scholarly journals New Researches and Application Progress of Commonly Used Optical Molecular Imaging Technology

2014 ◽  
Vol 2014 ◽  
pp. 1-22 ◽  
Author(s):  
Zhi-Yi Chen ◽  
Yi-Xiang Wang ◽  
Feng Yang ◽  
Yan Lin ◽  
Qiu-Lan Zhou ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Drug Research ◽  
Gene Expression Regulation ◽  
Imaging Technique ◽  
Imaging Techniques ◽  
High Sensitivity ◽  
Effect Evaluation ◽  
Optical Molecular Imaging ◽  
Biological Development ◽  
Therapeutic Effect Evaluation

Optical molecular imaging, a new medical imaging technique, is developed based on genomics, proteomics and modern optical imaging technique, characterized by non-invasiveness, non-radiativity, high cost-effectiveness, high resolution, high sensitivity and simple operation in comparison with conventional imaging modalities. Currently, it has become one of the most widely used molecular imaging techniques and has been applied in gene expression regulation and activity detection, biological development and cytological detection, drug research and development, pathogenesis research, pharmaceutical effect evaluation and therapeutic effect evaluation, and so forth, This paper will review the latest researches and application progresses of commonly used optical molecular imaging techniques such as bioluminescence imaging and fluorescence molecular imaging.

scholarly journals Ocular Biodistribution Studies Using Molecular Imaging

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 237 ◽  
Author(s):  
Ana Castro-Balado ◽  
Cristina Mondelo-García ◽  
Miguel González-Barcia ◽  
Irene Zarra-Ferro ◽  
Francisco J Otero-Espinar ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Single Photon ◽  
Imaging Techniques ◽  
Photon Emission ◽  
High Sensitivity ◽  
New Drugs ◽  
Emission Computed Tomography ◽  
Pharmacokinetic Data ◽  
Biodistribution Studies

Classical methodologies used in ocular pharmacokinetics studies have difficulties to obtain information about topical and intraocular distribution and clearance of drugs and formulations. This is associated with multiple factors related to ophthalmic physiology, as well as the complexity and invasiveness intrinsic to the sampling. Molecular imaging is a new diagnostic discipline for in vivo imaging, which is emerging and spreading rapidly. Recent developments in molecular imaging techniques, such as positron emission tomography (PET), single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI), allow obtaining reliable pharmacokinetic data, which can be translated into improving the permanence of the ophthalmic drugs in its action site, leading to dosage optimisation. They can be used to study either topical or intraocular administration. With these techniques it is possible to obtain real-time visualisation, localisation, characterisation and quantification of the compounds after their administration, all in a reliable, safe and non-invasive way. None of these novel techniques presents simultaneously high sensitivity and specificity, but it is possible to study biological procedures with the information provided when the techniques are combined. With the results obtained, it is possible to assume that molecular imaging techniques are postulated as a resource with great potential for the research and development of new drugs and ophthalmic delivery systems.

scholarly journals Multimodal Molecular Imaging: Current Status and Future Directions

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Min Wu ◽  
Jian Shu
Keyword(s):  
Molecular Imaging ◽  
Drug Research ◽  
Molecular Level ◽  
Imaging Techniques ◽  
Current Status ◽  
Biological Processes ◽  
Future Directions ◽  
Detection Techniques ◽  
Imaging Mode

Molecular imaging has emerged at the end of the last century as an interdisciplinary method involvingin vivoimaging and molecular biology aiming at identifying living biological processes at a cellular and molecular level in a noninvasive manner. It has a profound role in determining disease changes and facilitating drug research and development, thus creating new medical modalities to monitor human health. At present, a variety of different molecular imaging techniques have their advantages, disadvantages, and limitations. In order to overcome these shortcomings, researchers combine two or more detection techniques to create a new imaging mode, such as multimodal molecular imaging, to obtain a better result and more information regarding monitoring, diagnosis, and treatment. In this review, we first describe the classic molecular imaging technology and its key advantages, and then, we offer some of the latest multimodal molecular imaging modes. Finally, we summarize the great challenges, the future development, and the great potential in this field.

scholarly journals Confocal Imaging: Blood and Lymphatic Capillaries

2006 ◽  
Vol 6 ◽  
pp. 12-15 ◽  
Author(s):  
Yingjie Cui
Keyword(s):  
Molecular Markers ◽  
Molecular Imaging ◽  
Blood Vessel ◽  
Imaging Technique ◽  
Imaging Techniques ◽  
Lymphatic Vessels ◽  
Confocal Imaging ◽  
Short Report ◽  
The Relationship ◽  
Molecular Imaging Technique

Traditional imaging techniques are quite limited for the study of the relationship between blood vessels and lymphatic vessels. Therefore, a new imaging technique is required based on blood vessel and lymphatic endothelial-specific molecular markers. In this short report, vascular molecular markers are reviewed and a new molecular imaging technique for blood vessel and lymphatic co-staining is introduced.

High sensitivity optical molecular imaging system

2018 ◽  
Author(s):  
Jie Tian ◽  
Yu An ◽  
Kun Wang ◽  
Peng Zhang ◽  
Yuan Gao ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Imaging System ◽  
High Sensitivity ◽  
Optical Molecular Imaging

An x-ray microprobe based upon a close-coupled focal-spot / glass capillary arrangement

1992 ◽  
Vol 50 (2) ◽  
pp. 1758-1759
Author(s):  
D. A. Carpenter ◽  
M. A. Taylor
Keyword(s):  
Imaging Techniques ◽  
Fluorescence Analysis ◽  
High Sensitivity ◽  
Specimen Preparation ◽  
X Rays ◽  
Glass Capillary ◽  
Close Coupling ◽  
X Ray ◽  
Point To Point ◽  
Beam Damage

The development of intense sources of x rays has led to renewed interest in the use of microbeams of x rays in x-ray fluorescence analysis. Sparks pointed out that the use of x rays as a probe offered the advantages of high sensitivity, low detection limits, low beam damage, and large penetration depths with minimal specimen preparation or perturbation. In addition, the option of air operation provided special advantages for examination of hydrated systems or for nondestructive microanalysis of large specimens.The disadvantages of synchrotron sources prompted the development of laboratory-based instrumentation with various schemes to maximize the beam flux while maintaining small point-to-point resolution. Nichols and Ryon developed a microprobe using a rotating anode source and a modified microdiffractometer. Cross and Wherry showed that by close-coupling the x-ray source, specimen, and detector, good intensities could be obtained for beam sizes between 30 and 100μm. More importantly, both groups combined specimen scanning with modern imaging techniques for rapid element mapping.

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