scholarly journals Population-Based Analysis of Incidence Rates of Cancer and Noncancer Chronic Diseases in the US Elderly Using NLTCS/Medicare-Linked Database

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
I. Akushevich ◽  
J. Kravchenko ◽  
S. Ukraintseva ◽  
K. Arbeev ◽  
A. Yashin
Keyword(s):  
Heart Failure ◽  
Severe Disabilities ◽  
Population Based ◽  
Incidence Rates ◽  
Term Care ◽  
Asthma Incidence ◽  
The Us ◽  
Nationally Representative ◽  
Alzheimer’S Diseases ◽  
Alzheimer's Diseases

The age, disability, and comorbidity patterns of incidence rates of cancer and chronic noncancer diseases such as heart failure, diabetes mellitus, asthma, Parkinson's disease, Alzheimer's disease, skin melanoma, and cancers of breast, prostate, lung, and colon were studied for the US elderly population (aged 65+) using the National Long-Term Care Survey (NLTCS) data linked to Medicare records for 1991–2005. Opposite to breast cancer and asthma, incidence rates of heart failure and Alzheimer's diseases were increasing with age. Higher incidence rates of heart failure, diabetes, asthma, and Parkinson's and Alzheimer's diseases were observed among individuals with severe disabilities or/and comorbidities, while rates of breast and prostate cancers were higher among those with minor disabilities or fewer comorbidities. Our results were in agreement with those obtained from other epidemiological datasets, thus suggesting that Medicare administrative records can provide nationally representative incidence rates. Detailed sensitivity analysis that focused on the effects of alternative onset definitions, latent censoring, study design, and other procedural uncertainties showed the stability of reconstructed incidence rates. This Medicare-linked dataset can be used for studying highly debated effects of new medical technologies on aging-related diseases burden and future Medicare costs.

scholarly journals Changes in the Incidence of Endstage Renal Disease Due to Lupus Nephritis in the United States, 1996–2004

2009 ◽  
Vol 36 (1) ◽  
pp. 63-67 ◽  
Author(s):  
MICHAEL M. WARD
Keyword(s):  
United States ◽  
Lupus Nephritis ◽  
Renal Disease ◽  
The United States ◽  
Population Based ◽  
Incidence Rates ◽  
Endstage Renal Disease ◽  
The Us ◽  
Population Based Registry ◽  
Us Census

ObjectiveTo determine if the incidence of endstage renal disease (ESRD) due to lupus nephritis has decreased from 1996 to 2004.MethodsPatients age 15 years or older with incident ESRD due to lupus nephritis in 1996–2004 and living in one of the 50 United States or the District of Columbia were identified using the US Renal Data System, a national population-based registry of all patients receiving renal replacement therapy for ESRD. Incidence rates were computed for each calendar year, using population estimates of the US census as denominators.ResultsOver the 9-year study period, 9199 new cases of ESRD due to lupus nephritis were observed. Incidence rates, adjusted to the age, sex, and race composition of the US population in 2000, were 4.4 per million in 1996 and 4.9 per million in 2004. Compared to the pooled incidence rate in 1996–1998, the relative risk of ESRD due to lupus nephritis in 1999–2000 was 0.99 (95% CI 0.93–1.06), in 2001–2002 was 0.99 (95% CI 0.92–1.06), and in 2003–2004 was 0.96 (95% CI 0.89–1.02). Findings were similar in analyses stratified by sex, age group, race, and socioeconomic status.ConclusionThere was no decrease in the incidence of ESRD due to lupus nephritis between 1996 and 2004. This may reflect the limits of effectiveness of current treatments, or limitations in access, use, or adherence to treatment.

scholarly journals High but stable incidence of adult-onset asthma in northern Sweden over the last decades

2021 ◽  
pp. 00262-2021
Author(s):  
Petri Räisänen ◽  
Helena Backman ◽  
Linnea Hedman ◽  
Martin Andersson ◽  
Caroline Stridsman ◽  
...  
Keyword(s):  
Risk Factor ◽  
Incidence Rate ◽  
Age Groups ◽  
Population Based ◽  
Incidence Rates ◽  
Asthma Prevalence ◽  
Adult Onset ◽  
Northern Sweden ◽  
Asthma Incidence ◽  
Validated Questionnaire

BackgroundThe prevalence of asthma has increased both among children and adults during the latter half of the 20th century. The prevalence among adults is affected by the incidence of asthma in childhood but also in adulthood. Time trends in asthma incidence are poorly studied.AimThe aim was to study the incidence of adult-onset asthma from 1996–2006 and 2006–2016, and compare the risk factor patterns.MethodsWithin the Obstructive Lung Disease in Northern Sweden (OLIN) studies, two randomly selected population-based samples in ages 20–69 years participated in postal questionnaire surveys about asthma in 1996 (n=7104, 85%) and 2006 (n=6165, 77%), respectively. A 10-year follow-up of the two cohorts with the same validated questionnaire was performed, and n=5709 and n=4552, respectively, responded. Different definitions of population at risk were used in the calculations of asthma incidence. The protocol followed a study performed 1986 to 1996 in the same area.ResultsThe crude incidence rate of physician-diagnosed asthma was 4.4/1000/year (men 3.8, women 5.5) from 1996–2006, and 4.8/1000/year (men 3.7, women 6.2) from 2006–2016. When correcting for possible under-diagnosis at study entry, the incidence rate was 2.4/1000/year from 1996–2006 and 2.6/1000/year from 2006–2016. The incidence rates were similar across age groups. Allergic rhino-conjunctivitis was the main risk factor for incident asthma in both observation periods (risk ratios 2.4–2.6).ConclusionsThe incidence of adult-onset asthma has been stable over the last two decades, and on similar level since the 1980s. The high incidence contributes to the increase in asthma prevalence.

scholarly journals Prevalence and Incidence of Osteoarthritis: A Population-Based Retrospective Cohort Study

2021 ◽  
Vol 10 (18) ◽  
pp. 4282
Author(s):  
Rola Hamood ◽  
Matanya Tirosh ◽  
Noga Fallach ◽  
Gabriel Chodick ◽  
Elon Eisenberg ◽  
...  
Keyword(s):  
Western Europe ◽  
Middle Eastern ◽  
Temporal Trends ◽  
Population Based ◽  
Therapeutic Interventions ◽  
P Value ◽  
Modifiable Risk Factors ◽  
The Us ◽  
Nationally Representative ◽  
Care Database

While trends data of osteoarthritis (OA) are accumulating, primarily from Western Europe and the US, a gap persists in the knowledge of OA epidemiology in Middle Eastern populations. This study aimed to explore the prevalence, incidence, correlations, and temporal trends of OA in Israel during 2013–2018, using a nationally representative primary care database. On 31 December 2018, a total of 180,126 OA patients were identified, representing a point prevalence of 115.3 per 1000 persons (95% CI, 114.8–115.8 per 1000 persons). Geographically, OA prevalence was not uniformly distributed, with the Southern and Northern peripheral districts having a higher prevalence than the rest of the Israeli regions. OA incidence increased over time from 7.36 per 1000 persons (95% CI 6.21–7.50 per 1000 persons) in 2013 to 8.23 per 1000 persons (95% CI 8.09–8.38 per 1000 persons) in 2017 (p-value for trend = 0.02). The incidence was lowest in patients under 60 years (in both sexes) and peaked at 60–70 years. In older ages, the incidence leveled off in men and declined in women. The growing risk of OA warrants a greater attention to timely preventive and therapeutic interventions. Further population-based studies in the Middle East are needed to identify modifiable risk factors for timely preventive and therapeutic interventions.

scholarly journals Incidence of Silent Stroke in the United States

Stroke ◽  
2001 ◽  
Vol 32 (suppl_1) ◽  
pp. 363-363
Author(s):  
Megan C Leary ◽  
Jeffrey L Saver
Keyword(s):  
United States ◽  
Stroke Prevention ◽  
The United States ◽  
Population Based ◽  
Incidence Rates ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Stroke Incidence ◽  
Age Cohorts ◽  
The Us

P134 Background: Recent estimates of stroke incidence in the US range from 715,000–750,000 annually. These estimates, however, do not reflect silent infarcts and hemorrhages. Since population-based studies have found that prevalence of silent stroke is 10–20 times that of symptomatic, estimates of stroke incidence based solely on symptomatic events may substantially underestimate the annual burden of stroke. Silent strokes contribute to vascular dementia, gait impairment, and other major adverse patient outcomes. Methods: Incidence of silent infarcts for different age strata were derived from two US population-based studies of the prevalence of silent infarct-like lesions on MRI, Atherosclerosis Risk In Communities and Cardiovascular Health Study. Prevalence observations in these studies and age-specific death rates from the US Census Bureau were inputted to calculate silent infarct incidence (method of Leske et al). Similarly, incidence rates of silent hemorrhage at differing ages were extrapolated from population-based prevalence observations employing MR GRE imaging in the Austrian Stroke Prevention Study. Age-specific incidence rates were projected onto age cohorts in the 1998 US population to calculate annual burden of silent stroke. Results: Derived incidence rates per 100,000 of silent infarct ranged from 6400 in the age 50–59 strata to 16400 at ages 75–79. Extrapolated incidence rates of silent hemorrhage ranged from 230 in the age 30–39 strata to 7360 at ages > 80. Incidence rates of both subclinical infarcts and hemorrhage increased exponentially with age. Overall estimated annual US occurrence of silent infarct was 9,039,000, and of silent hemorrhage 2,130,000. Conclusion: In 1998, nearly 12 million strokes occurred in the United States, of which ∼750,000 were symptomatic and over 11 million were subclinical. Among the silent strokes, ∼81% were infarcts and ∼19% hemorrhages. These findings demonstrate that the annual burden of stroke is substantially higher than suggested by estimates based solely on clinically manifest events, and suggest that greater research and clinical resources should be allocated to stroke prevention and treatment.

scholarly journals Willingness to vaccinate against COVID-19 in the US: Representative longitudinal evidence from April–October 2020

2021 ◽  
Author(s):  
Michael Daly ◽  
Eric Robinson
Keyword(s):  
Side Effects ◽  
Longitudinal Data ◽  
Representative Sample ◽  
Public Attitudes ◽  
Likert Scale ◽  
Population Based ◽  
Population Based Study ◽  
The Us ◽  
Nationally Representative

Introduction: Vaccines against COVID-19 have been developed in unprecedented time. However, the effectiveness of any vaccine is dictated by the proportion of the population willing to be vaccinated. In this observational population-based study we examined intentions to be vaccinated against COVID-19 throughout the pandemic. Methods: In November, 2020 we analyzed longitudinal data from a nationally representative sample of 7,547 US adults enrolled in the Understanding America Study (UAS) using multinomial logistic regresion. Participants reporting being willing, undecided and unwilling to get vaccinated against coronavirus across 13 assessments conducted from April-October, 2020. Public attitudes to vaccination against the coronavirus were also assessed on a four-point Likert scale. Results: Willingness to vaccinate declined from 71% in April to 53.6% in October. This was explained by an increase in the percentage of participants undecided about vaccinating (from 10.5% to 14.4%) and the portion of the sample unwilling to vaccinate (from 18.5% to 32%). The population subgroups most likely to be undecided/unwilling to vaccinate were those without a degree (undecided: RRR=2.47, 95% CI: 2.04-3.00; unwilling: RRR=1.92, 95% CI:1.67-2.20), Black participants (undecided: RRR=2.18, 95% CI: 1.73-2.74; unwilling: RRR=1.98, 95% CI:1.63-2.42), and females (undecided: RRR=1.41, 95% CI:1.20-1.65; unwilling: RRR=1.29, 95% CI:1.14-1.46). Participants who were older or were on higher incomes were least likely to be undecided or unwilling to vaccinate. Concerns about potential side effects of a vaccine were common.Conclusions: Intentions to be vaccinated against coronavirus have declined rapidly during the pandemic and close to half of Americans are undecided or unwilling to be vaccinated.

Suicide risk in persons with colorectal cancer: A population-based study.

2017 ◽  
Vol 35 (31_suppl) ◽  
pp. 196-196
Author(s):  
Aileen Deng ◽  
Atrayee Basu Mallick
Keyword(s):  
Colorectal Cancer ◽  
General Population ◽  
Fold Increase ◽  
Population Based ◽  
Incidence Rates ◽  
Mortality Data ◽  
Standardized Mortality Ratio ◽  
First Year ◽  
The Us ◽  
Patients At Risk

196 Background: Patients with cancer have nearly twice the incidence of suicide compared to the general population. To date, identifying patients at risk for suicide remains challenging. Colorectal cancer (CRC) is the third most common cancer in the US. The purpose of this study was to identify risk factors associated with higher suicide rates (SR) among patients with CRC. Methods: A retrospective analysis was completed using Surveillance, Epidemiology, and End Results data from 1973 to 2014. Comparisons with the general US population were based on US mortality data collected by the National Center for Health Statistics. Suicide incidence, rates and standardized mortality ratio (SMR) were obtained by SEER*Stat 8.3.4. Results: Among 414788 patients with CRC observed for 2785811 person-years, 747 suicides were identified, for an adjusted SR of 26.7/100,000 person-years (SMR 1.40 [95% CI 1.30-1.50]). Higher SRs were associated with male sex, non-white or non-black race, being unmarried and having advanced disease at diagnosis (Table 1). SR was highest in the first year after diagnosis (SMR 2.00 [95% CI 1.68-2.37]) and with increasing age at diagnosis among unmarried patients. In patients 60 to 64 years at diagnosis, SR was highest in unmarried men (SMR 3.72 [95% CI 2.61-5.15]) and lowest in married women (SMR 0.61 [95% CI 0.17-1.57]). Conclusions: CRC is one of the most common cancers in the US. Patients with CRC have a 1.5-fold increase in SR compared to the general population. Suicide screening should especially target those in their first year after diagnosis, particularly older, unmarried patients. [Table: see text]

scholarly journals Editorial: Molecular Mechanisms Involved in Heart Failure, Parkinson’s, and Alzheimer’s Diseases

2021 ◽  
Vol 8 ◽  
Author(s):  
Grazia Daniela Femminella ◽  
Gennaro Pagano ◽  
Daniela Liccardo ◽  
Alessandro Cannavo
Keyword(s):  
Heart Failure ◽  
Molecular Mechanisms ◽  
Alzheimer’S Diseases ◽  
Alzheimer's Diseases

scholarly journals Incidence of rhinitis and asthma related to welding in Northern Europe

2015 ◽  
Vol 46 (5) ◽  
pp. 1290-1297 ◽  
Author(s):  
Torgeir Storaas ◽  
Jan-Paul Zock ◽  
Ana Espinosa Morano ◽  
Mathias Holm ◽  
Eythor Bjørnsson ◽  
...  
Keyword(s):  
Parental Education ◽  
Respiratory Health ◽  
Population Sample ◽  
Disease Onset ◽  
Population Based ◽  
Incidence Rates ◽  
Northern Europe ◽  
Adult Onset ◽  
Asthma Incidence ◽  
Kaplan Meier

Welding-related asthma is well recognised but less is known about rhinitis in relation to welding. The aim here, was to study associations between welding, rhinitis and asthma in a general population sample, and factors influencing selection into and out of a welding occupation.Adult-onset asthma and non-infectious rhinitis were investigated in the international multicentre population-based Respiratory Health in Northern Europe (RHINE) study, including 16 191 responders aged 26–54 years. Ever welding (n=2181), welding >25% of working time (n=747), and welding in stainless steel >6 months (n=173) were assessed by questionnaire. Subjects with rhinitis or asthma onset when aged <18 years were excluded. Incidence rates for asthma and rhinitis were calculated from year of disease onset, and start and end of welding job. Cox's proportional hazard models adjusting for age, sex, parental education and study centre, and Kaplan–Meier curves were used.Rhinitis incidence was higher among welders (hazard ratio (HR) 1.4, 95% CI 1.3–1.6), consistent in men and women, and across centres (pheterogeneity=0.4). In men, asthma incidence was higher among welders (HR 1.4, 95% CI 1.04–1.97). Quitting welding was indicated higher after adult-onset rhinitis (HR 1.1, 95% CI 1.0–1.3).Adult-onset rhinitis and asthma was higher among welders, consistent across population samples from Northern Europe. No pre-employment selection was found, whereas selection out of welding jobs was suggested.

Descriptive epidemiology of pituitary tumors in the United States, 2004–2009

2014 ◽  
Vol 121 (3) ◽  
pp. 527-535 ◽  
Author(s):  
Haley Gittleman ◽  
Quinn T. Ostrom ◽  
Paul D. Farah ◽  
Annie Ondracek ◽  
Yanwen Chen ◽  
...  
Keyword(s):  
United States ◽  
Incidence Rate ◽  
Pituitary Tumors ◽  
The United States ◽  
Population Based ◽  
Incidence Rates ◽  
Annual Incidence ◽  
Annual Incidence Rate ◽  
The Us ◽  
Adjusted Incidence

Object Pituitary tumors are abnormal growths that develop in the pituitary gland. The Central Brain Tumor Registry of the United States (CBTRUS) contains the largest aggregation of population-based data on the incidence of primary CNS tumors in the US. These data were used to determine the incidence of tumors of the pituitary and associated trends between 2004 and 2009. Methods Using incidence data from 49 population-based state cancer registries, 2004–2009, age-adjusted incidence rates per 100,000 population for pituitary tumors with ICD-O-3 (International Classification of Diseases for Oncology, Third Edition) histology codes 8040, 8140, 8146, 8246, 8260, 8270, 8271, 8272, 8280, 8281, 8290, 8300, 8310, 8323, 9492 (site C75.1 only), and 9582 were calculated overall and by patient sex, race, Hispanic ethnicity, and age at diagnosis. Corresponding annual percent change (APC) scores and 95% confidence intervals were also calculated using Joinpoint to characterize trends in incidence rates over time. Diagnostic confirmation by subregion of the US was also examined. Results The overall annual incidence rate increased from 2.52 (95% CI 2.46–2.58) in 2004 to 3.13 (95% CI 3.07–3.20) in 2009. Associated time trend yielded an APC of 4.25% (95% CI 2.91%–5.61%). When stratifying by patient sex, the annual incidence rate increased from 2.42 (95% CI 2.33–2.50) to 2.94 (95% CI 2.85–3.03) in men and 2.70 (95% CI 2.62–2.79) to 3.40 (95% CI 3.31–3.49) in women, with APCs of 4.35% (95% CI 3.21%–5.51%) and 4.34% (95% CI 2.23%–6.49%), respectively. When stratifying by race, the annual incidence rate increased from 2.31 (95% CI 2.25–2.37) to 2.81 (95% CI 2.74–2.88) in whites, 3.99 (95% CI 3.77–4.23) to 5.31 (95% CI 5.06–5.56) in blacks, 1.77 (95% CI 1.26–2.42) to 2.52 (95% CI 1.96–3.19) in American Indians or Alaska Natives, and 1.86 (95% CI 1.62–2.13) to 2.03 (95% CI 1.80–2.28) in Asians or Pacific Islanders, with APCs of 3.91% (95% CI 2.88%–4.95%), 5.25% (95% CI 3.19%–7.36%), 5.31% (95% CI –0.11% to 11.03%), and 2.40% (95% CI –3.20% to 8.31%), respectively. When stratifying by Hispanic ethnicity, the annual incidence rate increased from 2.46 (95% CI 2.40–2.52) to 3.03 (95% CI 2.97–3.10) in non-Hispanics and 3.12 (95% CI 2.91–3.34) to 4.01 (95% CI 3.80–4.24) in Hispanics, with APCs of 4.15% (95% CI 2.67%–5.65%) and 5.01% (95% CI 4.42%–5.60%), respectively. When stratifying by age at diagnosis, the incidence of pituitary tumor was highest for those 65–74 years old and lowest for those 15–24 years old, with corresponding overall age-adjusted incidence rates of 6.39 (95% CI 6.24–6.54) and 1.56 (95% CI 1.51–1.61), respectively. Conclusions In this large patient cohort, the incidence of pituitary tumors reported between 2004 and 2009 was found to increase. Possible explanations for this increase include changes in documentation, changes in the diagnosis and registration of these tumors, improved diagnostics, improved data collection, increased awareness of pituitary diseases among physicians and the public, longer life expectancies, and/or an actual increase in the incidence of these tumors in the US population.

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