scholarly journals Polymicrobial Bacteremia InvolvingComamonas testosteroni

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Jose Orsini ◽  
Eric Tam ◽  
Naomi Hauser ◽  
Salil Rajayer
Keyword(s):  
Case Report ◽  
Infectious Agent ◽  
Bloodstream Infections ◽  
Opportunistic Pathogen ◽  
Comamonas Testosteroni ◽  
Environmental Distribution ◽  
Delftia Acidovorans ◽  
Polymicrobial Bacteremia ◽  
Respiratory Treatment ◽  
Intravenous Catheters

Comamonasspp. are uncommon isolates in microbiology laboratories and have been rarely observed as an infectious agent in clinical practice. They have widespread environmental distribution and have been isolated from water, soil, and plants as well as from some hospital devices such as intravenous catheters and water contained in humidifier reservoirs used in respiratory treatment. The genusComamonasoriginally contained the following species:acidovorans, testosteroni, kerstersii, terrigena, denitrificans, andnitrativorans. It now contains 17 species, whileacidovoransspp. have been reclassified asDelftia acidovorans. In spite of its uncommon human pathogenesis, there are few reports on the aggressive manner of it as an opportunistic pathogen, mostly related totestosteronispp. We present a case of polymicrobial bacteremia involvingComamonas testosteroni. The aim of this case report is to alert clinicians to the potential diagnosis of bloodstream infections caused by uncommon pathogens.

scholarly journals Bacteremia caused by Comamonas testosteroni an unusual pathogen

2019 ◽  
Vol 11 (01) ◽  
pp. 087-090
Author(s):  
Shreekant Tiwari ◽  
Monalisah Nanda
Keyword(s):  
Infectious Agent ◽  
Bloodstream Infections ◽  
Opportunistic Pathogen ◽  
Routine Clinical Practice ◽  
Clinical Approach ◽  
Comamonas Testosteroni ◽  
Human Pathogen ◽  
Natural Habitats ◽  
Reservoir Water ◽  
Wide Range

Abstract Comamonas species are rare isolates in microbiology laboratories and have been infrequently reported as an infectious agent in routine clinical practice. They have a wide range of natural habitats including water, soil, and plants as well as from some hospital devices, such as intravenous lines and the reservoir water in the humidifiers of respiratory therapy equipment. Comamonas testosteroni is rarely recognized as a human pathogen. In spite of its uncommon human pathogenesis, there are few reports where it was reported as an aggressive opportunistic pathogen, and that was mostly related to Testosterone species. Herewith, we are reporting this pathogen from the blood of an immunocompetent female. The aim of this case report is to alert clinicians and laboratory physicians for the potential diagnosis and clinical approach of bloodstream infections caused by such unusual pathogens. This is the first documented case of bacteremia caused by C. testosteroni from India.

scholarly journals 998. Missclassification of Community and Hospital Onset Bloodstream Infections Using Laboratory-Identified Events

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S297-S297
Author(s):  
Riad Khatib ◽  
Mamta Sharma ◽  
Mohamad G Fakih ◽  
Kathleen Riederer ◽  
Leonard Johnson
Keyword(s):  
Infective Endocarditis ◽  
Hospital Setting ◽  
Bloodstream Infections ◽  
Candida Spp ◽  
Chi Square ◽  
Gram Negative ◽  
Chi Square Test ◽  
Polymicrobial Bacteremia ◽  
Intravenous Catheters ◽  
Community Onset

Abstract Background Laboratory-identified bloodstream infections (LAB-ID-BSI) are classified as community onset (CO) if blood culture (BC) is collected within 3 days after facility admission and hospital onset if ≥4 days. This classification is often based on a computer-generated subtraction of the day of admission from day of onset. This method may miss recent prior hospitalizations at the same or different facilities. Methods We reviewed BC results (January 1, 2010–December 31, 2016), selected patients with BSI and defined the place of onset as CO (day 0–3) and HO (≥4 days) of admission based on LABID-BSI. All patients with CO were further evaluated to determine whether they were recently hospitalized. The source and microbiology of patients with hospitalization within 14 days of the onset of BSI was compared with HO and CO without prior admission within 6 months. Results We encountered 5,179 BSI episodes, 3866 (74.6%) were CO. Prior hospitalization in any hospital within 1–14 and 15–180 days of onset was documented in 659 (17.0%) and 1,465 (37.9%), respectively. Source of bacteremia and type of organisms in patients with prior hospitalization within 1–14 days were closer to HO than patients without prior hospitalization with higher frequency of Intravenous catheters (IVC), polymicrobial bacteremia, and candidemia (table). Conclusion Using Lab-ID events to classify BSI, one in six patients may risk being misclassified as CO. This underestimates BSI related to hospital setting. Onset classification should be based on thorough historical information and not a computer-generated subtraction of admission and Lab event dates. Infective endocarditis; soft tissue/bone; pneumonia; abdomen; unknown/miscellaneous; polymicrobial. Gram-positive; Gram-negative; anaerobes; Candida spp. a: P < 0.01; chi square test. Disclosures All authors: No reported disclosures.

A Rare Pathogen in Acute Appendicitis: Two Cases with Comamonas testosteroni Infection and Literature Review

2018 ◽  
Vol 15 (02) ◽  
pp. 110-112
Author(s):  
Ayşe Sağmak Tartar ◽  
Tugay Tartar
Keyword(s):  
Clinical Practice ◽  
Literature Review ◽  
Human Microbiome ◽  
Infectious Agent ◽  
Opportunistic Pathogen ◽  
Immunocompromised Patients ◽  
Comamonas Testosteroni ◽  
Tissue Samples ◽  
Environmental Bacterium ◽  
Abdominal Infections

Abstract Comamonas testosteroni (formerly Pseudomonas testosteroni) is a common environmental bacterium, which is not a part of the human microbiome. It is rarely found as an infectious agent in clinical practice. The bacterium has low virulence potency and rarely causes human disease. Although this agent is generally considered to be of low virulence, reports of infections with C. testosteroni are increasing. With the exception of intra-abdominal infections, C. testosteroni is mainly reported as an opportunistic pathogen in immunocompromised patients. However, C. testosteroni has also been reported as a pathogen in patients with appendicitis (especially when perforated), suggesting that this bacterium may belong to the normal intestinal microbiota of some individuals. In this article, we present two children with appendicitis in whom C. testosteroni was isolated from appendix tissue samples.

scholarly journals A Case Report on Post COVID -19 Vaccine Associated Guillain–Barré Syndrome

2021 ◽  
pp. 454-458
Author(s):  
S. Hemalatha ◽  
M. Karishma ◽  
J. Bera ◽  
S. Blessy ◽  
J. Thirumaran ◽  
...  
Keyword(s):  
Case Report ◽  
Nerve Conduction ◽  
Muscle Power ◽  
Ventilatory Support ◽  
Infectious Agent ◽  
Guillain Barre Syndrome ◽  
Autonomic Nerves ◽  
Intravenous Immunoglobulin Therapy ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Guillain–Barré syndrome (GBS) is an autoimmune demyelinating illness in which a patient’s immune system attacks and cause deterioration of peripheral nervous system leading to progressive paralysis and polyneuropathy. The exact cause of the GBS is unclear but the main mechanism of behindis the demyelination of nerves especially the motor, sensory, and autonomic nerves which can be triggered by any immunologic or infectious agent. The infectious agent elicits the humoral and cellular mediated immune response due to their molecular mimicry in which the antibodies created against the infection matches with the proteins on the nerve. The characteristic features of Guillain–Barré syndrome are ascending flaccid paralysis, paresthesia, impairment of muscle reflexes, respiratory failureetc. The GBS is diagnosed via nerve conduction studies, lumbar puncture (Cerebrospinal fluid analysis), electromyography, Brighton criteria. Treatments like intravenous immunoglobulin therapy, plasma exchange can ease the symptoms and reduce the duration of the illness. This case report focusing on a 43-year-old female patient admitted seeking ventilatory support for respiratory distress caused by Guillain–Barré Syndrome in a tertiary hospital. Patient had developed limb weakness with ascending paralysis along with facial weakness within a couple of weeks after receiving the COVID -19 vaccination (COVISHIELD)one month back. Patient underwent nerve conduction study and routine monitoring of vital parameters. After conservative management with physiotherapy, ventilation, intravenous immunoglobulins and prophylaxis for pain and DVT patient gradually started improving the muscle power and was discharged to continue the rehabilitation care at home.

scholarly journals Deterioration in hygiene behavior among fifth-year medical students during the placement of intravenous catheters: a prospective cohort comparison of practical skills

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Annika Meyer ◽  
Jakob Schreiber ◽  
Julian Brinkmann ◽  
Andreas R. Klatt ◽  
Christoph Stosch ◽  
...  
Keyword(s):  
Medical Students ◽  
Bloodstream Infections ◽  
Management Training ◽  
Practical Skills ◽  
Stress Management Training ◽  
Hygiene Behavior ◽  
Before And After ◽  
Hygiene Compliance ◽  
The University ◽  
Intravenous Catheters

Abstract Background The American Association of Medical Colleges has defined peripheral intravenous cannulation as one of the eight practical skills that a medical student should possess upon graduation. Since following a standard hygiene protocol can reduce the rate of complications such as bloodstream infections, the medical student’s compliance to hygienic standards is highly relevant. Methods This unicentric longitudinal cohort study included 177 medical students undergoing OSCE 1 in the winter semesters 2016/2017 and 2017/2018 as well as OSCE 2 during the winter semesters 2018/2019 and 2019/2020 at the University of Cologne. Their performance in peripheral intravenous cannulation was rated by trained student supervisors using a scaled 13-item questionnaire and compared between OSCE 1 and OSCE 2. Results Overall, a decline in the correct placement of peripheral intravenous catheters was observed among advanced medical students during OSCE 2 (mean total score: 6.27 ± 1.84) in comparison to their results in OSCE 1 (mean total score: 7.67 ± 1.7). During OSCE 2, the students were more negligent in regard to hygienic behavior, such as disinfection of the puncture site as well as hand disinfection before and after venipuncture. Their patients were also less likely to be informed about the procedure as compared to OSCE 1. Conclusions An unsatisfying performance in regard to peripheral intravenous cannulation was observed in medical students with hygiene compliance deteriorating between the third and fifth year of their study. Thus, we promote an extension of practical hygiene and stress management training in medical school to reduce complications associated with intravenous catheters, such as bloodstream infections.

scholarly journals An Uncommon Cause Of Bacteremia: Comamonas Testosteroni (A Case Report)

2018 ◽  
Author(s):  
Gülseren Samancı Aktar ◽  
Zeynep Ayaydın ◽  
Arzu Rahmanalı Onur ◽  
Demet Gür Vural ◽  
Hakan Temiz
Keyword(s):  
Case Report ◽  
Comamonas Testosteroni

Intravascular Catheter Colonization and Related Bloodstream Infection in Critically III Neonates

1990 ◽  
Vol 11 (6) ◽  
pp. 301-308 ◽  
Author(s):  
Wendy A. Cronin ◽  
Teresa P. Germanson ◽  
Leigh G. Donowitz
Keyword(s):  
Bloodstream Infection ◽  
Insertion Site ◽  
Bloodstream Infections ◽  
Coagulase Negative Staphylococcus ◽  
Intravascular Catheter ◽  
Catheter Colonization ◽  
Catheter Tip ◽  
Critically Ill Neonates ◽  
Peripheral Arterial ◽  
Intravenous Catheters

AbstractIntravascular catheter tip colonization was prospectively evaluated in critically ill neonates to determine its relationship to the type of device used, duration of catheterization, insertion site and nosocomial bloodstream infection. Sixty-one percent (376 of 621) of all intravascular catheter tips were retrieved from 91 infants. Thirteen percent (41 of 310) of peripheral intravenous, 14% (6 of 42) of umbilical, 21% (3 of 11) of central venous, 36% (4 of 11) of peripheral arterial and 100% (2 of 2) of femoral catheters were colonized. Duration of catheterization was significantly longer for colonized lines (p < .001). Eight of 26 (30.8%) peripheral intravenous catheters remaining in place for more than three days were colonized, compared with 33 of 284 (11.6%) at three days or less (p= 0.012). Coagulase-negative staphylococcus was the organism most frequently isolated from catheter tips and bloodstream infections. Catheter colonization rates in this population were higher than those found in adults. Heavily manipulated devices and those in place for longer periods of time were the most frequently colonized.

scholarly journals Phylogenetic Analysis ofStenotrophomonasspp. Isolates Contributes to the Identification of Nosocomial and Community-Acquired Infections

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Vinicius Godoy Cerezer ◽  
Silvia Yumi Bando ◽  
Jacyr Pasternak ◽  
Marcia Regina Franzolin ◽  
Carlos Alberto Moreira-Filho
Keyword(s):  
Phylogenetic Analysis ◽  
Multidrug Resistance ◽  
Phylogenetic Profile ◽  
Opportunistic Pathogen ◽  
Clinical Isolates ◽  
Environmental Distribution ◽  
Pathogenic Potential ◽  
Clinical Strains ◽  
Specific Fragment ◽  
Clonal Variability

Stenotrophomonasssp. has a wide environmental distribution and is also found as an opportunistic pathogen, causing nosocomial or community-acquired infections. One species,S. maltophilia, presents multidrug resistance and has been associated with serious infections in pediatric and immunocompromised patients. Therefore, it is relevant to conduct resistance profile and phylogenetic studies in clinical isolates for identifying infection origins and isolates with augmented pathogenic potential. Here, multilocus sequence typing was performed for phylogenetic analysis of nosocomial isolates ofStenotrophomonasspp. and, environmental and clinical strains ofS. maltophilia. Biochemical and multidrug resistance profiles of nosocomial and clinical strains were determined. The inferred phylogenetic profile showed high clonal variability, what correlates with the adaptability process ofStenotrophomonasto different habitats. Two clinical isolates subgroups ofS. maltophiliasharing high phylogenetic homogeneity presented intergroup recombination, thus indicating the high permittivity to horizontal gene transfer, a mechanism involved in the acquisition of antibiotic resistance and expression of virulence factors. For most of the clinical strains, phylogenetic inference was made using only partialppsA gene sequence. Therefore, the sequencing of just one specific fragment of this gene would allow, in many cases, determining whether the infection withS. maltophiliawas nosocomial or community-acquired.

scholarly journals Routine Replacement versus Clinical Monitoring of Peripheral Intravenous Catheters in a Regional Hospital in the Home Program A Randomized Controlled Trial

2009 ◽  
Vol 30 (9) ◽  
pp. 915-917 ◽  
Author(s):  
Patricia Van Donk ◽  
Claire M. Rickard ◽  
Matthew R. McGrail ◽  
Glenn Doolan
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Bloodstream Infections ◽  
Clinical Indication ◽  
Intravenous Catheter ◽  
Home Setting ◽  
Home Program ◽  
Randomized Controlled ◽  
Peripheral Intravenous Catheter ◽  
Intravenous Catheters

This randomized, controlled trial involving 316 patients in the home setting found no difference in the rate of phlebitis and/or occlusion among patients for whom a peripheral intravenous catheter was routinely resited at 72-96 hours and those for whom it was replaced only on clinical indication (76.8 events per 1,000 device-days vs 87.3 events per 1,000 device-days; P = .71). There were no bloodstream infections.

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