scholarly journals An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Hirayuki Enomoto ◽  
Nobuhiro Aizawa ◽  
Hideji Nakamura ◽  
Yoshiyuki Sakai ◽  
Yoshinori Iwata ◽  
...  
Keyword(s):  
Platelet Count ◽  
Hepatitis B Virus ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Liver Function ◽  
Glycated Hemoglobin ◽  
Glycated Albumin ◽  
B Virus ◽  
Metabolic Variables ◽  
The Relationship

Background. In hepatitis B virus- (HBV-) positive patients, the relationship between the metabolic variables and histological degree of liver fibrosis has been poorly investigated.Methods. A total of 176 HBV-positive patients were assessed in whom the ratios of glycated albumin-to-glycated hemoglobin (GA/HbA1c) were calculated in order to investigate the relationship with the degree of liver fibrosis.Results. The GA/HbA1c ratio increased in association with the severity of fibrosis (METAVIR scores: F0-1: 2.61 ± 0.24, F2: 2.65 ± 0.24, F3: 2.74 ± 0.38, and F4: 2.91 ± 0.63). The GA/HbA1c ratios were inversely correlated with four variables of liver function: the prothrombin time (PT) percentage (P<0.0001), platelet count (P<0.0001), albumin value (P<0.0001), and cholinesterase value (P<0.0001). The GA/HbA1c ratio was positively correlated with two well-known markers of liver fibrosis, FIB-4 (P<0.0001) and the AST-to-platelet ratio index (APRI) (P<0.0001). Furthermore, the GA/HbA1c showed better correlations with two variables of liver function (PT percentage and cholinesterase value) than did FIB-4 and with all four variables than did the APRI.Conclusion. The GA/HbA1c ratio is associated with the degree of liver fibrosis in HBV-positive patients.Corrigendum to “An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients”

scholarly journals A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Hirayuki Enomoto ◽  
Nobuhiro Aizawa ◽  
Hideji Nakamura ◽  
Ryo Takata ◽  
Yoshiyuki Sakai ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Liver Function ◽  
Glycated Hemoglobin ◽  
Glycated Albumin ◽  
Albumin Level ◽  
Metabolic Variables ◽  
Branched Chain ◽  
The Relationship

Background. Only a few biomarkers based on metabolic parameters for evaluating liver fibrosis have been reported. The aim of this study was to investigate the relevance of an index obtained from three metabolic variables (glycated albumin: GA, glycated hemoglobin: HbA1c, and branched-chain amino acids to tyrosine ratio: BTR) to the degree of liver fibrosis in hepatitis C virus virus- (HCV-) positive patients.Methods. A total of 394 HCV-positive patients were assessed based on the values of a new index (GA/HbA1c/BTR). The index findings were used to investigate the relationship with the degree of liver fibrosis.Results. The new index showed an association with the stage of fibrosis (METAVIR scores: F0-1: 0.42 ± 0.10, F2: 0.48 ± 0.15, F3: 0.56 ± 0.22, and F4: 0.71 ± 0.30). The index was negatively correlated with three variables of liver function: the prothrombin time percentage (P<0.0001), albumin level (P<0.0001), and cholinesterase level (P<0.0001). The new index showed a higher correlation related to liver function than FIB-4 and the APRI did. In addition, the index showed a higher AUROC value than that of FIB-4 and the APRI for prediction of liver cirrhosis.Conclusion. The new metabolism-related index, GA/HbA1c/BTR value, is shown to relate to the degree of liver fibrosis in HCV-positive patients.

scholarly journals Corrigendum to “An Increased Ratio of Glycated Albumin to HbA1c Is Associated with the Degree of Liver Fibrosis in Hepatitis B Virus-Positive Patients”

2016 ◽  
Vol 2016 ◽  
pp. 1-1
Author(s):  
Hirayuki Enomoto ◽  
Nobuhiro Aizawa ◽  
Hideji Nakamura ◽  
Yoshiyuki Sakai ◽  
Yoshinori Iwata ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Glycated Albumin ◽  
B Virus

Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients

2020 ◽  
Vol 26 (27) ◽  
pp. 3948-3958
Author(s):  
Na-Ling Kang ◽  
Jie-Min Zhang ◽  
Meng-Xin Lin ◽  
Xu-Dong Chen ◽  
Zu-Xiong Huang ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Serum Ceruloplasmin ◽  
B Virus

Hepatitis B virus quasispecies susceptibility to entecavir confirms the relationship between genotypic resistance and patient virologic response

2008 ◽  
Vol 48 (6) ◽  
pp. 895-902 ◽  
Author(s):  
Carl J. Baldick ◽  
Betsy J. Eggers ◽  
Jie Fang ◽  
Steven M. Levine ◽  
Kevin A. Pokornowski ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virologic Response ◽  
Genotypic Resistance ◽  
B Virus ◽  
The Relationship

scholarly journals Accelerated liver fibrosis in hepatitis B virus transgenic mice: Involvement of natural killer T cells

Hepatology ◽  
2010 ◽  
Vol 53 (1) ◽  
pp. 219-229 ◽  
Author(s):  
Zixue Jin ◽  
Rui Sun ◽  
Haiming Wei ◽  
Xiang Gao ◽  
Yongyan Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis B Virus ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Transgenic Mice ◽  
Natural Killer ◽  
Natural Killer T Cells ◽  
B Virus ◽  
Killer T Cells ◽  
Natural Killer T

Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus

2018 ◽  
Vol 67 (3) ◽  
pp. 681-685 ◽  
Author(s):  
Ali Sobhy ◽  
Mohammed Fakhry M. ◽  
Haitham A Azeem ◽  
Ahmed M Ashmawy ◽  
Hamed Omar Khalifa
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B ◽  
Non Invasive ◽  
B Virus

Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This study was performed on 100 patients with CHB virus, 100 patients with CHC virus and 100 normal controls. All participants were subjected to the following laboratory tests: hemoglobin, platelet, alanine aminotransferase, aspartate aminotransferase, albumin, international normalized ratio, HBs Ag, hepatitis C virus (HCV) antibody, hepatitis B virus DNA, HCV RNA, liver biopsy, BGN and OPN. We found that BGN level was significantly increased in the CHB group compared with the controls (p<0.001), but the level was not different between the CHC group and the controls (p<0.96). OPN was increased in both the CHB and CHC groups compared with the controls (p<0.001). Positive correlation was found between fibrosis stages and BGN level of the CHB group (r=0.64; p<0.001) and between fibrosis stages and OPN level of the CHB (r=0.63; p<0.001) and CHC (r=0.59; p<0.03) groups. The area under the curve (AUC), sensitivity and specificity of BGN were 1.0, 100% and 100% in predicting fibrosis in patients with CHB, and 0.50, 26% and 78% in predicting fibrosis in patients with CHC. OPN had an AUC of 0.997, sensitivity of 96% and specificity of 100% in predicting fibrosis in patients with CHB, and 0.974, 96.5% and 100% in predicting fibrosis in patients with CHC. In conclusion, BGN and OPN could be considered non-invasive markers for liver fibrosis assessment.

scholarly journals THE PREVALENCE LIVER FUNCTION AND IMMUNOLOGIC STATUS OF CHILDREN WITH HIV AND HEPATITIS B VIRUS COINFECTION IN ENUGU, NIGERIA

2016 ◽  
Vol 10 (2) ◽  
pp. 61-68
Author(s):  
Uleanya Nwachinemere Davidson ◽  
Nwokoye Ikenna Chidiebele ◽  
Emodi Ifeoma Josephine ◽  
Obidike Egbuna Olakunle ◽  
Ikefuna Anthony Nnaemeka ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Function ◽  
B Virus ◽  
Immunologic Status

Improvement of liver function and non-invasive fibrosis markers in hepatitis B virus-associated cirrhosis: 2 years of entecavir treatment

2015 ◽  
Vol 30 (12) ◽  
pp. 1775-1781 ◽  
Author(s):  
Seung Kak Shin ◽  
Jeong Han Kim ◽  
Hyeonsu Park ◽  
Oh Sang Kwon ◽  
Hyun Jung Lee ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Function ◽  
Non Invasive ◽  
B Virus
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