scholarly journals Therapeutic Potential of Natural Pharmacological Agents in the Treatment of Human Diseases

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Kota V. Ramana ◽  
Sharad S. Singhal ◽  
Aramati B. Reddy
Keyword(s):  
Therapeutic Potential ◽  
Human Diseases ◽  
Pharmacological Agents

Therapeutic potential of pharmacological agents targeting TRP channels in CNS disorders

2020 ◽  
Vol 159 ◽  
pp. 105026 ◽  
Author(s):  
Pavan Thapak ◽  
Bhupesh Vaidya ◽  
Hem Chandra Joshi ◽  
Jitendra N. Singh ◽  
Shyam S. Sharma
Keyword(s):  
Trp Channels ◽  
Therapeutic Potential ◽  
Cns Disorders ◽  
Pharmacological Agents

scholarly journals The Functional Role of MnSOD as a Biomarker of Human Diseases and Therapeutic Potential of a New Isoform of a Human Recombinant MnSOD

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Antonella Borrelli ◽  
Antonietta Schiattarella ◽  
Patrizia Bonelli ◽  
Franca Maria Tuccillo ◽  
Franco Maria Buonaguro ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Manganese Superoxide Dismutase ◽  
Therapeutic Potential ◽  
Human Diseases ◽  
Leader Peptide ◽  
X Rays ◽  
Normal Cells ◽  
Initial Application ◽  
Prevention Of Cancer

Reactive oxygen species (ROS) are generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells. This work describes the role of the manganese superoxide dismutase (MnSOD) as a biomarker of different human diseases and proposes a new therapeutic application for the prevention of cancer and its treatment. The paper also describes how a new form of human MnSOD was discovered, its initial application, and its clinical potentials. The MnSOD isolated from a human liposarcoma cell line (LSA) was able to kill cancer cells expressing estrogen receptors, but it did not have cytotoxic effects on normal cells. Together with its oncotoxic activity, the recombinant MnSOD (rMnSOD) exerts a radioprotective effect on normal cells irradiated with X-rays. The rMnSOD is characterized by the presence of a leader peptide, which allows the protein to enter cells: this unique property can be used in the radiodiagnosis of cancer or chemotherapy, conjugating radioactive substances or chemotherapic drugs to the leader peptide of the MnSOD. Compared to traditional chemotherapic agents, the drugs conjugated with the leader peptide of MnSOD can selectively reach and enter cancer cells, thus reducing the side effects of traditional treatments.

scholarly journals Revealing the Therapeutic Uses of Garlic (Allium sativum) and Its Potential for Drug Discovery

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Azene Tesfaye
Keyword(s):  
Drug Development ◽  
Therapeutic Potential ◽  
Biologically Active ◽  
Human Diseases ◽  
Active Components ◽  
Runny Nose ◽  
Medicinal Value ◽  
Therapeutic Uses ◽  
Tract Disease ◽  
Chronic Fever

Background. Garlic is a common bulb vegetable that is used to flavor and flavor food. The plant contains biologically active components that contribute to its pharmacological properties. This paper attempts to examine the therapeutic uses and potential role in the drug development of garlic for various human diseases. Methods. To obtain crucial data and scientific knowledge about the therapeutic uses of garlic, systematic literature searches were conducted using key terms on well-known indexed platforms such as PubMed, Scopus, Web of Science, Medline, Embase, and popular search engines. Results. Garlic, which is utilized as a spice and flavoring ingredient, is found to have fundamental nutritional components. Carbohydrates, protein, fat, minerals, water, and vitamins are all found in abundance in this plant. The plant also has a high medicinal value and is used to cure a variety of human diseases. It has anti-inflammatory, rheumatological, ulcer inhibiting, anticholinergic, analgesic, antimicrobial, antistress, antidiabetes, anticancer, liver protection, anthelmintics, antioxidants, antifungal, and wound healing properties, as well as properties that help with asthma, arthritis, chronic fever, tuberculosis, runny nose, malaria, leprosy, skin discoloration, and itching, indigestion, colic, enlarged spleen, hemorrhoids, fistula, bone fracture, gout, urinary tract disease, diabetes, kidney stones, anemia, jaundice, epilepsy, cataract, and night blindness. Conclusions. The nutritional content of the plant is significant, and it has incredible therapeutic potential. The findings of this study are needed to investigate the therapeutic potential, as it may be a promising option for drug development.

scholarly journals A Review on Therapeutic Potential of Protease Inhibitors from Medicinal Plants

2019 ◽  
pp. 1-11
Author(s):  
R. N. N. Gamage ◽  
K. D. K. P. Kumari
Keyword(s):  
Protease Inhibitor ◽  
Protease Inhibitors ◽  
Blood Clotting ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Geographical Location ◽  
Therapeutic Agents ◽  
Human Diseases ◽  
Plant Protease ◽  
Protease Specificity

Most of the currently available therapeutic agents, particularly for cardiovascular disorders and cancers are very expensive and induce some serious side effects. Some of these drugs have also become less effective due to the emergence of antibiotic resistance. There is a necessity and great demand for the development of novel efficacious plant-based agents that are of pharmacologically effective. In this connection, this review focuses on therapeutic potential of plant protease inhibitors. Protease inhibitors are of a particular concern at present due to their potent ability to inhibit protease enzymes that are involved in pathogenesis of various human diseases. In addition to their function as protein-degrading enzymes, protease inhibitors are now well-known for their capability to involve in many biological activities as signaling molecules. Plant protease inhibitors are also engaged in several physiological and pathological processes, such as blood clotting, inflammation, immune regulation, apoptosis and carcinogenesis. Therefore, isolation of plant protease inhibitors and evaluation of their therapeutic capacity against chronic human diseases have become a major research interest. Nevertheless, protease inhibitor content and protease specificity vary significantly even in the same plant species depending on the geographical location and environmental factors. Consequently, it is important to identify potent therapeutic potential of each plant protease inhibitor on human health individually.

scholarly journals Spasmolytic Activity of Carvone and Limonene Enantiomers

2015 ◽  
Vol 10 (11) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Damião Pergentino de Sousa ◽  
Rafael Ferreira Mesquita ◽  
Luciano Augusto de Araújo Ribeiro ◽  
Julianeli Tolentino de Lima
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Essential Oils ◽  
Cardiovascular System ◽  
Pharmacological Activity ◽  
Therapeutic Potential ◽  
Rat Aorta ◽  
Aromatic Plants ◽  
Pharmacological Agents ◽  
Spasmolytic Activity

Aromatic plants produce volatile substances with high therapeutic potential. In view of the need for new respiratory and cardiovascular system pharmacological agents, the present study reports on the spasmolytic activity of two enantiomers of carvone and limonene, constituents of essential oils. The enantiomers tested showed pharmacological activity in Guinea pig trachea and rat aorta smooth muscle. No differences were observed in the pharmacological profiles of the enantiomer pairs. The oxygenated monoterpenes (+)-carvone and (-)-carvone were pharmacologically more effective than the hydrocarbon monoterpenes (+)-limonene and (-)-limonene. The results of this study show the therapeutic potential of these compounds found in many aromatic plants for the treatment of respiratory and cardiovascular system diseases.

Old and New Drugs for Treatment of Advanced Heart Failure

2020 ◽  
Vol 26 (14) ◽  
pp. 1571-1583
Author(s):  
Carmelo Buttá ◽  
Marco Roberto ◽  
Antonino Tuttolomondo ◽  
Rossella Petrantoni ◽  
Giuseppe Miceli ◽  
...  
Keyword(s):  
Heart Failure ◽  
Therapeutic Potential ◽  
Diuretic Therapy ◽  
Advanced Heart Failure ◽  
Therapeutic Options ◽  
New Drugs ◽  
Circulatory Support ◽  
Water Restriction ◽  
Hypertonic Saline Solution ◽  
Pharmacological Agents

Background: Advanced heart failure (HF) is a progressive disease with high mortality and limited medical therapeutic options. Long-term mechanical circulatory support and heart transplantation remain goldstandard treatments for these patients; however, access to these therapies is limited by the advanced age and multiple comorbidities of affected patients, as well as by the limited number of organs available. Methods: Traditional and new drugs available for the treatment of advanced HF have been researched. Results: To date, the cornerstone for the treatment of patients with advanced HF remains water restriction, intravenous loop diuretic therapy and inotropic support. However, many patients with advanced HF experience loop diuretics resistance and alternative therapeutic strategies to overcome this problem have been developed, including sequential nephron blockade or use of the hypertonic saline solution in combination with high-doses of furosemide. As classic inotropes augment myocardial oxygen consumption, new promising drugs have been introduced, including levosimendan, istaroxime and omecamtiv mecarbil. However, pharmacological agents still remain mainly short-term or palliative options in patients with acute decompensation or excluded from mechanical therapy. Conclusions: Traditional drugs, especially when administered in combination, and new medicaments represent important therapeutic options in advanced HF. However, their impact on prognosis remains unclear. Large trials are necessary to clarify their therapeutic potential and prognostic role in these fragile patients.

Therapeutic Potential of Medicinal Plant Proteins: Present Status and Future Perspectives

2020 ◽  
Vol 21 (5) ◽  
pp. 443-487
Author(s):  
Snober Shabeer Wani ◽  
Parvaiz A. Dar ◽  
Sajad M. Zargar ◽  
Tanveer A. Dar
Keyword(s):  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Medicinal Plant ◽  
Therapeutic Potential ◽  
Biologically Active ◽  
Human Diseases ◽  
Current Status ◽  
Mistletoe Lectin ◽  
Plant Proteins ◽  
Drug Candidates

Biologically active molecules obtained from plant sources, mostly including secondary metabolites, have been considered to be of immense value with respect to the treatment of various human diseases. However, some inevitable limitations associated with these secondary metabolites like high cytotoxicity, low bioavailability, poor absorption, low abundance, improper metabolism, etc., have forced the scientific community to explore medicinal plants for alternate biologically active molecules. In this context, therapeutically active proteins/peptides from medicinal plants have been promoted as a promising therapeutic intervention for various human diseases. A large number of proteins isolated from the medicinal plants have been shown to exhibit anti-microbial, anti-oxidant, anti-HIV, anticancerous, ribosome-inactivating and neuro-modulatory activities. Moreover, with advanced technological developments in the medicinal plant research, medicinal plant proteins such as Bowman-Birk protease inhibitor and Mistletoe Lectin-I are presently under clinical trials against prostate cancer, oral carcinomas and malignant melanoma. Despite these developments and proteins being potential drug candidates, to date, not a single systematic review article has documented the therapeutical potential of the available biologically active medicinal plant proteome. The present article was therefore designed to describe the current status of the therapeutically active medicinal plant proteins/peptides vis-à-vis their potential as future protein-based drugs for various human diseases. Future insights in this direction have also been highlighted.

scholarly journals Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas

2022 ◽  
Vol 21 (1) ◽  
Author(s):  
Yan Wang ◽  
Chunjie Wu ◽  
Yu Du ◽  
Zhongwei Li ◽  
Minle Li ◽  
...  
Keyword(s):  
Internal Ribosome Entry Site ◽  
Therapeutic Potential ◽  
Circular Rna ◽  
Human Diseases ◽  
Circular Rnas ◽  
Host Proteins ◽  
Entry Site ◽  
Internal Ribosome Entry ◽  
Polysome Profiling ◽  
Translation Mechanism

AbstractCircular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a 5’ end cap and a 3’ end poly (A) tail necessary for cap-dependent translation. However, increasing numbers of translated circRNAs identified through high-throughput RNA sequencing overlapping with polysome profiling indicate that this rule is being broken. CircRNAs can be translated in cap-independent mechanism, including IRES (internal ribosome entry site)-initiated pattern, MIRES (m6A internal ribosome entry site) -initiated patterns, and rolling translation mechanism (RCA). CircRNA-encoded proteins harbour diverse functions similar to or different from host proteins. In addition, they are linked to the modulation of human disease including carcinomas and noncarcinomas. CircRNA-related translatomics and proteomics have attracted increasing attention. This review discusses the progress and exclusive characteristics of circRNA translation and highlights the latest mechanisms and regulation of circRNA translatomics. Furthermore, we summarize the extensive functions and mechanisms of circRNA-derived proteins in human diseases, which contribute to a better understanding of intricate noncanonical circRNA translatomics and proteomics and their therapeutic potential in human diseases.

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