scholarly journals Track-to-Track Association Based on Structural Similarity in the Presence of Sensor Biases

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Hongyan Zhu ◽  
Suying Han
Keyword(s):  
Structural Feature ◽  
Spatial Relationship ◽  
Structural Similarity ◽  
Structural Features ◽  
Bias Estimation ◽  
Track Association ◽  
Simulation Results ◽  
The Absolute ◽  
Absolute Coordinates ◽  
Computational Intractability

The paper addresses the problem of track-to-track association in the presence of sensor biases. In some challenging scenarios, it may be infeasible to implement bias estimation and compensation in time due to the computational intractability or weak observability about sensor biases. In this paper, we introduce the structural feature for each local track, which describes the spatial relationship with its neighboring targets. Although the absolute coordinates of local tracks from the same target are severely different in the presence of sensor biases, their structural features may be similar. As a result, instead of using the absolute kinematic states only, we employee the structural similarity to define the association cost. When there are missed detections, the structural similarity between local tracks is evaluated by solving another 2D assignment subproblem. Simulation results demonstrated the power of the proposed approach.

Biological and In silico Studies on Synthetic Analogues of Tyrosine Betaine as Inhibitors of Neprilysin - A Drug Target for the Treatment of Heart Failure

2018 ◽  
Vol 24 (17) ◽  
pp. 1899-1904
Author(s):  
Daniel Fabio Kawano ◽  
Marcelo Rodrigues de Carvalho ◽  
Mauricio Ferreira Marcondes Machado ◽  
Adriana Karaoglanovic Carmona ◽  
Gilberto Ubida Leite Braga ◽  
...  
Keyword(s):  
Heart Failure ◽  
Secondary Metabolites ◽  
Structural Similarity ◽  
Structural Features ◽  
Major Constituent ◽  
Binding Modes ◽  
Starting Point ◽  
In Silico Studies ◽  
Nep Inhibition

Background: Fungal secondary metabolites are important sources for the discovery of new pharmaceuticals, as exemplified by penicillin, lovastatin and cyclosporine. Searching for secondary metabolites of the fungi Metarhizium spp., we previously identified tyrosine betaine as a major constituent. Methods: Because of the structural similarity with other inhibitors of neprilysin (NEP), an enzyme explored for the treatment of heart failure, we devised the synthesis of tyrosine betaine and three analogues to be subjected to in vitro NEP inhibition assays and to molecular modeling studies. Results: In spite of the similar binding modes with other NEP inhibitors, these compounds only displayed moderate inhibitory activities (IC50 ranging from 170.0 to 52.9 µM). However, they enclose structural features required to hinder passive blood brain barrier permeation (BBB). Conclusions: Tyrosine betaine remains as a starting point for the development of NEP inhibitors because of the low probability of BBB permeation and, consequently, of NEP inhibition at the Central Nervous System, which is associated to an increment in the Aβ levels and, accordingly, with a higher risk for the onset of Alzheimer's disease.

Towards effective link prediction: A hybrid similarity model

2020 ◽  
pp. 1-14
Author(s):  
Longjie Li ◽  
Lu Wang ◽  
Hongsheng Luo ◽  
Xiaoyun Chen
Keyword(s):  
Link Prediction ◽  
Structural Similarity ◽  
Research Direction ◽  
Structural Features ◽  
Proposed Model ◽  
Similarity Model ◽  
Weight Calculation ◽  
Stable Performance ◽  
Grey Relation ◽  
Important Research Direction

Link prediction is an important research direction in complex network analysis and has drawn increasing attention from researchers in various fields. So far, a plethora of structural similarity-based methods have been proposed to solve the link prediction problem. To achieve stable performance on different networks, this paper proposes a hybrid similarity model to conduct link prediction. In the proposed model, the Grey Relation Analysis (GRA) approach is employed to integrate four carefully selected similarity indexes, which are designed according to different structural features. In addition, to adaptively estimate the weight for each index based on the observed network structures, a new weight calculation method is presented by considering the distribution of similarity scores. Due to taking separate similarity indexes into account, the proposed method is applicable to multiple different types of network. Experimental results show that the proposed method outperforms other prediction methods in terms of accuracy and stableness on 10 benchmark networks.

scholarly journals Numerical Simulation and Experimental Study on Axial Stiffness and Stress Deformation of the Braided Corrugated Hose

2021 ◽  
Vol 11 (10) ◽  
pp. 4709
Author(s):  
Dacheng Huang ◽  
Jianrun Zhang
Keyword(s):  
Numerical Simulation ◽  
Geometric Model ◽  
Equivalent Stress ◽  
Element Model ◽  
Maximum Error ◽  
Structural Features ◽  
Axial Stiffness ◽  
Frictional Stress ◽  
Maximum Equivalent Stress ◽  
Simulation Results

To explore the mechanical properties of the braided corrugated hose, the space curve parametric equation of the braided tube is deduced, specific to the structural features of the braided tube. On this basis, the equivalent braided tube model is proposed based on the same axial stiffness in order to improve the calculational efficiency. The geometric model and the Finite Element Model of the DN25 braided corrugated hose is established. The numerical simulation results are analyzed, and the distribution of the equivalent stress and frictional stress is discussed. The maximum equivalent stress of the braided corrugated hose occurs at the braided tube, with the value of 903MPa. The maximum equivalent stress of the bellows occurs at the area in contact with the braided tube, with the value of 314MPa. The maximum frictional stress between the bellows and the braided tube is 88.46MPa. The tensile experiment of the DN25 braided corrugated hose is performed. The simulation results are in good agreement with test data, with a maximum error of 9.4%, verifying the rationality of the model. The study is helpful to the research of the axial stiffness of the braided corrugated hose and provides the base for wear and life studies on the braided corrugated hose.

scholarly journals Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2

2015 ◽  
Vol 198 (4) ◽  
pp. 720-730 ◽  
Author(s):  
Stephanie Swanson ◽  
Thomas R. Ioerger ◽  
Nathan W. Rigel ◽  
Brittany K. Miller ◽  
Miriam Braunstein ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Signal Peptide ◽  
Protein A ◽  
Structural Difference ◽  
Structural Similarity ◽  
Structural Features ◽  
Dominant Negative ◽  
Content Type ◽  
Functional Regions ◽  
Suppressor Mutations

ABSTRACTWhile SecA is the ATPase component of the major bacterial secretory (Sec) system, mycobacteria and some Gram-positive pathogens have a second paralog, SecA2. In bacteria with two SecA paralogs, each SecA is functionally distinct, and they cannot compensate for one another. Compared to SecA1, SecA2 exports a distinct and smaller set of substrates, some of which have roles in virulence. In the mycobacterial system, some SecA2-dependent substrates lack a signal peptide, while others contain a signal peptide but possess features in the mature protein that necessitate a role for SecA2 in their export. It is unclear how SecA2 functions in protein export, and one open question is whether SecA2 works with the canonical SecYEG channel to export proteins. In this study, we report the structure ofMycobacterium tuberculosisSecA2 (MtbSecA2), which is the first structure of any SecA2 protein. A high level of structural similarity is observed between SecA2 and SecA1. The major structural difference is the absence of the helical wing domain, which is likely to play a role in howMtbSecA2 recognizes its unique substrates. Importantly, structural features critical to the interaction between SecA1 and SecYEG are preserved in SecA2. Furthermore, suppressor mutations of a dominant-negativesecA2mutant map to the surface of SecA2 and help identify functional regions of SecA2 that may promote interactions with SecYEG or the translocating polypeptide substrate. These results support a model in which the mycobacterial SecA2 works with SecYEG.IMPORTANCESecA2 is a paralog of SecA1, which is the ATPase of the canonical bacterial Sec secretion system. SecA2 has a nonredundant function with SecA1, and SecA2 exports a distinct and smaller set of substrates than SecA1. This work reports the crystal structure of SecA2 ofMycobacterium tuberculosis(the first SecA2 structure reported for any organism). Many of the structural features of SecA1 are conserved in the SecA2 structure, including putative contacts with the SecYEG channel. Several structural differences are also identified that could relate to the unique function and selectivity of SecA2. Suppressor mutations of asecA2mutant map to the surface of SecA2 and help identify functional regions of SecA2 that may promote interactions with SecYEG.

Singularity-Free Lie Group Integration and Geometrically Consistent Evaluation of Multibody System Models described in terms of Standard Absolute Coordinates

2021 ◽  
Author(s):  
Andreas Mueller
Keyword(s):  
Rigid Body ◽  
Lie Group ◽  
Time Integration ◽  
Integration Methods ◽  
Product Group ◽  
Local Coordinates ◽  
Group Integration ◽  
The Absolute ◽  
Lie Group Integration ◽  
Absolute Coordinates

Abstract A classical approach to the MBS modeling is to use absolute coordinates, i.e. a set of (possibly redundant) coordinates that describe the absolute position and orientation of the individual bodies w.r.t. to an inertial frame (IFR). A well-known problem for the time integration of the equations of motion (EOM) is the lack of a singularity-free parameterization of spatial motions, which is usually tackled by using unit quaternions. Lie group integration methods were proposed as alternative approach to the singularity-free time integration. Lie group integration methods, operating directly on the configuration space Lie group, are incompatible with standard formulations of the EOM, and cannot be implemented in existing MBS simulation codes without a major restructuring. A framework for interfacing Lie group integrators to standard EOM formulations is presented in this paper. It allows describing MBS in terms of various absolute coordinates and at the same using Lie group integration schemes. The direct product group SO(3)xR3; and the semidirect product group SE(3) are use for representing rigid body motions. The key element of this method is the local-global transitions (LGT) transition map, which facilitates the update of (global) absolute coordinates in terms of the (local) coordinates on the Lie group. This LGT map is specific to the absolute coordinates, the local coordinates on the Lie group, and the Lie group used to represent rigid body configurations. This embedding of Lie group integration methods allows for interfacing with standard vector space integration methods.

scholarly journals Absolute Stereochemistry of the β-Hydroxy Acid Unit in Hantupeptins and Trungapeptins

2016 ◽  
Vol 11 (1) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Deepak Kumar Gupta ◽  
Gary Chi Ying Ding ◽  
Yong Chua Teo ◽  
Lik Tong Tan
Keyword(s):  
Amino Acid ◽  
Structural Feature ◽  
Absolute Configuration ◽  
Hydroxy Acid ◽  
Hplc Analysis ◽  
The Absolute ◽  
Absolute Stereochemistry ◽  
Common Structural Feature ◽  
Acid Unit

The β-hydroxy/amino acid unit is a common structural feature of many bioactive marine cyanobacterial depsipeptides. In this study, the absolute stereochemistry of the β-hydroxy acid moieties in hantupeptins and trungapeptins were determined through their synthesis and HPLC analysis of the Mosher ester derivatives. Synthesis of two3-hydroxy-2-methyloctanoic acid (Hmoa) stereoisomers, (2 S,3 R)-Hmoa and (2 S,3 S)-Hmoa, were achieved using diastereoselective asymmetric method and the retention times of all four Hmoa isomers were established indirectly by RPLC-MS analysis of their Mosher ester derivative standards. Based on the retention times of the standards, the absolute configuration of the Hmoa unit in hantupeptin C (3) and trungapeptin C (6) was assigned as (2 R,3 S)- and (2 S,3 R)-Hmoa, respectively. The use of the Mosher's reagents, coupled with HPLC analysis, provided a viable alternative to the absolute stereochemical determination of β-hydroxy acid units in depsipeptides.

The Tapping Machine Mathematical Modeling Simulation Study

2013 ◽  
Vol 373-375 ◽  
pp. 2073-2077
Author(s):  
Bing Hua Jiang ◽  
Li Fang ◽  
Hang Biao Guo
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Blast Furnace ◽  
Rotation Speed ◽  
Pulse Signal ◽  
Structural Features ◽  
Machine Model ◽  
Modeling Simulation ◽  
Impact Attenuation ◽  
Simulation Results

Based on the tapping machines special structural features and practices, from both directions of rotation and impact established the tapping machine mechanism rotating borer and impact dynamic mathematical model, analysed the effect of different tapping machines parameters on the model itself, simulated the model with inputting wide pulse signal, the simulation results show that: firstly, the tapping machine model established in this paper is reasonable; secondly, increase the damping coefficient of the blast furnace, the tapping machines rotating borer rotation speed and impact attenuation speed decrease.

scholarly journals Characterization of Borrelia burgdorferiBlyA and BlyB Proteins: a Prophage-Encoded Holin-Like System

2000 ◽  
Vol 182 (23) ◽  
pp. 6791-6797 ◽  
Author(s):  
Christopher J. Damman ◽  
Christian H. Eggers ◽  
D. Scott Samuels ◽  
Donald B. Oliver
Keyword(s):  
Escherichia Coli ◽  
Hemolytic Activity ◽  
Soluble Protein ◽  
Structural Similarity ◽  
Structural Features ◽  
Accessory Protein ◽  
E Coli ◽  
Bacteriophage Particle ◽  
Membrane Interactive

ABSTRACT The conserved cp32 plasmid family of Borrelia burgdorferi was recently shown to be packaged into a bacteriophage particle (C. H. Eggers and D. S. Samuels, J. Bacteriol. 181:7308–7313, 1999). This plasmid encodes BlyA, a 7.4-kDa membrane-interactive protein, and BlyB, an accessory protein, which were previously proposed to comprise a hemolysis system. Our genetic and biochemical evidence suggests that this hypothesis is incorrect and that BlyA and BlyB function instead as a prophage-encoded holin or holin-like system for this newly described bacteriophage. AnEscherichia coli mutant containing the blyABlocus that was defective for the normally cryptic host hemolysin SheA was found to be nonhemolytic, suggesting that induction ofsheA by blyAB expression was responsible for the hemolytic activity observed previously. Analysis of the structural features of BlyA indicated greater structural similarity to bacteriophage-encoded holins than to hemolysins. Consistent with holin characteristics, subcellular localization studies with E. coli and B. burgdorferi indicated that BlyA is solely membrane associated and that BlyB is a soluble protein. Furthermore, BlyA exhibited a holin-like function by promoting the endolysin-dependent lysis of an induced lambda lysogen that was defective in the holin gene. Finally, induction of the cp32 prophage inB. burgdorferi dramatically stimulated blyABexpression. Our results provide the first evidence of a prophage-encoded holin within Borrelia.

Subunit II (b') and Not Subunit I (b) of Photosynthetic ATP Synthases is Equivalent to Subunit b of the ATP Synthases from Nonphotosynthetic Eubacteria. Evidence for a New Assignment of b-Type F0 Subunits

1997 ◽  
Vol 52 (11-12) ◽  
pp. 789-798 ◽  
Author(s):  
Hans-Jürgen Tiburzy ◽  
Richard J. Berzborn
Keyword(s):  
Escherichia Coli ◽  
Amino Acid ◽  
Structural Feature ◽  
Atp Synthase ◽  
Primary Structure ◽  
Structural Features ◽  
Amino Acid Sequences ◽  
E Coli ◽  
Subunit B ◽  
Atp Synthases

Abstract Subunit I of chloroplast ATP synthase is reviewed until now to be equivalent to subunit b of Escherichia coli ATP synthase, whereas subunit II is suggested to be an additional subunit in photosynthetic ATP synthases lacking a counterpart in E. coli. After publication of some sequences of subunits II a revision of this assignment is necessary. Based on the analysis of 51 amino acid sequences of b-type subunits concerning similarities in primary structure, iso­electric point and a discovered discontinuous structural feature, our data provide evidence that chloroplast subunit II (subunit b' of photosynthetic eubacteria) and not chloroplast subunit I (subunit b of photosynthetic eubacteria) is the equivalent of subunit b of nonphoto­ synthetic eubacteria, and therefore does have a counterpart in e.g. E. coli. In consequence, structural features essential for function should be looked for on subunit II (b').

scholarly journals Visual-Inertial Odometry of Smartphone under Manhattan World

2020 ◽  
Vol 12 (22) ◽  
pp. 3818
Author(s):  
YuAn Wang ◽  
Liang Chen ◽  
Peng Wei ◽  
XiangChen Lu
Keyword(s):  
Mobile Phone ◽  
Structural Feature ◽  
Real Time ◽  
Structural Features ◽  
Feature Extraction Method ◽  
The Public ◽  
Window Method ◽  
Tightly Coupled ◽  
Sliding Window Method ◽  
Public Datasets

Based on the hypothesis of the Manhattan world, we propose a tightly-coupled monocular visual-inertial odometry (VIO) system that combines structural features with point features and can run on a mobile phone in real-time. The back-end optimization is based on the sliding window method to improve computing efficiency. As the Manhattan world is abundant in the man-made environment, this regular world can use structural features to encode the orthogonality and parallelism concealed in the building to eliminate the accumulated rotation error. We define a structural feature as an orthogonal basis composed of three orthogonal vanishing points in the Manhattan world. Meanwhile, to extract structural features in real-time on the mobile phone, we propose a fast structural feature extraction method based on the known vertical dominant direction. Our experiments on the public datasets and self-collected dataset show that our system is superior to most existing open-source systems, especially in the situations where the images are texture-less, dark, and blurry.

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