scholarly journals Role of Pentoxifylline and Sparfloxacin in Prophylaxis of Spontaneous Bacterial Peritonitis in Cirrhotic Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Tarek Mohammed Mostafa ◽  
Osama Mohamed Ibrahim ◽  
Gamal Abd El-Khalek Badra ◽  
Mahmoud Samy Abdallah
Keyword(s):  
Treatment Duration ◽  
Spontaneous Bacterial Peritonitis ◽  
Inflammatory Marker ◽  
Control Group ◽  
Bacterial Peritonitis ◽  
Nonsignificant Difference ◽  
Cirrhotic Patients ◽  
Resistant Strains ◽  
Control Group Group

This study was directed to evaluate the role of sparfloxacin and pentoxifylline in the prophylaxis of spontaneous bacterial peritonitis in cirrhotic patients. Forty cirrhotic patients with ascites were included in the study. Patients were randomized into four groups in a blind fashion; each group consists of ten patients. Group one received ciprofloxacin (control group), group two received sparfloxacin, group three received pentoxifylline, and group four received a combination of sparfloxacin and pentoxifylline. Treatment duration was six months. Serum TNF-α level was the primary inflammatory marker of the study to evaluate the effect of the used medications. In group two, TNF-α level showed a statistically significant decrease in comparison with group one (P=0.001), while in group three, TNF-α level showed nonsignificant difference in comparison with the control group (P>0.05). In addition, group four showed a statistically significant decrease in TNF-α level compared to the other three groups (P<0.05). The finding from our study indicates that sparfloxacin as well as pentoxifylline could be used in prophylaxis of spontaneous bacterial peritonitis. Combination of sparfloxacin and pentoxifylline showed some of synergism which may be useful in decreasing emergence of resistant strains.

scholarly journals Role of Commiphora Mol Mol and Doxycycline in Prophylaxis of Spontaneous Bacterial Peritonitis in Egyptians Cirrhotic Patients

2015 ◽  
pp. 176-189
Author(s):  
Tarek Mohammed Mostafa ◽  
Osama Mohamed Hassan Ibrahim ◽  
Gamal Ahmed Abd El-Khalek Badra ◽  
Eman Ibrahim Abd El-Kader El-Berri
Keyword(s):  
Spontaneous Bacterial Peritonitis ◽  
Bacterial Peritonitis ◽  
Cirrhotic Patients

Fluoroquinolone-resistant strains in cirrhotic patients with spontaneous bacterial peritonitis

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ali A. Ghweil ◽  
Shamardan Ezzeldin S. Bazeed ◽  
M.H. Al Rawy ◽  
Ashraf Khodeary ◽  
Mostafa I. El-Amir
Keyword(s):  
Spontaneous Bacterial Peritonitis ◽  
Bacterial Peritonitis ◽  
Cirrhotic Patients ◽  
Resistant Strains

scholarly journals The Role of MicroRNAs (miRNA 155, miRNA-146b) and Procalcitonin as Novel Markers for the Diagnosis of Spontaneous Bacterial Peritonitis

2021 ◽  
Vol 11 (1) ◽  
pp. 28-38
Author(s):  
Dalia M. A. El-Hassib ◽  
Dina M. Abo-elmatty ◽  
Noha M. Mesbah ◽  
Sherief Abd-Elsalam ◽  
Shorouk A. Bastawisy ◽  
...  
Keyword(s):  
Spontaneous Bacterial Peritonitis ◽  
Quantitative Polymerase Chain Reaction ◽  
Serum Levels ◽  
Serum Marker ◽  
Control Group ◽  
Serum Samples ◽  
Rna Molecules ◽  
Bacterial Peritonitis ◽  
Infection And Inflammation

Background: MircoRNAs are endogenous, small non-coding RNA molecules that have been recognized as important modulators of gene expression. MicroRNA is considered one of the potential biomarkers of infection and inflammation. Our study aims to identify the potential role of miRNA-155, miRNA-146b, and Procalcitonin (PCT) in the early detection of spontaneous bacterial peritonitis in cirrhotic liver patients. miRNA-155 and 146b are molecular biomarkers , while procalcitonin is a serum marker in ascites patients complicated with Spontaneous Bacterial Peritonitis (SBP) . Methods: This study was conducted on 199 patients, 101 of them have ascites complicated with spontaneous bacterial peritonitis, and 98 patients without spontaneous bacterial peritonitis (control group). Ascitic fluid samples were collected from patients with SBP undergoing paracentesis at National Hepatology Institute in Egypt. MicroRNAs were determined in the serum using qPCR (quantitative polymerase chain reaction), while procalcitonin has been assessed in serum samples using ELISA (Enzyme-linked immune assay) technique. Results: Serum levels of miRNA-146b & miRNA-155 were significantly higher (p<0.001) in spontaneous bacterial peritonitis patients (79.2% and 97.0% respectively) than ascites patients (17.3% and 7.1%, respectively). Furthermore, the serum level of procalcitonin was significantly higher (p<0.001) in spontaneous bacterial peritonitis patients than that in ascites patients (68.3% and 27.6%, respectively). Conclusion: miRNA-155, miRNA-146b and procalcitonin can be used as early markers for the detection of SBP in hepatic patients with ascites.

Role of proton pump inhibitors in the occurrence and the prognosis of spontaneous bacterial peritonitis in cirrhotic patients with ascites

2013 ◽  
Vol 33 (9) ◽  
pp. 1316-1323 ◽  
Author(s):  
Marie de Vos ◽  
Bénédicte De Vroey ◽  
Béatrice Garcia Garcia ◽  
Clothilde Roy ◽  
François Kidd ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Spontaneous Bacterial Peritonitis ◽  
Bacterial Peritonitis ◽  
Cirrhotic Patients

scholarly journals Role of Prostaglandin E2 in Cirrhotic Patients with Spontaneous Bacterial Peritonitis

2021 ◽  
Vol 85 (2) ◽  
pp. 3663-3667
Author(s):  
Ahmed Ibraheem Aboghiaty ◽  
Ihab Barsoum Fahim ◽  
Hanan Samir Ahmed ◽  
Ahmed Fathy Gomaa
Keyword(s):  
Prostaglandin E2 ◽  
Spontaneous Bacterial Peritonitis ◽  
Bacterial Peritonitis ◽  
Cirrhotic Patients

Microbial epidemiology in cirrhotic patients with spontaneous bacterial peritonitis in Vienna

2013 ◽  
Vol 51 (05) ◽  
Author(s):  
P Schwabl ◽  
K Soucek ◽  
T Bucsics ◽  
M Mandorfer ◽  
A Blacky ◽  
...  
Keyword(s):  
Spontaneous Bacterial Peritonitis ◽  
Bacterial Peritonitis ◽  
Cirrhotic Patients
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