scholarly journals Bilateral Maxillary Sinus Hypoplasia

2014 ◽  
Vol 2014 ◽  
pp. 1-3
Author(s):  
Sachin Khanduri ◽  
Sumit Agrawal ◽  
Saakshi Chhabra ◽  
Swati Goyal
Keyword(s):  
Computed Tomography ◽  
Clinical Practice ◽  
Maxillary Sinus ◽  
Anatomical Variation ◽  
Endoscopic Examination ◽  
Uncinate Process ◽  
Type 3 ◽  
Maxillary Sinus Hypoplasia

Maxillary sinus hypoplasia (MSH) is an uncommon abnormality of paranasal sinuses noted in clinical practice. Computed tomography (CT) scan helps in diagnosing the anomaly along with any anatomical variation that may be associated with it. MSH is usually associated with other anomalies like uncinate process hypoplasia. Three types of MSH have been described. Type 1 MSH shows mild maxillary sinus hypoplasia, type 2 shows significant sinus hypoplasia with narrowed infundibular passage and hypoplastic or absent uncinate process, and type 3 is cleft like maxillary sinus hypoplasia with absent uncinate process. CT and endoscopic examination usually complement each other in diagnosing MSH.

scholarly journals Extralaryngeal Terminal Division of the Inferior Laryngeal Nerve: Anatomical Classification by a Surgical Point of View

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Emin Gurleyik
Keyword(s):  
Anatomical Variation ◽  
Great Majority ◽  
Laryngeal Nerve ◽  
Point Of View ◽  
Entry Point ◽  
Inferior Laryngeal Nerve ◽  
Anatomical Classification ◽  
Type 3

Background. Complete anatomic knowledge including all variations of the inferior laryngeal nerve (ILN) is mandatory for thyroid surgeon. Extralaryngeal terminal division (ETD) of the ILN has significant importance for the safety of thyroidectomy.Material and Methods. Surgical dissection of 200 ILNs was performed on 100 cases. The presence of ETD of the nerve was determined intraoperatively. We propose by a surgical point of view a regional (segmental) classification of ETD of the ILN along its cervical course.Results. ETD has been observed in 54/200 nerves (27%). Great majority are bifurcated nerves (trifurcation 2%). Four types of ETD are classified. In type 1 (arterial; 46.3%), ETD has occurred near inferior thyroid artery (ITA). In type 2 (postarterial; 31.5%), division has been found on postarterial segment. In type 3 (prelaryngeal; 11%), division has been located very close to laryngeal entry point. In type 4 (prearterial; 11%), ETD has occurred before the nerve crossing the ITA.Conclusions. ETD of the ILN is a common anatomical variation. The bifurcation occurs in the ILN at various distances from laryngeal entry point. The classification increasing surgeons’ awareness may help to simplify identification and exposure of terminal branches. Preservation of both extralaryngeal terminal branches of the ILN has paramount importance for the safety of thyroid operations.

New Concept: Different Types of Insufficiency of the Saphenofemoral Junction Identified by Duplex as a Chance for a More Differentiated Therapy of the Great Saphenous Vein

2013 ◽  
Vol 28 (5) ◽  
pp. 268-274 ◽  
Author(s):  
M Stücker ◽  
R Moritz ◽  
P Altmeyer ◽  
S Reich-Schupke
Keyword(s):  
Clinical Practice ◽  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Effective Therapy ◽  
Optimal Therapy ◽  
Different Types ◽  
Type 3 ◽  
Saphenofemoral Junction

Even though the item ‘saphenofemoral junction’ (SFJ) is anatomically well defined, the incontinence of the SFJ is often incompetently described in clinical practice and studies. Especially with regard to the optimal therapy of the great saphenous vein, it might be of importance to have a more distinct regard to the SFJ as it is known that about 10–30% of the saphenous refluxes have no femoral origin. Considering the terminal and preterminal valve three types of incompetence of the SFJ may be differentiated: Type 1: Incompetent terminal, but competent preterminal valve; Type 2: Competent terminal, but incompetent preterminal valve; Type 3: Incompetent terminal and preterminal valve (complete incompetence). A review on prior studies and reports leads to the assumption that the differentiation of the distinct types of SFJ-incompetence allows a more individual and – perhaps – more effective therapy. Finally, studies are necessary to evaluate the here given new concept.

scholarly journals Semiautomatic VWF Multimer Densitometric Analysis: Validation of the Clinical Accuracy and Clinical Implications in Von Willebrand Disease

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 15-16
Author(s):  
Ferdows Atiq ◽  
Johan Boender ◽  
Marjon H. Cnossen ◽  
Johanna G van der Bom ◽  
Karin Fijnvandraat ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Research Funding ◽  
Von Willebrand Disease ◽  
Densitometric Analysis ◽  
Travel Grant ◽  
Bleeding Score ◽  
Type 3 ◽  
Von Willebrand

Introduction Von Willebrand factor (VWF) multimer analysis is an essential tool in the diagnosis and classification of von Willebrand disease (VWD). Current visual VWF multimer analysis is observer dependent, time consuming and is inaccurate in detecting subtle changes in multimer patterns. Therefore, recent studies have investigated VWF multimer quantification using semiautomatic densitometric analysis. The accuracy of VWF multimer densitometric analysis in clinical practice needs further investigation before it can be widely used. The aim of the study was to validate the accuracy of VWF multimer densitometric analysis in clinical practice. Additionally, we aimed to identify patient characteristics associated with VWF multimer densitometry outcomes in type 1 and type 2 VWD patients, and we investigated whether subtle differences in VWF multimer pattern are associated with the bleeding phenotype of VWD patients. Methods We included patients from the nationwide Willebrand in the Netherlands (WiN) study. The inclusion criteria of the WiN study were a personal hemorrhagic diathesis or family history of VWD, and historically lowest VWF antigen (VWF:Ag), VWF activity (measured with the monoclonal antibody assay: VWF:Ab) or VWF collagen binding (VWF:CB) ≤0.30 IU/mL or FVIII activity (FVIII:C) ≤0.40 IU/mL in case of type 2N VWD. At inclusion in the WiN study, blood was drawn and patients filled in an extensive questionnaire containing a self-administered Tosetto bleeding score (BS). For multimer analysis, citrated blood samples were separated on 0.9% agarose gel and visualized by Western blotting. We used IMAGEJ for densitometric analysis. The five smallest bands on densitometric images were defined as small multimers, next five bands were defined as medium multimers and the remaining bands were defined as large multimers. Medium-large VWF multimer index was calculated by dividing the patient's multimer ratio (intensity of the medium and large multimers divided by the total intensity of all multimers) by the multimer ratio of a normal control in the same western blot. If no multimers could be detected, the multimer index was set as 0. Results We included 561 VWD patients: 328 type 1, 211 type 2 and 21 type 3 patients. The median age was 44 [IQR 29-58] and 351 patients (62.7%) were female (Table 1). Figure 1 illustrates typical densitometric outcomes of a type 1 VWD patient with normal VWF multimers (A) and a type 2A patient with reduced high-molecular-weight (HMW) VWF multimers (B). Medium-large VWF multimer index was 1.06 [0.99-1.12] in type 1 and 0.53 [0.29-0.89] in type 2 and 0.00 [0.00-0.00] in type 3 VWD. Medium-large VWF multimer index was in patients visually classified as normal, reduced and absent HMW VWF multimers, respectively 1.07 [1.02-1.12], 0.84 [0.71-0.91] and 0.31 [0.20-0.44] (p<0.001, Figure 2A). With visual examination as gold standard, medium-large VWF multimer index had a very good accuracy in distinguishing normal VWF multimers from reduced HMW VWF multimers (AUC: 0.96 (0.94-0.98) p<0.001, Figure 2B). It could also accurately distinguish reduced HMW VWF multimers from absence of HMW multimers, with an AUC of 0.95 (0.92-0.97, p<0.001), and type 2A and 2B from type 2M and 2N (AUC: 0.96 (0.94-0.99), p<0.001, Figure 2C and 2D). From VWF activity measurements, medium-large VWF multimer index was strongest correlated with VWF:CB (ρ=0.79, p<0.001). From the ratio of the various functional VWF measurements (divided by VWF:Ag), the strongest correlation was again found for VWF:CB/VWF:Ag ratio (ρ=0.80, p<0.001). In type 1 VWD, an increased clearance of VWF (defined as VWFpropeptide/VWF:Ag ratio ≥2.2) was independently associated with lower medium-large VWF multimer index (β=-0.10 (-0.14; -0.07), p<0.001). Also, type 1 VWD patients with a VWF gene variant had relatively lower medium-large VWF multimer index compared to type 1 patients without a VWF variant, respectively 1.03 [0.95-1.10] vs 1.08 [1.04-1.12] (p<0.001). In the total population, higher medium-large VWF multimer index was associated with a lower bleeding score: β=-4.6 (-7.2; -2.0), p=0.001, adjusted for age, sex, blood group and type of VWD. Conclusion Semiautomatic densitometric analysis of VWF multimers has an excellent accuracy in clinical practice, and may have an additional value in providing a better understanding of the clinical features such as the bleeding phenotype of VWD patients. Disclosures Atiq: CSL Behring: Research Funding; SOBI: Other: travel grant. Boender:SOBI: Current Employment; CSL Behring: Research Funding. Cnossen:Bayer: Research Funding; Novo Nordisk: Research Funding; Nordic Pharma: Research Funding; Sobi: Research Funding; Takeda: Research Funding; CSL behring: Research Funding; Pfizer: Research Funding; Shire: Research Funding; Baxter: Research Funding. van der Bom:Bayer: Speakers Bureau. Fijnvandraat:SOBI: Research Funding; NovoNordisk: Consultancy; Grifols: Consultancy; Takeda: Consultancy; Roche: Consultancy; CSL Behring: Research Funding; NovoNordisk: Research Funding. Van Galen:Bayer: Research Funding; Takeda: Speakers Bureau; CSL Behring: Research Funding. Laros-Van Gorkom:Baxter: Other: Educational grant; CSL Behring: Other: Educational grant. Meijer:Bayer: Research Funding; Sanquin: Research Funding; Pfizer: Research Funding; Bayer: Speakers Bureau; Sanquin: Speakers Bureau; Boehringer Ingelheim: Speakers Bureau; BMS: Speakers Bureau; Aspen: Speakers Bureau; Uniqure: Consultancy. Eikenboom:CSL Behring: Research Funding; Roche: Other: Teacher on educational activities. Leebeek:Roche: Other: DSMB member for a study; SOBI: Other: Travel grant; Novo Nordisk: Consultancy; Shire/Takeda: Consultancy; Uniqure: Consultancy; Shire/Takeda: Research Funding; CSL Behring: Research Funding.

Anterior Ethmoidal Artery: A Computed Tomography Analysis and New Classifications

2020 ◽  
Author(s):  
Mohammad Waheed El-Anwar ◽  
Alaa Omar Khazbak ◽  
Diaa Bakry Eldib ◽  
Hesham Youssef Algazzar
Keyword(s):  
Computed Tomography ◽  
Skull Base ◽  
Frontal Sinus ◽  
Ethmoidal Artery ◽  
Anterior Ethmoidal Artery ◽  
The Mean ◽  
Type 3 ◽  
Sinus Ostium

Abstract Objective to determine the anterior ethmoidal artery (AEA) anatomy and variations by computed tomography (CT) in adult and their relations to and presents new AEA classifications. Methods One hundred and fifty paranasal CT scans (300 sides) were included. Axial images were acquired with multiplanar reformates to obtain delicate details in coronal and sagittal planes. Results One hundred and forty-four AEAs canal (48%), 293 AEAs foramen (97.7%), and 229 AEAs sulcus could be detected (76.3%). The mean AEA intranasal length was 6.7 ± 1.27 mm (range: 4.24–10.6 mm). The mean angle between AEA and lamina papyracea was 105.49 ± 9.28 degrees (range: 76.41–129.76 degrees). Of them, 95.8% AEAs had an angle with lamina >90 degrees, while 4.2% had angle <90 degrees. The mean angle between AEA and lateral lamella of cribriform plate was 103.95 ± 13.08 degrees (range: 65.57–141.36 degrees). Of them, 87.5% AEAs had an angle >90 degrees and 12.5% had an angle <90 degrees. The mean distance between AEA and skull base was 1.37 ± 1.98 mm (range: 0–8.35 mm). The AEA types in relation to skull base was type 1 (0–2 mm from skull base; 64.6%), type 2 (2–4 mm; 22.2%), type 3 (4–6 mm; 11.1%), and type 4 (>6 mm; 2.1%). The mean distance between the AEA and frontal sinus ostium was 9.17 ± 4.72 mm (range: 0–25.36 mm). AEA classification according to distance from AEA to frontal sinus ostium was 17.4% type 1 (<5 mm), 41.7% type 2 (5–10 mm), 31.9% type 3 (10–15 mm), and 9% type 4 (>15 mm). Conclusion Provided AEA details improve surgeons' awareness of AEA variations in the endoscopic field and can help residents in training.

scholarly journals Effect of aging on the configurational change of the aortic arch

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Atsuhiro Kojima ◽  
Isako Saga
Keyword(s):  
Computed Tomography ◽  
Aortic Arch ◽  
Computed Tomography Angiography ◽  
Smoking Habit ◽  
Patient Characteristics ◽  
The Mean ◽  
Type 3 ◽  
The Relationship

We explored the relationship between aging and the configuration of the aortic arch using computed tomography angiography (CTA). We retrospectively reviewed CTA obtained in 140 cases. The configuration of the aortic arch was categorized into three types based on the criteria mentioned by Madhwal <em>et al</em>., and the relationships between each configuration and patient characteristics were analyzed. Anomalies of the aortic arch were also explored. Twenty patients had a type-1 aortic arch (mean age, 56.1 years), 30 patients had a type-2 aortic arch (mean age, 66.3 years), and 89 patients had a type-3 aortic arch (mean age, 71.7 years). The mean age of patients with a type-3 aortic arch was significantly higher than that of patients with a type-1 aortic arch. No significant correlations between the type of aortic arch and other factors, such as smoking habit, were seen. The configuration of the aortic arch in our study appears to be significantly affected by the age of the patients.

scholarly journals Final Results from a Non-Interventional Safety and Efficacy Study of a VWF/FVIII Concentrate (wilate®) in Patients with Von Willebrand Disease

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 1182-1182
Author(s):  
Hassan M. Yaish ◽  
Maria Sol Cruz ◽  
Kay Decker ◽  
Eva M.K. Zetterberg ◽  
Sylvia Werner ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Real Life ◽  
Routine Clinical Practice ◽  
Median Dose ◽  
Surgical Prophylaxis ◽  
On Demand ◽  
Safety Population ◽  
Type 3

Abstract Introduction: Post-marketing studies provide important insight into the consistency of data from clinical studies and routine clinical use. This non-interventional, prospective, multicentre study (WIL-20) collected real-life data on the use of a human VWF/FVIII concentrate with the native VWF/FVIII complex in a physiological 1:1 ratio (wilate®; pdVWF/FVIII) in routine clinical practice. Here, we report the final results from this study. Methods: The primary objective was to document the safety and tolerability of pdVWF/FVIII in routine clinical practice, with a planned observation period per patient of 2 years. Secondary objectives were to document the efficacy in on-demand treatment of acute bleeding, long-term prophylaxis, and surgical prophylaxis. Male and female patients of any age and with any type of VWD who were prescribed pdVWF/FVIII were eligible for the study. pdVWF/FVIII was administered at the investigator's discretion. Data recorded included patient demographics, laboratory parameters, treatment details, and occurrence of adverse drug reactions (ADRs), including immunogenicity and thrombogenicity. Tolerability was assessed using a verbal rating scale; efficacy of on-demand treatment and surgical prophylaxis using a haemostatic scale; and prophylactic efficacy based on the frequency of spontaneous breakthrough bleeds. Results: The study enrolled 120 patients from 11 countries. Within the safety population (111 patients who received at least one dose of pdVWF/FVIII), 45% of patients had type 1 VWD, 29% type 2 and 18% type 3; disease type was unavailable for 8 patients, and 1 patient was diagnosed with haemophilia A during the study. Of the 111 patients, 33% were previously untreated with a FVIII/VWF product. A total of 7024 infusions were administered to the safety population over a median observation time of 2 years; median dose was 320.5 IU/kg. A total of 26 ADRs were reported in 8 patients; 4 were mild, 3 moderate and 1 severe. Three patients discontinued treatment and 1 stopped treatment temporarily due to adverse events. Using an experimental assay, 3 cases of VWF inhibitors were identified, with no impact on clinical outcome. No thromboembolic events were reported. Tolerability was rated for 6497 infusions, with 96.2% rated 'excellent', 3.7% 'satisfactory', and 0.1% 'unsatisfactory'. Of the 29 patients treated on-demand, 150 bleeding events (BEs), excluding menstrual bleeds, were reported in 25 patients; 18% of BEs were mild, 71.3% were moderate, and 10% were severe. 94% of treated bleeds (130/138) resolved with 1 or 2 infusions, with a median dose per BE of 33 IU/kg. The efficacy of treatment was rated as 'excellent' or 'good' for 100% of BEs. Of the 25 patients treated with pdVWF/FVIII for prophylaxis, 18 patients had a total of 233 breakthrough BEs; 37% mild, 44% moderate, and 9% severe (severity information was unavailable for 11% of bleeds). Of the breakthrough BEs that required treatment, 85% (149/175) were treated with 1 or 2 infusions of pdVWF/FVIII, with a median dose per BE of 55.4 IU/kg. Efficacy of pdVWF/FVIII was rated as 'excellent' or 'good' by investigators for 99% of 139 evaluable breakthrough BEs. For patients on prophylaxis (n = 25), the median annualised bleeding rate for spontaneous BEs was 1.5 (range 0.0-19.7). The efficacy of prophylaxis for prevention of spontaneous breakthrough bleeds was rated as 'excellent' or 'good' in 96% (24/25) of these patients. A total of 99 surgical procedures were performed in 62 patients; 56% with type 1 VWD, 29% type 2 and 13% type 3 (2% were type unknown). Of the procedures, 46 were major and 53 minor. All but one of the surgeries were managed with pdVWF/FVIII prophylaxis, and the efficacy was rated as 'excellent' or 'good' in 99% (96/97) of surgeries with assessments available. Conclusions: The final results of this non-interventional study indicate that pdVWF/FVIII is well tolerated and effective for on-demand treatment, prophylaxis, and surgical prophylaxis in patients with all types of VWD treated as part of routine clinical practice. The data are consistent with those from previous clinical studies and provide real-life evidence from around the world on the use of pdVWF/FVIIIfor management of VWD in all clinical settings. Disclosures Werner: Octapharma USA Inc.: Employment. Hashimoto:Octapharma USA Inc.: Employment. Knaub:Octapharma AG: Employment. Rodgers:Octapharma: Membership on an entity's Board of Directors or advisory committees, Research Funding.

scholarly journals Analysis digital panoramic radiograph about positions root of maxillary posterior teeth with maxillary sinus floor

2016 ◽  
Vol 28 (3) ◽  
Author(s):  
Aprilia Dian Pertiwi ◽  
Ria Noerianingsih Firman ◽  
Farina Pramanik
Keyword(s):  
Maxillary Sinus ◽  
Alveolar Bone ◽  
Panoramic Radiograph ◽  
Age Group ◽  
Posterior Teeth ◽  
Maxillary Sinus Floor ◽  
Sinus Floor ◽  
Type 3

Introduction: Maxillary sinus floor is a part of the alveolar bone adjacent to the apex of the posterior maxillary teeth that often causes complications in dentistry. Anatomical relationship between the maxillary posterior tooth root and the maxillary sinus floor can be obtained by panoramic radiograph.  The purpose of this study is to analysis digital panoramic radiograph about positions root of maxillary posterior teeth’s with  maxillary sinus floor by age and gender using. Methods: Research method is descriptive with purposive sampling technique. Study population was taken from archives of patient’s digital panoramic radiograph in Radiography Installation from January to March 2016. 88 samples were obtained from 207 digital panoramic radiographs archives. Results: The result showed that type 3 was dominated by P1 (86.8% right, 88.2% left), type 2 is dominated by P2 (24.7% right, 21% left), type 1 is dominated by M2 in the right (31.2%) and M1 in the left (38.1%). Conclusion: This study concludes that overall, the most commonly found was type 3. Based on the age, type 1 majority occurs in age group of above 49 years old; type 2 in age group of 40-49 years old; and type 3 in age group 30-39 years old, 40-49 years old, and above 49 years old. By gender, type 1 and type 2 are more common in males, while type 3 is more common in female.

scholarly journals Computed Tomography Analysis of the Ethmoid Roof: A Region at Risk in Endoscopic Sinus Injury

2019 ◽  
Vol 19 (2) ◽  
pp. 108-115
Author(s):  
Pra Urusopone
Keyword(s):  
Computed Tomography ◽  
Facial Bones ◽  
Significant Difference ◽  
The Mean ◽  
Type 3 ◽  
Tomography Analysis

Objective: To determine the olfactory fossa depth according to the Keros classification and determine the incidence of asymmetry in height and configuration of the ethmoid roof. Materials and Methods: Retrospective analysis of 75 coronal computed tomography studies of paranasal sinuses and facial bones were performed. Measurement of the depth of the lateral lamella, classification of the depth according to Keros type and determination of the asymmetries in the ethmoid roof depth and configuration were done. Results: The mean height of the lateral lamella cribiform plate (LLCP) was 2.15+1.29 mm. The cases were classified as 87.33% Keros type1 and 12.67 % as Keros type 2. No Keros type 3 was found .There was asymmetry in the LLCP height of 33.33% of cases and a configuration asymmetry in 8% of the cases. No significant difference between the mean height and distribution of Keros type between gender and laterality were also found. Conclusion: As regards the olfactory fossa depth, the Keros type 1 was most frequently found. Asymmetry in the depth and configuration were detected in 33.33 and 8% respectively. Risk of inadvertent intracranial entry through the lateral lamella among Thai may be lower than other studies with majority of cases classified as Keros type 2 or 3.

FUNCTIONAL STATUS AND ADAPTIVE POTENTIAL IN FOREIGN STUDENTS WITH DIFFERENT TYPES OF VEGETATIVE REGULATION DURING TUITION

2020 ◽  
pp. 118-126
Author(s):  
A.M. Satarkulova
Keyword(s):  
Heart Rate ◽  
Foreign Students ◽  
Autonomic Regulation ◽  
The Body ◽  
Functional Changes ◽  
Different Types ◽  
Type 3 ◽  
Adaptive Abilities

The assessment and dynamic control over students’ status is a very important task. It allows timely detection of prenosological status prior to pathology and health maintenance in students. The objective of the paper is to assess the adaptive abilities of the body, to analyze changes in heart rate variability indicators in students with various types of autonomic regulation, to identify prenosological status and precursory pathological symptoms. Materials and Methods. The study enrolled 302 students from India, aged 21.54±1.43. Programming complex «Psychophysiologist» was used to register the main HRV parameters within 5 minutes. Health status was evaluated according to the index of functional changes and the scale of functional states. Results. N.I. Shlyk (2009) distinguished two groups of students with different types of autonomic regulation: type 1 (53 %) with moderate and type 2 (5 %) with marked characteristics of central regulation profile, type 3 (35 %) with moderate and type 4 (7 %) with marked characteristics of autonomous regulation profile. Main parameters of HRV and adaptation potential were defined for each student.All the parameters characterized functional and health status. Conclusions. It was shown that 82 % of trial subjects (type 1), 53 % (type 2), 94 % (type 3) and 95 % (type 4) demonstrated satisfactory adaptation and their physiological processes were at an optimal level. 18 % of students (type 1) demonstrated reduced adaptive abilities of the body. Moreover, they were under moderate stress. 47 % of subjects (type 2) were also under a significant stress, which was proven by excessively high SI, low SDNN and TP, and an increased index of functional changes. 5 % of students (type 4) revealed dysfunctional characteristics in the heart rhythm, peculiar to pathology. Keywords: foreign students, heart rate variability, types of autonomic regulation, adaptation potential, functional status. Оценка состояния студентов и динамический контроль за ним является важной задачей, поскольку позволяет своевременно выявлять у студентов донозологические состояния, предшествующие патологии, и способствовать сохранению здоровья. Цель. Оценка адаптивных возможностей организма, анализ изменений показателей вариабельности сердечного ритма у студентов с различными типами вегетативной регуляции, выявление донозологических состояний и ранних признаков патологии. Материалы и методы. В исследовании участвовало 302 студента в возрасте 21,54+1,43 года из Индии. Регистрировались основные параметры ВСР в течение 5 мин с использованием программно-аппаратного комплекса «Психофизиолог». Состояние и уровень здоровья оценивались по индексу функциональных изменений и шкале функциональных состояний. Результаты. По способу, предложенному Н.И. Шлык, выделены группы студентов с различными типами вегетативной регуляции: I (53 %) и II типы (5 %) – с умеренным и выраженным преобладанием центрального контура регуляции соответственно, III (35 %) и IV типы (7 %) – с умеренным и выраженным преобладанием автономного контура регуляции соответственно. У каждого из студентов определены основные параметры ВСР и адаптационного потенциала, характеризующие функциональное состояние и уровень здоровья. Выводы. Показано, что для 82 % обследуемых с I типом, 53 % со II типом, 94 % c III типом и 95 % с IV типом регуляции характерно состояние удовлетворительной адаптации, физиологические процессы сохраняются на оптимальном уровне. В группе студентов I типа у 18 % студентов адаптивные возможности организма снижены, выявлено состояние умеренного напряжения. У 47 % обследуемых II типа также зафиксировано состояние резко выраженного напряжения, индикатором которого является чрезмерно высокое значение SI, низкие величины SDNN и ТP, повышенное значение индекса функциональных изменений. В группе студентов с IV типом у 5 % учащихсяв регуляции ритма сердца выявлены дисфункциональные признаки, характерные для патологии. Ключевые слова: иностранные студенты, вариабельность сердечного ритма, типы вегетативной регуляции, адаптационный потенциал, функциональное состояние.

POLIOMYELITIS IN CANADIAN ESKIMOS: LABORATORY STUDIES. V. TYPE 1 AND TYPE 3 POLIOMYELITIS ANTIBODY LEVELS IN BAFFIN ISLAND ESKIMOS

1954 ◽  
Vol 32 (1) ◽  
pp. 119-125
Author(s):  
W. Wood ◽  
Eina M. Clark ◽  
F. T. Shimada ◽  
A. J. Rhodes
Keyword(s):  
Medical Records ◽  
Baffin Island ◽  
Tissue Cultures ◽  
Laboratory Studies ◽  
Poliomyelitis Virus ◽  
Antibody Titers ◽  
Antibody Levels ◽  
Type 3

Studies on the basic immunology of poliomyelitis in Canadian Eskimos have been continued. Some 87 sera collected from Eskimos at Pangnirtung, Baffin Island, have been examined for the presence of Type 1 and Type 3 poliomyelitis antibody by quantitative tests in tissue cultures. The same sera were previously examined for Type 2 antibody by quantitative tests in mice. The results of the three determinations are now presented together for comparison. These sera came from Eskimos aged 2 to 72 years of age. None of the Eskimos showed any evidence of paralysis. Examination of the medical records did not suggest that any paralytic disease had been present in this part of Baffin Island. Very few of the sera showed the presence of poliomyelitis antibody; thus, Type 1 antibody was demonstrated in the sera of 8%, Type 2 antibody in the sera of 9%, and Type 3 antibody in the sera of 14%. No significant number of Eskimos below the age of 45 years had acquired poliomyelitis antibody. The antibody titers mostly ranged between 10−1.0 and 10−2.0, and were significantly lower than the titers customarily found in recently paralyzed cases. These findings suggest that poliomyelitis infection occurred in Pangnirtung Eskimos many years before the date on which the samples were taken (1951). These results point to the worldwide prevalence of the three types of poliomyelitis virus.

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