scholarly journals Modelling the Drugs Therapy for HIV Infection with Discrete-Time Delay

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Xueyong Zhou ◽  
Xiangyun Shi

A discrete-time-delay differential mathematical model that described HIV infection of CD4+T cells with drugs therapy is analyzed. The stability of the two equilibria and the existence of Hopf bifurcation at the positive equilibrium are investigated. Using the normal form theory and center manifold argument, the explicit formulas which determine the stability, the direction, and the period of bifurcating periodic solutions are derived. Numerical simulations are carried out to explain the mathematical conclusions.

2014 ◽  
Vol 2014 ◽  
pp. 1-8
Author(s):  
Yuanyuan Chen ◽  
Ya-Qing Bi

A delay-differential modelling of vector-borne is investigated. Its dynamics are studied in terms of local analysis and Hopf bifurcation theory, and its linear stability and Hopf bifurcation are demonstrated by studying the characteristic equation. The stability and direction of Hopf bifurcation are determined by applying the normal form theory and the center manifold argument.


2014 ◽  
Vol 2014 ◽  
pp. 1-18 ◽  
Author(s):  
P. Balasubramaniam ◽  
M. Prakash ◽  
Fathalla A. Rihan ◽  
S. Lakshmanan

This paper deals with stability and Hopf bifurcation analyses of a mathematical model of HIV infection ofCD4+T-cells. The model is based on a system of delay differential equations with logistic growth term and antiretroviral treatment with a discrete time delay, which plays a main role in changing the stability of each steady state. By fixing the time delay as a bifurcation parameter, we get a limit cycle bifurcation about the infected steady state. We study the effect of the time delay on the stability of the endemically infected equilibrium. We derive explicit formulae to determine the stability and direction of the limit cycles by using center manifold theory and normal form method. Numerical simulations are presented to illustrate the results.


2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Beibei Wang ◽  
Min Zhao ◽  
Chuanjun Dai ◽  
Hengguo Yu ◽  
Nan Wang ◽  
...  

We analyze a nutrient-plankton system with a time delay. We choose the time delay as a bifurcation parameter and investigate the stability of a positive equilibrium and the existence of Hopf bifurcations. By using the center manifold theorem and the normal form theory, the direction of the Hopf bifurcation and the stability of the bifurcating periodic solutions are researched. The theoretical results indicate that the time delay can induce a positive equilibrium to switch from a stable to an unstable to a stable state and so on. Numerical simulations show that the theoretical results are correct and feasible, and the system exhibits rich complex dynamics.


2008 ◽  
Vol 01 (02) ◽  
pp. 209-224 ◽  
Author(s):  
QINTAO GAN ◽  
RUI XU ◽  
PINGHUA YANG

In this paper, a predator-prey model with prey dispersal and time delay is investigated. By analyzing the corresponding characteristic equation of a positive equilibrium, the local stability of the positive equilibrium and the existence of Hopf bifurcation are discussed. By using the normal form theory and center manifold reduction, explicit formulae are derived to determine the stability, direction and other properties of bifurcating periodic solutions. Numerical simulations are given to illustrate the theoretical predictions.


2017 ◽  
Vol 10 (03) ◽  
pp. 1750032 ◽  
Author(s):  
Wei Liu ◽  
Yaolin Jiang

In this paper, a differential-algebraic predator–prey system with time delay is investigated, where the time delay is regarded as a parameter. By analyzing the corresponding characteristic equations, the local stability of the positive equilibrium and the existence of Hopf bifurcation are demonstrated. Furthermore, the explicit formulae which determine the stability, direction and other properties of bifurcating periodic solutions are obtained by applying the normal form theory and the center manifold argument. At last, some numerical simulations are carried out to illustrate the feasibility of our main results.


2019 ◽  
Vol 12 (03) ◽  
pp. 1950028
Author(s):  
Keying Song ◽  
Wanbiao Ma ◽  
Zhichao Jiang

In this paper, a model with time delay describing biodegradation of Microcystins (MCs) is investigated. Firstly, the stability of the positive equilibrium and the existence of Hopf bifurcations are obtained. Furthermore, an explicit algorithm for determining the direction and the stability of the bifurcating periodic solutions is derived by using the normal form theory and center manifold argument. Finally, some numerical simulations are carried out to illustrate the applications of the results.


2020 ◽  
Vol 30 (16) ◽  
pp. 2050244
Author(s):  
Xin Zhang ◽  
Renxiang Shi ◽  
Ruizhi Yang ◽  
Zhangzhi Wei

This work investigates a prey–predator model with Beddington–DeAngelis functional response and discrete time delay in both theoretical and numerical ways. Firstly, we incorporate into the system a discrete time delay between the capture of the prey by the predator and its conversion to predator biomass. Moreover, by taking the delay as a bifurcation parameter, we analyze the stability of the positive equilibrium in the delayed system. We analytically prove that the local Hopf bifurcation critical values are neatly paired, and each pair is joined by a bounded global Hopf branch. Also, we show that the predator becomes extinct with an increase of the time delay. Finally, before the extinction of the predator, we find the abundance of dynamical complexity, such as supercritical Hopf bifurcation, using the numerical continuation package DDE-BIFTOOL.


2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Zizhen Zhang ◽  
Huizhong Yang

A delayed SEIRS epidemic model with vertical transmission in computer network is considered. Sufficient conditions for local stability of the positive equilibrium and existence of local Hopf bifurcation are obtained by analyzing distribution of the roots of the associated characteristic equation. Furthermore, the direction of the local Hopf bifurcation and the stability of the bifurcating periodic solutions are determined by using the normal form theory and center manifold theorem. Finally, a numerical example is presented to verify the theoretical analysis.


2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Chunru Li ◽  
Zujun Ma

In this paper, a mathematical model with time-delay-related parameters and media coverage to describe the diffusion process of new products is proposed, in which the time-delay-related parameters denote the stage in which potential customers decide whether to adopt a new product. Then, the stability and the Hopf bifurcation of the proposed model are analyzed in detail. The center manifold theorem and the normal form theory are used to investigate the stability of the bifurcating periodic solution. Moreover, a numerical simulation is conducted to investigate the difference between the model with delay-dependent parameters and that with delay-independent parameters. The results show that there is significant difference between the two models.


2015 ◽  
Vol 25 (10) ◽  
pp. 1530026 ◽  
Author(s):  
Rui Yang ◽  
Yongli Song

In this paper, a diffusive activator–inhibitor model in vascular mesenchymal cells is considered. On one hand, we investigate the stability of the equilibria of the system without diffusion. On the other hand, for the unique positive equilibrium of the system with diffusion the conditions ensuring stability, existence of Hopf and steady state bifurcations are given. By applying the center manifold and normal form theory, the normal forms corresponding to Hopf bifurcation and steady state bifurcation are derived explicitly. Numerical simulations are employed to illustrate where the spatially homogeneous and nonhomogeneous periodic solutions and the steady states can emerge. The numerical results verify the obtained theoretical conclusions.


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