scholarly journals Evaluation of Human Amniotic Membrane as a Wound Dressing for Split-Thickness Skin-Graft Donor Sites

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Denys J. Loeffelbein ◽  
Nils H. Rohleder ◽  
Matthias Eddicks ◽  
Claudia M. Baumann ◽  
Mechthild Stoeckelhuber ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Skin Graft ◽  
Amniotic Membrane ◽  
Wound Dressing ◽  
Membrane Integrity ◽  
Split Thickness Skin Graft ◽  
Human Amniotic Membrane ◽  
Swine Model ◽  
Pu Foam ◽  
Thickness Skin

Human amniotic membrane (HAM) has been used as a biomaterial in various surgical procedures and exceeds some qualities of common materials. We evaluated HAM as wound dressing for split-thickness skin-graft (STSG) donor sites in a swine model (Part A) and a clinical trial (Part B). Part A: STSG donor sites in 4 piglets were treated with HAM or a clinically used conventional polyurethane (PU) foil (n=8each). Biopsies were taken on days 5, 7, 10, 20, 40, and 60 and investigated immunohistochemically for alpha-smooth muscle actin (αSMA: wound contraction marker), von Willebrand factor (vWF: angiogenesis), Ki-67 (cell proliferation), and laminin (basement membrane integrity). Part B: STSG donor sites in 45 adult patients (16 female/29 male) were treated with HAM covered by PU foam, solely by PU foam, or PU foil/paraffin gauze (n=15each). Part A revealed no difference in the rate of wound closure between groups. HAM showed improved esthetic results and inhibitory effects on cicatrization. Angioneogenesis was reduced, and basement membrane formation was accelerated in HAM group. Part B: no difference in re-epithelialization/infection rate was found. HAM caused less ichor exudation and less pruritus. HAM has no relevant advantage over conventional dressings but might be a cost-effective alternative.

Effects of argon beam coagulation on split thickness skin graft survival in the swine model

Burns ◽  
1994 ◽  
Vol 20 (2) ◽  
pp. 115-117 ◽  
Author(s):  
J.W. Canady ◽  
J.M. Hiebert ◽  
M.M. Mani ◽  
P. Briscoe ◽  
S.A. Thompson
Keyword(s):  
Graft Survival ◽  
Skin Graft ◽  
Split Thickness Skin Graft ◽  
Swine Model ◽  
Thickness Skin ◽  
Argon Beam Coagulation

scholarly journals Evaluation of Six Split-Thickness Skin Graft Donor Site Dressing Materials in a Swine Model

2013 ◽  
Vol 132 ◽  
pp. 50-51
Author(s):  
Pamela C. Masella ◽  
Eric M. Balent ◽  
Terri L. Carlson ◽  
Karen W. Lee ◽  
Lisa M. Pierce
Keyword(s):  
Skin Graft ◽  
Donor Site ◽  
Split Thickness Skin Graft ◽  
Swine Model ◽  
Thickness Skin ◽  
Graft Donor ◽  
Dressing Materials

scholarly journals Randomized Clinical Trial of the Innovative Bilayered Wound Dressing Made of Silk and Gelatin: Safety and Efficacy Tests Using a Split-Thickness Skin Graft Model

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Sukhontha Hasatsri ◽  
Apichai Angspatt ◽  
Pornanong Aramwit
Keyword(s):  
Skin Graft ◽  
Wound Dressing ◽  
Donor Site ◽  
Systemic Reaction ◽  
Healing Time ◽  
Skin Barrier Function ◽  
Split Thickness Skin Graft ◽  
Safety And Efficacy ◽  
Thickness Skin ◽  
Graft Donor

We developed the novel silk fibroin-based bilayered wound dressing for the treatment of partial thickness wounds. And it showed relevant characteristics and accelerated the healing of full-thickness wounds in a rat model. This study is the clinical evaluation of the bilayered wound dressing to confirm its safety and efficacy for the treatment of split-thickness skin donor sites. The safety test was performed using a patch model and no evidence of marked and severe cutaneous reactions was found. The efficacy test of the bilayered wound dressing was conducted on 23 patients with 30 split-thickness skin graft donor sites to evaluate healing time, pain score, skin barrier function, and systemic reaction in comparison to Bactigras. We found that the healing time of donor site wounds treated with the bilayered wound dressing (11 ± 6 days) was significantly faster than those treated with Bactigras (14 ± 6 days) (p=10-6). The wound sites treated with the bilayered wound dressing showed significantly less pain and more rapid skin functional barrier recovery than those treated with Bactigras (p=10-5). Therefore, these results confirmed the clinical safety and efficacy of the bilayered wound dressing for the treatment of split-thickness skin graft donor sites.

Clinical Potential of a Silk Sericin-Releasing Bioactive Wound Dressing for the Treatment of Split-Thickness Skin Graft Donor Sites

2013 ◽  
Vol 31 (1) ◽  
pp. 104-116 ◽  
Author(s):  
Tippawan Siritientong ◽  
Apichai Angspatt ◽  
Juthamas Ratanavaraporn ◽  
Pornanong Aramwit
Keyword(s):  
Skin Graft ◽  
Wound Dressing ◽  
Split Thickness Skin Graft ◽  
Silk Sericin ◽  
Thickness Skin ◽  
Graft Donor ◽  
Clinical Potential

Evaluation of Dried Amniotic Membrane on Wound Healing at Split-Thickness Skin Graft Donor Sites: A Randomized, Placebo-Controlled, Double-blind Trial

2020 ◽  
Vol 33 (12) ◽  
pp. 636-641
Author(s):  
Mojtaba Vaheb ◽  
Bahareh Mohajer Kohestani ◽  
Maryam Karrabi ◽  
Maryam Khosrojerdi ◽  
Mahtab Khajeh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Graft ◽  
Amniotic Membrane ◽  
Split Thickness Skin Graft ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Thickness Skin ◽  
Graft Donor
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