scholarly journals Study Assessing the Quality of Quantification of Estrogen Receptor Protein Expression by Immunohistochemistry and Gene Expression in Breast Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Sas Leen ◽  
Van Laere Steven ◽  
Dierick Anne Marie ◽  
Duwel Valérie ◽  
De Pauw Annemie ◽  
...  
Keyword(s):  
Gene Expression ◽  
Significant Positive Correlation ◽  
Target Genes ◽  
Correlation Coefficients ◽  
Receptor Protein ◽  
Estrogen Receptor Protein ◽  
Positive Correlation ◽  
Esr1 Gene ◽  
Er Positive

Although immunohistochemistry (IHC) is a widely used technique to classify tumors in ER-positive versus ER-negative ones, interlab variabilities can occur. This study aims to investigate the influences of preanalytical and analytical factors on IHC results. For this purpose, the different steps of the preparation of IHC sections and scoring procedures were compared between two participating laboratories and a central lab. There was a significant positive correlation between the IHC results of the participating laboratories and those of the central lab (correlation coefficient > 0.600; P<0.05). Nevertheless, some discordant cases for immunostaining (5.3% for ER and 5.6% for PR) and for scoring (10.5% for PR) occur at site 1. Comparing IHC results with ESR1 gene expression results revealed a significant positive correlation (correlation coefficients > 0.769; P<0.05). PCR results of ER target genes showed some heterogeneity in the ER-signalling pathway. These results suggest that differences in the IHC procedure between these laboratories did not have a big influence on the end result. Nevertheless, discordant cases caused by preanalytical and analytical lab-specific procedures have been identified.

scholarly journals Lecturers’ competence and the Quality of University Graduates; The Case of Private and Public Universities in Uganda.

2019 ◽  
Author(s):  
Godfrey Bagonza ◽  
Anthony Muwagga Mugagga ◽  
Nicholas Itaaga
Keyword(s):  
Qualitative Methods ◽  
Public Universities ◽  
Significant Positive Correlation ◽  
University Graduates ◽  
Positive Correlation ◽  
Private And Public ◽  
Quantitative And Qualitative Methods

This study investigated the effect of Lecturers' Competence on the Quality of University graduates in Uganda. The study used both quantitative and qualitative methods to collect data from key university stakeholders. The study found a significant positive correlation between Lecturers' Competence and the quality of university graduates in Uganda.<br>

scholarly journals Quality of life of alcohol dependent patients attending a deaddiction centre in Kannur district

2019 ◽  
Vol 9 (1) ◽  
pp. 36
Author(s):  
R. Ratheesh ◽  
Bindu Mohandas ◽  
P. P. Venugopalan ◽  
A. K. Sarada ◽  
Suprej K. ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Significant Positive Correlation ◽  
Public Health Problem ◽  
Perceived Health ◽  
Major Public Health Problem ◽  
Positive Correlation ◽  
Psychological Domain ◽  
The Mean ◽  
Alcohol Dependent

Background: Quality of life (QOL) is individuals' perceptions of their position in life. QOL of alcohol dependent patients is an area that has received relatively less attention compared to other alcohol related problems.Methods: A deaddiction centre based cross sectional study was done on 370 individuals using a predesigned questionnaire during the period of 2012-2013. The data was analyzed using SPSS version 17. Spearman’s rank correlation test was used to find association between the study variables.Results: The mean age of the study subjects was 38.08±8.46 years. The mean duration of drinking was 12.62±7.47 years. The overall score of the QOL and the perceived health in alcohol dependent patients was 3.19±0.89 and 3.01±0.98 respectively. The mean of the transformed scores of physical, psychological, social and environmental domains are 69.12±12.82, 57.84±12.81, 58.52±17.05, 68.62±10.23 respectively. Statistical analysis of age with physical, environmental and social domains showed a significant negative correlation; literacy status with QOL, perceived health, physical, psychological, social and environmental domains showed a significant positive correlation; socio economic status with QOL and psychological domain showed a significant positive correlation; duration of drinking with QOL, perceived health, physical and psychological domain showed a significant negative correlation.Conclusions: Harm from alcohol use is a major public health problem. Reducing the level of social and health harms from alcohol requires preparation and planning.

Hot flash placebo responses: Related to baseline hot flash frequency?

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 9628-9628
Author(s):  
J. M. Jones ◽  
C. L. Loprinzi ◽  
R. Qin ◽  
D. L. Barton
Keyword(s):  
Significant Positive Correlation ◽  
Hot Flashes ◽  
Placebo Response ◽  
Correlation Coefficients ◽  
Baseline Period ◽  
Percent Reduction ◽  
Hot Flash ◽  
Positive Correlation ◽  
Pubmed Search ◽  
Multiple Treatments

9628 Background: As multiple treatments have been studied for the management of hot flashes in randomized, controlled trials, hot flash placebo responses have been quite variable across trials. Based on observations of trial reports, it was hypothesized that the magnitude of placebo effect might correlate with the number of baseline hot flashes in different studies. The current project examines the effect of the baseline hot flash frequency required for study participation and also the actual number of baseline hot flashes observed as these individually relate to the eventual reductions of hot flash frequency observed in patients receiving placebos. Methods: Data were collected from placebo-controlled, double-blinded, randomized trials, identified by a PubMed search, which reported hot flash frequency at baseline, 4–6 weeks and 12 weeks. Trials were excluded if they had less than 20 participants completing the placebo arm. Data gathered, in each study, included the number of hot flashes required to enroll in the study, the average hot flash number during the baseline period, and the hot flash changes in the placebo arms of each study (percent reduction from the baseline period). A simple statistical analysis was conducted in a descriptive fashion since standard deviation was not available in many trials. Scatter plots and Pearson's correlation coefficients demonstrated the relationships between the placebo hot flash percent reduction from baseline and both the minimum required number of hot flashes at baseline, and the mean number of hot flashes at baseline. Results: 45 trials with 49 placebo arms were included in this analysis. A significant positive correlation was seen between the number of hot flashes required to enroll in a study and the percent reduction of hot flashes from baseline at 4–6 weeks (Rho = 0.481, p = 0.003). There was also a significant positive correlation between the number of hot flashes at baseline and the percent reduction of hot flashes from baseline at 4–6 weeks (Rho = 0.481, p= 0.002) and at 12 weeks (Rho = 0.573, p= 0.003). Conclusions: These data support that higher baseline hot flash enrollment requirements and also higher baseline hot flash frequencies are associated with an increased placebo response. No significant financial relationships to disclose.

scholarly journals Leaf Nutrient Status Vis-à-vis Fruit Yield and Quality of Sweet Orange (Citrus sinensis (L.) Osbeck)

2020 ◽  
pp. 1-8
Author(s):  
A. Ramanjaneya Reddy ◽  
V. Munaswamy ◽  
P. Venkataram Muni Reddy ◽  
B. Ravindra Reddy ◽  
P. Sudhakar
Keyword(s):  
Citrus Sinensis ◽  
Significant Positive Correlation ◽  
Sweet Orange ◽  
Nutrient Status ◽  
Significant Negative Correlation ◽  
Fruit Yield ◽  
Positive Correlation ◽  
Yield And Quality ◽  
Leaf N

The present study was conducted to know the effect of leaf nutrient status on fruit yield and quality of sweet orange (Citrus sinensis (L.) Osbeck) in YSR district of Andhra Pradesh, India. In this investigation fifty sweet orange orchards aged between 12 to 13 years were selected and plant samples such as index leaves and matured fruits were collected from 10 per cent of plants in each orchard. Leaf Zn deficiency (62%) was the most severe among the 10 mineral elements tested and followed by Fe (54%), Mn (52%) and Cu (26%). Fruit yield showed significant positive correlation with leaf N (r =0.519**) and P (r =0.409**). Fruit weight had significant positive correlation with leaf Nitrogen (r = 0.469**), Phosphorus (r = 0.446**) and Potassium (r = 0.415**). Fruit juice percent was significantly and positively correlated with leaf N (r =0.353**) and P (r =0.364**). Titrable acidity had significant negative correlation with leaf Fe (r = -0.371**) and leaf Mn (r = -0.292*). Total Soluble Solids (TSS) showed a significant positive relation with leaf P (r = 0.438**) and significant negative correlation with leaf Mn (r = -0.311*). Vitamin C content of the sweet orange fruit had significant positive correlation with leaf N (r = 0.437**), P (r = 0.516**) and K (r = 0.398**).

scholarly journals Quality of life, depression and self-perceived burden among geriatric and non-geriatric hemodialysis patients

2021 ◽  
Vol 9 (8) ◽  
pp. 2225
Author(s):  
Kenan Evren Oztop ◽  
Ferhat Cetin ◽  
Ahmed Bilal Genc ◽  
Ceyhun Varim ◽  
Savas Sipahi
Keyword(s):  
Quality Of Life ◽  
Significant Positive Correlation ◽  
Depression Scale ◽  
Hemodialysis Patients ◽  
Life Questionnaire ◽  
Care Burden ◽  
Positive Correlation ◽  
Perceived Burden ◽  
Quality Of Life Scale

Background: Many hemodialysis patients need support at various levels from their relatives while performing their daily activities. The ‘burden’ of these needs of patients on their relatives and their negative effects on their lives have been shown in the literature. The aim of the study was to evaluate the ‘care burden’ in terms of the patient.Methods: The patient who had received hemodialysis for at least 3 months was included in the study. A patient identification form including demographic data and medical history data was prepared. The Perceived care burden scale, Beck depression scale and WHO Quality of life questionnaire were applied to the patients.Results: A statistically significant positive correlation was found between SPBS and BDI (p<0.001, r=0.820). A statistically significant negative correlation was observed between the perceived care burden and all sub-dimensions of the quality of life scale (p<0.001). The frequency of comorbidity in the geriatric group was higher than non-geriatric group. A statistically significant positive correlation was found between comorbidity and QOL (p<0.001).   The median scores of all sub-dimensions of the QOL scale were lower in geriatric group and there were significance differences except environment dimension.Conclusions: The self-perceived burden on caregivers of hemodialysis patients was positively associated with depression and negatively associated with QOL. Decrease in QOL was more pronounced in geriatric patients.

Rate of Variety and its Relation to Creativity Factors

2018 ◽  
Author(s):  
Morgan B. Weaver ◽  
Caleb Bennetts ◽  
Benjamin W. Caldwell
Keyword(s):  
Problem Solving ◽  
Quantitative Study ◽  
Significant Positive Correlation ◽  
Confounding Factor ◽  
Space Exploration ◽  
Solution Space ◽  
Problem Solving Skills ◽  
Positive Correlation ◽  
The Relationship

Individual designers demonstrate different styles of ideation in conceptual design. These styles have been quantified and described primarily through protocol, think-aloud studies that examine a designer’s thought sequence during ideation. In this paper, we examine ideation style with an outcome-based approach, examining style on a continuum of rate of variety, or solution space exploration rate. We investigate the relationship between this exploration rate and creativity factors of quality and novelty using a quantitative study of problem-solving skills. We found a significant positive correlation between broad-search style and novelty and a significant positive correlation between detail-search style and quality of ideas. These correlations are in agreement with protocol studies found in literature. We also identified quantity of ideas as a possible confounding factor and discuss potential improvements to these types of studies.

Pan-cancer analysis on microRNA-mediated gene activation

2018 ◽  
Author(s):  
Hua Tan ◽  
Shan Huang ◽  
Zhigang Zhang ◽  
Xiaohua Qian ◽  
Peiqing Sun ◽  
...  
Keyword(s):  
Gene Expression ◽  
Target Genes ◽  
Immune Cell ◽  
Critical Role ◽  
Mirna Gene ◽  
Regulation Of Gene Expression ◽  
The Cancer Genome Atlas ◽  
Positive Correlation ◽  
Positive Correlations

ABSTRACTWhile microRNAs (miRNAs) were widely considered to repress target genes at mRNA and/or protein levels, emerging evidence from in vitro experiments has shown that miRNAs can also activate gene expression in particular contexts. However, this counterintuitive observation has rarely been reported or interpreted in in vivo conditions. We systematically explored the positive correlation between miRNA and gene expressions and its potential implications in tumorigenesis, based on 8375 patient samples across 31 major human cancers from The Cancer Genome Atlas (TCGA). Results indicated that positive miRNA-gene correlations are surprisingly prevalent and consistent across cancer types, and show distinct patterns than negative correlations. The top-ranked positive correlations are significantly involved in the immune cell differentiation and cell membrane signaling related processes, and display strong power in stratifying patients in terms of survival rate, demonstrating their promising clinical relevance. Although intragenic miRNAs generally tend to co-express with their host genes, a substantial portion of miRNAs shows no obvious correlation with their host gene due to non-conservation. A miRNA can upregulate a gene by inhibiting its upstream suppressor, or shares transcription factors with that gene, both leading to positive correlation. The miRNA/gene sites associated with the top-ranked positive correlations are more likely to form super-enhancers compared to randomly chosen pairs, suggesting a potential epigenetics mechanism underlying the upregulation. Wet-lab experiments revealed that positive correlations partially remain in the in vitro condition. Our study provides the field with new perspectives on the critical role of miRNA in gene regulation and novel insights regarding the complex mechanisms underlying miRNA functions, and reveals the clinical significance of the potential positive regulation of gene expression by miRNA.

scholarly journals ESR1 gene status correlates with estrogen receptor protein levels measured by ligand binding assay and immunohistochemistry

2012 ◽  
Vol 6 (4) ◽  
pp. 428-436 ◽  
Author(s):  
Anne-Vibeke Laenkholm ◽  
Ann Knoop ◽  
Bent Ejlertsen ◽  
Tine Rudbeck ◽  
Maj-Britt Jensen ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Ligand Binding ◽  
Binding Assay ◽  
Receptor Protein ◽  
Ligand Binding Assay ◽  
Estrogen Receptor Protein ◽  
Protein Levels ◽  
Esr1 Gene ◽  
Gene Status

scholarly journals Individual focus and knowledge contribution

First Monday ◽  
2010 ◽  
Author(s):  
Lada A. Adamic ◽  
Xiao Wei ◽  
Jiang Yang ◽  
Sean Gerrish ◽  
Kevin K Nam ◽  
...  
Keyword(s):  
Knowledge Sharing ◽  
Significant Positive Correlation ◽  
Background Knowledge ◽  
Limited Time ◽  
Positive Correlation ◽  
New Knowledge ◽  
Knowledge Contribution ◽  
The Relationship ◽  
Training Practice

Before contributing new knowledge, individuals must attain requisite background knowledge or skills through schooling, training, practice, and experience. Given limited time, individuals often choose either to focus on few areas, where they build deep expertise, or to delve less deeply and distribute their attention and efforts across several areas. In this paper we measure the relationship between the narrowness of focus and the quality of contribution across a range of both traditional and recent knowledge sharing media, including scholarly articles, patents, Wikipedia, and online question and answer forums. Across all systems, we observe a small but significant positive correlation between focus and quality.

scholarly journals Lecturers’ competence and the Quality of University Graduates; The Case of Private and Public Universities in Uganda.

2019 ◽  
Author(s):  
Godfrey Bagonza ◽  
Anthony Muwagga Mugagga ◽  
Nicholas Itaaga
Keyword(s):  
Qualitative Methods ◽  
Public Universities ◽  
Significant Positive Correlation ◽  
University Graduates ◽  
Positive Correlation ◽  
Private And Public ◽  
Quantitative And Qualitative Methods

This study investigated the effect of Lecturers' Competence on the Quality of University graduates in Uganda. The study used both quantitative and qualitative methods to collect data from key university stakeholders. The study found a significant positive correlation between Lecturers' Competence and the quality of university graduates in Uganda.<br>

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