scholarly journals Association between −308 G/A TNF-αPolymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome

2013 ◽  
Vol 35 ◽  
pp. 615-623 ◽  
Author(s):  
L. Di Renzo ◽  
F. Sarlo ◽  
L. Petramala ◽  
L. Iacopino ◽  
G. Monteleone ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Composition ◽  
Muscle Mass ◽  
Lean Mass ◽  
Skeletal Muscle Mass ◽  
Normal Weight ◽  
Sarcopenic Obesity ◽  
Appendicular Skeletal Muscle ◽  
Skeletal Muscle Mass Index ◽  
Appendicular Skeletal Muscle Mass

Background and Aim. Normal weight obese (NWO) syndrome is characterized by normal body mass index (BMI), but high amount of fat mass and reduced lean mass. We evaluated allelic frequency of the G/A −308 TNF-αpolymorphism and prevalence of sarcopenia in NWO.Methods. We enrolled 120 Italian healthy women, distinguished into 3 groups: normal weight (NW); NWO, and preobese-obese (PreOB/OB) and evaluated anthropometric parameters, body composition by dual X-ray absorptiometry, blood tests, and genotyping of G/A −308 TNF-αpolymorphism.Results. We found a positive association between sarcopenic obesity and −308 TNF-αpolymorphism. All obese women were sarcopenic and were no carrier of mutation (G/G). Among all G/G, NWO showed significant differences in lean mass and total body lean mass (TBLean) with respect to NW and PreOB/OB (P<0.001). Regarding appendicular skeletal muscle mass index values, 4.21% of NW were sarcopenic (50% G/G and 50% G/A); the same percentage was observed in NWO subjects (100% G/G). Moreover, 2.10% of PreOB/OB were sarcopenic and all were G/G.Conclusion. Our study suggests that TNF-αpolymorphism contributes to sarcopenic obesity susceptibility, in association with body composition. This is the first study that shows the importance of TNF-αpolymorphism to determine TBLean variation in NWO syndrome.

Appendicular skeletal muscle mass to truncal fat mass ratio as a new index for osteosarcopenic obesity syndrome in older adults: emphasizing the role of central obesity

2020 ◽  
Author(s):  
Lazuardhi Dwipa ◽  
Rini Widiastuti ◽  
Alif Bagus Rakhimullah ◽  
Marcellinus Maharsidi ◽  
Yuni Susanti Pratiwi ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Body Composition ◽  
Muscle Mass ◽  
Fat Mass ◽  
Central Obesity ◽  
Skeletal Muscle Mass ◽  
Positive Correlation ◽  
Appendicular Skeletal Muscle ◽  
Appendicular Skeletal Muscle Mass

Abstract Background The relationship between obesity and low bone mineral density (BMD) in older adults is still unclear. Most of the previous study did not account the factor of sarcopenia which is the progressive loss of skeletal muscle mass due to aging, and distribution of fat in obesity. Thus, this study was aimed to explore the correlation between appendicular skeletal muscle mass (ASMM), total fat mass (FM), and truncal fat mass (TrFM) as well as indexes (ASMM/FM and ASMM/TrFM ratio) with BMD in older adults.Methods This was an analytic cross-sectional study. Dual x-ray absorptiometry (DXA) and bioelectric impedance analysis (BIA) were used to assess BMD and body composition, respectively. Appendicular Skeletal Muscle Mass (ASMM) were used in the analysis to reflect sarcopenia, Fat Mass (FM) and Trunkal Fat Mass (TrFM) were used to reflect general and central obesity, respectively. All data were obtained from medical records of Geriatric Clinic of Hasan Sadikin General Hospital Bandung Indonesia from January 2014 to December 2018. The correlation between body compositions variable with BMD were analyzed using Spearman’s test. We also conducted a comparison analysis of body composition variables between low and normal BMD using Mann-Whitney test. Results A total of 112 subjects were enrolled in the study. ASMM and TrFM were positive (rs=0.517, p<0.001) and negative (rS=-0.22, p=0.02) correlated with BMD, respectively. FM were not correlated with BMD, rS=-0.113 (p=0.234). As indexes, ASMM/FM and ASMM/TrFM had positive correlation with BMD, rS=0.277 (p<0.001), and rS=0.391 (p<0.001), respectively. The ASMM, TrFM, and ASMM/TrFM ratio between normal and low BMD also significantly different (p<0.001), meanwhile FM were not (p=0.204).Conclusion ASMM and TrFM have a positive and negative correlation with BMD, respectively. ASMM/TrFM ratio as new sarcopenia-central obesity index has a positive correlation with BMD.

The Independent Relationship Between Leg Skeletal Muscle Mass Asymmetry and Gait Speed in Community-Dwelling Older Adults

2020 ◽  
Vol 28 (6) ◽  
pp. 943-951
Author(s):  
Chiharu Iwasaka ◽  
Tsubasa Mitsutake ◽  
Etsuo Horikawa
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Gait Speed ◽  
Skeletal Muscle Mass ◽  
Asymmetry Index ◽  
Mass Asymmetry ◽  
Appendicular Skeletal Muscle ◽  
Skeletal Muscle Mass Index ◽  
Appendicular Skeletal Muscle Mass

Objectives: To investigate the relationship between leg skeletal muscle mass asymmetry and usual gait speed in older adults. Methods: The subjects were 139 community-dwelling older adults. The asymmetry index was calculated using the leg skeletal muscle mass index (LSMI) values of both legs. The subjects were divided into “large” and “small” asymmetry groups based on the asymmetry index. The relationship between asymmetry and gait speed was analyzed using a linear regression model. The appendicular skeletal muscle mass index and LSMI were included as adjustment variables in the analysis. Results: The asymmetry index and having a “large” asymmetry were independently related to gait speed, even after adjusting for covariates such as appendicular skeletal muscle mass index and LSMI. Discussion: Leg skeletal muscle mass asymmetry was related to gait speed independently of the appendicular skeletal muscle mass index and LSMI values. A skeletal muscle mass evaluation among older adults should include an assessment of the total skeletal muscle mass and its asymmetry.

scholarly journals Appendicular Skeletal Muscle Mass Index and Physiological Performance in Post-Menopausal Women with Total Thyroidectomy

2021 ◽  
Vol 11 (16) ◽  
pp. 7555
Author(s):  
Wei-Lun Wen ◽  
Hsiu-Chu Lin ◽  
Hui-Chen Yu ◽  
Yi-Pen Chen ◽  
Ching-Chao Liang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Total Thyroidectomy ◽  
Postmenopausal Women ◽  
Muscle Mass ◽  
Gait Speed ◽  
Skeletal Muscle Mass ◽  
Handgrip Strength ◽  
Appendicular Skeletal Muscle ◽  
Skeletal Muscle Mass Index ◽  
Appendicular Skeletal Muscle Mass

Sarcopenia is prevalent in postmenopausal women but is inconclusive in total thyroidectomy and under levothyroxine replacement. We aim to analyze the determinants of sarcopenia and investigate the early detection of sarcopenia in this group. Fifty postmenopausal women with total thyroidectomy were measured for body composition via Dual-energy X-ray Absorptiometry (DXA) and Appendicular Skeletal Muscle mass divided by the height square (ASM/ht2). Handgrip strength and gait speed and Geriatric Nutritional Risk Index (GNRI) were calculated. Eight determinants associated with sarcopenia include GNRI (β, 0.042; 95% confidence interval (CI), 0.021 to 0.064), femoral neck BMD (β, 0.989; 95% CI, 0.049 to 1.929), TSH (β, 0.192; 95% CI, 0.027 to 0.357), and thyroglobulin Ab (0.657; 95% CI, 0.210 to 1.103) for ASM/height2; menopausal years (β, −3.112; 95% CI, −5.661 to −0.563) and ASM/height2 (β, 2.669; 95% CI, 1.073 to 4.265) for handgrip strength; and GNRI (β, 0.062; 95% CI, 0.019 to 0.105), T3 (β, −3.541; 95% CI, −7.019 to −0.063), and age (β, 0.043; 95% CI, 0.003 to 0.084) for gait speed. Our study confirmed a high prevalence of low skeletal muscle mass index in postmenopausal women with total thyroidectomy and revealed a number of determinants that could help early diagnosis and management this disease in daily clinical practice.

scholarly journals Total protein, animal protein and physical activity in relation to muscle mass in middle-aged and older Americans

2012 ◽  
Vol 109 (7) ◽  
pp. 1294-1303 ◽  
Author(s):  
Martha Savaria Morris ◽  
Paul F. Jacques
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Muscle Mass ◽  
Protein Intake ◽  
Skeletal Muscle Mass ◽  
Muscle Strengthening ◽  
Appendicular Skeletal Muscle ◽  
Obese Subjects ◽  
Skeletal Muscle Mass Index ◽  
Appendicular Skeletal Muscle Mass

Resistance training is recognised as a good strategy for retarding age-related declines in muscle mass and strength. Recent studies have also highlighted the potential value of protein intakes in excess of present recommendations. The roles that leisure-time physical activity and protein quality play in the preservation of skeletal muscle during ageing, and how such influences interact in free-living people are unclear. We sought to clarify these issues using data collected on 2425 participants aged ≥ 50 years in the US National Health and Nutrition Examination Survey (2003–2006). We estimated subjects’ usual intakes of total protein and beef from two 24 h diet recalls and computed the appendicular skeletal muscle mass index from anthropometric measures. Participants self-reported their physical activity levels. Analyses accounted for demographic factors and smoking. The association between muscle-strengthening activity and the appendicular skeletal muscle mass index varied with protein intake. Furthermore, among obese subjects with protein intakes < 70 g/d, those who performed such activities had a lower appendicular skeletal muscle mass index than those who were physically inactive. Protein intakes above the present recommendations were associated with benefits to obese subjects only. The appendicular skeletal muscle mass index of non-obese subjects who performed vigorous aerobic activities was consistently high; in obese subjects, it varied with protein intake. High-protein intake was associated with a modest increase in the appendicular skeletal muscle mass index in non-obese, physically inactive subjects. The present findings reinforce the idea that muscle-strengthening exercise preserves muscle when combined with adequate dietary protein. Vigorous aerobic activity may also help.

scholarly journals The prevalence of sarcopenia in patients with rheumatological pathology

2021 ◽  
Vol 93 (5) ◽  
Author(s):  
Iuliia V. Lavrishcheva ◽  
Aleksandr A. Jakovenko ◽  
Aleksandr S. Rumyantsev
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Muscle Performance ◽  
Speed Test ◽  
European Working ◽  
Appendicular Skeletal Muscle ◽  
Rheumatological Disease ◽  
Skeletal Muscle Mass Index ◽  
Appendicular Skeletal Muscle Mass

Aim. To assess the prevalence of sarcopenia in rheumatological patients. Materials and methods. 317 patients with rheumatological pathology were examined, among them 201 women and 116 men, the age of patients ranged from 21 to 58 years, the average age at the time of inclusion of patients in the study was 41.17.3 years. Sarcopenia was diagnosed using the method recommended by The European Working Group on Sarcopenia in Older People 2. Results. The frequency of occurrence of a decrease in the appendicular skeletal muscle mass to the appendicular skeletal muscle mass index was 31.2% (99 patients), a decrease in muscle strength according to the wrist dynamometry was observed in 44.5% (141) patients, low skeletal muscle performance according to the results NIH Toolbox 4 Meter Walk Gait Speed Test in 42.8% (135) patients. The prevalence of suspected sarcopenia (probable sarcopenia) was 13.3% (42 patients) and sarcopenia, including severe 31.2% (99) patients. Statistically significant differences were obtained between groups of patients depending on the duration of rheumatological disease and the prevalence of sarcopenia (2=19.328; p=0.001). Conclusion. Sarcopenia occurs in a third of hospitalized rheumatological patients.

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