scholarly journals Risk of Second Cancers in Merkel Cell Carcinoma: A Meta-Analysis of Population Based Cohort Studies

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Anshul Saxena ◽  
Muni Rubens ◽  
Venkataraghavan Ramamoorthy ◽  
Hafiz Khan
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Meta Analysis ◽  
Relevant Literature ◽  
Population Based ◽  
Merkel Cell ◽  
Second Malignancies ◽  
Second Cancers ◽  
Cochrane Database ◽  
Increased Risk

The risk of second cancers in Merkel cell carcinoma (MCC) remains uncertain since risk estimates vary worldwide. The global MCC population is growing and there is a demand for better knowledge of prognosis of this disease. The Cochrane Database of Systematic Reviews, MEDLINE, and EMBASE search engines were searched for the relevant literature between January 1999 and September 2014 by use of explicit search criteria. The main outcome was second malignancies associated with MCC patients measured by standardized incidence ratios (SIRs) or other estimates of risks. Five papers fulfilled the inclusion criteria and reported SIRs of second cancer in MCC which varied from 1.07 to 2.80. Performing meta-analysis using random effects model revealed that there was an increased risk for second malignancies due to MCC (SIR, 1.52; 95% CI, 1.10–2.11). There was a significant increase in risk for malignant melanoma (SIR, 3.09; 95% CI, 2.02–4.73) as compared to all common second malignancies among the studies. Updated knowledge about risk of second malignancies in MCC will help in better assessment of the disease prognosis and will help in optimizing the medical and surgical treatment, radiotherapy, follow-up, and surveillance procedures.

scholarly journals Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia

2010 ◽  
Vol 104 (1) ◽  
pp. 178-180 ◽  
Author(s):  
D Bzhalava ◽  
F Bray ◽  
H Storm ◽  
J Dillner
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell ◽  
Second Cancers

Patterns and Predictors of Relapse in Merkel Cell Carcinoma: Results from a Population-Based Study

2021 ◽  
Author(s):  
Kurian Joseph ◽  
Justina Wong ◽  
Aswin Abraham ◽  
Julia Zebak ◽  
Anushree Patel ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Population Based ◽  
Merkel Cell ◽  
Population Based Study

Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival

2011 ◽  
Vol 165 (5) ◽  
pp. 1051-1057 ◽  
Author(s):  
J. Girschik ◽  
K. Thorn ◽  
T.W. Beer ◽  
P.J. Heenan ◽  
L. Fritschi
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Western Australia ◽  
Population Based ◽  
Merkel Cell ◽  
Population Based Study

scholarly journals Epidemiology of Merkel cell carcinoma. A population-based study from 1985 to 2013, in northeastern of France

2018 ◽  
Vol 144 (4) ◽  
pp. 741-745 ◽  
Author(s):  
Alice Kieny ◽  
Bernard Cribier ◽  
Nicolas Meyer ◽  
Michel Velten ◽  
Jérémie Jégu ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Population Based ◽  
Merkel Cell ◽  
Population Based Study

scholarly journals Tumor Infiltrating Immune Cells and Outcome of Merkel Cell Carcinoma: A Population-Based Study

2012 ◽  
Vol 18 (10) ◽  
pp. 2872-2881 ◽  
Author(s):  
Harri Sihto ◽  
Tom Böhling ◽  
Heli Kavola ◽  
Virve Koljonen ◽  
Marko Salmi ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Immune Cells ◽  
Population Based ◽  
Merkel Cell ◽  
Population Based Study

Merkel cell carcinoma and Merkel cell polyomavirus: a systematic review and meta-analysis

2015 ◽  
Vol 173 (1) ◽  
pp. 42-49 ◽  
Author(s):  
J. Santos-Juanes ◽  
I. Fernández-Vega ◽  
N. Fuentes ◽  
C. Galache ◽  
P. Coto-Segura ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Meta Analysis ◽  
Merkel Cell Polyomavirus ◽  
Merkel Cell

Neoadjuvant Checkpoint Inhibitor Therapy for Merkel Cell Carcinoma

2020 ◽  
Vol 38 (22) ◽  
pp. 2471-2475
Author(s):  
Andrew S. Brohl ◽  
Vernon K. Sondak
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Past History ◽  
Relevant Literature ◽  
Neuroendocrine Neoplasm ◽  
Cytokeratin 20 ◽  
Merkel Cell ◽  
Management Options ◽  
Borderline Resectable ◽  
Cross Sectional

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 78-year-old man presented with rapidly enlarging lymph nodes in the right preauricular region and neck. Needle biopsy revealed a cytokeratin 20–positive, high-grade neuroendocrine neoplasm consistent with Merkel cell carcinoma (MCC). Cross-sectional imaging disclosed a 5.2-cm intraparotid mass and extensive adenopathy in the ipsilateral cervical and submental chains ( Figs 1A and 1C ), without distant metastatic disease. A skin examination did not reveal a primary lesion (hence, stage IIIA, T0N1bM0). The patient’s history was notable for hypertension, diet-controlled diabetes type II, high cholesterol, and a past history of numerous cutaneous basal and squamous cell carcinomas. He was quite active but reported discomfort from the bulk of the tumors. The patient was evaluated by the surgical oncology team, who believed that the parotid mass and cervical adenopathy were technically resectable but that resection carried a substantial risk of morbidity because of the potential need to sacrifice the facial and/or spinal accessory nerves and because of a likely margin-positive (R1 or R2) result. He was referred to the medical oncology team to discuss management options for regionally advanced, “borderline-resectable” MCC.

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