scholarly journals Nonattenuated Polymyxin B Used for the Treatment of Extreme-Drug ResistantAcinetobacter baumannii-Related Infections in Patients with Preexisting End Stage Renal Failure

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Yvonne Peijun Zhou ◽  
Nathalie Grace Sy Chua ◽  
Maciej Piotr Chlebicki ◽  
Winnie Hui Ling Lee ◽  
Andrea Lay Hoon Kwa

Recent pharmacokinetic studies have suggested that nonrenal clearance predominates the elimination of polymyxin B. We present 2 patients with preexisting end stage renal failure, who were given nonattenuated doses of polymyxin B for the treatment of extreme-drug resistant organism. No evidence of adverse events occurred and microbiological clearance was documented.

1988 ◽  
Vol 11 (3) ◽  
pp. 181-185 ◽  
Author(s):  
J. Woo ◽  
A. Leung ◽  
K. Chan ◽  
K.N. Lai ◽  
R. Teoh

We measured pyrazinamide and rifampicin plasma concentrations in five patients with pulmonary tuberculosis and end stage renal failure treated by haemodialysis or continuous ambulatory peritoneal dialysis. Using conventional daily doses of oral pyrazinamide and rifampicin, we found that the drugs were removed efficiently by both dialysis methods, so that plasma levels were sub-optimal for maximal bactericidal action. These findings suggest that in patients with tuberculosis on maintenance dialysis, treatment should be either with higher doses of these two drugs, or with additional replacement doses given after each dialysis. Further detailed pharmacokinetic studies on larger numbers of patients are indicated.


2000 ◽  
Vol 15 (12) ◽  
pp. H2-H2
Author(s):  
IS Mertasudira ◽  
JR Saketi ◽  
A. Djumhana ◽  
J. Widjojo ◽  
SA Abdurachman

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
T Krabatsch ◽  
M Bechtel ◽  
C Detter ◽  
T Fischlein ◽  
FC Riess ◽  
...  

2017 ◽  
Vol 68 (6) ◽  
pp. 1325-1328
Author(s):  
Andrada Raluca Doscas ◽  
Mihail Balan ◽  
Mihai Liviu Ciofu ◽  
Doriana Agop Forna ◽  
Marius Cristian Martu ◽  
...  

Chronic kidney disease (CKD) is a multifactorial syndrome and a global health concern. As renal function declines, there is a progressive deterioration of mineral homeostasis. Starting from stage 3 of CKD oral manifestations of mineral disorders can occasionally appear and become more frequent and evident in stage 5. We retrospectively analysed 43 patients diagnosed with end stage renal failure undergoing dialysis, hospitalized in our clinic for different oral and maxillofacial pathologies. The mean dialysis period was 5.43 years. Radiographic alterations afecting the jaws were found in all patients. The most common feature was partial or total loss of lamina dura, followed by alterations of the bony trabeculae. 9 patients presented brown tumors which are considered the final stage of secondary hyperparathyroidism associated with renal failure.


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