scholarly journals Myeloid Sarcoma: A Rare Case of an Orbital Mass Mimicking Orbital Pseudotumor Requiring Neurosurgical Intervention

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Christopher Payne ◽  
William C. Olivero ◽  
Bonnie Wang ◽  
Seong-Jin Moon ◽  
Arash Farahvar ◽  
...  
Keyword(s):  
Myeloid Leukemia ◽  
Rare Case ◽  
Granulocytic Sarcoma ◽  
Myeloid Sarcoma ◽  
Initial Presentation ◽  
Illustrative Case ◽  
Orbital Pseudotumor ◽  
Superior Orbital Fissure ◽  
Orbital Mass ◽  
Neurosurgical Intervention

Objective. A rare case of myeloid sarcoma (MS), previously referred to as granulocytic sarcoma or chloroma, is presented. Representing a unique form of acute myeloid leukemia (AML), MS may rarely occur in adults. Even rarer, MS may occur as the initial presentation of AML.Methods. We report a singular and illustrative case of an orbital pseudotumor mimicking mass in a 65-year-old male as the initial presentation of AML.Results. Neurosurgical intervention was required to establish the definitive diagnosis via right modified orbitofrontozygomatic craniotomy as well as to decompress the optic canal, superior orbital fissure, and orbit.Conclusion. Postoperatively, he reported decreased pain and improvement of his vision. Further examination revealed decreased proptosis and improved extraocular mobility. Pathological findings demonstrated MS. We review the literature and discuss the neurosurgical relevance of MS as the initial presentation of AML.

scholarly journals Primary Myeloid Sarcoma of the Ileum and Mesentery Causing Small Bowel Obstruction: Case Report and Literature Review

2020 ◽  
Vol 19 (1-2) ◽  
pp. 55-61
Author(s):  
Andrej Nikolovski ◽  
Dragoslav Mladenovikj ◽  
Aleksandra Veljanovska ◽  
Gordana Petrusevka
Keyword(s):  
Small Bowel ◽  
Small Bowel Obstruction ◽  
Bowel Obstruction ◽  
Myeloid Leukemia ◽  
Young Male ◽  
Granulocytic Sarcoma ◽  
The Body ◽  
Myeloid Sarcoma ◽  
Immunohistochemistry Analysis ◽  
Palpable Tumor

Myeloid sarcoma (extramedullary myeloblastoma, granulocytic sarcoma, chloroma) is an extramedullary isolated malignant tumor of myeloblasts and immature myelocytes. It can occur anywhere in the body as a solitary tumor or can be accompanied with acute myeloid leukemia. We are presenting a case of a young male patient that presented with sings of a small bowel obstruction and a palpable tumor mass in the abdomen. After uneventful postoperative period, the immunohistochemistry analysis reported an extramedullary myeloid sarcoma since a normal bone marrow biopsy was revealed.

scholarly journals Extramedullary Monoblastic Sarcoma/Myeloid Sarcoma of Paraspinal Region Without Myeloid Leukemia: A Rare Case Report

2018 ◽  
Vol 150 (suppl_1) ◽  
pp. S49-S50
Author(s):  
Mitul Modi ◽  
Vipulkumar Prajapati ◽  
Irappa Madabhavi ◽  
Himanshu Kavani ◽  
Mansi Shah
Keyword(s):  
Case Report ◽  
Myeloid Leukemia ◽  
Rare Case ◽  
Myeloid Sarcoma ◽  
Rare Case Report

scholarly journals Thoracic t(9;22)-Positive Granulocytic Sarcoma as Initial Presentation of Chronic Myeloid Leukemia

2013 ◽  
Vol 13 (5) ◽  
pp. 619-621 ◽  
Author(s):  
Mhairi Mitchell ◽  
Doha Itani ◽  
Jonathan Gerber ◽  
Nilanjan Ghosh ◽  
Ivana Gojo ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Granulocytic Sarcoma ◽  
Initial Presentation

scholarly journals A Rare Case of Myeloid Sarcoma Presenting as an Anorectal Ulcer

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Laxmi Parsa ◽  
Priti Bijpuria ◽  
Daniel Ringold ◽  
David Stein
Keyword(s):  
Immunohistochemical Staining ◽  
Myeloid Leukemia ◽  
Rare Case ◽  
Soft Tissues ◽  
Histochemical Staining ◽  
Myeloid Sarcoma ◽  
Atypical Presentation ◽  
Rare Tumor ◽  
Gastrointestinal Complaint ◽  
Acute Myeloid

Myeloid Sarcoma is a rare tumor composed of myeloblasts occurring at an extramedullary site like bones, or various soft tissues. Myeloid sarcoma may involve the gastrointestinal tract very rarely either solitarily, or occurring simultaneously with acute myeloid leukemia. Its diagnosis is challenging and needs biopsy and immunohistochemical staining. We are describing a case of myeloid sarcoma which presented as a painful anal ulcer mimicking an atypical fissure. Its appearance resembled crohn’s disease on sigmoidoscopy. A biopsy of the ulcer along with histochemical staining led to the diagnosis of myeloid sarcoma. Our case demonstrates the need for aggressive evaluation of any common gastrointestinal complaint with an atypical presentation.

scholarly journals Orbital myeloid sarcoma misdiagnosed for subperiostal hematoma: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Bahaa Razem ◽  
Mohamed Raiteb ◽  
Sanaa El Mrini ◽  
Faiçal Slimani
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Myeloid Leukemia ◽  
De Novo ◽  
Myeloid Sarcoma ◽  
Orbital Mass ◽  
Genetic Features ◽  
Immature Myeloid Cells ◽  
Acute Myeloid

Abstract Background Myeloid sarcoma is a solid tumor that consists of immature myeloid cells occurring at an extramedullary site. It can present before, concurrent with, or after the diagnosis of acute myeloid leukemia or other myeloproliferative diseases, and a proportion of patients never develop bone marrow infiltration. Only a few isolated cases of pediatric orbital myeloid sarcoma have been reported, and they are often associated with a high misdiagnosis rate. Case report We report a rare case of pediatric orbital myeloid sarcoma associated with blunt trauma in a 3-year-old Caucasian male patient, which was clinically and radiologically misdiagnosed for orbital subperiostal hematoma. The patient underwent a surgical intervention to drain the hematoma when an orbital mass was found. The microscopic, immunologic, and genetic features of the tumor and the myelogram were in favor of LAM2, and the patient was started with chemotherapy with a favorable evolution within 18 months follow-up. Conclusion Orbital myeloid sarcoma usually exhibits clinical and radiological features that can be easily misleading, especially if it happens de novo or as the first manifestation of acute myeloid leukemia. Only a few isolated cases have reported and proposed trauma as a trigger event of the onset of this type of tumor proliferation, but further investigations and evidence are needed to support this hypothesis.

Sarcoma Mieloide Intestinal. Un gran desafío en el diagnóstico clínico y anatomopatológico. Presentación de caso y revisión de la literatura.

2020 ◽  
Vol 1 (4) ◽  
Author(s):  
Nohelia Rojas Ferrer ◽  
María D Berenguer Romero ◽  
M. Cano Medina ◽  
Amparo de Fez Satores ◽  
Jorge Escandón Álvarez
Keyword(s):  
Bone Marrow ◽  
Flow Cytometry ◽  
Differential Diagnosis ◽  
Abdominal Pain ◽  
Myeloid Leukemia ◽  
Granulocytic Sarcoma ◽  
Abdominal Distension ◽  
Final Diagnosis ◽  
Myeloid Sarcoma ◽  
Old Men

Myeloid sarcoma, granulocytic sarcoma, chloroma or extramedullary myeloid leukemia, is an unusual tumor, with a dire prognosis. Up today, the clinical diagnosis continues to be extremely difficult due to the nonspecific symptoms. Histology, immunohistochemistry, and flow cytometry are valuable in the diagnose of the tumor, as well as in the differential diagnosis from multiple entities with different prognoses and treatments. We present 61-year-old men who presented with three days evolution abdominal pain, vomiting and abdominal distension. A diagnosis of adenocarcinoma was presumed. A final diagnosis of intestinal myeloid sarcoma without evidence of bone marrow infiltration was established. A review of the most relevant aspects of this disease is presented.

scholarly journals Dermal myeloid sarcoma as an initial presentation of acute myeloid leukemia

Blood ◽  
2017 ◽  
Vol 129 (8) ◽  
pp. 1056-1056 ◽  
Author(s):  
Yahya Daneshbod ◽  
L. Jeffrey Medeiros
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Myeloid Sarcoma ◽  
Initial Presentation ◽  
Acute Myeloid

scholarly journals Myeloid Sarcoma of the Orbit Preceding Acute Myeloid Leukaemia: A Diagnostic Challenge

2019 ◽  
Vol 11 (14) ◽  
pp. 98
Author(s):  
Oluomachi Charity Nnachi ◽  
Robert Azu Nnachi ◽  
Innocent Paul Ezenwenyi ◽  
Ogah Emeka Onwe ◽  
Augustine Ejike Okoye ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Clinical Condition ◽  
Tumour Progression ◽  
Correct Diagnosis ◽  
Myeloid Sarcoma ◽  
Initial Presentation ◽  
Orbital Mass ◽  
Management Of Complications ◽  
Acute Myeloid

Objective: Myeloid sarcoma is a rare form of acute myeloid leukaemia characterized by extramedullary proliferation of myeloid blasts which can occur as an isolated lesion in any organ. Even rarer it may occur in the orbit as the initial presentation without a leukaemic phase and diagnosis may be challenging when it is not suspected.           Methods: We report a case of orbital myeloid sarcoma as the initial presentation of acute myeloid leukaemia in an adult who was misdiagnosed and treated as a case of a pseudotumour with resultant significant disease progression and worsening of the clinical condition. There was a lag of four months from the onset of eye mass to the development of acute myeloid leukaemia. Result: Due to patients worsening condition and tumour progression, a repeat biopsy for a second histology opinion at a different facility, immunophenotyping and immunohistochemistry were employed to arrive at the correct diagnosis. Following chemotherapy, the orbital mass reduced markedly and clinical condition improved. The patient was indigent and could not sustain further funding of his treatment because he had already spent much on for management of complications he developed before a definitive diagnosis could be made. Conclusion: Myeloid sarcoma can present as an orbital mass without a leukemic disease. Therefore a high index of suspicion, meticulous examination of biopsy, immunohistochemistry and collaboration between oncologists and ophthalmologists, are required to arrive at an early accurate diagnosis.

Multiple Lung Nodules and a Pancreatic Mass at the Initial Presentation of Multiple Myeloma: A Rare Case.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 5071-5071
Author(s):  
Lavanya Aribandi ◽  
Adel Z. Makary
Keyword(s):  
Multiple Myeloma ◽  
Radiation Therapy ◽  
Rare Case ◽  
Pulmonary Nodules ◽  
Initial Presentation ◽  
Pancreatic Mass ◽  
Lung Nodules ◽  
Orbital Mass ◽  
Rare Manifestation ◽  
Multiple Lung Nodules

Abstract Extramedullary tumors are a rare manifestation of multiple myeloma. Approximately half of these are present at initial diagnosis and the rest occur during the course of the disease. Pancreas is rarely involved by multiple myeloma and the diagnosis is often made postmortem. Lung lesions are also rarely encountered. We present a rare case of multiple myeloma with asymptomatic extraosseous soft tissue lesions in the form of multiple lung nodules and a pancreatic mass at the initial presentation. Despite his multiple extraosseous lesions, he responded well to chemotherapy and radiation therapy with resolution of pulmonary nodules, pancreatic mass and orbital mass.

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