scholarly journals Acute Hemolysis in the Emergency Department: Think aboutClostridium perfringens!

2013 ◽  
Vol 2013 ◽  
pp. 1-2
Author(s):  
Roustit Cécilia ◽  
Vallé Baptiste ◽  
Clouzeau Benjamin ◽  
Heydel Virginie ◽  
Valdenaire Guillaume ◽  
...  
Keyword(s):  
Emergency Department ◽  
Structural Integrity ◽  
Symptomatic Treatment ◽  
Clinical Settings ◽  
Red Cell ◽  
Alpha Toxin ◽  
Intravascular Hemolysis ◽  
Red Cell Membrane ◽  
Septic Syndrome ◽  
Starting Point

Clostridium perfringens(CP) gives several clinical settings, from an asymptomatic to a massive intravascular hemolysis. We report a case of fatal intravascular hemolysis due to CP septicemia having a hepatic supposed starting point in the emergency department. Like in many cases, the diagnosis was made when patient had already gone into shock and died. The CP septicemia often complicated the course of the digestive or genital pathologies. The alpha toxin can damage the structural integrity of the red cell membrane by means of a phospholipase activity. Nevertheless, a massive intravascular hemolysis arises only rarely in this septicemia, only from 7 to 15% of the cases. The emergency physician has to think about this complication in case of hemoglobinuria and/or signs of hemolysis associated with a septic syndrome. An immediate antibiotic treatment adapted as well as the symptomatic treatment of the spread intravascular coagulation could improve the survival of these patients.

Ca2+ transport and permeability in inside-out red cell membrane vesicles after freezing

Cryobiology ◽  
1986 ◽  
Vol 23 (2) ◽  
pp. 134-140 ◽  
Author(s):  
A. Rubinacci ◽  
B. Fuller ◽  
F. Wuytack ◽  
W. De Loecker
Keyword(s):  
Cell Membrane ◽  
Membrane Vesicles ◽  
Red Cell ◽  
Red Cell Membrane ◽  
Inside Out

scholarly journals Mechanical Properties of the Red Cell Membrane

1964 ◽  
Vol 4 (2) ◽  
pp. 115-135 ◽  
Author(s):  
R.P. Rand ◽  
A.C. Burton
Keyword(s):  
Mechanical Properties ◽  
Cell Membrane ◽  
Red Cell ◽  
Red Cell Membrane

scholarly journals Red Cell Membrane Permeability Deduced from Bulk Diffusion Coefficients

1974 ◽  
Vol 64 (6) ◽  
pp. 706-729 ◽  
Author(s):  
W. R. Redwood ◽  
E. Rall ◽  
W. Perl
Keyword(s):  
Cell Membrane ◽  
Membrane Permeability ◽  
Diffusion Coefficients ◽  
Bulk Diffusion ◽  
Red Cells ◽  
Cell Membrane Permeability ◽  
Red Cell ◽  
Cell Column ◽  
Red Cell Membrane ◽  
One Dimensional

The permeability coefficients of dog red cell membrane to tritiated water and to a series of[14C]amides have been deduced from bulk diffusion measurements through a "tissue" composed of packed red cells. Red cells were packed by centrifugation inside polyethylene tubing. The red cell column was pulsed at one end with radiolabeled solute and diffusion was allowed to proceed for several hours. The distribution of radioactivity along the red cell column was measured by sequential slicing and counting, and the diffusion coefficient was determined by a simple plotting technique, assuming a one-dimensional diffusional model. In order to derive the red cell membrane permeability coefficient from the bulk diffusion coefficient, the red cells were assumed to be packed in a regular manner approximating closely spaced parallelopipeds. The local steady-state diffusional flux was idealized as a one-dimensional intracellular pathway in parallel with a one-dimensional extracellular pathway with solute exchange occurring within the series pathway and between the pathways. The diffusion coefficients in the intracellular and extracellular pathways were estimated from bulk diffusion measurements through concentrated hemoglobin solutions and plasma, respectively; while the volume of the extracellular pathway was determined using radiolabeled sucrose. The membrane permeability coefficients were in satisfactory agreement with the data of Sha'afi, R. I., C. M. Gary-Bobo, and A. K. Solomon (1971. J. Gen. Physiol. 58:238) obtained by a rapid-reaction technique. The method is simple and particularly well suited for rapidly permeating solutes.

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