scholarly journals Effects of Dietary Supplementation withAgaricus sylvaticusSchaeffer on Glycemia and Cholesterol after Streptozotocin-Induced Diabetes in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Marcelo Betti Mascaro ◽  
Cristiane Miranda França ◽  
Kamilla F. Esquerdo ◽  
Marx A. N. Lara ◽  
Nilsa S. Y. Wadt ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Sugar ◽  
Type I Diabetes ◽  
Microscopic Analysis ◽  
Diabetic Group ◽  
Control Group ◽  
Type I ◽  
Biochemical Tests ◽  
Glucose Levels ◽  
Normoglycemic Control

This study evaluated the effect of theAgaricus sylvaticus(sun mushroom) on biochemical tests of the plasma and on the morphology of the pancreas in an experimental model of type I diabetes mellitus (DM1) induced by streptozotocin. One gram of dryA. sylvaticuswas homogenized and mixed with the chow. Male Wistar rats were allocated as follows: normoglycemic control that received commercial chow; normoglycemic control group that received chow withA. sylvaticus;diabetic group that received commercial chow; and diabetic group that received chow withA. sylvaticus. Weight, food, and water consumption were measured every two days. Blood glucose levels were measured twice a week. After 30 days, the animals were euthanized and blood was collected for the analysis of cholesterol, HDL, triglycerides, blood sugar, glutamic-pyruvic transaminase (GPT), alkaline phosphatase, iron, transferrin, and urea. The pancreas was processed for microscopic analysis.A. sylvaticusmodulated the levels of cholesterol, HDL, triglycerides, blood sugar, GPT, alkaline phosphatase, iron, transferrin, and urea to levels similar to those found in the controls and led to compensatory hyperplasia of the islets of Langerhans.A. sylvaticusis potentially beneficial in the control of type 1 diabetes, and it may also prevent pancreas damage.

scholarly journals Changes in Frequency-Doubling Perimetry in Patients with Type I Diabetes prior to Retinopathy

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Isabel Pinilla ◽  
Antonio Ferreras ◽  
Miriam Idoipe ◽  
Ana I. Sanchez-Cano ◽  
Diana Perez-Garcia ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Type I Diabetes ◽  
Frequency Doubling ◽  
Diabetic Group ◽  
Control Group ◽  
Mean Deviation ◽  
Diabetic Patients ◽  
Type I ◽  
Pattern Standard Deviation ◽  
The Mean

Purpose. To evaluate the ability of frequency-doubling technology (FDT) perimetry in detecting visual field defects in young adults with type I diabetes prior to retinopathy or with minor retinovascular changes.Methods. This comparative cross-sectional study included 30 healthy subjects and 73 age-matched patients with type I diabetes mellitus. All subjects underwent a full ocular examination including an FDT with the threshold C-20-5 strategy. Only one eye per subject was randomly included in the statistical analysis. FDT results and time to perform the test were compared between the groups.Results. The mean age was 27.1 years in the control group and 26.6 years in the diabetic group (P=0.875). The mean period from the onset of diabetes was12.6±6.7years, while minimal retinovascular changes were observed in 18 eyes. Mean deviation of FDT did not differ between the groups. Although global indices of FDT were within normal limits, pattern standard deviation of FDT was higher in the diabetic group (P=0.035). The area under the receiver operating characteristic curve was 0.647 for pattern standard deviation of FDT (standard error = 0.052;P=0.017).Conclusion. FDT can detect retinal dysfunctions in diabetic patients prior to the onset of significant vascular complications.

Antidiabetic effect of Psychotria malayana Jack in induced type 1 diabetic rat

MEDISAINS ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 19
Author(s):  
Fairuz Fairuz ◽  
Hasna Dewi ◽  
Humaryanto Humaryanto
Keyword(s):  
Blood Glucose ◽  
Side Effects ◽  
Type I Diabetes ◽  
Langerhans Cell ◽  
Diabetic Rat ◽  
Type I ◽  
Antidiabetic Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: Therapies for hyperglycemic treatment, including insulin and oral diabetes medications, have been confirmed to cause several side effects. Thus, finding new drugs with fewer side effects is of high importance. Salung leaf herb (Psychotria malayana Jack) reported used in traditional societies as a treatment for diabetes. However, the scientific proof of this plant for diabetes treatment is still lacking.Objective: To evaluate the antidiabetic effect of the P. malayana jack in induced type 1 diabetic rats by assessing blood glucose level and pancreatic cells in white rats.Methods: Alloxan used to induce type I diabetes. Rats randomly divided into six groups. A Group P1 received 250 mg/kg BW; group P2 received 500 mg/kg BW, group P3 received 1000 mg/kg BW. While group 4 basal received no treatment, group 5 received distilled water as a negative control, and group 6 received glibenclamide as a positive control. Medications are given for six days. Glucose levels were measured, and observation of pancreatic Langerhans cell damages.Results:  A decrease in blood glucose levels observed in all treatment groups. The most significant reduction (49.76%; 1000 mg/kg BW) occurred in the P3 group. Morphological features of pancreatic Langerhans cell damage were slightly high in the P1 group.Conclusion: P. malayana Jack can consider having an antidiabetic effect in a type 1 diabetic rat by reducing blood glucose levels.

Antidiabetic and Hypolipidemic Effects of Extracts of Gymnema Sylvestre in Streptozotocin Induced Type I Diabetes in Rats

2017 ◽  
Vol 12 (3) ◽  
Author(s):  
Nishtha R. Mahida ◽  
G. . Mandali ◽  
Vijaysinh V. Sindha ◽  
S. K. Raval
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Type I Diabetes ◽  
Histopathological Examination ◽  
Diabetic Control ◽  
Hypolipidemic Activity ◽  
Control Group ◽  
Type I ◽  
Gymnema Sylvestre ◽  
Altered Glucose

Gymnema sylvestre of the family Asclepiadaceae is one of the most important medicinal plants of the central eco-region. It is popularly known as Gurmar, which means “sugar killer”. Extract of leaves is reported to have tannins, gum, flavonoids, proteins and saponins. It has displayed a wide array of pharmacological activities. This study was aimed to investigate the antidiabetic and hypolipidemic effects of Gymnema sylvestre extract in experimentally induced diabetes in rats. Diabetes was produced in adult Wistar rats with single dose of streptozotocin (STZ) @ 60 mg/kg b.wt. intraperitoneally. After the confirmation of diabetes on 7th day (sugar >200 mg/dl), alcoholic and aqueous extracts of G. sylvestre (400 mg/kg) were administered orally to the experimental rats from 8th day and continued for 42 days thereafter. The antidiabetic and hypolipidemic activity was estimated by measuring blood glucose, lipid profile and histopathological examination of various tissues from all the groups. Administration of STZ resulted in a significant (p less than 0.01) increase in blood glucose and lipid profile and histopathological alterations in Diabetic control group as compared to healthy control group. Gymnema treatment demonstrated significant (p less than 0.01) antidiabetic effect indicated by restoration of blood glucose compared to STZ control group. The study concluded that extracts of Gymnema sylvestre improved the altered glucose and lipid profile in diabetic rats, suggesting that the Gymnema Sylvestre extracts exhibit the antidiabetic and hypolipidemic activity.

scholarly journals Clinical and cytological characteristic of a condition of the oral cavity at pregnant women with various types of a diabetes mellitus

2016 ◽  
Vol 65 (6) ◽  
pp. 45-51 ◽  
Author(s):  
Ludmila Yu Orekhova ◽  
Anna A Aleksandrova ◽  
Ludmila A Aleksandrova ◽  
Ramila S Musaeva ◽  
Gulrukhsor Kh Tolibova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Oral Cavity ◽  
Pregnant Women ◽  
Inflammatory Diseases ◽  
Type I Diabetes ◽  
Periodontal Diseases ◽  
Diabetes Mellitus Type 1 ◽  
Control Group ◽  
Type I ◽  
Liquid Based Cytology

Introduction. More and more researches dedicated to the communication of diseases of the oral cavity of pregnant women with diabetes. It is proved that the intensity of caries and inflammatory periodontal diseases (gingivitis and periodontitis) increase significantly during pregnancy, while the presence of comorbidities, such as diabetes, increase these indexes.Aim. The aim of the work was to study the dental status of pregnant women with diabetes.Materials and methods. The study compared women with gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes, to a control group of pregnant women without diabetes. In addition to clinical research methods, liquid-based cytology of the contents of the gingival sulcus was performed.Results. The results of clinical and laboratory studies have shown that inflammatory diseases of periodontium and teeth within pregnant women with diabetes are more common than within the pregnant women without this disease. It should be noted that the frequency of occurrence and severity of these diseases in the pregnant women with type I diabetes is higher than in the other groups.Conclusion. Pregnant women with diabetes are at risk for dental disease and require more attention from dentists, endocrinologists and obstetricians. The use of liquid-based cytology method helps in the diagnosis of inflammatory periodontal diseases.

scholarly journals Diabetic polyneuropathy: features of the clinical picture and electroneuromyographic parameters in the presence of comorbidity

2020 ◽  
pp. 39-49
Author(s):  
V. M. Dubynetska
Keyword(s):  
Clinical Picture ◽  
Type I Diabetes ◽  
Diabetic Polyneuropathy ◽  
Neurological Status ◽  
Control Group ◽  
Type I ◽  
Abductor Hallucis ◽  
Fiber Damage ◽  
Left And Right ◽  
Group B

Knowledges of certain key moments in the clinical course of diabetic polyneuropathy (DP) combined with varied comorbidity will allow the disease to be identified more effectively and treated comprehensively at different stages of onset. The aim of the research: was to investigate and summarize the features of the clinical picture, electroneuromyographic parameters in patients with DP in the presence of comorbidity. Materials and methods. 111 patients aged 19 to 69 years with DP were examined. The patients were divided into two groups: DP due to type I diabetes mellitus (DM) (group A; n = 61) and type II (group B; n = 50). According to the detected comorbidity, the following subgroups were identified: persons with DP as the result of type I, II DM with only one pathology (subgroup 1; n = 53) and the presence of multimorbidity (two or more pathologies) (subgroup 2; n = 21). The control group – 30 healthy persons representative by age and gender, 37 patients with DP without comorbidity. The patients were examined for neurological status, laboratory tests, instrumental examination methods. Results and discussion. In general, among the studied groups, the lowest nerve conduction velocity in the motor fibers was in abductor hallucis, tibialis on the left, extensor digitorum brevis, peroneus on the left and right, in sensory fibers – peroneus superficialis on the left and right, n. suralis on the left and right. Such changes primarily reflect the lesion of the distal extremities, which clinically looks like a distal symmetrical DP. Was dominated axonal and demyelinating type of nerve fiber damage. Conclusions. Comorbidity contributes to the progression of DP and deterioration of its clinical picture, electroneuromyographic rates, even in the presence of a single pathology, low duration of DM and HbA1c level.

scholarly journals Implications of Aerobic Exercises and Walking Parallel to Diabetes Medications on Diabetic Sportspersons

2021 ◽  
pp. 197-204
Author(s):  
Fehmida Ayub ◽  
Abida Naseer ◽  
Saeed Javed ◽  
Adnan Asghar ◽  
Abd Rahim Mohd Shariff ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Blood Glucose Control ◽  
Daily Basis ◽  
Control Group ◽  
Type I ◽  
Type Ii ◽  
Glucose Levels ◽  
Spare Time ◽  
And Control ◽  
Experimental Group

Objective: Diabetes have a central contribution with type I or type II towards the healthy lifestyles of sportspersons. Aerobic exercise and daily walking stay them fit and control their glucose levels in their bloodstream. The aim of this study was to find out the effects of aerobic exercises and walk on the sportspersons of type I and II diabetes. Methodology: The existing research has experimental design itself wherein pre-tests and post-tests were employed to make sure the novelty of results. The data was collected from the diabetic sportspersons dividing them equally into control group (N-20) and experimental group (N-20). Both groups had type I (N-20) and type II (N-20) diabetic individuals. Aerobic exercise and walk protocol was applied for six weeks on experimental group, whereas, control group continued their routine activities. Afterwards, the data was collected through pre and post treatments and edited into SPSS (v-26). The collected data was analyzed through descriptive statistics using frequencies and percentages, whereas, T-test was applied to make the differences of pre and post treatments. Results: The findings has shown that aerobic exercises and walk decrease the higher levels of glucose in blood and enable to stable glycemic balance, weight loss maintenance, decrease insulin resistance, blood pressure decrease, and blood glucose control. Conclusion: The prominent differences were observed between control and experimental groups either type I or type II. It was concluded that the sportspersons may reduce the excessive glucose engaging in aerobic exercises and walk on daily basis rather than using medications. They should spend their happy lives and get rid of medications and insulin through spending their spare time using light exercises and maintain their glucose levels in blood as well.

Effectiveness of Dry Extract Mahoni Seed Consumption on Blood Sugar Level in Diabetes Mellitus

2020 ◽  
Author(s):  
Ganda Ardiansyah ◽  
◽  
Henny Purwandari ◽  
Heni Prastika Damayanti ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Treatment Group ◽  
Blood Sugar ◽  
Complementary Therapy ◽  
Health Science ◽  
Control Group ◽  
Dry Extract ◽  
Glucose Levels ◽  
Patients With Diabetes ◽  
Sugar Levels

ABSTRACT Background: An increase in blood sugar levels caused diabetes mellitus, and various other health complications. One of the herbal therapy approaches can be used by consuming mahogany seeds which are believed to reduce blood glucose levels. The purpose of this study was to determine the effectiveness of consuming mahogany seeds to reduce blood sugar levels. Subjects and Method: This was a quasi-experiment with non-randomized control group pretest-posttest design conducted on March 24-26 2020. A sample of 22 respondents was divided into 2 groups: treatment group and control group selected by purposive sampling. The data was collected by observation. The data was analysed by Paired t-test. Results: The treatment group before consuming the dry extract of Mahogany seeds (Mean= 258.27; SD= 46.98), and after consuming the dry extract of Mahogany seeds (Mean= 185.36; SD= 38.85). In the control group, before consuming the extract of Mahogany seed ekring (Mean= 224.27; SD= 14.73), and after consuming Mahogany seed extract (Mean= 213.27; SD= 6.75). It was statistically significant (p= 0.001). Conclusion: Consumption of dry extract of Mahogany seeds effectively reduces blood sugar levels in patients with Diabetes Mellitus. Consumption of mahogany seeds can be used as a complementary therapy in nursing to reduce blood sugar. Keywords: Consumption of dry extract of Mahogany Seeds, Diabetes Mellitus. Correspondence: Ganda Ardiansyah. School of health science Satria Bhakti Nganjuk, East Java. Email: gandaa- [email protected] DOI: https://doi.org/10.26911/the7thicph.05.25

scholarly journals Integration of Islet/Beta-Cell Transplants with Host Tissue Using Biomaterial Platforms

Endocrinology ◽  
2020 ◽  
Vol 161 (11) ◽  
Author(s):  
Daniel W Clough ◽  
Jessica L King ◽  
Feiran Li ◽  
Lonnie D Shea
Keyword(s):  
Stem Cell ◽  
Immune Responses ◽  
Cell Function ◽  
Type I Diabetes ◽  
Glucose Sensing ◽  
Trophic Factors ◽  
Design Parameters ◽  
Type I ◽  
Β Cells ◽  
Glucose Levels

Abstract Cell-based therapies are emerging for type I diabetes mellitus (T1D), an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells, as a means to provide long-term restoration of glycemic control. Biomaterial scaffolds provide an opportunity to enhance the manufacturing and transplantation of islets or stem cell–derived β-cells. In contrast to encapsulation strategies that prevent host contact with the graft, recent approaches aim to integrate the transplant with the host to facilitate glucose sensing and insulin distribution, while also needing to modulate the immune response. Scaffolds can provide a supportive niche for cells either during the manufacturing process or following transplantation at extrahepatic sites. Scaffolds are being functionalized to deliver oxygen, angiogenic, anti-inflammatory, or trophic factors, and may facilitate cotransplantation of cells that can enhance engraftment or modulate immune responses. This local engineering of the transplant environment can complement systemic approaches for maximizing β-cell function or modulating immune responses leading to rejection. This review discusses the various scaffold platforms and design parameters that have been identified for the manufacture of human pluripotent stem cell–derived β-cells, and the transplantation of islets/β-cells to maintain normal blood glucose levels.

scholarly journals Early alterations in myocardia and vessels of the diabetic rat heart: an FTIR microspectroscopic study

2006 ◽  
Vol 397 (3) ◽  
pp. 427-436 ◽  
Author(s):  
Neslihan Toyran ◽  
Peter Lasch ◽  
Dieter Naumann ◽  
Belma Turan ◽  
Feride Severcan
Keyword(s):  
Left Ventricle ◽  
Right Ventricle ◽  
Rat Heart ◽  
Molecular Level ◽  
Diabetic Group ◽  
Control Group ◽  
Type I ◽  
Short Term ◽  
The Right ◽  
Left Ventricle Myocardium

Diabetes mellitus is associated with a high incidence and poor prognosis of cardiovascular disease. The aim of the present study was to examine the effect of relatively short-term (5 weeks) Type I diabetes on the left ventricle, the right ventricle and the vessel (vein) on the left ventricle of the myocardium at molecular level by FTIR (Fourier-transform infrared) microspectroscopy. The rats were categorized into two groups: control group (for the left ventricle myocardium, n=8; for the right ventricle myocardium, n=9; for the vein, n=9) and streptozotocin-induced diabetic group (for the left ventricle myocardium, n=7; for the right ventricle myocardium, n=9; for the vein, n=8). Two adjacent cross-sections of 9 μm thickness were taken from the ventricles of the hearts in two groups of rats by using a cryotome. The first sections were used for FTIR microspectroscopy measurements. The second serial sections were stained by haematoxylin/eosin for comparative purposes. Diabetes caused an increase in the content of lipids, an alteration in protein profile with a decrease in α-helix and an increase in β-sheet structure as well as an increase in glycogen and glycolipid contents in both ventricles and the vein. Additionally, the collagen content was found to be increased in the vein of the diabetic group. The present study demonstrated that diabetes-induced alterations in the rat heart can be detected by correlating the IR spectral changes with biochemical profiles in detail. The present study for the first time demonstrated the diabetes-induced alterations at molecular level in both ventricle myocardia and the veins in relatively short-term diabetes.

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