scholarly journals Pepsinogen II Can Be a Potential Surrogate Marker of Morphological Changes in Corpus before and afterH. pyloriEradication

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Sadegh Massarrat ◽  
Arghavan Haj-Sheykholeslami ◽  
Ashraf Mohamadkhani ◽  
Nasrin Zendehdel ◽  
Ali Aliasgari ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Surrogate Marker ◽  
Pepsinogen I ◽  
Good Marker ◽  
Before And After ◽  
H Pylori ◽  
Lower Ratio ◽  
Gastric Cancer Patients ◽  
The Relationship ◽  
Pepsinogen Ii

Background.The aim of this investigation is to study the relationship between gastric morphology and serum biomarkers before and afterHelicobacter pylorieradication.Methods. First-degree relatives of gastric cancer patients underwent gastroscopy before and 2.5 years afterH. pylorieradication. The morphological changes in two categories (normal to mild and moderate to severe) were compared with level of pepsinogens I and II before eradication (n=369), after eradication (n=115), and in those with persistent infection (n=250).Results: After eradication, pepsinogen I decreased to 70% and pepsinogen II to 45% of the previous values. Unlike pepsinogen II and pepsinogen I to II ratio that were affected by the severity of inflammation and atrophy in corpus in all groups, pepsinogen I generally did not change. After eradication, subjects with high mononuclear infiltration in corpus had lower pepsinogen I (54 versus 77.1 μ/mL), higher pepsinogen II (9.4 versus 6.9 μ/mL), and lower ratio (7.9 versus 11.6) than those without (P<0.05).Conclusion. Pepsinogen II is a good marker of corpus morphological changes before and afterH. pylorieradication.

scholarly journals White opaque substance visualized by magnifying narrow-band imaging is associated with intragastric acid conditions

2018 ◽  
Vol 06 (07) ◽  
pp. E830-E837 ◽  
Author(s):  
Kazumi Togo ◽  
Tetsuya Ueo ◽  
Kenshi Yao ◽  
Kurato Wada ◽  
Hideho Honda ◽  
...  
Keyword(s):  
Gastric Juice ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Lipid Absorption ◽  
Before And After ◽  
Strong Acidity ◽  
Intragastric Acid ◽  
H Pylori ◽  
Ph Level ◽  
The Relationship

Abstract Background and study aims The presence of white opaque substance (WOS) is an endoscopic marker of intestinal metaplasia. Considering that the nature of WOS is absorbed lipid droplets, lipase plays an important role in the lipid absorption process and is inactivated at strong acidity. WOS may only be present in a hypochlorhydria state following Helicobacter pylori infection, and, thus, may not be highly sensitive marker, especially in H. pylori-eradicated patients. We investigated the relationship between WOS and gastric acid conditions. Patients and methods A total of 501 patients were retrospectively evaluated for the presence of WOS at 2 regions of interest using magnifying narrow-band imaging. The pH level of collected gastric juice was also measured. Study end points were (1) prevalence of WOS and its relationship with gastric juice pH in 3 groups: H. pylori-uninfected, H. pylori-infected, and H. pylori-eradicated; (2) the relationship between prevalence of WOS and gastric juice pH before and after proton pump inhibitor (PPI) administration in 29 H. pylori-eradicated cases. Results Prevalence of WOS was 0 % (0 /206), 28.4 % (31/109), and 3.2 % (6/186) in the H. pylori-uninfected, H. pylori-infected, and H. pylori-eradicated groups, respectively. Mean gastric juice pH was significantly higher in WOS-positive cases than in WOS-negative cases in the H. pylori-infected and H. pylori-eradicated groups (P < 0.0001). Mean gastric juice pH increased from 1.1 to 6.9 after PPI administration and WOS prevalence increased from 0 % (0/29) to 45 % (13/29) of cases. Conclusion The prevalence of WOS is closely associated with the neutralization of intragastric pH.

Changes in Teat Morphology (Doka Phenomenon) and Estrus Prediction in Riverine Buffaloes (Bubalus bubalis)

2019 ◽  
Author(s):  
S K Joshi ◽  
T K Mohanty ◽  
A Kumaresan ◽  
M Bhakat ◽  
S Sathapathy
Keyword(s):  
Morphological Changes ◽  
Bubalus Bubalis ◽  
North India ◽  
Research Centre ◽  
Murrah Buffaloes ◽  
Group I ◽  
Before And After ◽  
Group Ii ◽  
The Difference ◽  
The Relationship

The objective of the study was to characterize the term Doka and to capture morphological changes in teat to find out the relationship between Doka and onset of estrus in Murrah buffaloes (Bubalus bubalis). The Murrah buffaloes maintained at of Livestock Research Centre (LRC), ICAR-NDRI, Karnal were classified into two groups based on the lactation number for the study of Doka characteristics. In group I, twenty animals up to 3rd lactation were incorporated, whereas thirty animals from 4th to 5th lactation were included in group II. The period when buffaloes showed teat engorgement was called as Doka period, is the local term used by the farmers in North India that can be taken as a visual sign for prediction of estrus. The length and diameter of teats, before and after milking were measured, for both the groups during morning and evening milking and subsequently analyzed. The present study confirmed that the teat diameter (mm) before milking during Doka was significantly (plessthan0.05) higher as compared to pre Doka period in both the groups (group-I - 37.01 ±2.13 vs 28.42 ±1.64, group-II - 53.49 ±2.82 vs 41.096±2.16). The teat diameter (mm) during Doka period after milking was significantly (plessthan0.05) more in both the groups (group-I - 26.65 ±1.26 vs 24.44 ±1.16, group-II - 39.27 ±2.41 vs 35.31 ±2.17) as compared to pre Doka period. So, it can be concluded that the changes in teat diameter can safely be considered as a sign of Doka and the forthcoming heat in Murrah buffaloes. However, the difference in teat length between different stages of Doka was found to be non significant.

scholarly journals Serum pepsinogen I and pepsinogen II levels and its ratio in patients with gastric cancer: a case control study

2016 ◽  
Vol 4 (1) ◽  
pp. 356
Author(s):  
Amal Abraham ◽  
T. U. Girish ◽  
B. J. Sharathchandra ◽  
Subbarao V. Madhunapantula ◽  
Manish Kumar Yadav ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Early Stage ◽  
Developed Countries ◽  
Screening Tools ◽  
P Value ◽  
Serum Pepsinogen ◽  
Pepsinogen I ◽  
Gastric Cancer Patients ◽  
Pepsinogen Ii

Background:Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The incidence of gastric cancer is found to increase in the developing countries like India due to change in the life style like having smoked food containing nitrates, smoking , alcoholism and consumption of large amount of red chillies. The objective of this study was to measure the serum pepsinogen I and pepsinogen II levels and its ratio in gastric cancer patients admitted in JSS hospital and Bharath Cancer Centre during the period October 2012 to October 2014 and to compare with controls.Methods: 80 patients - 40 patients with gastric cancer and 40 patients control were studied. Serum pepsinogen I (PG I) and pepsinogen II (PG II) levels were measured using ELISA.Results:The mean PG I levels for cancer patients and controls were 93.98μg/dl and 82.156μg/dl respectively, the mean PG II levels were 42.67 μg/dl and 18.79 μg/dl respectively. The PG I/II ratio in cancer patients is 2.75 and 5.73 in controls, the ratio was significantly lower in cancer patients (P value significant).Conclusions:The ultimate aim in the management of carcinoma stomach is the early detection of the disease. At present endoscopy and biopsy is the gold standard of diagnosis. Different screening tools are under development for the diagnosis of the disease. Our study evaluates a test which can be recommended as an alternative to the diagnosis of gastric carcinoma at an early stage.

scholarly journals The relationship between Helicobacter pylori infection and reflux esophagitis and the long-term effects of eradication of Helicobacter pylori on reflux esophagitis

2021 ◽  
Vol 14 ◽  
pp. 175628482110599
Author(s):  
Mariko Hojo ◽  
Kumiko Ueda ◽  
Tsutomu Takeda ◽  
Yoichi Akazawa ◽  
Hiroya Ueyama ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Acid Secretion ◽  
Reflux Esophagitis ◽  
Gastroesophageal Junction ◽  
Long Term Effects ◽  
Exact Test ◽  
Before And After ◽  
H Pylori ◽  
The Relationship ◽  
New Onset

Introduction: Whether the incidence of reflux esophagitis (RE) increases after the eradication of Helicobacter pylori ( H. pylori) is controversial. Few reports have evaluated the presence or absence of RE after a long period of time, taking into account the degree of atrophy and/or administration of acid secretion inhibitors. We investigated the relationship between H. pylori and RE taking into account these factors. Methods: This was a retrospective cohort study with approval by the Ethics Committee. Patients who succeeded in H. pylori eradication treatment, and in whom there were images of the gastroesophageal junction on endoscopic examinations within 1 year before eradication treatment and more than 3 years after eradication were included. The degrees of RE and atrophy were retrospectively determined from the endoscopic images. The prevalence of RE before and after eradication and the incidence of newly developed RE after eradication between patients with or without atrophy improvement were compared using Fisher’s exact test. Results: A total of 185 cases (male:female = 104:81; mean age, 63.5 years; mean observation period, 6.4 years) were examined. The prevalence of RE before and after eradication was 1.6% (3/185) and 7.0% (13/185), respectively ( P = 0.019). RE was present in 8 (7.5%) of 106 cases with closed-type atrophy and in 5 (6.3%) of 79 cases with open-type atrophy after eradication ( P = 0.75). Atrophy improved after eradication in 56 cases, of whom 4 (7.1%) had new onset of RE; the degree of atrophy did not improve in 126 cases, of whom 7 (5.4%) had new onset of RE ( P = 0.74). There was no difference between the percentage of cases who took acid secretion inhibitors before and after eradication ( P = 0.14). Conclusion: The prevalence of RE increased a long time after eradication, even in patients who were taking an acid secretion inhibitor. The prevalence of RE was not related to the degree of atrophy or change in atrophy.

scholarly journals A Study Based on CASIA2: What the Subtle Changes Has Taken Place in the Shape of the Crystalline Lens After Cycloplegia?

2021 ◽  
Author(s):  
Cheng Dai ◽  
Meng Liu ◽  
Xiaodong Lv ◽  
Binzhong Li
Keyword(s):  
Children And Adolescents ◽  
Crystal Morphology ◽  
Morphological Changes ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Crystalline Lens ◽  
Equivalent Diameter ◽  
Swept Source ◽  
Before And After ◽  
The Relationship

Abstract Background: To evaluate the shape of the crystalline lens biometry and the diopter before and after cycloplegia using the CASIA2 swept-source (SS) optical coherence tomography (OCT) system on the anterior segment.Methods: This is a retrospective study. Children and adolescents (26 males and 29 females, aged 4–21 years) with simple ametropia were selected for optometry and CASIA2 imaging at 2 separate visits before and after cycloplegia. Diopter is derived from the spherical power (S) obtained by optometry. The Biometric parameters of the crystalline lens, including anterior chamber depth (ACD), anterior and posterior curvature of the lens (ACL and PCL), lens thickness (LTH), lens decentration(LD), lens tilt(LT), and the equivalent diameter of the lens (LED), were measured by CASIA2. The differences of these parameters before and after cycloplegia were compared, and the relationship between them was analyzed.Results: Fifty-five participants (106 eyes) were initially enrolled. The differences were statistically significant(P<0.05) in S (t=-7.026, P=0.000), ACD (t=-8.796, P=0.000), ACL (t=-13.263, P=0.000) and LTH（t=7.363, P=0.000）before and after cycloplegia. The change of PCL (t=1.557,P=0.122), LD (t=0.876, P=0.383), LT (t=0.440, P=0.661) and LED（t=-0.351, P=0.726） was not statistically significant (P>0.05). There was a significant (P<0.05) correlation between the change in S and ACL(r=0.466, P=0.000),LTH (r=-0.592, P=0.000),and LED (r=0.223, P=0.021) but not between the PCL(r=0.19, P=0.051), LD (r=-0.048, P=0.0628) and LT (r=-0.022, P=0.822). Furthermore, the change of ACD is closely related to the change of crystal morphology. However, in children and adolescents, we found that the change of crystal morphology will not have anything to do with age.Conclusion: The morphological changes of the lens before and after cycloplegia are mainly the ACL and LTH, but there is no difference in the PCL, LD, LT, and LED. In the adolescent population, the change of S is related to the change of ACL, LED and LTH. However, age gets nothing to do with the shape of the crystalline lens. For different refractive states (myopia, hyperopia, emmetropia), whether groups of different ages can reach the same conclusion needs further research.

Serum Pepsinogen I, Pepsinogen II, and Gastrin 17 in Relatives of Gastric Cancer Patients: Comparative Study With Type and Severity of Gastritis

2008 ◽  
Vol 6 (2) ◽  
pp. 174-179 ◽  
Author(s):  
Arghavan Haj–sheykholeslami ◽  
Naser Rakhshani ◽  
Aliakbar Amirzargar ◽  
Reza Rafiee ◽  
S. Mehdi Shahidi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Comparative Study ◽  
Cancer Patients ◽  
Serum Pepsinogen ◽  
Pepsinogen I ◽  
Gastric Cancer Patients ◽  
Pepsinogen Ii

scholarly journals The Relationship betweenHelicobacter pyloriand Beta-2 Microglobulin in Humans

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Abdullah Özgür Yeniova ◽  
Metin Kucukazman ◽  
Naim Ata ◽  
Kursat Dal ◽  
Ayşe Kefeli ◽  
...  
Keyword(s):  
Eradication Therapy ◽  
Gastrointestinal Diseases ◽  
Low Grade ◽  
Mhc I ◽  
Histocompatibility Complex ◽  
Before And After ◽  
Caga Status ◽  
H Pylori ◽  
Beta 2 Microglobulin ◽  
The Relationship

H. pyloriis related to various gastrointestinal diseases.β2Microglobulin (β2M) is an intrinsic element of major histocompatibility complex (MHC I). Serumβ2M level may increase in inflammatory states. The aim of current study is to evaluate the relationship betweenβ2M andH. pyloribearing CagA strains.Methods.H. pyloristatus was determined by histopathology of samples taken from stomach. CagA status andβ2M level were measured from blood samples of patients. Eradication therapy was administered to the patients withH. pyloriinfection.β2Microglobulin levels were measured before and after treatment.Results. 35 (29.2%)H. pylori(−) patients and 85 (70.8%)H. pylori(+) patients were included in the study. There were 52 (43.3%) patients with CagA negative and 33 (27.5%) patients with CagA positiveH. pyloriinfection. The mean serumβ2M level was 1.83 mg/L inH. pylori(−) group, 1.76 mg/L inH. pylori(+) CagA (−) group, and 1.93 mg/L inH. pyloriand CagA (+) group (P>0.05). Serumβ2M levels (1.82 versus 1.64 mg/LP<0.05) were decreased after eradication.Conclusion.H. pyloriand CagA status did not affectβ2M level. Relationship between low grade systematic inflammation andH. pylorishould be investigated to find out new predictors for diseases associated with inflammation.

Helicobacter pylori infection: place of serological and cultural diagnostics in clinical guidelines

2021 ◽  
Vol 66 (8) ◽  
pp. 496-501
Author(s):  
L. A. Kornoukhova ◽  
V. L. Emanuel ◽  
N. L. Denisov ◽  
E. L. Nikonov
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Blood Serum ◽  
Clinical Guidelines ◽  
Reference Intervals ◽  
Healthy People ◽  
Helicobacter Pylori Infection ◽  
Pepsinogen I ◽  
H Pylori ◽  
Pepsinogen Ii

The purpose of this work was to familiarize doctors with the methods and significance of serological and cultural diagnostics of H. pylori infection on the example of the test for diagnosing the state of the gastric mucosa «Gastropanel». Blood serum tests were performed for 1057 patients and 122 healthy people aged 18-64 years: pepsinogen I (PG I), pepsinogen II (PG II), gastrin-17 (G-17), basal/stimulated), antibodies (IgGHp) to H. pylori (Biohit Oyj, Finland). The medians of the studied group indicators did not exceed the reference intervals. 398 (34%) patients have negative H. pylori status (IgGHp-). 275 (26%) patients with serum PG I≤70 mcg/ml were identified. The ratio of PG I/II≤3 in 84 (8%), 36 of them (43% of the group PG I/II≤3) - IgGHp-.

EXPERIENCE OF USING THE TEST SYSTEM «GASTROPANEL» IN THE PREVENTIVE MEDICAL EXAMINATION OF WORKFORCE IN JSC RZD

2021 ◽  
Author(s):  
A.O. Devyatko ◽  
◽  
T.A. Noskova ◽  
N.V. Shevchenko
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Enzyme Immunoassay ◽  
Test System ◽  
Medical Examination ◽  
Pepsinogen I ◽  
Non Invasive ◽  
H Pylori ◽  
Pepsinogen Ii

Abstract: Non-invasive diagnosis of the gastric mucosa was carried out in 181 people in the preventive medical examination of workforce in JSC RZD. A set of diagnostics from Vector-Best (Novosibirsk, Russia) was used for enzyme immunoassay of pepsinogen I, pepsinogen II, and immunoglobulins for Helicobacter pylori. The prevalence of H. pylori infection in more than half of the employees, the presence of deviations of biomarkers from the norm in more than one in three employees were revealed. Laboratory signs of atrophy were detected eight times less frequently than signs of inflammation of the gastric mucosa, but when infected with H. pylori and increased with age.

Enhancing Spatial Ability Through Sport Practice

2012 ◽  
Vol 33 (2) ◽  
pp. 83-88 ◽  
Author(s):  
David Moreau ◽  
Jérome Clerc ◽  
Annie Mansy-Dannay ◽  
Alain Guerrien
Keyword(s):  
Mental Rotation ◽  
Spatial Representations ◽  
Mental Rotation Test ◽  
Sport Training ◽  
Sport Practice ◽  
Undergraduate University Students ◽  
Before And After ◽  
Cognitive Plasticity ◽  
Reported Data ◽  
The Relationship

This experiment investigated the relationship between mental rotation and sport training. Undergraduate university students (n = 62) completed the Mental Rotation Test ( Vandenberg & Kuse, 1978 ), before and after a 10-month training in two different sports, which either involved extensive mental rotation ability (wrestling group) or did not (running group). Both groups showed comparable results in the pretest, but the wrestling group outperformed the running group in the posttest. As expected from previous studies, males outperformed women in the pretest and the posttest. Besides, self-reported data gathered after both sessions indicated an increase in adaptive strategies following training in wrestling, but not subsequent to training in running. These findings demonstrate the significant effect of training in particular sports on mental rotation performance, thus showing consistency with the notion of cognitive plasticity induced from motor training involving manipulation of spatial representations. They are discussed within an embodied cognition framework.

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