scholarly journals Synthesis and Characterization of Tolvaptan Impurities

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Madhuresh Kumar Sethi ◽  
Vijendra Singh Rawat ◽  
Jayaprakash Thirunavukarasu ◽  
Rajakrishna Yerramalla ◽  
Anish Kumar
Keyword(s):  
Nuclear Magnetic Resonance ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Magnetic Resonance ◽  
High Performance ◽  
Mass Spectra ◽  
Synthesis And Characterization ◽  
Nuclear Magnetic

Twenty-six possible as well as observed impurities during the preparation of Tolvaptan have been identified, prepared, and characterized by HPLC (high performance liquid chromatography), NMR (nuclear magnetic resonance), and mass spectra. Control of these impurities, formed during various stages of Tolvaptan preparation, has been mentioned in this paper.

Investigation of a cyclopropyl-containing drug by on-line high-performance liquid chromatography/nuclear magnetic resonance

1989 ◽  
Vol 61 (7) ◽  
pp. 772-775 ◽  
Author(s):  
Klaus. Albert ◽  
Manuel. Kunst ◽  
Ernst. Bayer ◽  
Hendrik Jan. De Jong ◽  
Patrick. Genissel ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Magnetic Resonance ◽  
High Performance ◽  
On Line ◽  
Nuclear Magnetic
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