scholarly journals Malignant Trigeminal Nerve Sheath Tumor and Anaplastic Astrocytoma Collision Tumor with High Proliferative Activity and Tumor SuppressorP53 Expression

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Maher Kurdi ◽  
Hosam Al-Ardati ◽  
Saleh S. Baeesa
Keyword(s):  
Trigeminal Nerve ◽  
Anaplastic Astrocytoma ◽  
Proliferative Activity ◽  
Histopathological Examination ◽  
Infratemporal Fossa ◽  
Collision Tumor ◽  
Nerve Sheath Tumor ◽  
Cell Of Origin ◽  
Nerve Sheath ◽  
First Case

Background. The synchronous development of two primary brain tumors of distinct cell of origin in close proximity or in contact with each other is extremely rare. We present the first case of collision tumor with two histological distinct tumors.Case Presentation. A 54-year-old woman presented with progressive atypical left facial pain and numbness for 8 months. MRI of the brain showed left middle cranial fossa heterogeneous mass extending into the infratemporal fossa. At surgery, a distinct but intermingled intra- and extradural tumor was demonstrated which was completely removed through left orbitozygomatic-temporal craniotomy. Histopathological examination showed that the tumor had two distinct components: malignant nerve sheath tumor of the trigeminal nerve and temporal lobe anaplastic astrocytoma. Proliferative activity and expressed tumor protein 53 (TP53) gene mutations were demonstrated in both tumors.Conclusions. We describe the first case of malignant trigeminal nerve sheath tumor (MTNST) and anaplastic astrocytoma in collision and discuss the possible hypothesis of this rare occurrence. We propose that MTNST, with TP53 mutation, have participated in the formation of anaplastic astrocytoma, or vice versa.

Multidisciplinary Approach to Malignant Peripheral Nerve Sheath Tumor of the Trigeminal Nerve: 2-Dimensional Operative Video

2019 ◽  
Vol 17 (5) ◽  
pp. E205-E205
Author(s):  
Hussam Abou-Al-Shaar ◽  
Yair M Gozal ◽  
Jason P Hunt ◽  
William T Couldwell
Keyword(s):  
Peripheral Nerve ◽  
Trigeminal Nerve ◽  
External Ventricular Drain ◽  
Infratemporal Fossa ◽  
Csf Leak ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumors ◽  
Nerve Sheath ◽  
Patient Reported ◽  
Facial Numbness

Abstract Malignant peripheral nerve sheath tumors (MPNSTs) of the trigeminal nerve are uncommon lesions that pose a surgical challenge to neurosurgeons. The case described in this video involved a 67-yr-old man who presented with a 2-yr history of left-sided facial numbness spreading from his chin along the left mandible to the preauricular area. He also reported left-sided tongue numbness and decreased taste on the left side of the tongue. On examination, he had left-sided facial numbness along the V3 distribution to pinprick and light touch. Magnetic resonance imaging (MRI) revealed an enhancing left V3 lesion extending from Meckel's cave to the angle of the mandible. The patient underwent a left temporal craniotomy for biopsy of the lesion, formalizing the diagnosis of a MPNST of the left trigeminal nerve. A multidisciplinary resection of his lesion was performed. Left infratemporal fossa approach with neck dissection, mandibulectomy, and frontotemporal craniotomy were performed. Additionally, a frontal external ventricular drain was placed for 3 d to aid in CSF diversion to avoid CSF leak, and free-flap reconstruction was undertaken. The patient tolerated the procedure well. Postoperatively, he retained his facial numbness, dysphagia, and dysarthria. The patient was discharged to inpatient rehabilitation on postoperative day 12. Postoperative computed tomography and MRI depicted complete resection of the left trigeminal nerve MPNST. At his last follow-up appointment, 3 mo after surgery, the patient reported significant improvement in his symptoms. Neuroimaging demonstrated no residual tumor and adjuvant radiotherapy was recommended. The patient provided consent for publication.

scholarly journals Microcystic/Reticular Schwannoma of the Frontal Lobe: An Unusual Occurrence

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Lauren Pearson ◽  
Erinc Akture ◽  
Julien Wonderlick ◽  
Gregory Fuller ◽  
Maryam Zenali
Keyword(s):  
Frontal Lobe ◽  
Cranial Nerves ◽  
Neck Region ◽  
Nerve Sheath Tumor ◽  
Head And Neck Region ◽  
Peripheral Nerve Sheath Tumor ◽  
Reticular Pattern ◽  
Nerve Sheath ◽  
First Case ◽  
Unusual Occurrence

Schwannoma is a benign peripheral nerve sheath tumor that typically involves cranial nerves of the head and neck region. Intraparenchymal occurrence of this tumor is uncommon. Even rarer in this site is the microcystic/reticular pattern of schwannoma. This histologic variant, first described in 2008, has a predilection for visceral organs. Herein, we report the first case of microcystic/reticular schwannoma of the frontal lobe.

Melanotic nerve sheath tumor of the gasserian ganglion and trigeminal nerve

1979 ◽  
Vol 133 (1) ◽  
pp. 142-144 ◽  
Author(s):  
RM Quencer ◽  
NA Stokes ◽  
D Wolfe ◽  
LK Page
Keyword(s):  
Trigeminal Nerve ◽  
Nerve Sheath Tumor ◽  
Gasserian Ganglion ◽  
Nerve Sheath

Auricular Schwannoma: A Rare Presentation

2014 ◽  
Vol 6 (1) ◽  
pp. 16-18
Author(s):  
Satish Kumar Sharma ◽  
Rashmi Raina ◽  
Vikas Deep Gupta
Keyword(s):  
Local Anesthesia ◽  
World Literature ◽  
Rare Case ◽  
Histopathological Examination ◽  
Nerve Sheath Tumor ◽  
Rare Tumor ◽  
Rare Presentation ◽  
Nerve Sheath ◽  
Ear Piercing

ABSTRACT Schwannoma is an extremely rare tumor of auricle. We are presenting a rare case of auricular schwannoma, perhaps the fifth in world literature, with traumatic etiology. Twenty-five years old female presented with swelling left pinna since 6 years following ear piercing. She desires surgery for cosmetic reasons only. Swelling was excised under local anesthesia and sent for histopathological examination. HPE report was suggestive of nerve sheath tumor. No recurrence has reported so far in followup of 9 months period.

scholarly journals Auricular Schwannoma: A Rare Presentation

2013 ◽  
Vol 5 (3) ◽  
pp. 166-168
Author(s):  
Satish Kumar Sharma ◽  
Rashmi Raina ◽  
Vikas Deep Gupta
Keyword(s):  
Local Anesthesia ◽  
World Literature ◽  
Rare Case ◽  
Histopathological Examination ◽  
Nerve Sheath Tumor ◽  
Rare Tumor ◽  
Rare Presentation ◽  
Nerve Sheath ◽  
Ear Piercing

ABSTRACT Schwannoma is an extremely rare tumor of auricle. We are presenting a rare case of auricular schwannoma, perhaps the fifth in world literature, with traumatic etiology. Twenty-five years old female presented with swelling left pinna since 6 years following ear piercing. She desires surgery for cosmetic reasons only. Swelling was excised under local anesthesia and sent for histopathological examination. HPE report was suggestive of nerve sheath tumor. No recurrence has reported so far in followup of 9 months period. How to cite this article Thakur K, Sharma SK, Raina R, Gupta VD. Auricular Schwannoma: A Rare Presentation. Int J Otorhinolaryngol Clin 2013;5(3):166-168.

Malignant intracerebral nerve sheath tumor with intratumoral calcification

2000 ◽  
Vol 92 (2) ◽  
pp. 338-341 ◽  
Author(s):  
Minoru Tanaka ◽  
Soichiro Shibui ◽  
Kazuhiro Nomura ◽  
Yukihiro Nakanishi ◽  
Tadashi Hasegawa ◽  
...  
Keyword(s):  
Nerve Sheath Tumor ◽  
Pathological Features ◽  
Resonance Imaging ◽  
Content Type ◽  
Nerve Sheath ◽  
First Case ◽  
The Right ◽  
Tomography Scanning ◽  
Considerable Enhancement ◽  
Fine Print

✓ The authors present the clinical, radiological, and pathological features of a malignant intracerebral nerve sheath tumor that occurred in the right parietooccipital lobe of a 4-year-old girl. Computerized tomography scanning and magnetic resonance imaging demonstrated a 5 × 5 × 4—cm multiloculated mass with considerable enhancement of the irregularly shaped septa and clearly calcified areas within the mass. Among five cases reported in the literature, this patient is the youngest and represents the first case in which there is radiological evidence of intratumoral calcification.

scholarly journals First documented case of intracranial falcine malignant peripheral nerve sheath tumor: illustrative case

2021 ◽  
Vol 2 (6) ◽  
Author(s):  
Renato J. Galzio ◽  
Mattia Del Maestro ◽  
Diamantoula Pagkou ◽  
Massimo Caulo ◽  
Sofia Asioli ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Cranial Nerves ◽  
Illustrative Case ◽  
Nerve Sheath Tumor ◽  
Falx Cerebri ◽  
Peripheral Nerve Sheath Tumor ◽  
Documented Case ◽  
Nerve Sheath ◽  
First Case ◽  
The Right

BACKGROUND The authors reported the first documented case of intracranial extraaxial nonneurofibromatosis type 1–related nontriton malignant peripheral nerve sheath tumor (MPNST) originating from the falx cerebri. OBSERVATIONS A 34-year-old man with headache, short-term memory deficit, postural instability, and blurred vision presented with a large heterogenous contrast-enhanced intraventricular cystic lesion originating from the free margin of the falx cerebri. The patient received surgery using the right posterior interhemispheric approach. Gross total resection was performed, and the inferior border of the falx cerebri was resected. The postoperative course was uneventful. Histological examination revealed hypercellular foci of neoplastic spindle cells with hyperchromatic and wavy nuclei. Hence, a diagnosis of MPNST was made based on concomitant immunochemistry findings, including mouse double minute 2 homolog focal positivity and geographic loss of H3K27me3. The patient received adjuvant radiotherapy, and recurrence was not observed. LESSONS Intracranial MPNSTs are extremely rare tumors, typically originating from the cranial nerves in the posterior cranial fossa. An even rarer variant of these tumors, referred to as malignant intracerebral nerve sheath tumors, may directly arise from the brain parenchyma. The authors reported the first case of an intracranial MPNST originating from the dura mater of the falx cerebri, acting as an extraaxial lesion with prevalent expansion in the right ventricle.

Chronic Recurrent Subarachnoid Hemorrhage from a Trigeminal Nerve Malignant Peripheral Nerve Sheath Tumor

Neurosurgery ◽  
2006 ◽  
Vol 59 (2) ◽  
pp. E425-E425 ◽  
Author(s):  
Andreas M. Stark ◽  
Ralf Buhl ◽  
Heinz-Herrmann Hugo ◽  
Thorsten Straube ◽  
H Maximilian Mehdorn
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Peripheral Nerve ◽  
Trigeminal Nerve ◽  
Nerve Sheath Tumor ◽  
Facial Weakness ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Clinically Significant ◽  
Total Tumor Removal ◽  
Intratumoral Bleeding

Abstract OBJECTIVE: Clinically significant intratumoral or peritumoral bleeding from trigeminal nerve tumors is very rare. CLINICAL PRESENTATION: We report the case of a 59-year-old man who presented with recurrent subarachnoid hemorrhage from a left trigeminal nerve malignant peripheral nerve sheath tumor. He presented with decreased consciousness, left facial hypesthesia, and left facial weakness. Trigeminal neuralgia was present for 18 months. Cranial computed tomographic and magnetic resonance imaging scans revealed a left parapontine mass with cystic changes and intratumoral bleeding. Furthermore, signs of hemosiderosis of the subarachnoid space were noted. Lumbar puncture revealed fresh bleeding. Angiography detected no aneurysm or other causes of bleeding. The patient became fully alert within hours, the facial weakness improved within a few days. There was no evidence of vasospasm or persisting hydrocephalus. He underwent left-sided suboccipital craniotomy for macroscopically total tumor removal. INTERVENTION: The patient underwent total tumor removal via a left suboccipital approach. Intraoperatively, evidence of recurrent intratumoral bleeding was noted. Histological examination revealed a malignant peripheral nerve sheath tumor (World Health Organization Grade III). Postoperatively, the hypesthesia improved significantly. The patient was transferred to radiotherapy for external beam radiation. CONCLUSIONS: This is the first report regarding a malignant peripheral nerve sheath tumor of the trigeminal nerve that caused clinically significant subarachnoid hemorrhage caused by intratumoral bleeding.

Trigeminal Nerve Sheath Tumor Presenting as a Cluster Headache

2018 ◽  
Vol 58 (6) ◽  
pp. 896-897
Author(s):  
Ario Mirian ◽  
Adrian Budhram ◽  
Andrew Leung ◽  
Michelle-Lee Jones
Keyword(s):  
Cluster Headache ◽  
Trigeminal Nerve ◽  
Nerve Sheath Tumor ◽  
Nerve Sheath

Malignant Peripheral Nerve Sheath Tumor of the Trigeminal Nerve Involving the Middle and Posterior Cranial Fossa

2018 ◽  
Vol 112 ◽  
pp. 221-226 ◽  
Author(s):  
Aijun Liang ◽  
Bin Xi ◽  
Chaoyang Zhou ◽  
Yu Yang ◽  
Jianzhong Zhang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Trigeminal Nerve ◽  
Posterior Cranial Fossa ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Cranial Fossa
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