scholarly journals A Randomized Clinical Trial ofSchinus terebinthifoliusMouthwash to Treat Biofilm-Induced Gingivitis

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Irlan de Almeida Freires ◽  
Livia Araújo Alves ◽  
Gabriela Lacet Silva Ferreira ◽  
Vanessa de Carvalho Jovito ◽  
Ricardo Dias de Castro ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Phase Ii ◽  
Oral Hygiene ◽  
Gingival Inflammation ◽  
Randomized Controlled ◽  
Gingival Bleeding ◽  
Significant Difference ◽  
Intervention Protocol ◽  
And Control

Objectives. This study aimed to investigate the efficacy of aSchinus terebinthifolius(ST) mouthwash in reducing gingival inflammation levels (GI) and biofilm accumulation (BA) in children with gingivitis.Methods. This was a randomized, controlled, triple blind, and phase II clinical trial, with children aged 9–13 years presenting with biofilm-induced gingivitis. The sample was randomized into experimental (0.3125% ST, ) and control (0.12% chlorhexidine/CHX, ) groups. Products were masked as regards color, flavor and aroma. Intervention protocol consisted in supervised rinsing of 10 mL/day for 01 minute for 10 days. Gingival bleeding and simplified oral hygiene indexes were used to assess the efficacy variables, measured at baseline and after intervention by calibrated examiners. Data were statistically treated with pairedt-test, unpairedt-test, and Wilcoxon and Mann-Whitney tests (α= .05).Results. It was found that both ST and CHX were able to significantly reduce GI levels after 10 days and there was no significant difference between them . CHX was the only product able to significantly reduce BA after 10 days when compared to baseline .Conclusion. ST mouthwash showed significant anti-inflammatory activity (equivalent to CHX), but it was not able to reduce biofilm accumulation.

scholarly journals Evaluating the Effects of Spraying Oxytetracycline on Diabetic Foot Ulcers: A Randomized Clinical Trial

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Gholam Hosein Kazemzadeh ◽  
Hasan Ravari ◽  
Masomeh Nabavizadeh ◽  
Saeid Pasban Noghabi
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Diabetic Foot ◽  
Intervention Group ◽  
Purulent Discharge ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Diabetic Foot Ulcers ◽  
Significant Difference ◽  
And Control

Background: Diabetic foot ulcers (DFUs) can be created due to neuropathy and peripheral vascular disease in the lower limbs. Objectives: This study aimed to evaluate the effects of spraying oxytetracycline on DFU. Methods: This randomized clinical trial was conducted on 60 diabetic patients suffering from DFU. The patients were randomly assigned into two equal groups of intervention and control (n = 30 each). While all subjects received antibiotic therapy, blood sugar control, and, if necessary debridement, the intervention group received oxytetracycline spraying on the DFUs twice a day. After the intervention, the patients were visited every week (for three weeks), photos were taken of the DFUs by special software, and the size of the DFUs was checked. The DFUs were also studied in terms of purulent discharge, the smell, and erythema, and edema around the ulcer. After three weeks, the healing of ulcers were compared in the two groups. Data were gathered and analyzed using the SPSS software version 11.5, descriptive statistical test, chi-square, and t-test. Results: Before the study, the size of the DFUs in the intervention and control groups was 110.87 ± 38.3 and 127.12 ± 40 mm2, respectively. After the treatment, the alterations in the intervention group in the first, second, and third weeks were 14.90 ± 14.41, 26.93 ± 18.86, and 41.25 ± 19.51, respectively. Also, in the control group, the alterations were 19.45 ± 1.35, 23.78 ± 5.31, and 13.29 ± 8.75, respectively. There was a statistically significant difference in the size of DFUs between the two groups (P < 0.05). Conclusions: According to the results, spraying oxytetracycline on DFUs facilitated the process of healing. Thus, it can be used as an affordable, available, and effective method.

Effect of Low-Pressure Drainage Suction on Pharyngocutaneous Fistula After Total Laryngectomy

2020 ◽  
Vol 130 (1) ◽  
pp. 32-37
Author(s):  
Mojtaba Maleki Delarestaghi ◽  
Aslan Ahmadi ◽  
Fatemeh Dehghani Firouzabadi ◽  
Maryam Roomiani ◽  
Mohammad Dehghani Firouzabadi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Total Laryngectomy ◽  
Recovery Time ◽  
Low Pressure ◽  
Control Group ◽  
Pharyngocutaneous Fistula ◽  
Significant Difference ◽  
Drain Group ◽  
And Control

Objective: Pharyngocutaneous fistula (PCF) is one of the most severe multifactorial complications following laryngectomy. The current study aimed at determining the effect of a low-pressure vacuum drain on the incidence of PCF after total laryngectomy. Methods: The current randomized clinical trial was conducted on 35 patients undergoing total laryngectomy in Hazrat Rasoul Akram and Firoozgar hospitals in Tehran, Iran. The subjects were divided into the vacuum drain (n = 15) and control (without vacuum drain) (n = 20) groups. The incidence of PCF and the recovery time were recorded. Results: The rate of PCF formation from the stoma and wound edges was significantly lower in the low-pressure vacuum drain group than in the control group (6.7% vs 40%) ( P < .05). There was no significant difference between the groups in time to recovery from PCF. Conclusion: The low-pressure vacuum drain method is effective in reducing the incidence of PCF after total laryngectomy.

scholarly journals Effect of lavender aromatherapy on well-being among hemodialysis patients: A randomized clinical trial

2018 ◽  
Author(s):  
Masoumeh Bagheri Nesami ◽  
Seyed Afshin Shorofi ◽  
Attieh Nikkhah ◽  
Hossein Roohi Moghaddam ◽  
Ali Mahdavi
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Well Being ◽  
Underlying Disease ◽  
Hemodialysis Patients ◽  
Control Group ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Experimental Group

  In spite of the improvement of dialysis techniques, hemodialysis patients still experience debilitation. Impaired functioning, well-being, and quality of life are among the factors that are of a great concern in these patients. The current study aimed to examine the effects of lavender essential oil on well-being among hemodialysis patients. This randomized clinical trial was conducted on 30 hemodialysis patients. For each patient in the experimental group, five cotton balls were prepared using two drops of lavender essence diluted with sweet almond oil. Lavender was used at five concentrations of 10%, 20%, 30%, 40%, and 50%, administered through pinning the soaked cotton ball on the patients' collar on the first, second, third, fourth, and fifth weeks of the intervention, respectively. The patients were asked to breathe normally for 20 min. On the other hand, the control group received only routine nursing care. The perceived sense of well-being was measured in both groups at the end of each week using a visual analog scale. The mean ages of patients were obtained as 58.9 ± 14.31 and 53.03 ± 15.84 years for the experimental and control groups, respectively. Hypertension was reported to be the most common underlying disease in both groups. The results showed a significant difference in the mean level of well-being in the experimental group in the fourth and fifth weeks of the intervention, compared to that before the intervention. Inhalation aromatherapy with 40% and 50% lavender essence had a positive effect on the perceived sense of well-being in hemodialysis patients. However, lower concentrations of 10%, 20%, and 30% did not exert a comparable effect.

scholarly journals The Effect of Valerian and Ginger on Dysmenorrhea: A Randomized Clinical Trial

2018 ◽  
Vol 8 (1) ◽  
pp. 101-105
Author(s):  
Masoumeh Davood Abadi ◽  
Katayon Vakilian ◽  
Nafiseh Seyyed Zadeh Aghdam ◽  
Mehdi Ranjbaran
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Chi Square ◽  
Significance Level ◽  
Young Females ◽  
Analgesic Effects ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Analgesic Use

Objectives: Dysmenorrhea is a frequent complaint in young females. In recent years, researchers have grown an interest in the use of herbal drugs to decrease menstrual pain given the side effects of chemical drugs. This project was conducted to evaluate the effect of valerian and ginger on the duration of pain and analgesic use in dysmenorrhea. Materials and Methods: This triple-blind randomized clinical trial was performed on 210 dormitory females who were randomly divided into valerian, ginger, and control groups after opening an envelope. In this study, 250 and 350 mg of ginger and valerian in each capsule were administered, respectively, and 250 mg sugar was used as a placebo. The number of days with pain and analgesic use were evaluated as well. Finally, descriptive (percentage and mean) and inferential (t test, post hoc, and chi-square at a significance level of 0.05) statistics were used to analyze the data. Results: The results of the study showed a marginally significant difference in the duration of pain between ginger (1.61±0.64 days) and control (2.12±0.81 days) groups (P=0.052), and significant difference between ginger (1.61±0.64 days) and valerian (2.53±1.43 days) groups (P=0.001). The mean days of analgesic use among the three groups were not different significantly (P>0.05). However, the mean severity of symptoms significantly differed between ginger (0.73±0.28) and control (0.3±0.04) groups and increased in the ginger group (P=0.003). Conclusions: In general, the administration of valerian and ginger at the doses used in this study failed to produce desirable analgesic effects and thus could not decrease the symptoms associated with dysmenorrhea

Evaluation of periodontal indices in young adults submitted to chlorhexidine 0.12% mouthwash: a randomized clinical trial

2021 ◽  
Vol 50 ◽  
Author(s):  
Nathale Cruz BATISTA ◽  
Camila Possal de PAULA ◽  
Isis Andréa Venturini Pola POIATE ◽  
Edgard POIATE JUNIOR ◽  
Elizangela Cruvinel ZUZA ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Young Adults ◽  
Randomized Clinical Trial ◽  
Oral Hygiene ◽  
Saline Solution ◽  
Gingival Index ◽  
Gingival Inflammation ◽  
Inflammatory Agent ◽  
Probing Depth ◽  
Periodontal Indices

Abstract Introduction Gingivitis is a gingival inflammation which can often be treated with oral hygiene such as brushing, flossing, and an antiseptic mouthwash. Objective The aim of this randomized clinical trial was to clinically evaluate the effectiveness of 0.12% chlorhexidine (CHX) solution as an anti-inflammatory agent and for reducing the presence of plaque and inflammation in young adults. Material and method Thirty patients with gingivitis aged 18 to 30 years with a probing depth ≤ 3 mm and a minimum of 20 teeth in the whole mouth were selected and evaluated at baseline and 30 days after treatment. Periodontal clinical parameters were verified: plaque index (PI), gingival index (GI), Simplified Oral Hygiene Index (OHI-S), Simplified Debris Index (DI-S), and Simplified Calculus Index (CI-S) Patients were then randomly allocated into two groups: CHX Group, received chlorhexidine 0.12% labeled as solution 1, and Placebo Group, received saline solution labeled as solution 2. Both groups were included in a hygiene program and received mouthwash. Result Statistically significant differences between CHX and Placebo groups were observed for the variables PI, GI, DI-S, CI-S, and OHI-S (p<0.05 - Paired T Test) after 30 days. The CHX group presented improved GI compared to Placebo at 30 days. Chlorhexidine 0.12% was efficient in the control of periodontium inflammation. Conclusion It can be concluded that chlorhexidine as a mouthwash is efficient in improving periodontal indices in young adults, but it is still controversial whether age can influence GI and OHI-S.

scholarly journals EFFECTIVENESS OF TOOTHPASTE CONTAINING PROPOLIS, TEA TREE OIL, AND SODIUM MONOFLUOROPHOSPHATE AGAINST PLAQUE AND GINGIVITIS

2019 ◽  
pp. 114-116 ◽  
Author(s):  
NELLY SURIAMAH ◽  
ROBERT LESSANG ◽  
YULIANTI KEMAL
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Dental Plaque ◽  
Periodontal Diseases ◽  
Test Group ◽  
Plaque Index ◽  
Tea Tree Oil ◽  
Tea Tree ◽  
Gingival Bleeding ◽  
And Control

Objective: Natural ingredients such as propolis and tea tree oil are known to possess antibacterial and anti-inflammatory effects that areeffective against periodontal diseases. This study aimed to determine the effectiveness of toothpaste containing propolis, tea tree oil, and sodiummonofluorophosphate against dental plaque and gingivitis.Methods: A randomized clinical trial was conducted for 7 days with 20 subjects in test (using the experimental toothpaste) and control (usingtoothpaste without any natural ingredients) groups each. Measurements of plaque index (PI) and papillary bleeding index (PBI) scores wereperformed on days 0 and 7.Results: Significant decreases (p<0.05) in PI (0.53–0.27) and PBI (0.55–0.11) scores were noted in the test group but not in the control group.Conclusions: Brushing teeth with toothpaste containing propolis, tea tree oil, and sodium monofluorophosphate might be effective in reducing theaccumulation of dental plaque and the severity of gingival bleeding.

scholarly journals Effectiveness of Acupressure on the Taichong Acupoint in Lowering Blood Pressure in Patients with Hypertension: A Randomized Clinical Trial

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Gan-Hon Lin ◽  
Wei-Chun Chang ◽  
Kuan-Ju Chen ◽  
Chen-Chen Tsai ◽  
Sung-Yuan Hu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Care Plan ◽  
Control Group ◽  
Optimal Dosage ◽  
Hypertensive Patients ◽  
Significant Difference ◽  
And Control ◽  
Experimental Group

Objectives. To evaluate the effectiveness of acupressure on the Taichong acupoint in lowering systolic and diastolic blood pressure (BP) in hypertensive patients.Methods. Eighty patients with hypertension attending a cardiology outpatient department in central Taiwan were included in this randomized clinical trial. Acupressure was applied to the Taichong acupoint in the experimental group (n=40) and to the first metatarsal (sham acupoint) in the control group (n=40). Blood pressure was measured by electronic monitoring before and immediately 15 min and 30 min after acupressure.Results. The average age of the experimental and control participants was 59.3 ± 9.2 years and 62.7 ± 8.4 years, respectively. The two groups were similar for demographics and antihypertensive drug use. Mean systolic and diastolic BP in the experimental group decreased at 0, 15, and 30 min after acupressure (165.0/96.3, 150.4/92.7, 145.7/90.8, and 142.9/88.6 mmHg); no significant changes occurred in the control group. There was a significant difference in systolic and diastolic BP between the experimental and control groups immediately and 15 and 30 min after acupressure (p<0.05).Conclusion. Acupressure on the Taichong acupoint can lower BP in hypertensive patients and may be included in the nursing care plan for hypertension. However, additional studies are needed to determine the optimal dosage, frequency, and long-term effects of this therapy.

scholarly journals The herbal combination of Sugarcane, Black Myrobalan, and mastic as a supplementary treatment for COVID-19: a randomized clinical trial

2021 ◽  
Author(s):  
Alireza Hashemi Shiri ◽  
Esmaeil Raiatdoost ◽  
Hamid Afkhami ◽  
Ruhollah Ravanshad ◽  
Seyed Ehsan Hosseini ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Intervention Group ◽  
Treatment Protocol ◽  
Vital Signs ◽  
Control Group ◽  
Event Analysis ◽  
Herbal Supplement ◽  
Significant Difference ◽  
And Control

AbstractBackgroundGiven the COVID-19 pandemic’s, researchers are beseeched for effective treatments. Herbal medicine is also queried for potential supplementary treatments for COVID-19. We aimed to evaluate the effects of Sugarcane, Black Myrobalan, and Mastic herbal medications for COVID-19 patients.MethodsThis was a double-blinded randomized clinical trial study conducted over three months from May to July 2020 in patients admitted with a diagnosis of COVID-19 in Peymaniyeh Hospital in Jahrom, Iran. The intervention group received the treatment protocol approved by the Ministry of Health of Iran during the period of hospitalization and the herbal supplement obtained from the combination of black myrobalan and mastic and sugarcane, twice a day (3g of herbal supplements). All patients were compared in terms of demographic variables, vital signs, clinical and laboratory variables.Results72 patients with COVID-19, divided into intervention (n=37) and control (n=35) groups. intervention and control groups had not any significant difference in terms of baseline characteristics. The time-to-event analysis revealed a significant difference in 4 symptoms of cough, fever, dyspnea, and myalgia (P<0.05). The Control group had a significantly lower decrease in C-reactive protein during 7 days (P<0.05). Patients in the herbal supplement group were hospitalized for 4.12 days and in the control group were hospitalized for 8.37 days (P=0.001). ICU admission and death only happened in 3 (8.6%) patients of the control group.ConclusionWhile advanced studies with more sample size are needed; the proposed combination seems to be effective in the symptom treatment and reducing the length of hospitalization.

scholarly journals Evaluation of Dorema Ammoniacum and Acupuncture's Therapeutic Effects in Patients With Ischemic Stroke: A Randomized Controlled Clinical Trial 

2020 ◽  
Author(s):  
Mahsa Mehrpour ◽  
Mahdi Yousefi ◽  
Monavar AfzalAghaee ◽  
Hasan Rakhshandeh ◽  
Hoda Azizi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Ischemic Stroke ◽  
Acupuncture Group ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Control Groups ◽  
Randomized Controlled ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Abstract Aim: Stroke is the third prevalent cause of disability worldwide. This study aimed to evaluate the role of Dorema ammoniacum and acupuncture in the management of patients with stroke.Methods: In this randomized controlled clinical trial, patients with a recent ischemic stroke (within the first month of stroke) were investigated. The patients were divided into three groups. The first group was managed by acupuncture, while the second group received 1 g of Dorema ammoniacum (two 500 mg capsules per day) from ammoniacum gum. The two intervention groups also received standard treatment with routine medical therapy and physiotherapy. The final group was the control, which only received conventional treatment and physiotherapy. The patients were evaluated immediately before the interventions, and one month after the interventions, using the Modified Rankin Scale (mRS) and Modified National Institutes of Health Stroke Scale (mNIHSS).Results: There was a significant difference in the mean score of mNIHSS at the beginning and end of the study in all of the three studied groups (P<0.001). There were significant pre-treatment/post-treatment differences between the groups (P<0.001). After controlling for the effect of mNIHSS score at the beginning of the study and the follow-up visit, a significant difference was observed between the three groups regarding the mean mNIHSS score post-intervention (P<0.001). The results of the post-hoc test indicated a significant difference between the acupuncture and control groups, Dorema ammoniacum and control groups (P<0.001), acupuncture, and Dorema ammoniacum groups (P<0.001); the extent of reduction was greater in the acupuncture group. The mean mNIHSS scores of the acupuncture and Dorema ammoniacum groups were 1.82 and 1.04 lower than the control group's mean score, respectively. There was a significant difference in the mean mRS score at the beginning and end of the study in all three groups (P<0.001). However, the extent of reduction was greater in the acupuncture group.Conclusion: Acupuncture and Dorema ammoniacum may be beneficial if started within the first month of stroke incidence. However, acupuncture can cause a greater reduction in the mNIHSS score of stroke patients. Trial registration: Iranian Registry of Clinical Trials (IRCT20170227032797N2).Registered 5 March 2018 - Retrospectively registered, https://www.irct.ir/trial/25469

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