scholarly journals Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Nurbanu Gurbuzer ◽  
Eren Gozke ◽  
Zeliha Ayhan Basturk
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Cerebrovascular Risk ◽  
The Mean ◽  
And Gender ◽  
Glutamyl Transferase ◽  
Relationship Of ◽  
The Relationship

Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into four groups according to the location of the infarct area and evaluated as for GGT levels and the presence of diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL). Results. The frequency of DM, HT, and HL and gender distributions were similar. The mean GGT levels were significantly higher in patients with AIS and those with relatively larger areas of infarction (P<0.05). Increased mean GGT levels were found in the subgroup with hypertension, higher LDL-cholesterol, and triglyceride levels among cases with AIS (P<0.05). Conclusion. Higher GGT levels in AIS patients reinforce the relationship of GGT with inflammation and oxidative stress. The observation of higher GGT levels in patients with relatively larger areas of infarction is indicative of a positive correlation between increases in infarct areas and elevated GGT levels.

scholarly journals Association between Serum Gamma-glutamyl transferase and Intracranial Arterial Calcification in Acute Ischemic Stroke Subjects

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Tao Yao ◽  
Jing Li ◽  
Qi Long ◽  
Gang Li ◽  
Yanbin Ding ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Arterial Calcification ◽  
Gamma Glutamyl Transferase ◽  
Intracranial Artery ◽  
Gamma Glutamyl ◽  
Risk Of Death ◽  
All Cause Mortality ◽  
Male Patients ◽  
Glutamyl Transferase

AbstractIntracranial artery calcification (IAC) is an important risk factor for cerebral infarction and a key biomarker for intracranial artery stenosis. Gamma-glutamyl transferase (GGT) has been independently associated with increased cardiovascular events and coronary calcification. Our study assessed whether GGT is an independent factor for IAC in acute ischemic stroke (AIS) patients. This cross-sectional study involved a total of 754 patients with AIS (mean age: 65 ± 13.2 years). All the patients had received brain computed tomography angiography (CTA) examination to evaluate IAC. Further, serum GGT levels and other biochemical parameters were analyzed. The average GGT level in patients who died was also significantly increased (37.0 ± 26.8 vs 29.0 ± 21.5 U/L, p = 0.012). Partial correlation analysis showed that serum GGT levels were associated with NIHSS score at admission after adjustment for age and gender was considered (r = 0.150, p = 0.001). Logistic regression analysis showed that serum GGT levels independently predicted all-cause mortality (OR = 1.036, 95% CI: 1.014–1.060, p = 0.002), NIHSS scores (β = 0.051, 95% CI: 0.020–0.082, p = 0.001) and IAC scores (β = 0.006, 95% CI: 0.003–0.014, p = 0.005) in male patients. Each SD (standard deviation) increase of serum GGT levels was also associated with risk of all-cause mortality (OR = 2.272, 95% CI: 1.364–3.787, P = 0.002). GGT levels in patients with severe IAC were significantly elevated (37.6 ± 33.6 vs 28.6 ± 19.2, p < 0.001). However, serum GGT levels could not independently predict the severity of IAC in AIS patients. Our study identified that serum GGT levels were significantly elevated in patients who died, and the GGT levels had a certain association with the risk of death and IAC in male patients.

Association of collateral status and ischemic core growth in patients with acute ischemic stroke

Neurology ◽  
2020 ◽  
pp. 10.1212/WNL.0000000000011258
Author(s):  
Longting Lin ◽  
Jianhong Yang ◽  
Chushuang Chen ◽  
Huiqiao Tian ◽  
Andrew Bivard ◽  
...  
Keyword(s):  
Growth Rate ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Ct Perfusion ◽  
Study Cohort ◽  
Vessel Occlusion ◽  
Ischemic Core ◽  
Relationship Of ◽  
The Relationship ◽  
Linear Regressions

ObjectiveTo test the hypothesis that acute ischemic patients with poorer collaterals would have faster ischemic core growth, we included 2 cohorts in the study, cohort 1 of 342 patients for derivation and cohort 2 of 414 patients for validation purpose.MethodsAcute ischemic stroke patients with large vessel occlusion were included. Core growth rate was calculated by the following equation: Core growth rate = Acute core volume on CTP/Time from stroke onset to CTP. Collateral status was assessed by the ratio of severe hypoperfusion volume within the hypoperfusion region of CTP. The CTP collateral index was categorized in tertiles; for each tertile, core growth rate was summarized as median and inter-quartile range. Simple linear regressions were then performed to measure the predictive power of CTP collateral index in core growth rate.ResultsFor patients allocated to good collateral on CT perfusion (tertile 1 of collateral index), moderate collateral (tertile 2), and poor collateral (tertile 3), the median core growth rate was 2.93 mL/h (1.10–7.94), 8.65 mL/h (4.53–18.13), and 25.41 mL/h (12.83–45.07) respectively. Increments in the collateral index by 1% resulted in an increase of core growth by 0.57 mL/h (coefficient = 0.57, 95% confidence interval = [0.46, 0.68], p < 0.001). The relationship of core growth and CTP collateral index was validated in cohort 2. An increment in collateral index by 1% resulted in an increase of core growth by 0.59 mL/h (coefficient = 0.59 [0.48–0.71], p < 0.001) in cohort 2.ConclusionCollateral status is a major determinant of ischemic core growth.

Development of Radioimmunoassay for Gamma-Glutamyl Transferase Using Pancreatic Enzyme

1983 ◽  
Vol 20 (4) ◽  
pp. 247-250 ◽  
Author(s):  
Masanobu Masuike ◽  
Michio Ogawa ◽  
Takeshi Kitahara ◽  
Atsuo Murata ◽  
Kazuhiko Matsuda ◽  
...  
Keyword(s):  
Enzyme Assay ◽  
Pancreatic Enzyme ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Standard Curve ◽  
Normal Individuals ◽  
The Mean ◽  
Glutamyl Transferase ◽  
Dilution Curves

A radioimmunoassay (RIA) for the determination of gamma-glutamyl transferase (GGT) was developed using human pancreatic enzyme as antigen. The assay allows the determination of GGT in concentrations as low as 80 ng/ml, and it is reproducible and specific. A good parallel relation was demonstrated between the standard curve and dilution curves for serum, urine, bile, and partially purified kidney GGT. In normal individuals, the mean serum concentration of GGT determined by RIA was found to be 3·43 μg/ml (SD ± 1·20). Enzyme activity calculated from the GGT concentration measured by the radioimmunoassay using a regression equation was approximately twice as great as that determined by conventional enzyme assay.

scholarly journals Correlation of age, height, and gender with +Gz tolerance among healthy Indian participants

2020 ◽  
Vol 64 ◽  
pp. 14-17
Author(s):  
S Kasture ◽  
M Sharma ◽  
MS Nataraja
Keyword(s):  
High Performance ◽  
Aerospace Medicine ◽  
Factors Affecting ◽  
Modifiable Factors ◽  
Males And Females ◽  
The Mean ◽  
And Gender ◽  
Microsoft Office ◽  
Relationship Of ◽  
The Relationship

Introduction: Aircrew are repetitively exposed to positive Gz acceleration in fighter flying. Factors affecting +Gz tolerance vary among individuals and are determined by both modifiable and non-modifiable factors. Some of the non-modifiable factors influencing +Gz tolerance are age, gender, and height. The present study was undertaken to understand the relationship of these variables with relaxed +Gz tolerance. Material and Methods: The study involved a retrospective analysis of existing database of the high-performance human centrifuge at the Institute of Aerospace Medicine. Relevant data from 70 non-aircrew subjects were included for the study. Of these, 39 were male and 31 were female. The age and height varied from 27 to 38 years and 157 to 187 cm, respectively. The data were analyzed using Microsoft Office Excel® to find the correlation between age and height with relaxed +Gz tolerance. Relaxed +Gz tolerance of men and women was compared using unpaired t-test. Significance was set at P < 0.05. Results: The mean age, height, and relaxed +Gz tolerance of males were found to be 30.25 ± 4.3 years, 172.58 ± 6.5 cm, and 4.89 ± 0.67G, respectively, whereas those of females were 27.28 ± 3.36 years, 158.46 ± 6.78 cm, and 4.4 ± 0.85G, respectively. In both males and females, age and height showed no correlation with relaxed +Gz tolerance. However, the relaxed +Gz tolerance was found to be higher in males and this difference was statistically different (P = 0.008). Conclusion: Age and height showed no correlation with relaxed +Gz tolerance in both males and females nonaircrew subjects. Males exhibited a statistically significant, higher relaxed +Gz tolerance as compared to females.

The Relationship Between the Development of Alcoholic Liver and Pancreatic Diseases and the Induction of Gamma Glutamyl Transferase

1993 ◽  
Vol 28 (Supplement_1B) ◽  
pp. 27-33 ◽  
Author(s):  
Yoshiro Matsuda ◽  
Mutsumi Tsuchishima ◽  
Yasuhiro Ueshima ◽  
Shujiro Takase ◽  
Akira Takada
Keyword(s):  
Gamma Glutamyl Transferase ◽  
Pancreatic Diseases ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase ◽  
The Relationship

scholarly journals Evaluation of pancreatic lipase and gamma-glutamyl transferase in acute pancreatitis

2020 ◽  
Vol 24 (3) ◽  
pp. 401-405
Author(s):  
Ahmed Baban
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Lipase ◽  
Digestive Enzymes ◽  
Reference Group ◽  
Gamma Glutamyl Transferase ◽  
Serum Lipase ◽  
Gamma Glutamyl ◽  
Healthy Control ◽  
The Mean ◽  
Glutamyl Transferase

Background and objective: Pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormones. Pancreatitis is a condition characterized by inflammation of the pancreas. When the digestive enzymes are activated before they are released into the small intestine, they begin attacking the pancreas, and pancreatic damage happens. This study aimed to evaluate the association between pancreatic lipase, gamma-glutamyl transferase, and acute pancreatitis in patients living in Erbil city. Methods: The present study was carried out at the College of Medicine, Hawler Medical University from December 2017 to July 2018. A total of 35 patients with acute pancreatitis and 25 healthy controls were investigated. Examinations of serum pancreatic lipase and gamma glutamyl transferase were carried out spectrophotometrically for both groups using commercial diagnostics kits. Results: The results showed that the mean level of serum pancreatic lipase in patients with pancreatitis was significantly higher (P <0.01)compared to normal healthy control. The mean serum gamma glutamyl transferase was higher in patients with acute pancreatitis when compared to the reference group but not statistically significant. Conclusion: In the frame of this work, we delineate that pancreatic diseases had a significant effect on pancreatic enzymes reflected by a significant increase in serum lipase, whereas the level of gamma glutamyl transferase increased marginally. Keywords: Pancreatitis; Pancreatic lipoprotein lipase; Gamma glutamyl transferase.

scholarly journals Increased concentration of serum gamma-glutamyl transferase in ischemic stroke patients

2021 ◽  
Vol 7 (2) ◽  
pp. 71
Author(s):  
Pinki Tak ◽  
TejaRam Kalirawna ◽  
Jitendra Rohilla ◽  
ShyamSunder Bairwa ◽  
SunilKumar Gothwal ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Gamma Glutamyl Transferase ◽  
Stroke Patients ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

Abstract WP60: Evaluation of Tissue Reversibility by Relative Apparent Diffusion Coefficient Value in Acute Ischemic Stroke Patients Treated With Successful Thrombectomy

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Toshihiro Ueda ◽  
Tatsuro Takada ◽  
Shinji Nogoshi ◽  
Satoshi Takaishi ◽  
Tomohide Yoshie ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Ischemic Stroke ◽  
Apparent Diffusion Coefficient ◽  
Acute Ischemic Stroke ◽  
Stroke Patients ◽  
Infarcted Area ◽  
Apparent Diffusion Coefficient Value ◽  
Apparent Diffusion ◽  
The Mean ◽  
The Relationship

Background: By recent advance of endovascular thrombectomy, we have often experienced acute ischemic patients who have diffusion weighted imaging (DWI) reversal lesions after earlier successful recanalization. We retrospectively investigated the relationship between apparent diffusion coefficient (ADC) thresholds of tissue infarction and time from onset to recanalization in acute ischemic stroke patients. Methods: We assessed 24 patients who have occlusion of internal carotid artery (n=11) and the main trunk of middle cerebral artery (n=13) and obtained recanalization of TICI2b (n=12) and TICI3 (n=12) by thrombectomy and performed MRI before and after treatment. Relative ADC (rADC) value were calculated for initial DWI lesions and around hypoperfused regions. We evaluated rADC values in infarcted and non-infarcted area and analyzed the relationship between rADC thresholds of tissue infarction and time. Results: The mean time from onset to recanalization was 209 minutes and mean initial NIHSS was 15.4. The mean rADC value was 0.633 in infarcted lesions and 0.905 in non-infarcted area (p<0.001). The thresholds for rADC value for infarction by the area under the curve derived from receiver operating characteristic curve analysis were 0.769 in the area which recanalized under 180 minutes form the onset, 0.792 in that from 180 to 240 minutes, and 0.798 in that over 240 minutes. Conclusion: The estimation of rADC value may be useful in predicting the likelihood of DWI lesion reversal. Marked decreasing of rADC value which is under thresholds of infarction indicated irreversible damage of ischemic tissue regardless of early successful recanalization.

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