scholarly journals Inflammatory Myofibroblastic Tumor of the Lung and the Maxillary Region: A Benign Lesion with Aggressive Behavior

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Lorena Gallego ◽  
Tania R. Santamarta ◽  
Verónica Blanco ◽  
Luis García-Consuegra ◽  
Tommaso Cutilli ◽  
...  
Keyword(s):  
Aggressive Behavior ◽  
Inflammatory Myofibroblastic Tumor ◽  
Smooth Muscle Actin ◽  
Benign Lesion ◽  
Distant Metastases ◽  
Oral Lesion ◽  
The Body ◽  
Spindle Cell Proliferation ◽  
Intense Immunoreactivity ◽  
Maxillary Region

Inflammatory myofibroblastic tumor (IMT) is a rare mass-forming lesion characterized by fibroblastic or myofibroblastic spindle cell proliferation with varying degrees of inflammatory cell infiltration. Although it has been reported in virtually every organ in the body, the lung is the most common site of involvement. Extrapulmonary IMTs, although rare, have been reported and are characterized by different, more aggressive behavior. We report an extremely rare case of maxillary metastases of pulmonary IMT. Lung IMT was initially misdiagnosed, and oral lesion mimicked clinically and radiologically a radicular cyst. On histologic examination, cells exhibited diffuse and intense immunoreactivity forα-smooth muscle actin and vimentin whereas both pulmonary and oral IMTs presented absence of cellular atypia and lack of expressivity of oncogenic determinants. Distant metastases of lung IMT are extremely unusual, and this is the first report to our knowledge with this particular clinical course. Despite the possibility that the present case could also represent a metachronous multifocal IMT, with pulmonary and extrapulmonary lesions, similar histopathological and immunohistochemical patterns in lung and maxillary region suggest a metastatic course.

Inflammatory myofibroblastic tumor of the lung: a benign lesion with aggressive behavior

2012 ◽  
Vol 60 (8) ◽  
pp. 531-533 ◽  
Author(s):  
Sonia Ezzine-Baccari ◽  
Dhouha Bacha ◽  
Sélim Sassi ◽  
Maher Abouda ◽  
Hédia Ghrairi ◽  
...  
Keyword(s):  
Aggressive Behavior ◽  
Inflammatory Myofibroblastic Tumor ◽  
Benign Lesion

scholarly journals Inflammatory Myofibroblastic Tumor of Bladder

2017 ◽  
Vol 03 (02) ◽  
pp. 109-110
Author(s):  
Rohit Juneja ◽  
H Veerendra
Keyword(s):  
Cell Proliferation ◽  
Transurethral Resection ◽  
Myoepithelial Cell ◽  
Inflammatory Myofibroblastic Tumor ◽  
Benign Lesion ◽  
Malignant Neoplasm ◽  
The Body ◽  
Gross Hematuria ◽  
Lymphoplasmacytic Infiltrate ◽  
Polypoidal Growth

AbstractInflammatory myofibroblastic tumor (IMT) is a rare benign lesion found in many locations throughout the body and genitourinary tract. In bladder, being very uncommon, it arises from submucosal stroma as a polypoidal growth, and is easily mistaken for a malignant neoplasm—both clinically and radiologically. Essential criteria for the diagnosis of IMT are spindle myoepithelial cell proliferation and lymphoplasmacytic infiltrate. Here, we report a case of a 29-year-old male who presented with painless gross hematuria for 3 days. The patient underwent transurethral resection of the tumor and the final pathological diagnosis was IMT of the bladder.

scholarly journals An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Sanjivini V. Jacob ◽  
John D. Reith ◽  
Angerika Y. Kojima ◽  
William D. Williams ◽  
Chen Liu ◽  
...  
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Smooth Muscle Actin ◽  
Portal Tract ◽  
Fish Analysis ◽  
Anaplastic Lymphoma ◽  
Alk Inhibitor ◽  
Spindle Cell Proliferation ◽  
History Of ◽  
Subcutaneous Tissues ◽  
Systemic Manifestations

Systemic inflammatory myofibroblastic tumor is an exceedingly rare entity. A 45-year-old Hispanic female presented with a 6-month history of left-sided thigh pain, low back pain, and generalized weakness. PET/CT scan revealed abnormal activity in the liver, adrenal gland, and pancreas. MRI of the abdomen demonstrated two 6-7 cm masses in the liver. MRI of the lumbar spine demonstrated lesions in the L2 to L4 spinous processes, paraspinal muscles, and subcutaneous tissues, as well as an 8 mm enhancing intradural lesion at T11, all thought to be metastatic disease. A biopsy of the liver showed portal tract expansion by a spindle cell proliferation rich in inflammation. Tumor cells showed immunoreactivity for smooth muscle actin and anaplastic lymphoma kinase 1 (ALK1). Tissue from the L5 vertebra showed a process histologically identical to that seen in the liver. FISH analysis of these lesions demonstrated an ALK (2p23) gene rearrangement. The patient was successfully treated with an ALK-inhibitor, Crizotinib, and is now in complete remission. We present the first reported case, to our knowledge, of inflammatory myofibroblastic tumor with systemic manifestations and ALK translocation. This case is a prime example of how personalized medicine has vastly improved patient care through the use of molecular-targeted therapy.

scholarly journals Voluminous Omental Inflammatory Myofibroblastic Tumor in an Elderly Man: A Case Report and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Pasquale Cianci ◽  
Antonio Ambrosi ◽  
Alberto Fersini ◽  
Nicola Tartaglia ◽  
Vincenzo Lizzi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Inflammatory Myofibroblastic Tumor ◽  
Plasma Cells ◽  
Smooth Muscle Actin ◽  
Abdominal Mass ◽  
Abdominal Distension ◽  
Greater Omentum ◽  
Anaplastic Lymphoma ◽  
Mesenchymal Neoplasm ◽  
Spindle Cell Proliferation

Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm of intermediate biologic potential, with uncertain etiology. This tumor occurs primarily in the lung, but the tumor may affect any organ system. A 75-year-old male was evaluated for voluminous palpable high abdominal mass with continuous and moderately abdominal pain, associated with abdominal distension for the last two months. Abdominal computed tomography showed a large (32×29×15 cm) heterogeneously enhanced mass with well-defined margins. At surgery, the mass originated from the greater omentum was completely excised. Histologically the tumor was a mesenchymal neoplasm in smooth muscle differentiation and was characterized by spindle-cell proliferation with lymphocytes, plasma cells, and rare eosinophils. Immunohistochemically, the tumor cells were positive for vimentin and smooth muscle actin and negative for anaplastic lymphoma kinase. Complete surgical resection of IMTs remains the mainstay of treatment associated with a low rate of recurrence. Final diagnosis should be based on histopathological and immunohistochemical findings. Appropriate awareness should be exercised by surgeons to abdominal IMTs in combination with constitutional symptoms, abnormal hematologic findings, and radiological definition, to avoid misdiagnosed.

scholarly journals Inflammatory myofibroblastic tumor of caecum presenting as recurrent intussusception: A case report

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Dr.Dinesh Kumar Barolia ◽  
Aditya Pratap Singh ◽  
Dr. Harsha Vinod Bathia ◽  
Vipal H Parmar ◽  
Bhavana Asit Mehta ◽  
...  
Keyword(s):  
Case Report ◽  
Inflammatory Myofibroblastic Tumor ◽  
Smooth Muscle Actin ◽  
Recurrent Abdominal Pain ◽  
The Body ◽  
Lymphoid Cells ◽  
Muscle Actin ◽  
Recurrent Intussusception ◽  
Mib 1 ◽  
Body Case

Background: Inflammatory myofibroblastic tumor is an uncommon tumor. It commonly affects the lung but it can be found anywhere in the body.   Case Report: We are reporting a case of caecal mass presenting as recurrent intussusceptions. Histopathology and immunohistochemistry confirmed it to be an inflammatory myofibroblastic tumor of caecum. Immunohistochemistry of tumor cells were positive for vimentin, smooth muscle actin, MIB 1, and CD 45 in lymphoid cells in the stroma of the tumor. Conclusion: Recurrent intussusception should be kept as one of the differential diagnosis in patient with caecal mass with recurrent abdominal pain. Inflammatory myofibroblastic tumor of the caecum is unusual in paediatric patients and may present as recurrent intussusception.

Mammary-type Myofibroblastoma with Leiomyomatous Differentiation: A Rare Variant with Potential Pitfalls

2021 ◽  
pp. 106689692110313
Author(s):  
Alexander M. Strait ◽  
Julia A. Bridge ◽  
Anthony J. Iafrate ◽  
Marilyn M. Li ◽  
Feng Xu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Transcriptome Sequencing ◽  
Smooth Muscle Actin ◽  
The Body ◽  
Muscle Actin ◽  
Mature Adipose Tissue ◽  
Spindle Cells ◽  
Whole Transcriptome Sequencing ◽  
Whole Transcriptome

Myofibroblastoma is a rare, benign stromal tumor with a diverse morphologic spectrum. Mammary-type myofibroblastoma (MTMF) is the extra-mammary counterpart of this neoplasm and its occurrence throughout the body has become increasingly recognized. Similar morphologic variations of MTMF have now been described which mirror those seen in the breast. We describe a case of intra-abdominal MTMF composed of short fascicles of eosinophilic spindle cells admixed with mature adipose tissue. The spindle cells stained diffusely positive for CD34, desmin, smooth muscle actin, and h-caldesmon by immunohistochemistry. Concurrent loss of RB1 (13q14) and 13q34 loci were confirmed by fluorescence in situ hybridization whereas anchored multiplex PCR and whole transcriptome sequencing did not reveal any pathognomonic fusions suggesting an alternative diagnosis. To the best of our knowledge this is the first documented case of leiomyomatous variant of MTMF.

Inflammatory myofibroblastic tumor of larynx: a benign lesion with variable morphological spectrum

2007 ◽  
Vol 11 (6) ◽  
pp. 433-439 ◽  
Author(s):  
Muhammud T. Idrees ◽  
Youming Huan ◽  
Peak Woo ◽  
Beverly Y. Wang
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Benign Lesion

Abstract 12: The Effect of Extracellular Matrix Stiffness on Human Bone Marrow-Derived Mesenchymal Stem Cell Differentiation

2014 ◽  
Vol 115 (suppl_1) ◽  
Author(s):  
Alison L Müller ◽  
Yun Li ◽  
Boris Hinz ◽  
Darren H Freed
Keyword(s):  
Bone Marrow ◽  
Extracellular Matrix ◽  
Heart Surgery ◽  
Smooth Muscle Actin ◽  
Open Heart Surgery ◽  
Human Mesenchymal Stem Cells ◽  
Stem Cell Differentiation ◽  
The Body ◽  
Surface Tensions ◽  
Alpha Smooth Muscle Actin

Differentiation of human mesenchymal stem cells (hMSCs) has been shown to be influenced by the surrounding microenvironment. It is important to understand the physiological implications of the hMSC microenvironment regarding differentiation within the body, especially in patients with cardiovascular disease. We are interested in understanding the influence of differing extracellular matrix (ECM) stiffness found in the body that the MSC encounters during its journey from the bone marrow to the infarct scar in patients recovering from a myocardial infarction. As hMSCs must respond rapidly to their environment, we also investigated the influence of microRNA at different surface tensions. HMSCs were isolated from the bone marrow of patients undergoing open heart surgery and cultured in standard DMEM/F12 with 20% FBS. We plated these cells on fibronectin-coated plates with surface tensions of 2kPa, simulating bone marrow; 15kPa, simulating left ventricle; and 100kPa, simulating a fibrotic environment. Protein and mRNA were collected for further analysis. Our data have revealed that softer surface tensions, representing a bone marrow-undifferentiating environment, cause a decrease in the protein expression of EDA-fibronectin and alpha-smooth muscle actin. There were also increases in mRNA of myosin heavy chain-9 and 10, and collagen-1. Softer surface tensions also show a slight increase in miR-301a, although at 15kPa, miR-301a expression is increased even further. Our lab has previously shown that miR-301a is involved in maintaining a proliferative phenotype of hMSCs. Interestingly, Dicer1, responsible for processing microRNAs, is upregulated at softer surface tensions and attenuated at 15kPa. Dicer1 mRNA expression is attenuated at 15kPa. These results indicate that ECM stiffness influences hMSC differentiation and the increase in Dicer1 found with softer matrices could represent an umbrella miRNA inhibition effect to effectively suppress hMSC differentiation.

scholarly journals Inflammatory myofibroblastic tumor of the pancreas in a dog

2019 ◽  
Vol 31 (6) ◽  
pp. 879-882
Author(s):  
Mariarita Romanucci ◽  
Sabrina V. P. Defourny ◽  
Marcella Massimini ◽  
Laura Bongiovanni ◽  
Giovanni Aste ◽  
...  
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Distress Syndrome ◽  
Plasma Cells ◽  
Smooth Muscle Actin ◽  
S100 Protein ◽  
Variable Number ◽  
Postmortem Examination ◽  
Muscle Actin ◽  
Coagulative Necrosis ◽  
Spindle Cells

A large, ill-defined, firm, multinodular mass involving the pancreas was confirmed on postmortem examination of a 5-y-old, male Rottweiler that died following acute respiratory distress syndrome, after a period of anorexia and lethargy. Histologically, the mass consisted of plump spindle cells admixed with a variable number of macrophages, lymphocytes, plasma cells, and neutrophils. Foci of coagulative necrosis and hemorrhage were also observed. Spindle cells strongly reacted to antibodies against vimentin, α–smooth muscle actin, and calponin, whereas desmin was expressed only mildly and focally. Pan-cytokeratin, KIT, glial fibrillary acidic protein, and S100 protein were nonreactive. Variable numbers of MAC 387–positive cells, CD3+ lymphocytes, and numerous blood vessels were also detected throughout the mass. Histologic and IHC findings were consistent with a diagnosis of inflammatory myofibroblastic tumor of the pancreas.

scholarly journals A Rare Presentation of Inflammatory Myofibroblastic Tumor in the Nasolabial Fold

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Hind K. Alshammari ◽  
Haya F. Alzamami ◽  
Mona Ashoor ◽  
Wasan F. Almarzouq ◽  
Haitham Kussaibi
Keyword(s):  
Inflammatory Myofibroblastic Tumor ◽  
Soft Tissues ◽  
Histopathological Examination ◽  
Benign Lesion ◽  
Neck Region ◽  
Surgical Excision ◽  
Nasolabial Fold ◽  
Rare Presentation ◽  
The Central Nervous System ◽  
Sublabial Approach

Inflammatory myofibroblastic tumor (IMT) is a benign lesion that occurs most frequently in the soft tissues and viscera. In the head and neck region, the tumor has been reported to occur in the orbit, tongue, nasopharynx, larynx, and paranasal sinuses and the central nervous system. Despite being a benign lesion, it exhibits infiltrative and destructive behaviours, making histopathological examination necessary to confirm the diagnosis. We report the case of a 38-year-old female presented with a right nasolabial fold mass, which was confirmed histologically to be an IMT. Surgical excision of the mass was achieved through a sublabial approach with an uneventful postoperative period. To the best of our knowledge, this is the first reported case of an IMT in the nasolabial fold.

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