scholarly journals Sarcoidosis Associated with Oxaliplatin-Based Chemotherapy for Colorectal Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Ji Hoon Choi ◽  
Jung A. Shin ◽  
Hye Kyeong Park ◽  
Su Young Kim ◽  
Hoon Jung ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Folinic Acid ◽  
Rectosigmoid Colon ◽  
Standard Chemotherapy ◽  
Radiographic Findings ◽  
Fluid Analysis ◽  
First Case

Acute lung injury occasionally occurs after chemotherapy, but pulmonary toxicities by oxaliplatin-based chemotherapy have rarely been identified. A 76-year-old female with rectosigmoid colon cancer presented with ongoing dyspnea after the eighth cycle of standard chemotherapy (5-fluorouracil, sodium folinic acid, and oxaliplatin: FOLFOX). Nodular consolidation progressed despite antibiotics and BAL fluid analysis was compatible with the diagnosis of sarcoidosis. Corticosteroid therapy rapidly improved the symptoms and radiographic findings. We report this first case of secondary sarcoidosis related to FOLFOX therapy with review of references.

Does Transumbilical Incision Influence Surgical Site Infection Rates of the Laparoscopic Sigmoidectomy and Anterior Resection?

2015 ◽  
Vol 81 (12) ◽  
pp. 1232-1236 ◽  
Author(s):  
Masashi Yamamoto ◽  
Keitaro Tanaka ◽  
Mitsuhiro Asakuma ◽  
Keisaku Kondo ◽  
Masatsugu Isii ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Laparoscopic Surgery ◽  
Surgical Site Infection ◽  
Univariate Analysis ◽  
Site Infection ◽  
Infection Rates ◽  
Rectosigmoid Colon ◽  
Lower Quadrant ◽  
Colon Cancer Surgery

Laparoscopic surgery is widespread and is safe and effective for the management of patients with colorectal cancer. However, surgical site infection (SSI) remains an unresolved complication. The present study investigated the comparative effect of supraumbilical incision versus transumbilical incision (TU) on the incidence of SSI in patients undergoing laparoscopic surgery for colon cancer. Medical records from patients with colorectal cancer who underwent laparoscopic sigmoid and rectosigmoid colon surgeries with either supraumbilical incision (n = 150) or TU (n = 150) were retrospectively reviewed. There was no difference in demographics, comorbidities, or operative variables between the two groups. The transumbilical group and the supraumbilical group were comparable with regards to overall SSI (6.0% vs 4.0%; P = 0.4062), superficial SSI (6.0% vs 3.3%; P = 0.2704), and deep SSI (0% vs 0.7%; P = 0.2385). SSI developed after laparoscopic sigmoid and rectosigmoid colon cancer surgery in 15 (5.0%) of the 300 patients. Of these superficial SSI, all wounds were in the left lower quadrant incision, and the transumbilical port sites did not become infected. Univariate analysis failed to identify any risk factors for SSI. Avoidance of the umbilicus offers no benefit with regard to SSI compared with TU.

scholarly journals Vaping Related Acute Lung Injury: First Case from Our Hospital

2020 ◽  
Author(s):  
T. Alexander ◽  
S.M. Farooqui ◽  
K.R. Jones ◽  
N.F. Mehdi ◽  
R. Katz
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
First Case

scholarly journals Dysphonia after Bevacizumab Rechallenge: A Case Report

2015 ◽  
Vol 8 (3) ◽  
pp. 423-425 ◽  
Author(s):  
Corey A. Carter ◽  
Scott Z. Caroen ◽  
Arnold L. Oronsky ◽  
Bryan T. Oronsky
Keyword(s):  
Colorectal Cancer ◽  
Case Report ◽  
Advanced Colorectal Cancer ◽  
Vascular Endothelial ◽  
Standard Chemotherapy ◽  
Vegf Signaling ◽  
First Case ◽  
Voice Changes ◽  
Endothelial Growth Factor ◽  
Tumor Growth And Invasion

Inhibition of vascular endothelial growth factor (VEGF) signaling, an initiator of tumor angiogenesis, inhibits tumor growth and invasion. Bevacizumab, a monoclonal antibody to VEGF, in common use as an adjunct to standard chemotherapy like irinotecan in advanced colorectal cancer, also affects the normal (nontumor) vasculature. Dysphonia or voice changes have been anecdotally reported in patients that have been exposed to antiangiogenics. In this case report, we present an occurrence of severe dysphonia in a 60-year-old male with metastatic colorectal cancer after reintroduction of irinotecan and bevacizumab. To our knowledge, this is the first case of dysphonia associated with bevacizumab rechallenge.

scholarly journals Severe rhabdomyolysis related to oxaliplatin adjuvant therapy for colorectal cancer

2019 ◽  
Vol 12 (4) ◽  
pp. e228673 ◽  
Author(s):  
Ana Pissarra ◽  
Mariana Malheiro ◽  
Leonor Vasconcelos Matos ◽  
Ana Neto Plácido
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Adjuvant Chemotherapy ◽  
Stage Iii ◽  
Standard Chemotherapy ◽  
Postoperative Adjuvant Chemotherapy ◽  
Stage Iii Colon Cancer ◽  
Distal Muscle ◽  
Common Cancer ◽  
Resected Stage

Colorectal cancer is the third most common cancer in men and the second in women. The standard chemotherapy regiment in stage III colon cancer is based in oxaliplatin. The most common side effects include neutropenia, peripheral neuropathy, vomiting and diarrhoea. Rhabdomyolysis due to oxaliplatin is rare, and there are no established guidelines for managing this adverse event. This report describes a case of a 52-year-old man, with a resected stage III colon cancer that started postoperative adjuvant chemotherapy with capecitabine plus oxaliplatin. After the second cycle, the patient developed distal muscle pain and weakness, with a total inability to walk. Blood tests showed an elevated creatine kinase and renal injury. Severe drug-related rhabdomyolysis was diagnosed. The goal of this case report is to discuss the side effect of adjuvant chemotherapy, given its rarity and severity.

Colorectal cancer survival following adjuvant chemotherapy with weekly i.v. fluorouracil 425 mg/m2 and folinic acid 50mg

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e15089-e15089
Author(s):  
M. B. Jameson ◽  
M. Head ◽  
S. Deva
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Colon Cancer ◽  
Adjuvant Chemotherapy ◽  
Folinic Acid ◽  
Cancer Survival ◽  
Indirect Comparison ◽  
Analysis Data ◽  
Actuarial Survival ◽  
Colon And Rectal Cancer

e15089 Background: Adjuvant chemotherapy for colorectal cancer (CRC) using fluorouracil (5FU) and folinic acid (FA) has been proven effective and the QUASAR trial showed that a weekly administration schedule was as effective as, and less toxic than, the same daily doses delivered over 5 days every 4 weeks (the “Mayo regimen”). However the 5FU dose used (370 mg/m2) was lower than in some trials and a higher 5FU dose was considered desirable if tolerated. We therefore implemented a weekly regimen using 5FU 425 mg/m2 and DL-folinic acid 50mg in 2001 and retrospectively evaluated its efficacy and tolerability. Methods: Patients with non-metastatic CRC at assessment by medical oncologists in this institution between 2001 and 2004 were included in the analysis. Data was gathered on patient characteristics, duration of adjuvant chemotherapy and survival. Actuarial survival was calculated using the Kaplan-Meier method. Results: 417 patients (pts) were seen: 181 females, 236 males; median age 67 yrs (24–89); 291 with colon cancer, 126 with rectal cancer; 1 stage 1; 100 stage 2, 316 stage 3. Median follow-up was 6.2 years. 210 pts with colon cancer received adjuvant weekly 5FU/FA (32 stage 2, 178 stage 3) as did 58 pts with rectal cancer (50 of whom also received concurrent chemoradiation). 75% of pts with colon cancer received all 30 planned doses and 59% of rectal cancer pts received all 20 planned doses. 3 year survival for all pts treated with this regimen was 83.0% and for the subgroups with colon and rectal cancer it was 82.4% and 84.5% respectively. For stage 2 and 3 colon cancer pts treated with this regimen 3 year survival was 87.9% and 76.0% respectively; for stage III rectal cancer pts it was 84.1%. Conclusions: These outcomes compare favorably on indirect comparison with results from the QUASAR trial (which reported 3 year survival of 70.6%) and suggest that using a higher 5FU dose in this regimen is tolerable and may be advantageous. No significant financial relationships to disclose.

scholarly journals Acute pneumonitis consequent on pleurodesis with Viscum album extract: severe chest images but benign clinical course

2014 ◽  
Vol 9 ◽  
Author(s):  
Suk Ju Cho ◽  
Su Wan Kim ◽  
Jee Wo Chang
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Autologous Blood ◽  
Viscum Album ◽  
Chemical Agent ◽  
Chemical Pleurodesis ◽  
First Case ◽  
Metastatic Lung ◽  
Chest X Ray

Chemical pleurodesis is widely recommended in the treatment of pulmonary air leak of different etiologies as well as malignant pleural effusions and chylothorax. Conventional chemical pleurodesis using erythromycin, tetracycline, hydrophilic fumed silica, autologous blood and talc slurry has been standardized, and its complications, including high fever, intractable chest pain, and acute lung injury, seem to be frequent. Viscum album extract is a new chemical agent for pleurodesis, and only a few studies have reported outcomes of such chemical pleurodesis in the treatment of malignant pleural effusion. Moreover, the complications resulting from pleurodesis using Viscum album extract are very rare, and acute pneumonitis has not been reported. in this paper we report the first case of acute pneumonitis after pleurodesis using Viscum album extract in a 58-year-old man who had prolonged air leaks after a left upper lingularsegmentectomy for metastatic lung cancer. We performed repeated pleurodesis four times with 2 to 4 days intervals. While the patient had no symptoms of pneumonia, such as cough, sputum, chilling, and fatigue, a follow-up chest X-ray revealed increasing peribronchial consolidations and infiltrations in the left upper lobe. A chest tomography showed extensive parenchymal consolidations and ground-glass appearances in the left lungs, representing pneumonia with acute lung injury. The acute pneumonitis was spontaneously resolved with supportive care, and the patient was discharged ten days after the development of pneumonitis. We think that pleurodesis with Viscum album extract is effective, but repeated pleurodesis should be avoided for possible onset of acute pneumonitis.

Radiation Induced Acute Lung Injury: Chest Radiographic Findings

1994 ◽  
Vol 30 (1) ◽  
pp. 91
Author(s):  
Seog Hee Park ◽  
Kyung Sub Shinn ◽  
Su Mi Chung ◽  
Jeong Mi Park ◽  
Il Bong Choi ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Radiographic Findings ◽  
Radiation Induced

A Tale of Two Colons and Two Cancers

Swiss Surgery ◽  
2003 ◽  
Vol 9 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Gervaz ◽  
Bühler ◽  
Scheiwiller ◽  
Morel
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Adjuvant Chemotherapy ◽  
Splenic Flexure ◽  
Chromosomal Instability ◽  
Proximal Colon ◽  
Colorectal Carcinogenesis ◽  
Physiological Data ◽  
Central Hypothesis ◽  
Group Stratification

The central hypothesis explored in this paper is that colorectal cancer (CRC) is a heterogeneous disease. The initial clue to this heterogeneity was provided by genetic findings; however, embryological and physiological data had previously been gathered, showing that proximal (in relation to the splenic flexure) and distal parts of the colon represent distinct entities. Molecular biologists have identified two distinct pathways, microsatellite instability (MSI) and chromosomal instability (CIN), which are involved in CRC progression. In summary, there may be not one, but two colons and two types of colorectal carcinogenesis, with distinct clinical outcome. The implications for the clinicians are two-folds; 1) tumors originating from the proximal colon have a better prognosis due to a high percentage of MSI-positive lesions; and 2) location of the neoplasm in reference to the splenic flexure should be documented before group stratification in future trials of adjuvant chemotherapy in patients with stage II and III colon cancer.

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