scholarly journals Application of Genetic Algorithm for Discovery of Core Effective Formulae in TCM Clinical Data

2013 ◽  
Vol 2013 ◽  
pp. 1-16 ◽  
Author(s):  
Ming Yang ◽  
Josiah Poon ◽  
Shaomo Wang ◽  
Lijing Jiao ◽  
Simon Poon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Genetic Algorithm ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Data ◽  
Cancer Dataset ◽  
Synergy Index ◽  
Average Confidence ◽  
Group A ◽  
Tcm Theory

Research on core and effective formulae (CEF) does not only summarize traditional Chinese medicine (TCM) treatment experience, it also helps to reveal the underlying knowledge in the formulation of a TCM prescription. In this paper, CEF discovery from tumor clinical data is discussed. The concepts of confidence, support, and effectiveness of the CEF are defined. Genetic algorithm (GA) is applied to find the CEF from a lung cancer dataset with 595 records from 161 patients. The results had 9 CEF with positive fitness values with 15 distinct herbs. The CEF have all had relative high average confidence and support. A herb-herb network was constructed and it shows that all the herbs in CEF are core herbs. The dataset was divided into CEF group and non-CEF group. The effective proportions of former group are significantly greater than those of latter group. A Synergy index (SI) was defined to evaluate the interaction between two herbs. There were 4 pairs of herbs with high SI values to indicate the synergy between the herbs. All the results agreed with the TCM theory, which demonstrates the feasibility of our approach.

scholarly journals Could Scutellaria barbata D. Don be used for treating lung cancer and SARS-CoV-2?

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Siukan Law ◽  
Albert Wingnang Leung ◽  
Chuanshan Xu
Keyword(s):  
Lung Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Blood Stasis ◽  
Perennial Herb ◽  
Scutellaria Barbata ◽  
Long Time ◽  
Tcm Theory

Dear Editor, Scutellaria barbata D. Don (SBD) is a perennial herb and belongs to the “Lamiaceae” family. This is widely used in China for a long time as Traditional Chinese Medicine (TCM). Based on the TCM theory, SBD is in the category of “Heat-Clearing”. Its functions are to remove heat and detoxification, disperse blood stasis and diuresis. [...]

scholarly journals Utilization Pattern of Traditional Chinese Medicine among Fracture Patients: A Taiwan Hospital-Based Cross-Sectional Study

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Chu-Yao Tseng ◽  
Ching-Wen Huang ◽  
Hsin-Chia Huang ◽  
Wei-Chen Tseng
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Early Period ◽  
Clinic Visit ◽  
Research Database ◽  
Late Period ◽  
Utilization Pattern ◽  
Cross Sectional ◽  
Herbal Products ◽  
Tcm Theory

Traditional Chinese medicine (TCM) divides fracture treatment into three stages. Many TCM herbs and formulas have been used to treat fractures for thousands of years. However, research regarding the Chinese herbal products (CHPs) that should be used at different periods of treatment is still lacking. This study aims to identify the CHPs that should be used at different periods of treatment as well as confirm the TCM theory of fracture periods medicine. We used prescriptions of TCM outpatients with fracture diagnoses analyzed using the Chang Gung Research Database (CGRD) from 2000 to 2015. According to the number of days between the date of the fracture and the clinic visit date, all patients were assigned to one of three groups. Patients with a date gap of 0-13 days were assigned to the early period group; those with a date gap of 14-82 days were assigned to the middle period group; and those with a date gap of 83-182 days were assigned to the late period group. We observed the average number of herbal formulas prescribed by the TCM doctor at each visit was 2.78, and the average number of single herbs prescribed was 6.47. The top three prescriptions in the early fracture period were Zheng-gu-zi-jin-dang, Shu-jing-huo-xue-tang, and Wu-ling-san. In the middle fracture period, the top three formulas were Zheng-gu-zi-jin-dang, Shu-jing-huo-xue-tang, and Zhi-bai-di-huang-wan. In the late fracture period, the top three formulas were Shu-jing-huo-xue-tang, Gui-lu-er-xian-jiao, and Du-huo-ji-sheng-tang. The main single herbs used in the early fracture period were Yan-hu-suo, Gu-sui-bu, and Dan-shen. From the middle to the late period, the most prescribed single herbs were Xu-duan, Gu-sui-bu, and Yan-hu-suo. We concluded that the results showed that the CGRD utilization pattern roughly meets the TCM theory at different fracture periods.

scholarly journals Clinical application and mechanism of traditional Chinese medicine in treatment of lung cancer

2020 ◽  
Vol 133 (24) ◽  
pp. 2987-2997
Author(s):  
Xiao-Lin Su ◽  
Jiang-Wei Wang ◽  
Hui Che ◽  
Chang-Fu Wang ◽  
Hai Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Application

scholarly journals Evidence of TCM Theory in Treating the Same Disease with Different Methods: Treatment of Pneumonia with Ephedra sinica and Scutellariae Radix as an Example

2020 ◽  
Vol 2020 ◽  
pp. 1-23
Author(s):  
Liping Sun ◽  
Dandan Wang ◽  
Yan Xu ◽  
Wenxiu Qi ◽  
Yanbo Wang
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Network Pharmacology ◽  
Ppi Network ◽  
Future Directions ◽  
Network Construction ◽  
Ephedra Sinica ◽  
Scutellariae Radix ◽  
Tcm Theory ◽  
Global Health Problem

Pneumonia is a serious global health problem and the leading cause of mortality in children. Antibiotics are the main treatment for bacterial pneumonia, but there are serious drug resistance problems. Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and has a unique theory. This article takes the treatment of pneumonia with Ephedra sinica as a representative hot medicine and Scutellariae Radix as a representative cold medicine as an example. We explore and explain the theory of treating the same disease with different TCM treatments. Using transcriptomics and network pharmacology methods, GO, KEGG enrichment, and PPI network construction were carried out, demonstrating that Ephedra sinica plays a therapeutic role through the NF-κB and apoptosis signaling pathways targeting PLAU, CD40LG, BLC2L1, CASP7, and CXCL8. The targets of Scutellariae Radix through the IL-17 signaling pathway are MMP9, CXCL8, and MAPK14. Molecular docking technology was also used to verify the results. In short, our results provide evidence for the theory of treating the same disease with different treatments, and we also discuss future directions for traditional Chinese medicine.

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