scholarly journals UVA-UVB Photoprotective Activity of Topical Formulations ContainingMorinda citrifoliaExtract

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Mairim Russo Serafini ◽  
Cassia Britto Detoni ◽  
Paula dos Passos Menezes ◽  
Rose Nely Pereira Filho ◽  
Vanessa Silveira Fortes ◽  
...  
Keyword(s):  
Immune Suppression ◽  
Skin Barrier ◽  
Morinda Citrifolia ◽  
Dorsal Skin ◽  
Topical Formulations ◽  
Thickness Skin ◽  
Potential Benefits ◽  
Baseline Values ◽  
Sunburn Cell ◽  
Harmful Effects

Exposure to solar radiation, particularly its ultraviolet (UV) component, has a variety of harmful effects on human health. Some of these effects include sunburn cell formations, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression. The beneficial photoprotective effects of topical formulations with the extract,Morinda citrifolia, have not been investigated. This present study aims to investigate the potential benefits ofM. citrifoliatopical application on the dorsal skin of mice, exposed to UVA-UVB light. Using 7 days of treatment, [before (baseline values) and 20 h after UV exposure], the thickness, skin barrier damage (TEWL), erythema, and histological alterations were evaluated. The results showed that the formulations containing the extract protected the skin against UV-induced damage.

Renewable Energy Distribution and Management in Green Buildings

2020 ◽  
pp. 208-219
Author(s):  
Suman Kumar ◽  
Gurjit Kaur
Keyword(s):  
Water Pollution ◽  
Machine Learning ◽  
Global Warming ◽  
Return On Investment ◽  
Green Buildings ◽  
Weather Forecasts ◽  
Demand Prediction ◽  
Potential Benefits ◽  
Harmful Effects

There are various environmental problems (i.e., “global warming,” air and water pollution), which need to be prevented. Construction of buildings plays a significant role in pollution. To reduce the harmful effects in constructing buildings, it is necessary to move on to sustainable architecture. In this chapter, different advantages and standards for green buildings will be discussed. Different organizations are contributing towards a green environment. There are even different sensors that are able to detect wastage of energy and can predict the requirement of energy. Machine learning, a hot topic these days, can also play its role in demand prediction. In this chapter, role of network communication and sensing to optimize the energy of green buildings and machine learning-based demand prediction to optimize the energy of green buildings are discussed. Further predicting energy harvesting from weather forecasts, return on investment of green buildings, and potential benefits of energy-efficient green buildings are also discussed.

scholarly journals Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 249 ◽  
Author(s):  
Kim ◽  
Seong ◽  
Choung
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Molecular Mechanisms ◽  
Inflammatory Diseases ◽  
Skin Barrier ◽  
Inflammatory Cells ◽  
Skin Lesions ◽  
Morinda Citrifolia ◽  
Skin Barrier Function ◽  
Immune Balance

Morinda citrifolia, a fruit generally known as “Noni”, has been traditionally used in parts of East Asia to relieve inflammatory diseases. Although several studies using noni have been reported, the effect of fermented Morinda citrifolia (F.NONI) on atopic dermatitis (AD) has not been investigated. Thus, we aimed to investigate the improving effect of F.NONI treatment on AD-like skin lesions and elucidate molecular mechanisms. F.NONI was prepared by the fermentation of noni fruit with probiotics and then extracted. F.NONI was orally administrated to NC/Nga mice to evaluate its therapeutic effect on 2,4-dinitrochlorobenzene (DNCB)-induced AD. Oral administration of F.NONI significantly alleviated AD lesions and symptoms such as dermatitis scores, ear thickness, scratching behavior, epidermal thickness, and infiltration of inflammatory cells (e.g., mast cells and eosinophils). In addition, F.NONI treatment reduced the levels of histamine, IgE and IgG1/IgG2a ratio, thymus and activation regulated chemokine (TARC), and thymic stromal lymphopoietin (TSLP) in serum and beneficially modulated the expressions of Th1, Th2, Th17, and Th22-mediated cytokines in lesioned skin and splenocytes. Furthermore, the expressions of the skin barrier-related proteins including filaggrin (FLG), loricrin (LOR), involucrin (IVL), zonula occludens-1 (ZO-1), and occludin (OCC) were restored by F.NONI treatment. Taken together, these results suggest that F.NONI could be a therapeutic agent to attenuate AD-like skin lesions through modulating the immune balance and skin barrier function.

Energy Expenditure During Acute Periods of Sitting, Standing, and Walking

2016 ◽  
Vol 13 (6) ◽  
pp. 573-578 ◽  
Author(s):  
Seth A. Creasy ◽  
Renee J. Rogers ◽  
Thomas D. Byard ◽  
Robert J. Kowalsky ◽  
John M. Jakicic
Keyword(s):  
Energy Expenditure ◽  
Sedentary Behavior ◽  
Indirect Calorimetry ◽  
Transition Period ◽  
Laptop Computer ◽  
Experimental Conditions ◽  
Increase Energy Expenditure ◽  
Potential Benefits ◽  
Harmful Effects

Background:Identifying strategies to increase energy expenditure (EE) may help combat the harmful effects of sedentary behavior. This study examined EE during sitting, standing, and walking.Methods:Participants (N = 74) were randomized to 2 of the following activities: sitting using a laptop computer (SIT-C), sitting watching television (SIT-T), standing watching television (STAND), and walking at a self-selected pace ≤3.0 (mph) (WALK). Each activity lasted 15 minutes with a 3-minute transition period between activities. The experimental conditions were: SIT-C to STAND (N = 18), SIT-T to WALK (N = 18), STAND to SIT-C (N = 20), and WALK to SIT-T (N = 18). EE was measured using indirect calorimetry.Results:Based on the first activity performed, EE during WALK (55.92 ± 14.19 kcal) was significantly greater than SIT-C (19.63 ± 6.90 kcal), SIT-T (18.66 ± 4.01 kcal), and STAND (21.92 ± 5.08 kcal) (P < .001). Cumulative EE in SIT-T to WALK (74.50 ± 17.88 kcal) and WALK to SIT-T (82.72 ± 21.70 kcal) was significantly greater than EE in SIT-C to STAND (45.38 ± 14.78 kcal) and STAND to SIT-C (45.64 ± 9.69 kcal) (P < .001).Conclusions:Conclusion: Substituting periods of sitting or standing with walking significantly increases EE, but substituting periods of sitting with standing may not affect EE. Thus, the potential benefits of standing as opposed to sitting need further investigation beyond the role of EE.

Newborn Percutaneous Absorption: Hazards and Therapeutic Uses

1999 ◽  
Vol 18 (8) ◽  
pp. 63-69 ◽  
Author(s):  
Marilyn Benis
Keyword(s):  
Percutaneous Absorption ◽  
Skin Barrier ◽  
Neonatal Nurses ◽  
Risks And Benefits ◽  
Therapeutic Drugs ◽  
Therapeutic Uses ◽  
Skin Integrity ◽  
Neonatal Skin ◽  
Pass Through ◽  
Harmful Effects

THE SKIN ACTS AS A VITAL BARRIER between an individual and the environment by limiting water loss and by protecting against the entry of harmful substances. Various material can pass through the skin barrier, a process called percutaneous absorption. Although the skin’s permeability can lead to harmful effects, it can be beneficial in making the skin a possible route for the delivery of therapeutic drugs. Differences between adult and neonatal skin, especially preterm skin, expose the neonate to a greater potential for percutaneous absorption.1 Neonatal nurses need to be familiar with the characteristics of newborn skin, principles for maintaining skin integrity, and the risks and benefits of percutaneous absorption.

scholarly journals Stress and Skin: An Overview of Mind Body Therapies as a Treatment Strategy in Dermatology

2021 ◽  
pp. e2021091
Author(s):  
Rachel Graubard ◽  
Ariadna Perez-Sanchez ◽  
Rajani Katta
Keyword(s):  
Stress Response ◽  
Skin Disease ◽  
Skin Barrier ◽  
Psychosocial Outcomes ◽  
Skin Inflammation ◽  
The Body ◽  
Skin Barrier Function ◽  
Beneficial Effects ◽  
Potential Benefits ◽  
The Mind

Stress has multiple and wide-ranging physiologic and clinical impacts on skin disease. This has led to an interest in mind body therapies as potential adjunct treatments for skin disease. The stress response results in the activation of the endocrine, neurologic, and immune systems, with a resulting cascade of impacts, that are both systemic and cutaneous. The 2 main arms of the stress response are the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis. The resultant release of cortisol, catecholamines, and neuropeptides has multiple effects. Clinically, these have been shown to increase skin inflammation, increase itching, impair skin barrier function, impair wound healing, and suppress immunity.Mind body therapies are those that focus on the interaction between the mind and the body, with the goal to influence physical function and impact health. These have been shown to ameliorate some of the harmful physiologic changes attributed to stress or to reduce harmful behaviors. In some cases, such as with biofeedback, they may also result in beneficial physiologic changes. Treatments such as meditation, biofeedback, hypnosis, guided imagery, and others have been evaluated in the treatment of skin disease and have shown some benefits. Although randomized controlled trials are limited, these interventions have shown beneficial effects on itching, psychosocial outcomes, and even skin severity. These interventions have been evaluated in diseases such as atopic dermatitis, psoriasis, trichotillomania, and others. Given the potential benefits, improvements in psychosocial outcomes, and a low risk profile, referral to qualified practitioners or multidisciplinary clinics should be considered for some patients.

scholarly journals Elemental and molecular imaging of human full thickness skin after exposure to heavy metals

Metallomics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 1555-1562
Author(s):  
Laurent Chavatte ◽  
Milène Juan ◽  
Sandra Mounicou ◽  
Emmanuelle Leblanc Noblesse ◽  
Karl Pays ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Molecular Imaging ◽  
Compelling Evidence ◽  
Full Thickness ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Harmful Effects

Compelling evidence suggests that heavy metals have potentially harmful effects on the skin.

scholarly journals The Suppressive Effect of Leucine-Rich Glioma Inactivated 3 (LGI3) Peptide on Impaired Skin Barrier Function in a Murine Model Atopic Dermatitis

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 750
Author(s):  
Ui Seok Kim ◽  
Jin Woo Park ◽  
Eon Sub Park ◽  
Joon Seok Bang ◽  
Tae Woo Jung ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Murine Model ◽  
Barrier Function ◽  
Skin Barrier ◽  
Clinical Score ◽  
Skin Lesions ◽  
Suppressive Effect ◽  
Skin Barrier Function ◽  
Skin Thickness ◽  
Dorsal Skin

This study aimed to restore the skin barrier function from atopic dermatitis (AD) via treatment with leucine-rich glioma inactivated 3 (LGI3) peptide. Male NC/Nga mice (7 weeks, 20 g) were randomly allocated into three groups (control, AD, and LGI3 group). After induction of AD skin lesions with Dermatophagoides farinae ointment, mice were treated with LGI3. The clinical score of AD was the highest and the dorsal skin thickness was the thickest in the AD group. In contrast, LGI3 treatment improved the clinical score and the dorsal skin thickness compared to the AD model. LGI3 treatment suppressed histopathological thickness of the epithelial cell layer of the dorsal skin. LGI3 treatment could indirectly reduce mast cell infiltration through restoring the barrier function of the skin. Additionally, the filaggrin expression was increased in immunohistochemical evaluation. In conclusion, the ameliorating effect and maintaining skin barrier homeostasis in the AD murine model treated with LGI3 could be attributed to complete re-epithelialization of keratinocytes. Hence, LGI3 might be considered as a new potential therapeutic target for restoring skin barrier function in AD.

scholarly journals Effects of Deacetylasperulosidic Acid on Atopic Dermatitis through Modulating Immune Balance and Skin Barrier Function in HaCaT, HMC-1, and EOL-1 Cells

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3298
Author(s):  
Jin Su Oh ◽  
Geum Su Seong ◽  
Yong Deok Kim ◽  
Se Young Choung
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Skin Barrier ◽  
Morinda Citrifolia ◽  
Mitogen Activated Protein Kinase ◽  
Skin Barrier Function ◽  
Necrosis Factor Alpha ◽  
Monocyte Chemoattractant Protein 1 ◽  
Cytokines And Chemokines ◽  
Immune Balance

The medicinal plant noni (Morinda citrifolia) is widely dispersed throughout Southeast Asia, the Caribbean, and Australia. We previously reported that fermented Noni could alleviate atopic dermatitis (AD) by recovering Th1/Th2 immune balance and enhancing skin barrier function induced by 2,4-dinitrochlorobenzene. Noni has a high deacetylasperulosidic acid (DAA) content, whose concentration further increased in fermented noni as an iridoid constituent. This study aimed to determine the anti-AD effects and mechanisms of DAA on HaCaT, HMC-1, and EOL-1 cells. DAA inhibited the gene expression and secretion of AD-related cytokines and chemokines including interleukin (IL)-1β, IL-4, IL-6, IL-8, IL-25, IL-33, thymic stromal lymphopoietin, tumor necrosis factor-alpha, monocyte chemoattractant protein-1, thymus and activation-regulated chemokine, macrophage-derived chemokine, and regulated upon activation, normal T cell expressed and secreted, in all cells, and inhibited histamine release in HMC-1 cells. DAA controlled mitogen-activated protein kinase phosphorylation levels and the translocation of nuclear factor-kappa light chain enhancer of activated B cells into the nucleus by inhibiting IκBα decomposition in all the cells. Furthermore, DAA increased the expression of proteins involved in skin barrier functions such as filaggrin and involucrin in HaCaT cells. These results confirmed that DAA could relieve AD by controlling immune balance and recovering skin barrier function.

scholarly journals Java plum (Syzygium cumini) extract cream effect on decreasing the number of sunburn cell on the dorsal skin of male Wistar rat (Rattus norvegicus) exposed to UV-radiation

2020 ◽  
Vol 3 (1) ◽  
pp. 1-4
Author(s):  
Dinesh Tanabbal ◽  
I Gusti Ayu Dewi Ratnayanti ◽  
I Gusti Nyoman Sri Wiryawan ◽  
I Gusti Kamasan Nyoman Arijana ◽  
Ida Ayu Ika Wahyuniari
Keyword(s):  
Uv Radiation ◽  
Ethanol Extract ◽  
Male Rats ◽  
Control Group ◽  
Syzygium Cumini ◽  
Dorsal Skin ◽  
High Concentration ◽  
Visual Evaluation ◽  
Control Group Design ◽  
Sunburn Cell

Background: The primary acute damage due to UV radiation is keratinocyte apoptosis or sunburn cell. Previous studies showed that antioxidants inhibit UV damage. Java plum (Syzygium cumini) which is found in Indonesia, was known to have a high concentration of antioxidants. This study was aimed to assess the Java plum ethanol extract cream effects on the number of sunburn cells on the dorsal skin of male Wistar rats that exposed to UV-B. Methods This experimental research was a post-test only control group design that was conducted on 30 male rats. Groups were divided into control, placebo, 5%, 10%, and 20% ethanol extract cream concentrations (P1, P2, P3, P4, and P5, respectively). The number of sunburn cell were then observed and recorded based on visual evaluation of the skin biopsy under a light microscope. Results: The mean results of P1, P2, P3, P4, and P5 were 132.67, 98.67, 118.67, 104.00, and 54.67 respectively. The control, placebo, 5%, and 10% ethanol extract cream showed no significant result (p>0.05). In contrast, 20% ethanol extract cream showed a protective effect (p<0.05).  Conclusion: Java plum ethanol extract cream with 20% dose could decrease the number of sunburn cells in the skin.

Sign in / Sign up

Export Citation Format

Share Document