scholarly journals Ubiquitous Transgenic Overexpression of C-C Chemokine Ligand 2: A Model to Assess the Combined Effect of High Energy Intake and Continuous Low-Grade Inflammation

2013 ◽  
Vol 2013 ◽  
pp. 1-19 ◽  
Author(s):  
Esther Rodríguez-Gallego ◽  
Marta Riera-Borrull ◽  
Anna Hernández-Aguilera ◽  
Roger Mariné-Casadó ◽  
Anna Rull ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Chemokine Receptors ◽  
Embryonic Stem ◽  
Premature Death ◽  
High Energy ◽  
Noncommunicable Diseases ◽  
Low Grade ◽  
Metabolic Disturbances ◽  
Chemokine Ligand ◽  
Chemokine Ligand 2

Excessive energy management leads to low-grade, chronic inflammation, which is a significant factor predicting noncommunicable diseases. In turn, inflammation, oxidation, and metabolism are associated with the course of these diseases; mitochondrial dysfunction seems to be at the crossroads of mutual relationships. The migration of immune cells during inflammation is governed by the interaction between chemokines and chemokine receptors. Chemokines, especially C-C-chemokine ligand 2 (CCL2), have a variety of additional functions that are involved in the maintenance of normal metabolism. It is our hypothesis that a ubiquitous and continuous secretion of CCL2 may represent an animal model of low-grade chronic inflammation that, in the presence of an energy surplus, could help to ascertain the afore-mentioned relationships and/or to search for specific therapeutic approaches. Here, we present preliminary data on a mouse model created by using targeted gene knock-in technology to integrate an additional copy of the CCl2 gene in the Gt(ROSA)26Sor locus of the mouse genome via homologous recombination in embryonic stem cells. Short-term dietary manipulations were assessed and the findings include metabolic disturbances, premature death, and the manipulation of macrophage plasticity and autophagy. These results raise a number of mechanistic questions for future study.

P249 UBIQUITOUS TRANSGENIC OVEREXPRESSION OF C–C CHEMOKINE LIGAND 2: A MODEL TO ASSESS THE COMBINED EFFECT OF HIGH ENERGY INTAKE AND CONTINUOUS LOW-GRADE INFLAMMATION?

2014 ◽  
Vol 60 (1) ◽  
pp. S148
Author(s):  
A. Hernández-Aguilera ◽  
M. Riera-Borrull ◽  
E. Rodríguez-Gallego ◽  
R. Mariné-Casadó ◽  
M. Guirro ◽  
...  
Keyword(s):  
Energy Intake ◽  
High Energy ◽  
Combined Effect ◽  
Low Grade ◽  
High Energy Intake ◽  
Chemokine Ligand ◽  
Low Grade Inflammation ◽  
Chemokine Ligand 2

scholarly journals COVID-19 Pandemic: Is Chronic Inflammation a Major Cause of Death?

2020 ◽  
Author(s):  
Albina Tskhay ◽  
Alena Yezhova ◽  
Kenneth Alibek
Keyword(s):  
Chronic Inflammation ◽  
Developed Countries ◽  
Noncommunicable Diseases ◽  
Low Grade ◽  
Chronic Respiratory Diseases ◽  
Incidence And Mortality ◽  
Treatment Measures ◽  
Emerging Virus ◽  
The Difference ◽  
Available Information

Abstract Background. Today humanity is facing another infectious threat: a newly emerging virus SARS-CoV-2 causing COVID-19. It was already described that COVID-19 mortality among elderly people and people with such underlying conditions as obesity, cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes s increased. Dysregulation of the immune responses vital for antiviral defense, which are typical for chronic inflammation, led us to a hypothesis that chronic inflammation is the main risk factor for increased susceptibility and mortality from COVID-19. Method. Based on the available information for 126 countries, statistical analysis to find out whether the difference in incidence and mortality within countries can be explained by the existing chronic inflammation among the countries population, was conducted. Results. A positive correlation between the percentage of people dying from chronic noncommunicable diseases and COVID-19 incidence (p<0.001) and mortality (p<0.001) within countries. Conclusion. The problem of COVID-19-caused high mortality rate may be a consequence of the high number of people having chronic low-grade inflammation as a precondition, and thus, one of the potential ways to reduce risk of morbidity and mortality is to focus on this widespread health problem, mainly occurring in developed countries and to take corresponding diagnostic, preventative, and treatment measures.

scholarly journals Maternal Low-Grade Chronic Inflammation and Intrauterine Programming of Health and Disease

2021 ◽  
Vol 22 (4) ◽  
pp. 1732
Author(s):  
Francesca Parisi ◽  
Roberta Milazzo ◽  
Valeria M. Savasi ◽  
Irene Cetin
Keyword(s):  
Chronic Inflammation ◽  
Maternal Obesity ◽  
Threshold Effect ◽  
Overweight And Obesity ◽  
Metabolic Reprogramming ◽  
Noncommunicable Diseases ◽  
Low Grade ◽  
Placental Development ◽  
Maternal Inflammation ◽  
The Impact

Overweight and obesity during pregnancy have been associated with increased birth weight, childhood obesity, and noncommunicable diseases in the offspring, leading to a vicious transgenerational perpetuating of metabolic derangements. Key components in intrauterine developmental programming still remain to be identified. Obesity involves chronic low-grade systemic inflammation that, in addition to physiological adaptations to pregnancy, may potentially expand to the placental interface and lead to intrauterine derangements with a threshold effect. Animal models, where maternal inflammation is mimicked by single injections with lipopolysaccharide (LPS) resembling the obesity-induced immune profile, showed increased adiposity and impaired metabolic homeostasis in the offspring, similar to the phenotype observed after exposure to maternal obesity. Cytokine levels might be specifically important for the metabolic imprinting, as cytokines are transferable from maternal to fetal circulation and have the capability to modulate placental nutrient transfer. Maternal inflammation may induce metabolic reprogramming at several levels, starting from the periconceptional period with effects on the oocyte going through early stages of embryonic and placental development. Given the potential to reduce inflammation through inexpensive, widely available therapies, examinations of the impact of chronic inflammation on reproductive and pregnancy outcomes, as well as preventive interventions, are now needed.

scholarly journals Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging

Aging ◽  
2020 ◽  
Vol 12 (20) ◽  
pp. 20001-20023
Author(s):  
Fedra Luciano-Mateo ◽  
Noemí Cabré ◽  
Gerard Baiges-Gaya ◽  
Salvador Fernández-Arroyo ◽  
Anna Hernández-Aguilera ◽  
...  
Keyword(s):  
Accelerated Aging ◽  
Premature Death ◽  
Metabolic Dysregulation ◽  
Chemokine Ligand ◽  
Chemokine Ligand 2

scholarly journals Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review

2021 ◽  
Vol 22 (18) ◽  
pp. 9825
Author(s):  
Tiago Alexandre Conde ◽  
Ioannis Zabetakis ◽  
Alexandros Tsoupras ◽  
Isabel Medina ◽  
Margarida Costa ◽  
...  
Keyword(s):  
Chronic Inflammation ◽  
Dietary Habits ◽  
Inflammatory Responses ◽  
Positive Impact ◽  
Noncommunicable Diseases ◽  
Low Grade ◽  
Bioactive Lipids ◽  
Inflammatory Status ◽  
Dietary Components ◽  
Anti Inflammatory

Noncommunicable diseases (NCD) and age-associated diseases (AAD) are some of the gravest health concerns worldwide, accounting for up to 70% of total deaths globally. NCD and AAD, such as diabetes, obesity, cardiovascular disease, and cancer, are associated with low-grade chronic inflammation and poor dietary habits. Modulation of the inflammatory status through dietary components is a very appellative approach to fight these diseases and is supported by increasing evidence of natural and dietary components with strong anti-inflammatory activities. The consumption of bioactive lipids has a positive impact on preventing chronic inflammation and consequently NCD and AAD. Thus, new sources of bioactive lipids have been sought out. Microalgae are rich sources of bioactive lipids such as omega-6 and -3 polyunsaturated fatty acids (PUFA) and polar lipids with associated anti-inflammatory activity. PUFAs are enzymatically and non-enzymatically catalyzed to oxylipins and have a significant role in anti and pro-resolving inflammatory responses. Therefore, a large and rapidly growing body of research has been conducted in vivo and in vitro, investigating the potential anti-inflammatory activities of microalgae lipids. This review sought to summarize and critically analyze recent evidence of the anti-inflammatory potential of microalgae lipids and their possible use to prevent or mitigate chronic inflammation.

scholarly journals Does C-C Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State?

2021 ◽  
Vol 22 (3) ◽  
pp. 1500
Author(s):  
Sebastian Dommel ◽  
Matthias Blüher
Keyword(s):  
Adipose Tissue ◽  
Metabolic Diseases ◽  
Immune Cell ◽  
Current Knowledge ◽  
Low Grade ◽  
Monocyte Chemoattractant Protein 1 ◽  
Tissue Macrophage ◽  
Metabolic Inflammation ◽  
Chemokine Ligand ◽  
Chemokine Ligand 2

The mechanisms of how obesity contributes to the development of cardio-metabolic diseases are not entirely understood. Obesity is frequently associated with adipose tissue dysfunction, characterized by, e.g., adipocyte hypertrophy, ectopic fat accumulation, immune cell infiltration, and the altered secretion of adipokines. Factors secreted from adipose tissue may induce and/or maintain a local and systemic low-grade activation of the innate immune system. Attraction of macrophages into adipose tissue and altered crosstalk between macrophages, adipocytes, and other cells of adipose tissue are symptoms of metabolic inflammation. Among several secreted factors attracting immune cells to adipose tissue, chemotactic C-C motif chemokine ligand 2 (CCL2) (also described as monocyte chemoattractant protein-1 (MCP-1)) has been shown to play a crucial role in adipose tissue macrophage infiltration. In this review, we aimed to summarize and discuss the current knowledge on CCL2 with a focus on its role in linking obesity to cardio-metabolic diseases.

Efficient Co-Harvesting of Solar Energy and Low-Grade Heat by Molecular Photoswitches for High Energy Density, Long-Term Stable Solar Thermal Battery

2019 ◽  
Author(s):  
Zhao-Yang Zhang ◽  
Tao LI
Keyword(s):  
Energy Density ◽  
Solar Energy ◽  
High Performance ◽  
High Energy ◽  
Solar Thermal ◽  
High Energy Density ◽  
Low Grade ◽  
Thermal Battery ◽  
Low Grade Heat

Solar energy and ambient heat are two inexhaustible energy sources for addressing the global challenge of energy and sustainability. Solar thermal battery based on molecular switches that can store solar energy and release it as heat has recently attracted great interest, but its development is severely limited by both low energy density and short storage stability. On the other hand, the efficient recovery and upgrading of low-grade heat, especially that of the ambient heat, has been a great challenge. Here we report that solar energy and ambient heat can be simultaneously harvested and stored, which is enabled by room-temperature photochemical crystal-to-liquid transitions of small-molecule photoswitches. The two forms of energy are released together to produce high-temperature heat during the reverse photochemical phase change. This strategy, combined with molecular design, provides high energy density of 320-370 J/g and long-term storage stability (half-life of about 3 months). On this basis, we fabricate high-performance, flexible film devices of solar thermal battery, which can be readily recharged at room temperature with good cycling ability, show fast rate of heat release, and produce high-temperature heat that is >20<sup> o</sup>C higher than the ambient temperature. Our work opens up a new avenue to harvest ambient heat, and demonstrate a feasible strategy to develop high-performance solar thermal battery.

Efficient Co-Harvesting of Solar Energy and Low-Grade Heat by Molecular Photoswitches for High Energy Density, Long-Term Stable Solar Thermal Battery

2019 ◽  
Author(s):  
Zhao-Yang Zhang ◽  
Tao LI
Keyword(s):  
Energy Density ◽  
Solar Energy ◽  
High Performance ◽  
High Energy ◽  
Solar Thermal ◽  
High Energy Density ◽  
Low Grade ◽  
Thermal Battery ◽  
Low Grade Heat

Solar energy and ambient heat are two inexhaustible energy sources for addressing the global challenge of energy and sustainability. Solar thermal battery based on molecular switches that can store solar energy and release it as heat has recently attracted great interest, but its development is severely limited by both low energy density and short storage stability. On the other hand, the efficient recovery and upgrading of low-grade heat, especially that of the ambient heat, has been a great challenge. Here we report that solar energy and ambient heat can be simultaneously harvested and stored, which is enabled by room-temperature photochemical crystal-to-liquid transitions of small-molecule photoswitches. The two forms of energy are released together to produce high-temperature heat during the reverse photochemical phase change. This strategy, combined with molecular design, provides high energy density of 320-370 J/g and long-term storage stability (half-life of about 3 months). On this basis, we fabricate high-performance, flexible film devices of solar thermal battery, which can be readily recharged at room temperature with good cycling ability, show fast rate of heat release, and produce high-temperature heat that is >20<sup> o</sup>C higher than the ambient temperature. Our work opens up a new avenue to harvest ambient heat, and demonstrate a feasible strategy to develop high-performance solar thermal battery.

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