scholarly journals Evaluation of Nonradiative Clinical Imaging Techniques for the Longitudinal Assessment of Tumour Growth in Murine CT26 Colon Carcinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Johanne Seguin ◽  
Bich-Thuy Doan ◽  
Heldmuth Latorre Ossa ◽  
Lauriane Jugé ◽  
Jean-Luc Gennisson ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Tumour Growth ◽  
Imaging Techniques ◽  
Acquisition Time ◽  
Longitudinal Assessment ◽  
Resonance Imaging ◽  
Orthotopic Model ◽  
Short Acquisition Time ◽  
Magnetic Resonance Imaging Mri ◽  
Good Delineation

Background and Objectives. To determine the most appropriate technique for tumour followup in experimental therapeutics, we compared ultrasound (US) and magnetic resonance imaging (MRI) to characterize ectopic and orthotopic colon carcinoma models. Methods. CT26 tumours were implanted subcutaneously (s.c.) in Balb/c mice for the ectopic model or into the caecum for the orthotopic model. Tumours were evaluated by histology, spectrofluorescence, MRI, and US. Results. Histology of CT26 tumour showed homogeneously dispersed cancer cells and blood vessels. The visualization of the vascular network using labelled albumin showed that CT26 tumours were highly vascularized and disorganized. MRI allowed high-resolution and accurate 3D tumour measurements and provided additional anatomical and functional information. Noninvasive US imaging allowed good delineation of tumours despite an hypoechogenic signal. Monitoring of tumour growth with US could be accomplished as early as 5 days after implantation with a shorter acquisition time (<5 min) compared to MRI. Conclusion. MRI and US afforded excellent noninvasive imaging techniques to accurately follow tumour growth of ectopic and orthotopic CT26 tumours. These two techniques can be appropriately used for tumour treatment followup, with a preference for US imaging, due to its short acquisition time and simplicity of use.

scholarly journals Perfusion Magnetic Resonance Imaging to Assess Brain Tumor Responses to New Therapies

1998 ◽  
Vol 5 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Michael H. Lev ◽  
Fred Hochberg
Keyword(s):  
Magnetic Resonance Imaging ◽  
Brain Tumor ◽  
Magnetic Resonance ◽  
Imaging Techniques ◽  
Perfusion Mri ◽  
Perfusion Magnetic Resonance Imaging ◽  
Normal Brain ◽  
Resonance Imaging ◽  
New Therapies ◽  
Magnetic Resonance Imaging Mri

Background: Although magnetic resonance imaging (MRI) is effective in detecting the location of intracranial tumors, new imaging techniques have been studied that may enhance the specificity for the prediction of histologic grade of tumor and for the distinction between recurrence and tumor necrosis associated with cancer therapy. Methods: The authors review their experience and that of others on the use of perfusion magnetic resonance imaging to evaluate responses of brain tumors to new therapies. Results: Functional imaging techniques that can distinguish tumor from normal brain tissue using physiological parameters. These new approaches provide maps of tumor perfusion to monitor the effects of novel compounds that restrict tumor angiogenesis. Conclusions: Perfusion MRI not only may be as effective as radionuclide-based techniques in sensitivity and specificity in assessing brain tumor responses to new therapies, but also may offer higher resolution and convenient co-registration with conventional MRI, as well as time- and cost-effectiveness. Further study is needed to determine the role of perfusion MRI in assessing brain tumor responses to new therapies.

scholarly journals Reasons for discordances between ultrasonography and magnetic resonance imaging in the evaluation of the ankle, hindfoot and heel of the patients with rheumatoid arthritis

2019 ◽  
Vol 21 (4) ◽  
pp. 405 ◽  
Author(s):  
Oana Șerban ◽  
Daniela Fodor ◽  
Iulia Papp ◽  
Mihaela Cosmina Micu ◽  
Dan Gabriel Duma ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Disease Activity ◽  
Activity Index ◽  
Imaging Techniques ◽  
Disease Activity Index ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Definition Of

Aim: To compare the ultrasonography (US) performance with magnetic resonance imaging (MRI) in identifying pathology in ankles, hindfeet and heels of rheumatoid arthritis (RA) patients and to evaluate the reasons for discordances between the two imaging methods.Material and methods: RA patients were enrolled and evaluated using the Clinical Disease Activity Index (CDAI) and the Disease Activity Score 28 with C-reactive Protein (DAS28-CRP). The ankle (tibiotalar joint, tendons), hindfoot (talonavicular, subtalar joints) and heel of the most symptomatic or dominant foot (for the asymptomatic patient)were evaluated by two pairs of examiners using US and contrast-enhanced MRI.Results: Totally, 105 joints, 245 tendons and 35 heels in 35 patients [mean age 59.2±11.25 years old, median disease duration 36 (16.5-114), mean CDAI 19.87±12.7] were evaluated. The interobserver agreements between the two sonographers, and the two radiologists were good and very good (k=0.624-0.940). The overall agreement between US and MRI was very good for subcalcaneal panniculitis (k=0.928, p<0.001), moderate for synovitis (k=0.463, p<0.001) and tenosynovitis (k=0.514, p<0.001), fair for osteophytes (k=0.260, p=0.004), and poor for erosions (k=0.063, p=0.308) and heel’s structures. MRI found more erosions, synovitis, osteophytes,tenosynovitis and retrocalcaneal bursitis, but US found more enthesophytes and plantar fasciitis. Many of the discordancesbetween the two imaging techniques have explanations related to the technique itself or definition of the pathologic findings.Conclusions: US is comparable to MRI for the evaluation of ankle, hindfoot and heel in RA patients and discordances in theinterpretation of the pathological findings/normal structures must be carefully analyzed.

scholarly journals Magnetic resonance imaging of salivary glands

2019 ◽  
Author(s):  
Danielle Ayumi Nishimura ◽  
Ana Luiza Esteves Carneiro ◽  
Kaisermann Costa ◽  
Wladimir Gushiken de Campos ◽  
Jefferson Xavier de Oliveira ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Salivary Glands ◽  
Imaging Techniques ◽  
Neck Region ◽  
Evaluation Instrument ◽  
Resonance Imaging ◽  
Tissue Contrast ◽  
Excellent Method ◽  
Magnetic Resonance Imaging Mri

Salivary glands tumors account for 2-5% of tumors in the head and neck region, possibly being benign or malignant. Magnetic resonance imaging (MRI) presents high soft tissue contrast resolution, thus being an excellent method for salivary gland analysis. The objective of this literature review is to analyze MRI as an evaluation instrument for the diagnosis of salivary glands lesions. Compared to other imaging techniques, MRI can better evaluate the relationship between adjacent anatomical structures, presenting greater sensitivity and specificity.

Multiple Sclerosis: MRI and Other Imaging Approaches in MS

2017 ◽  
Author(s):  
Martina Absinta ◽  
Daniel S. Reich
Keyword(s):  
Multiple Sclerosis ◽  
Current Knowledge ◽  
Imaging Techniques ◽  
Future Research ◽  
Multiple Time ◽  
Resonance Imaging ◽  
Lesion Development ◽  
Diagnostic Role ◽  
Magnetic Resonance Imaging Mri ◽  
Multiple Time Points

Aside from its paramount diagnostic role, imaging techniques, particularly magnetic resonance imaging (MRI), provide unparalleled insights into multiple sclerosis (MS) by assessing the spatiotemporal dynamics of the associated inflammation and neurodegeneration. This dynamical view, predicated on interrogation of individuals with MS at multiple time points, is impossible with pathology. The chapter approaches MRI in MS from this perspective, describing features related to lesion development and location, as well as assessment of global and regional damage. It summarizes current knowledge, addresses the limitations of that knowledge, and suggests ways in which imaging can advance future research.

Abbreviated Breast Magnetic Resonance Imaging (MRI): First Postcontrast Subtracted Images and Maximum-Intensity Projection—A Novel Approach to Breast Cancer Screening With MRI

2014 ◽  
Vol 32 (22) ◽  
pp. 2304-2310 ◽  
Author(s):  
Christiane K. Kuhl ◽  
Simone Schrading ◽  
Kevin Strobel ◽  
Hans H. Schild ◽  
Ralf-Dieter Hilgers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Reading Time ◽  
Breast Magnetic Resonance Imaging ◽  
Maximum Intensity Projection ◽  
Maximum Intensity ◽  
Acquisition Time ◽  
Resonance Imaging ◽  
Breast Magnetic Resonance ◽  
Magnetic Resonance Imaging Mri

Purpose We investigated whether an abbreviated protocol (AP), consisting of only one pre- and one postcontrast acquisition and their derived images (first postcontrast subtracted [FAST] and maximum-intensity projection [MIP] images), was suitable for breast magnetic resonance imaging (MRI) screening. Methods We conducted a prospective observational reader study in 443 women at mildly to moderately increased risk who underwent 606 screening MRIs. Eligible women had normal or benign digital mammograms and, for those with heterogeneously dense or extremely dense breasts (n = 427), normal or benign ultrasounds. Expert radiologists reviewed the MIP image first to search for significant enhancement and then reviewed the complete AP (consisting of MIP and FAST images and optionally their nonsubtracted source images) to characterize enhancement and establish a diagnosis. Only thereafter was the regular full diagnostic protocol (FDP) analyzed. Results MRI acquisition time for FDP was 17 minutes, versus 3 minutes for the AP. Average time to read the single MIP and complete AP was 2.8 and 28 seconds, respectively. Eleven breast cancers (four ductal carcinomas in situ and seven invasive cancers; all T1N0 intermediate or high grade) were diagnosed, for an additional cancer yield of 18.2 per 1,000. MIP readings were positive in 10 (90.9%) of 11 cancers and allowed establishment of the absence of breast cancer, with a negative predictive value (NPV) of 99.8% (418 of 419). Interpretation of the complete AP, as with the FDP, allowed diagnosis of all cancers (11 [100%] of 11). Specificity and positive predictive value (PPV) of AP versus FDP were equivalent (94.3% v 93.9% and 24.4% v 23.4%, respectively). Conclusion An MRI acquisition time of 3 minutes and an expert radiologist MIP image reading time of 3 seconds are sufficient to establish the absence of breast cancer, with an NPV of 99.8%. With a reading time < 30 seconds for the complete AP, diagnostic accuracy was equivalent to that of the FDP and resulted in an additional cancer yield of 18.2 per 1,000.

scholarly journals Diagnostic Features of Myelomeningocele: The Role of Ultrafast Fetal MRI

2014 ◽  
Vol 37 (3) ◽  
pp. 219-225 ◽  
Author(s):  
David M. Mirsky ◽  
Erin S. Schwartz ◽  
Deborah M. Zarnow
Keyword(s):  
Imaging Techniques ◽  
Fetal Mri ◽  
Resonance Imaging ◽  
Fetal Magnetic Resonance Imaging ◽  
Diagnostic Features ◽  
Technical Aspects ◽  
Ultrafast Imaging ◽  
Perinatal Management ◽  
Magnetic Resonance Imaging Mri

Fetal magnetic resonance imaging (MRI) is a useful adjunct to ultrasound in the evaluation of neural tube defects. The development of ultrafast imaging techniques has contributed to the increasing clinical use of fetal MRI. This review summarizes the utility, safety and technical aspects of fetal MRI and the role it plays in the evaluation of myelomeningocele. Emphasis is placed on the benefit of fetal MRI as it pertains to presurgical planning and perinatal management.

scholarly journals Magnetic Resonance Imaging of Rectal Cancer

2019 ◽  
Vol 02 (01) ◽  
pp. 018-032
Author(s):  
Ekta Maheshwari ◽  
Gitanjali Bajaj ◽  
Kedar Jambhekar ◽  
Tarun Pandey ◽  
Roopa Ram
Keyword(s):  
Magnetic Resonance Imaging ◽  
Rectal Cancer ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Imaging Techniques ◽  
Postoperative Recurrence ◽  
Response To Therapy ◽  
Resonance Imaging ◽  
Primary Rectal Cancer ◽  
Magnetic Resonance Imaging Mri

AbstractHigh-resolution magnetic resonance imaging (MRI) plays a pivotal role in the pretreatment assessment of primary rectal cancer. The success of this technique depends on obtaining good-quality high-resolution T2-weighted images of the primary tumor, orthogonal to rectal lumen. The goal of magnetic resonance staging is to identify patients who will benefit from neoadjuvant therapy prior to surgery to minimize postoperative recurrence and planning of optimal surgical approach. MRI also facilitates optimal identification of important prognostic factors, which improves both treatment selection and posttreatment follow-up. The objective of this article is to review the existing literature and provide a concise update on various aspects of rectal cancer imaging, discuss the current role of advanced imaging techniques such as diffusion-weighted and perfusion imaging in the evaluation of rectal cancer, and to assess response to therapy.

scholarly journals Illuminating the Brain With X-Rays: Contributions and Future Perspectives of High-Resolution Microtomography to Neuroscience

2021 ◽  
Vol 15 ◽  
Author(s):  
Paulla Vieira Rodrigues ◽  
Katiane Tostes ◽  
Beatriz Pelegrini Bosque ◽  
João Vitor Pereira de Godoy ◽  
Dionisio Pedro Amorim Neto ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Three Dimensional ◽  
X Rays ◽  
Future Perspectives ◽  
Resonance Imaging ◽  
X Ray ◽  
Cellular Resolution ◽  
Magnetic Resonance Imaging Mri ◽  
Non Destructive ◽  
The Brain

The assessment of three-dimensional (3D) brain cytoarchitecture at a cellular resolution remains a great challenge in the field of neuroscience and constant development of imaging techniques has become crucial, particularly when it comes to offering direct and clear obtention of data from macro to nano scales. Magnetic resonance imaging (MRI) and electron or optical microscopy, although valuable, still face some issues such as the lack of contrast and extensive sample preparation protocols. In this context, x-ray microtomography (μCT) has become a promising non-destructive tool for imaging a broad range of samples, from dense materials to soft biological specimens. It is a new supplemental method to be explored for deciphering the cytoarchitecture and connectivity of the brain. This review aims to bring together published works using x-ray μCT in neurobiology in order to discuss the achievements made so far and the future of this technique for neuroscience.

scholarly journals Chaotic Compressed Sensing and Its Application to Magnetic Resonance Imaging

2014 ◽  
Vol 3 (3-4) ◽  
Author(s):  
Nguyen Linh-Trung ◽  
Truong Minh-Chinh ◽  
Tan Tran-Duc ◽  
Ha Vu Le ◽  
Minh Ngoc Do
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Compressed Sensing ◽  
Acquisition Time ◽  
Parallel Mri ◽  
Resonance Imaging ◽  
Measurement Matrix ◽  
Fast Mri ◽  
Mri Scans ◽  
Magnetic Resonance Imaging Mri

Fast image acquisition in magnetic resonance imaging (MRI) is important, due to the need to find ways that help relieve patient’s stress during MRI scans. Methods for fast MRI have been proposed, most notably among them are pMRI (parallel MRI), SWIFT (SWeep Imaging with Fourier Transformation), and compressed sensing (CS) based MRI. Although it promises to significantly reduce acquisition time, applying CS to MRI leads to difficulties with hardware design because of the randomness nature of the measurement matrix used by the conventional CS methods. In this paper, we propose a novel method that combines the above-mentioned three approaches for fast MRI by designing a compound measurement matrix from a series of single measurement matrices corresponding to pMRI, SWIFT, and CS. In our method, the CS measurement matrix is designed to be deterministic via chaotic systems. This chaotic compressed sensing (CCS) measurement matrix, while retaining most features of the random CS matrix, is simpler to realize in hardware. Several compound measurement matrices have been constructed and examined in this work, including CCS-MRI, CCS-pMRI, CCS-SWIFT, and CCS-pSWIFT. Simulation results showed that the proposed method allows an increase in the speed of the MRI acquisition process while not compromising the quality of the acquired MR images.

3D MRI in Musculoskeletal Oncology

2021 ◽  
Vol 25 (03) ◽  
pp. 418-424
Author(s):  
Blake C. Jones ◽  
Shivani Ahlawat ◽  
Laura M. Fayad
Keyword(s):  
Tumor Imaging ◽  
Imaging Techniques ◽  
Three Dimensional ◽  
Motion Artifact ◽  
Whole Body ◽  
Acquisition Time ◽  
3D Mri ◽  
Isotropic Resolution ◽  
3D Acquisition ◽  
Magnetic Resonance Imaging Mri

AbstractAdvances in magnetic resonance imaging (MRI) technology now enable the feasible three-dimensional (3D) acquisition of images. With respect to the imaging of musculoskeletal (MSK) tumors, literature is beginning to accumulate on the use of 3D MRI acquisition for tumor detection and characterization. The benefits of 3D MRI, including general advantages, such as decreased acquisition time, isotropic resolution, and increased image quality, are not only inherently useful for tumor imaging, but they also contribute to the feasibility of more specialized tumor-imaging techniques, such as whole-body MRI, and are reviewed here. Disadvantages of 3D acquisition, such as motion artifact and equipment requirements, do exist and are also discussed. Although further study is needed, 3D MRI acquisition will likely prove increasingly useful in the evaluation of patients with tumors of the MSK system.

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