scholarly journals Dietary Consumption of Virgin Coconut Oil Ameliorates Lipid Profiles in Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
A. M. Akinnuga ◽  
S. O. Jeje ◽  
O. Bamidele ◽  
V. E. Sunday
Keyword(s):  
Diabetes Mellitus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coconut Oil ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Virgin Coconut Oil ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Virgin coconut oil (VCO) is a saturated fat with promising antidiabetic properties but its ameliorative effect on lipid profiles in diabetics is rarely reported. Therefore, in this study, a total of fifteen (15) male rats weighing 200–250 g were divided into 3 experimental groups (n=5). Group I (control) and Group II (diabetic control group) were fed a normal rat chow while Group III (diabetic test group) was fed a 10% VCO diet for 3 weeks. Group II and Group III were made diabetic by intraperitoneal injection of 150 mg/kg of alloxan. After 72 hours of injection, blood glucose was tested to confirm diabetes mellitus. After 3 weeks, the animals were sacrificed to collect blood samples for lipid profile analysis. The results showed a significant increase in concentrations of triglyceride, total cholesterol, low density lipoprotein, and very low density lipoprotein and decrease in concentration of high density lipoprotein in Group II when compared to Group I. Also, the concentrations of triglyceride, total cholesterol, low density lipoprotein, and very low density lipoprotein except high density lipoprotein significantly reduced in Group III when compared to Group II (P<0.01, 0.001). VCO consumption can be claimed to ameliorate lipid levels in diabetes mellitus.

scholarly journals HUBUNGAN LINGKAR PINGGANG DENGAN PROFIL LIPID PADA PASIEN DIABETES MELITUS TIPE 2

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Mentari Simbar ◽  
Karel Pandelaki ◽  
M. C.P Wongkar
Keyword(s):  
Diabetes Mellitus ◽  
Waist Circumference ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Cross Sectional ◽  
Diabetes Melitus

Abstract: Waist circumference is often used to evaluate abdominal fat mass. Waist circumference is correlated with abdominal mass and is a predictor of type 2 diabetes mellitus compared to BMI. Diabetes Mellitus Type 2 (T2DM) is more common in individuals with overweight and obesity. T2DM is not only occured due to carbohydrate metabolism disorder of lipid metabolism but also due to dyslipidemia. Dyslipidemia caused by substances called lipoprotein VLDL (Very Low Density Lipoprotein) or triglycerides, decreased HDL cholesterol (High Density Lipoprotein) and the formation of small dense LDL (Low Density Lipoprotein) which are atherogenic. This study aimed to determine the relationship of waist circumference with the lipid profile in T2DM patients Prof. R.D. Kandou Hospital Manado. This was a descriptive cross sectional analytic study. There were 53 respondents that met the inclusion criteria. This study was conducted for three months starting from September – November 2013 in the Endocrine Clinic. Conclusions: There was no significant correlation between waist circumference and total cholesterol, LDL, and triglycerides levels. However, there is a significant correlation between waist circumference and HDL levels.Keywords: Waist circumference, total cholesterol, HDL, LDL, Triglycerides, T2DMAbstrak: Lingkar pinggang sering digunakan sebagai penilai massa lemak abdominal, karena lingkar pinggang berkorelasi dengan massa lemak abdominal dan merupakan prediktor Diabetes Melitus Tipe 2 (DMT2) yang paling kuat dibandingkan dengan IMT. DMT2 lebih sering terjadi pada individu dengan berat badan lebih dan obesitas. Pada DMT2 bukan saja terjadi gangguan metabolisme karbohidrat melainkan juga terdapat metabolisme lipid, keadaan ini disebut dislipidemia. Dislipidemia terjadi akibat gangguan metabolisme lipoprotein yaitu Very Low Density Lipoprotein (VLDL), trigliserida, penurunan kolesterol High Density Lipoprotein (HDL), dan terbentuknya small dense Low Density Lipoprotein (LDL) yang bersifat aterogenik. Penelitian ini bertujuan untuk mengetahui hubungan lingkar pinggang dengan profil lipid pada pasien DMT2 di RSUP Prof. R.D. Kandou Manado. Jenis penelitian ini ialah deskriptif analitik dengan pendekatan cross sectional. Responden penelitian sebanyak 53 pasien yang memenuhi kriteria inklusi. Penelitian ini dilakukan selama tiga bulan yaitu dari bulan September – November 2013 di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP. Prof. R.D. Kandou Manado. Simpulan: Tidak terdapat hubungan yang bermakna antara lingkar pinggang dengan kadar kolesterol total, kadar LDL, dan trigliserida. Terdapat hubungan bermakna antara lingkar pinggang dan kadar HDL.Kata kunci: Lingkar Pinggang, Kolesterol Total, HDL, LDL, Trigliserida, DMT2

scholarly journals A study of lipid profile in subclinical hypothyroidism in tertiary care hospital, Kolkata, India

2020 ◽  
Vol 7 (5) ◽  
pp. 760
Author(s):  
Kaushik Saha ◽  
Dipa Saha
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Subclinical Hypothyroidism ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Care Hospital ◽  
Group I ◽  
Group Ii

Background: Objective was to study lipid profile in patients of subclinical hypothyroidism in tertiary centre in Kolkata, West Bengal and compare the same with matched controls.Methods: This observational study (single exposure) was conducted May 2019 to Nov 2019 at Department of Medicine, KPC Medical College, Jadavpur, Kolkata in subjects diagnosed with Sub Clinical Hypothyroidism [defined as normal T3 or FT3, normal T4 or FT4, and with increased TSH. Sixty patients with subclinical hypothyroidism were selected after careful exclusion; lipid profile was compared with matched controls.Results: Between the two groups (group I - controls vs. group II - cases), the values were as follows: Mean serum total T3 value was 114.03±29.22 ng/dl vs. 106.15±36.24 ng/dl (p = 0.3476); mean total T4 was 7.07±1.69 μg/dl vs. 6.86±1.31 μg/dl (p = 0.535); mean TSH was 3.17±1.28 μIU/ml vs. 9.77±4.19 μIU/ml (p <0.0001). Lipid profile pattern (group I vs. group II) was as follows: Mean total cholesterol (TC) 125.50±9.18 mg/dl vs. 162.07±42.32 mg/dl (p <0.0001), mean triglycerides (TG) is 136.65±14.82 mg/dl vs. 148.90±65.27 mg/dl (p = 0.3236), low-density lipoprotein (LDL)-cholesterol is 62.17±7.40 mg/dl vs. 98.81±33.26 mg/dl (p <0.0001), high-density lipoprotein (HDL)-cholesterol 39.17±6.62 mg/dl vs. 34.27±9.63 mg/dl (p = 0.0702), very low-density lipoprotein (VLDL) levels are 34.54±15.38 mg/dl vs. 32.08±13.21 mg/dl (p = 0.5245)..Conclusions: Subclinical hypothyroidism is associated with increased serum total cholesterol and LDL-Cholesterol levels. Therefore, there is a potential association between Subclinical hypothyroidism and atherosclerosis.

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