scholarly journals Measurement of Optical Scattering Coefficient of the Individual Layers of the Human Urinary Bladder Using Optical Coherence Tomography

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
O'tega Ejofodomi
Keyword(s):  
Optical Coherence Tomography ◽  
Urinary Bladder ◽  
Optical Scattering ◽  
Infrared Light ◽  
Optical Coherence ◽  
Exponential Relationship ◽  
Human Urinary Bladder ◽  
Scattering Coefficients ◽  
Optical Attenuation ◽  
The Individual

The author reports measurement of the optical attenuation of the urinary bladder using Optical Coherence Tomography. This method uses the exponential relationship that exists between the intensity of the back-scattered infrared light and the penetration depth. The method is applied to Optical Coherence Tomography images of the human urinary bladder and the scattering coefficients of the top three layers (urothelium, lamina propria, and muscle layers, resp.) are extracted. An optical attenuation ratio of 1 : 6.2 : 4.2 for the three layers is reported.

scholarly journals Coherence tomography with broad bandwidth extreme ultraviolet and soft X-ray radiation

2021 ◽  
Vol 127 (4) ◽  
Author(s):  
S. Skruszewicz ◽  
S. Fuchs ◽  
J. J. Abel ◽  
J. Nathanael ◽  
J. Reinhard ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Near Infrared ◽  
Extreme Ultraviolet ◽  
Infrared Light ◽  
Imaging Method ◽  
Optical Coherence ◽  
Axial Resolution ◽  
Cross Sectional ◽  
X Ray ◽  
Broad Bandwidth

AbstractWe present an overview of recent results on optical coherence tomography with the use of extreme ultraviolet and soft X-ray radiation (XCT). XCT is a cross-sectional imaging method that has emerged as a derivative of optical coherence tomography (OCT). In contrast to OCT, which typically uses near-infrared light, XCT utilizes broad bandwidth extreme ultraviolet (XUV) and soft X-ray (SXR) radiation (Fuchs et al in Sci Rep 6:20658, 2016). As in OCT, XCT’s axial resolution only scales with the coherence length of the light source. Thus, an axial resolution down to the nanometer range can be achieved. This is an improvement of up to three orders of magnitude in comparison to OCT. XCT measures the reflected spectrum in a common-path interferometric setup to retrieve the axial structure of nanometer-sized samples. The technique has been demonstrated with broad bandwidth XUV/SXR radiation from synchrotron facilities and recently with compact laboratory-based laser-driven sources. Axial resolutions down to 2.2 nm have been achieved experimentally. XCT has potential applications in three-dimensional imaging of silicon-based semiconductors, lithography masks, and layered structures like XUV mirrors and solar cells.

Wide-field optical coherence tomography deviation map for early glaucoma detection

2021 ◽  
pp. bjophthalmol-2021-319509
Author(s):  
Hyungjun Kim ◽  
Hae Min Park ◽  
Hyo Chan Jeong ◽  
So Yeon Moon ◽  
Hyunsoo Cho ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Characteristic Curve ◽  
Wide Field ◽  
Optical Coherence ◽  
Diagnostic Ability ◽  
Swept Source ◽  
Early Glaucoma ◽  
Field Database ◽  
The Individual ◽  
Healthy Eyes

Background/aimsThis study aimed to establish a wide-field optical coherence tomography (OCT) deviation map obtained from swept-source OCT (SS-OCT) scans. Moreover, it also aimed to compare the diagnostic ability of this wide-field deviation map with that of the peripapillary and macular deviation maps currently being used for the detection of early glaucoma (EG).MethodsFour hundred eyes, including 200 healthy eyes and 200 eyes with EG were enrolled in this retrospective observational study. Patients underwent a comprehensive ocular examination, including wide-field SS-OCT (DRI-OCT Triton; Topcon, Tokyo, Japan). The individual wide-field scan was converted into a uniform template using the fovea and optic disc centres as fixed landmarks. Subsequently, the wide-field deviation map was obtained via the comparison between individual wide-field data and a normative wide-field database that had been created by combining images of healthy eyes into a uniform template in a previous study. The ability of the new wide-field deviation map to distinguish between EG and healthy eyes was assessed by comparing it with conventional deviation maps based on the area under the receiver operating characteristic curve (AUC).ResultsThe wide-field deviation map obtained using the normative wide-field database showed the highest diagnostic ability for the diagnosis of EG (AUC=0.980 and 961 for colour-coded pixels presenting <5% and <1%, respectively) among various deviation maps. Its AUC was significantly superior to that of most conventional deviation maps (p<0.05). The wide-field deviation map demonstrated early structural glaucomatous damage well over a wider area.ConclusionThe wide-field SS-OCT deviation map exhibited good performance for distinguishing between eyes with EG and healthy eyes. The visualisation of the wider damaged area on the wide-field deviation map could be useful for the diagnosis of EG in clinical settings.

CHARACTERIZATION OF VITILIGO BY IN VIVO SCATTERING COEFFICIENT OF HUMAN SKIN

2011 ◽  
Vol 04 (01) ◽  
pp. 67-72 ◽  
Author(s):  
WANRONG GAO ◽  
PENG LEE ◽  
XIANLING ZHANG
Keyword(s):  
Optical Coherence Tomography ◽  
Human Skin ◽  
Experimental Results ◽  
Scattering Coefficient ◽  
Optical Coherence ◽  
Scattering Coefficients ◽  
Significant Difference

Scattering coefficients of human skin in vivo with and without vitiligo were measured with optical coherence tomography (OCT). The experimental results show that there exist significant difference between the scattering coefficient of the epidermis of in vivo human skin with and without vitiligo disease. The results may be helpful for quantitatively diagnosing or evaluating the treatment of the disease.

scholarly journals Quantitative Diagnosis of Colorectal Polyps by Spectral Domain Optical Coherence Tomography

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Chen Wang ◽  
Qinqin Zhang ◽  
Xiaojing Wu ◽  
Tao Tang ◽  
Hong Liu ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Early Diagnosis ◽  
Colorectal Polyp ◽  
Primary Diagnosis ◽  
Colorectal Polyps ◽  
Spectral Domain ◽  
Scattering Coefficient ◽  
Optical Coherence ◽  
Scattering Coefficients ◽  
Spectral Domain Oct

The principal aim of this study is to investigate the scattering coefficient of colorectal polyp tissues using an optical coherence tomography (OCT) technique. It combines the existing scattering coefficient model and spectral domain OCT to achieve method of early diagnosis of colorectal polyp in hospitals. Seventeen patients were studied, and a total of 1456 data points were extracted by curve-fitting the OCT signals into a confocal single-backscattering model. The results show that the mean scattering coefficient value for colorectal polyps is 1.91 mm−1(std: ±0.54 mm−1), which is between the values for normal and malignant tissues. In addition, we studied the difference between adenomatous polyps (n=15) and inflammatory polyps (n=2) quantitatively and found that the adenomatous tissues had lower scattering coefficients than the inflammatory ones. The quantitative measurements confirmed that OCT can be used in primary diagnosis to compensate for the deficiencies in methods of pathological diagnosis, with a great potential for early diagnosis of tissues.

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