scholarly journals Cisplatin-Induced Eosinophilic Pneumonia

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Hideharu Ideguchi ◽  
Keisuke Kojima ◽  
Susumu Hirosako ◽  
Hidenori Ichiyasu ◽  
Kazuhiko Fujii ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Esophageal Cancer ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Ground Glass Opacity ◽  
Lavage Fluid ◽  
Eosinophilic Pneumonia ◽  
Lymphocyte Stimulation Test ◽  
Drug Induced ◽  
Chest Computed Tomography

A 67-year-old man suffering from esophageal cancer was admitted to our hospital complaining of dyspnea and hypoxemia. He had been treated with cisplatin, docetaxel, and fluorouracil combined with radiotherapy. Chest computed tomography revealed bilateral ground-glass opacity, and bronchoalveolar lavage fluid showed increased eosinophils. Two episodes of transient eosinophilia in peripheral blood were observed after serial administration of anticancer drugs before the admission, and drug-induced lymphocyte stimulation test to cisplatin was positive. Thus cisplatin-induced eosinophilic pneumonia was suspected, and corticosteroid was effectively administered. To our knowledge, this is the first reported case of cisplatin-induced eosinophilic pneumonia.

scholarly journals Pneumocystis jirovecii Pneumonia in an Immunocompetent Japanese Man: A Case Report and Literature Review

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Hiromi Ide ◽  
Yoshikazu Yamaji ◽  
Kazunori Tobino ◽  
Masanobu Okahisa ◽  
Kojin Murakami ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bronchoalveolar Lavage Fluid ◽  
Immune Status ◽  
Ground Glass Opacity ◽  
Lavage Fluid ◽  
Pneumocystis Jirovecii ◽  
Pathological Examination ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Chest Computed Tomography ◽  
Methenamine Silver

We herein report the case of a 37-year-old immunocompetent man who died from Pneumocystis jirovecii pneumonia (PCP). He was initially treated for an acute exacerbation of interstitial pneumonia; however, the elevation of the patient’s serum (1-3) β-D glucan (BG) level suggested the possibility of PCP and sulfamethoxazole trimethoprim was added. A postmortem pathological examination and retrospective Grocott's methenamine silver (GMS) staining of the bronchoalveolar lavage fluid (BALF), which was obtained on the day of admission, revealed PCP. The present case suggests that it is essential to perform a BG assay and GMS staining of BALF specimens when patients show diffuse ground-glass opacity on chest computed tomography, regardless of their immune status.

Tryptase and IL-33 in Bronchoalveolar Lavage Fluid May Predict the Types of Eosinophilic Pneumonia and Disease Recurrence

2021 ◽  
pp. 1-9
Author(s):  
Tomohiro Akaba ◽  
Mitsuko Kondo ◽  
Kaori Hara ◽  
Rie Mizobuchi ◽  
Kazuhiro Abe ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Potential Role ◽  
Lavage Fluid ◽  
Disease Recurrence ◽  
Eosinophilic Pneumonia ◽  
Drug Induced ◽  
Marked Accumulation ◽  
Blood Eosinophils

<b><i>Introduction:</i></b> Eosinophilic pneumonia (EP) is characterized by a marked accumulation of eosinophils in the lungs and blood. Eosinophils and mast cells play an important role in the pathogenesis of EP via release of biomarkers such as tryptase and interleukin (IL)-33. However, the potential role of these biomarkers is not fully understood. <b><i>Objectives:</i></b> We aimed to evaluate the differences among the levels of tryptase and IL-33 in bronchoalveolar lavage fluid (BALF) from several types of EP. We evaluated the differences between the levels of these biomarkers in the recurrent and nonrecurrent cases. <b><i>Method:</i></b> We prospectively collected the clinical data of patients with EP, diagnosed between 2006 and 2015 in our institution. Bronchoscopy was performed before steroid treatment; BALF was collected. The clinical characteristics of EP patients and the levels of tryptase and IL-33 in BALF were evaluated. <b><i>Results:</i></b> We enrolled 15 patients with chronic EP (CEP), 5 with acute EP (AEP), 10 with drug-induced EP, and 6 with angiitis-related EP. Tryptase levels in the CEP group were significantly higher than that in the drug-induced EP group (<i>p</i> = 0.048), while the AEP group had the highest IL-33 levels. Recurrence of EP was noted in 67% of patients with CEP. The levels of tryptase and IL-33 were notably higher in the recurrent cases than that in the nonrecurrent CEP group (<i>p</i> = 0.004, <i>p</i> = 0.04, respectively). Furthermore, there was a positive correlation between the levels of tryptase and IL-33 in the BALF of patients with CEP (ρ = 0.69, <i>p</i> = 0.004). <b><i>Conclusions:</i></b> Tryptase and IL-33 in BALF are useful biomarkers for the assessment of EP types. These biomarkers could be used to predict disease recurrence.

A Useful Diagnostic Method for Drug-induced Pneumonitis

1994 ◽  
Vol 22 (03n04) ◽  
pp. 329-336 ◽  
Author(s):  
Akira Kawasaki ◽  
Yutaka Mizushima ◽  
Hitoshi Kunitani ◽  
Masanobu Kitagawa ◽  
Masashi Kobayashi
Keyword(s):  
Bronchoalveolar Lavage Fluid ◽  
Challenge Test ◽  
Lavage Fluid ◽  
Peripheral Blood Lymphocytes ◽  
Lymphocyte Stimulation Test ◽  
Drug Induced ◽  
Chief Complaints ◽  
History Of ◽  
Chest X Ray

A 51 year-old male was admitted to our hospital with chief complaints of fever, dry cough and dyspnea. Chest X -ray films and his history of taking Chinese medicine for liver dysfunction were suggestive of drug-induced pneumonitis. Lymphocyte stimulation test (LST) to causative Chinese medical drugs of Sho-saiko-to and Dai-saiko-to was negative with peripheral blood lymphocytes (PBL), but was positive with Iymphocytes from bronchoalveolar lavage fluid (BALF). In vivo challenge test for Sho-saiko-to was positive. The LST with BALF-lymphocytes proved to be very useful in making a diagnosis of drug-induced pneumonitis.

Waterproofing spray-associated pneumonitis: review of 29 cases and comparisons with acute eosinophilic pneumonia and hypersensitivity pneumonitis

2019 ◽  
Author(s):  
Masafumi Shimoda ◽  
Yoshiaki Tanaka ◽  
Keiji Fujiwara ◽  
Koji Furuuchi ◽  
Takeshi Osawa ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Retrospective Study ◽  
Hypersensitivity Pneumonitis ◽  
Bronchoalveolar Lavage Fluid ◽  
Smoking Habit ◽  
Lavage Fluid ◽  
Eosinophilic Pneumonia ◽  
Hospital Visit ◽  
Laboratory Findings ◽  
Acute Eosinophilic Pneumonia

Abstract Purpose: Waterproofing spray-associated pneumonitis (WAP) proceeds to acute respiratory failure and is characterized by diffuse bilateral ground-glass opacities on computed tomography. These features are similar to those of acute eosinophilic pneumonia (AEP) and hypersensitivity pneumonitis (HP). This study identified the characteristics of WAP and compared them with those of AEP and HP. Methods: We conducted a retrospective study of adult patients with WAP, AEP, and HP in Fukujuji Hospital from 1990 to 2018. Furthermore, data from patients with WAP were collected from publications in PubMed and the Japan Medical Abstracts Society and combined with data from our patients. Results: Twenty-nine patients with WAP, eleven patients with AEP, and thirty patients with HP were reviewed. There were no significant differences between the characteristics of WAP and AEP patients, such as age, sex, smoking habit, and laboratory findings. The features of WAP and HP were significantly different. The duration from symptom appearance to hospital visit was shorter in patients with WAP (median 1 day) than in patients with AEP (median 3 days, p =0.003) and HP (median 30 days, p <0.001). The dominant cells in the bronchoalveolar lavage fluid of patients with WAP, AEP, and HP were different (respectively macrophages, eosinophils, and lymphocytes). Conclusions: It was easy to distinguish between WAP and HP because there were many different features. However, the features of WAP and AEP were similar, making differentiation between those two diseases difficult. To distinguish among WAP, AEP and HP, the speed of disease progression and a bronchoscopic examination are very important.

scholarly journals IL-5 Predominant in Bronchoalveolar Lavage Fluid and Peripheral Blood in a Patient with Acute Eosinophilic Pneumonia.

1995 ◽  
Vol 34 (1) ◽  
pp. 65-68 ◽  
Author(s):  
Shinji YAMAGUCHI ◽  
Yoshio OKUBO ◽  
Mahboob HOSSAIN ◽  
Keisaku FUJIMOTO ◽  
Takayuki HONDA ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Peripheral Blood ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Eosinophilic Pneumonia ◽  
Acute Eosinophilic Pneumonia

Detection of IL-5 and IL-1 receptor antagonist in bronchoalveolar lavage fluid in acute eosinophilic pneumonia

1996 ◽  
Vol 97 (6) ◽  
pp. 1366-1374 ◽  
Author(s):  
James N. Allen ◽  
Zhiming Liao ◽  
Mark D. Wewers ◽  
Elizabeth A. Altenberger ◽  
Sherri A. Moore ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Receptor Antagonist ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Eosinophilic Pneumonia ◽  
Acute Eosinophilic Pneumonia
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