scholarly journals Fungal Malignant Otitis Externa with Facial Nerve Palsy: Tissue Biopsy Aids Diagnosis

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Jenny Walton ◽  
Chris Coulson
Keyword(s):  
Otitis Externa ◽  
Facial Nerve Palsy ◽  
Antifungal Drugs ◽  
Tissue Sampling ◽  
Tissue Biopsy ◽  
Malignant Otitis Externa ◽  
Threatening Condition ◽  
Life Threatening ◽  
Low Sensitivity ◽  
Aids Diagnosis

Fungal malignant otitis externa (FMOE) is a serious and potentially life-threatening condition that is challenging to manage. Diagnosis is often delayed due to the low sensitivity of aural swabs and many antifungal drugs have significant side effects. We present a case of FMOE, where formal tissue sampling revealed the diagnosis and the patient was successfully treated with voriconazole, in addition to an up to date review of the current literature. We would recommend tissue biopsy of the external auditory canal in all patients with suspected FMOE in addition to routine microbiology swabs.

scholarly journals Malignant otitis externa in a 21-year-old male patient with Prader–Willi syndrome

2019 ◽  
Vol 7 ◽  
pp. 2050313X1983482
Author(s):  
Marcos Frata Rihl ◽  
Felipe Marchiori Bau ◽  
Igor de Oliveira ◽  
Manoela Astolfi Vivan ◽  
Roseane Cardoso Marchiori
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Male Patient ◽  
Otitis Externa ◽  
Invasive Infection ◽  
Prader Willi Syndrome ◽  
Malignant Otitis Externa ◽  
Life Threatening

Malignant otitis externa is an invasive infection of the external auditory canal and temporal bone with potentially life-threatening complications. Elderly patients with type 2 diabetes mellitus are the population most commonly affected by malignant otitis externa, but any type of immunosuppression predisposes to the disease. Prader–Willi syndrome is a genetic cause of obesity, often associated with insulin resistance and type 2 diabetes mellitus. This report describes a case of a 21-year-old male patient with Prader–Willi syndrome who had malignant otitis externa that progressed to sepsis during hospitalization. To the best of the authors’ knowledge, this is the first description of malignant otitis externa in a young patient with Prader–Willi syndrome.

scholarly journals Atypical presentations of malignant otitis externa

2010 ◽  
Vol 124 (11) ◽  
pp. 1205-1208 ◽  
Author(s):  
Z Vourexakis ◽  
M-I Kos ◽  
J-P Guyot
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Skull Base ◽  
Diagnostic Criteria ◽  
Otitis Externa ◽  
Case Reports ◽  
Clinical Manifestations ◽  
Diabetic Patients ◽  
Malignant Otitis Externa ◽  
Life Threatening ◽  
Atypical Presentations

AbstractIntroduction:Malignant otitis externa is a life-threatening infection of the skull base. Its presentation is not always typical.Case reports:We report three cases of malignant otitis externa which illustrate the diversity of its clinical manifestations and the difficulties in its diagnosis.Discussion:The perception of malignant otitis externa as an infection caused by Pseudomonas aeruginosa in diabetic patients is not always correct. The adoption of diagnostic criteria could be helpful in identifying atypical cases.

scholarly journals Newer Horizon of Mesenchymal Stem Cell–Based Therapy in the Management of SARS-CoV-2–Associated Mucormycosis: A Safe Hope for Future Medicine

2021 ◽  
Vol 12 ◽  
Author(s):  
Alok Raghav ◽  
Syed Ghazanfar Ali ◽  
Goo-Bo Jeong ◽  
Kirti Amresh Gautam ◽  
Shahid Banday ◽  
...  
Keyword(s):  
Neurological Complications ◽  
Antifungal Drugs ◽  
Innate Immune ◽  
Short Term ◽  
Severe Condition ◽  
Cell Based Therapy ◽  
Threatening Condition ◽  
Regenerative Approach ◽  
Life Threatening ◽  
Extended Exposure

SARS-CoV-2–infected patients are reported to show immunocompromised behavior that gives rise to a wide variety of complications due to impaired innate immune response, cytokine storm, and thrombo-inflammation. Prolonged use of steroids, diabetes mellitus, and diabetic ketoacidosis (DKA) are some of the factors responsible for the growth of Mucorales in such immunocompromised patients and, thus, can lead to a life-threatening condition referred to as mucormycosis. Therefore, an early diagnosis and cell-based management cosis is the need of the hour to help affected patients overcome this severe condition. In addition, extended exposure to antifungal drugs/therapeutics is found to initiate hormonal and neurological complications. More recently, mesenchymal stem cells (MSCs) have been used to exhibit immunomodulatory function and proven to be beneficial in a clinical cell-based regenerative approach. The immunomodulation ability of MSCs in mucormycosis patient boosts the immunity by the release of chemotactic proteins. MSC-based therapy in mucormycosis along with the combination of short-term antifungal drugs can be utilized as a prospective approach for mucormycosis treatment with promising outcomes. However, preclinical and in mucormyIn mucormycosis, the hyphae of clinical trials are needed to establish the precise mechanism of MSCs in mucormycosis treatment.

Paralysis from an ear infection: a severe case of otitis externa leading to acute complete cervical cord syndrome

2021 ◽  
Vol 14 (12) ◽  
pp. e245594
Author(s):  
Rachael Collins ◽  
George Lafford ◽  
Laura Parry
Keyword(s):  
Otitis Externa ◽  
Severe Case ◽  
Complete Recovery ◽  
Cervical Cord ◽  
Team Approach ◽  
Neck Stiffness ◽  
Threatening Condition ◽  
Life Threatening ◽  
History Of ◽  
Red Flag

We report a case of a generally fit and well 54-year-old man who presented with a 2-day history of worsening left-sided otorrhea, headache, neck stiffness, vomiting and fever on the background of a 7-week history of otitis externa (OE). His condition progressed dramatically as he developed symptoms consistent with acute complete cervical cord syndrome with radiological evidence of skull base osteomyelitis, parapharyngeal, retropharyngeal and paravertebral abscesses and sigmoid sinus thrombus. Ultimately, he made a significant, although not complete, recovery. This case is unique in demonstrating how OE can develop into a potentially life threatening condition. It emphasises the importance of early diagnosis and treatment of OE, the recognition of ‘red flag’ symptoms and highlights the importance of a multidisciplinary team approach when managing complex complications of OE.

Malignant Otitis Externa (MOE) causing cerebral abscess and facial nerve palsy

2010 ◽  
Vol 5 (7) ◽  
pp. E6-E8 ◽  
Author(s):  
John Roberts ◽  
Línea Larson-Williams ◽  
Farrah Ibrahim ◽  
Ali Hassoun
Keyword(s):  
Facial Nerve ◽  
Otitis Externa ◽  
Nerve Palsy ◽  
Facial Nerve Palsy ◽  
Cerebral Abscess ◽  
Malignant Otitis Externa

scholarly journals A Case Series of Malignant Otitis Externa Mimicking Malignancy

2021 ◽  
Vol 64 (1) ◽  
pp. 36-41
Author(s):  
Vengathajalam Selvamalar ◽  
Nik Adilah Nik Othman ◽  
Mohd Khairi Daud
Keyword(s):  
Cranial Nerve ◽  
Otitis Externa ◽  
Nerve Palsy ◽  
Facial Nerve Palsy ◽  
Case Series ◽  
Lower Cranial Nerve ◽  
Cortical Mastoidectomy ◽  
Cranial Nerve Palsies ◽  
Adjacent Structures ◽  
Malignant Otitis Externa

Malignant otitis externa is an inflammation of the external auditory canal with preceding osteomyelitis of the temporal bone and the adjacent structures that could be potentially lethal. Malignant otitis externa may present with cranial nerve involvements and massive spread of disease mimicking nasopharyngeal carcinoma or any other malignancies on imaging. Two elderly patients who presented with severe otalgia and significant facial nerve palsy and lower cranial nerve palsies showing extensive spread of disease are reported in this case series. They both had resolution of disease after a prolonged course of antibiotics and cortical mastoidectomy for disease clearance in one of them.

Carcinoma of temporal bone presenting as malignant otitis externa

1992 ◽  
Vol 106 (10) ◽  
pp. 908-910 ◽  
Author(s):  
B. A. Al-Shihabi
Keyword(s):  
Otitis Externa ◽  
Facial Nerve Palsy ◽  
Cranial Nerves ◽  
Ear Canal ◽  
End Of Treatment ◽  
Malignant Otitis Externa ◽  
Parotid Swelling ◽  
History Of ◽  
Post Mortem Findings ◽  
The Right

AbstractA 69-year-old man presented with a three-month history of otalgia and tenderness of the right ear and a one-week history of a painful right parotid swelling. Examination revealed granulation tissue in the right ear canal with normal looking tympanic membranes and a parotid abscess. Repeated biopsies from the ear canal and parotid showed non-specific inflammation. Repeated cultures from both areas grew Ps. aeruginosa. The patient's condition improved following three weeks of intensive treatment for malignant otitis externa only to relapse five weeks after the end of treatment. He received a second course, only to improve temporarily. He developed a right facial nerve palsy five weeks after he was first seen, followed four months later by palsies of all cranial nerves except the olfactory, before dying, seven months after his first appointment.The radiological, histological and post-mortem findings are discussed.

scholarly journals Herpes zoster oticus with meningitis masquerading as malignant otitis externa

2019 ◽  
Vol 12 (6) ◽  
pp. e229569
Author(s):  
Harriet A Cunniffe ◽  
Nicholas G Cunniffe
Keyword(s):  
Otitis Externa ◽  
Nerve Palsy ◽  
Facial Nerve Palsy ◽  
Clinical Course ◽  
Abducens Nerve ◽  
Varicella Zoster ◽  
Seventh Cranial Nerve ◽  
Cranial Nerve Palsies ◽  
Malignant Otitis Externa

This is a case of an 85-year-old woman whom was admitted with otalgia and an abducens nerve palsy alongside a Pseudomonas otitis externa; she was presumed to have malignant otitis externa. However, despite optimum treatment and resolution of her otitis externa, she went on to develop an ipsilateral facial nerve palsy and sensorineural hearing loss. After further investigation, it was discovered that varicella-zoster meningitis was causing her polyneuropathy. She eventually responded to antivirals and steroids and, at follow-up, her sixth and seventh cranial nerve palsies had completely resolved, though a hearing deficit remained. This case highlights the importance of keeping a diagnosis under review, with the help of the multidisciplinary team, when the clinical course is not progressing as expected.

scholarly journals Facial nerve palsy in otitis externa: A red flag?

2021 ◽  
Vol 16 (1) ◽  
pp. 117-120
Author(s):  
Aliyya Badaruddin ◽  
May May Choo
Keyword(s):  
External Auditory Canal ◽  
Facial Palsy ◽  
Otitis Externa ◽  
Facial Nerve Palsy ◽  
Early Recognition ◽  
Invasive Infection ◽  
Necrotizing Otitis Externa ◽  
Appropriate Treatment ◽  
Life Threatening ◽  
Red Flag

Otitis externa is an infection of the external auditory canal. It rarely results in facial palsy except in severe cases such as necrotizing otitis externa, which is a life-threatening invasive infection of the external auditory canal. Early recognition with prompt and appropriate treatment of necrotizing otitis externa is crucial to prevent more sinister complications. Here we report a case of an elderly gentleman who presented with otitis externa and developed facial palsy a month later. We identified possible problems that may have led to the complication so that such an occurrence can be prevented in the future.

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