diabetes mellitus (DM) were known to have higher prevalence of gastroesophageal reflux disease (GERD) in the Western countries, but data on the impact of GERD on DM patients in our country are scarce. The aim of this study was to evaluate the prevalence of GERD in type II DM patients in Shanghai, China, and to explore its possible risk factors.Methods. 775 type II DM cases were randomly collected. Reflux Disease Questionnaire (RDQ) was used to check the presence of GERD. Patients’ characteristics, laboratory data, face-to-face interview, nerve conduction study, and needle electromyogram (EMG) test were analyzed.Results. 16% patients were found with typical GERD symptoms. Pathophysiological factors such as peripheral neuropathy, metabolism syndrome, and obesity were found to have no significant differences between GERD and non-GERD type II DM patients in the present study.Conclusion. The prevalence of GERD in type II DM patients is higher than that in adult inhabitants in Shanghai, China. No difference in pathophysiological factors, such as peripheral neuropathy, and metabolism syndrome was found in DM-GERD patients, suggesting that further study and efforts are needed to explore deeper the potential risk factors for the high prevalence rate of GERD in DM patients.

2020 ◽  
Vol 1 ◽  
pp. 27-34 ◽  
Author(s):  
Aleksey Oparin ◽  
Anton Kudriavtsev ◽  
Anatoliy Oparin

Diabetes mellitus is one of the most serious problems of the clinical medicine. This is determined by the fact that it is followed by multisystemic affects, as well as complications on the side of other organs and systems, among which a special place is occupied by gastroesophageal reflux disease. As for the combination and mutual influence of diabetes mellitus and gastroesophageal reflux disease, this issue has not been studied yet, the data of modern literature are not complete and quite contradictory. The aim of the study: to investigate the state of the factors of aggression and protection of the oesophageal mucosa in patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease without associated pathology. Method. There were two groups of patients under observation. The first group included 45 patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease (26 men and 19 women). The second group included 38 patients with gastroesophageal reflux disease without associated pathology – 20 men and 18 women. By sex, age, body weight, Helicobacter pylori infection, smoking and alcohol consumption, both groups were comparable. The surveillance program included determining the compensation ratio of carbohydrate metabolism and the state of the factor. The antioxidant protection factor was assessed by the level of catalase activity in the blood serum, as well as by the diameter of the celiac trunk and the blood flow velocity in it. Statistical processing of the obtained data was carried out with the aid of the program WINDOWS STATISTIKA 6.0. For all types of analysis, differences were considered statistically significant with p<0.05. Results. During the study, we found that in patients with diabetes mellitus type II with concomitant gastroesophageal reflux disease, as well as in patients with gastroesophageal reflux disease without associated pathology, the level of pH-metry was reduced, but with varying measures of confidence. At the same time, we found that patients with GERD without associated pathology had a decrease in the blood flow velocity in the celiac trunk. Concurrently, we ascertained that the decrease in the blood flow velocity in patients of both groups reduced the diameter of the celiac trunk. Conclusions. In patients with diabetes mellitus type II, concomitant gastroesophageal reflux disease has a subtle clinical presentation that is affected by a significant decline in mucosal sealing protection factors. In patients with GERD without associated pathology, typical clinical manifestations, accompanied by inflammation, acid regurgitation and dyspepsia, are more vivid.


2020 ◽  
Vol 16 (2) ◽  
pp. 144-157
Author(s):  
Nurannisa ◽  
R Ratianingsih ◽  
J W Puspita

ABSTRACTMetabolic syndrome (SM) is a compound of risk factors of cordiovascular disease occurancy. Obesity and type IIdiabetes mellitus are the main two of the risk factors. The epidemiological data shous that the prevalence ofmetabolic syndrome in the world is 20-25%. The objective of these research is control to minimize the prognosisof the disease among the SM population that have obesity and type II DM risk factors. The pontryagin minimumprinciple is used to determine the optimal solution of the prognosis model that the optimal control. The solution is derived from the state and co-state state equations that are evaluated of the drug that give to the sufferer in stationary conditions. The performance Index was designed to minimize the number of SM population that suffer obesity and type II diabetes mellitus and the use of sulfonilurea that given as the normoweighted populations and biguanid for obese populations. The simulation of the optional solution shows that the optimal control was derived to control the number SM that have population of the optional solution obesity and type II DM risk with optimal biguanide 500 mg and sulfonilurea 5 mg as much.Keywords : Metabolic Syndrome, Minimum Pontryagin, Obesity, Stability ,Type II Diabetes Mellitus.


2017 ◽  
Vol 14 (2) ◽  
Author(s):  
Masood Ziaee ◽  
Gholamreza Sharifzadeh ◽  
Zohreh Azarkar ◽  
Mohammad Hasan Namaei ◽  
Mahmood Zardast ◽  
...  

2019 ◽  
Vol 4 (1) ◽  

A study was carried out, in order to assess the risk factors associated with type-II diabetes mellitus in males (Age≥40 years) in district Mardan. Four hundred cases and controls (Each 200) were selected from 10 union councils (7 rural and 3 urban) by a systematic sampling method. In order to select cases and controls, all were interviewed for medical history, on fulfillment of which, cases and controls were separately included for study. In anthropometry, weight, and height were taken for Body Mass Index while waist and hip circumference were taken for waist-to-hip ratio. Fasting blood sugar of cases and controls was determined with the glucometer. Cases and controls were interviewed with Food frequency questionnaire and other questionnaires in order to assess the demographic and socioeconomic characters of the families. The results disclosed that most of the cases had family history of diabetes. In addition to that, cases were also found to have higher (p<0.05) average weight, height and body mass index, and fasting blood sugar level to those of controls. These results also revealed that there was a distinguished (p<0.05) association between dairy and fruit with the health status and about 1/3rd of both cases and controls had satisfactory consumption of dairy and fruit only. A significant link was found among family size, exercise, type of exercise, duration of exercise, watching television, duration of watching television and the status of disease. The study revealed that a combination of anthropometric, dietary and demographic variables were associated with type-II diabetes mellitus in male adult population of district Mardan.


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