scholarly journals Agomelatine Efficacy in the Night Eating Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Walter Milano ◽  
Michele De Rosa ◽  
Luca Milano ◽  
Anna Capasso

Night eating syndrome (NES) is a nosographic entity included among the forms not otherwise specified (EDNOS) in eating disorders (ED) of the DSM IV. It is characterized by a reduced food intake during the day, evening hyperphagia, and nocturnal awakenings associated with conscious episodes of compulsive ingestion of food. Frequently, NES patients show significant psychopathology comorbidity with affective disorders. This paper describes a case report of an NES patient treated with agomelatine, an antidepressant analogue of melatonin, which acts by improving not only the mood but also by regulating sleep cycles and appetite. After three months of observation, the use of Agomelatine not only improved the mood of our NES patient (assessed in the HAM-D scores) but it was also able to reduce the night eating questionnaire, by both reducing the number of nocturnal awakenings with food intake, the time of snoring, the minutes of movement during night sleep (assessed at polysomnography), and the weight (−5.5 kg) and optimizing blood glucose and lipid profile. In our clinical case report, agomelatine was able both to reduce the NES symptoms and to significantly improve the mood of our NES patient without adverse side effects during the duration of treatment. Therefore, our case report supports the rationale for further studies on the use of Agomelatine in the NES treatment.

2013 ◽  
Vol 28 (S2) ◽  
pp. 98-98
Author(s):  
C. Foulon

L’individualisation des troubles alimentaires dans le sens d’un excès d’alimentation s’est faite très tardivement par rapport aux troubles dits restrictifs. les critères de la boulimie ont été pour la première fois décrits par Russell en 1976. les troubles alimentaires se sont divisés en Anorexie mentale avec deux sous-types (restrictif et purgatif) et Boulimie dite « normopondérée ». Tous les autres tableaux cliniques qui ne remplissaient pas la totalité des critères d’un de ses deux troubles entraient dans la catégorie des troubles alimentaires non spécifiés « Eating Disorders not Otherwise Specified ou EDNOS » dans le DSM IV TR. Ces catégories ne semblaient pas pertinentes pour décrire l’ensemble de la pathologie et il est apparu nécessaire de les refondre. les critères de diagnostic tels qu’ils étaient proposés ne permettaient pas de décrire des formes modérées de ces troubles et de pouvoir rendre compte du degré de sévérité du symptôme ou de l’existence de stratégies de contrôle du poids. les classifications se sont faites de façon empirique. Parallèlement à ces classifications (DSM IV TR, CIM 10), différents travaux se sont appliqués à prendre en compte une plus grande diversité de symptômes avec en particulier la description du syndrome d’alimentation nocturne « Night Eating Syndrome ou NES ». Le DSM V a intégré ces travaux et a reconnu comme trouble l’hyperphagie boulimique « binge eating disorder » qui se définit comme l’ingestion de grandes quantités de nourriture sur une courte période avec sentiment de perte de contrôle ce qui le différencie du phénomène plus courant de l’hyperphagie qui est associé à moins de problèmes physiques et psychologiques. La conséquence de ces désordres liés à l’excès de nourriture sont le surpoids et surtout l’obésité avec ses conséquences somatiques. Le fait d’avoir une description clinique précise de ces troubles permet de leur appliquer des thérapeutiques pertinentes. les propositions de traitement doivent absolument tenir compte des caractéristiques cliniques et psychologiques des sujets.


2016 ◽  
Vol 33 (S1) ◽  
pp. S164-S165
Author(s):  
M. Martellini ◽  
M. Barchiesi ◽  
M.G. Oriani ◽  
B. Nardi

IntroductionThe night eating syndrome (NES) is a categorized in the diagnostic and statistic manual (DSM-5) as an “Other Specified Feeding or Eating Disorder” and it is characterized by a reduced feeding during the day, evening hyperphagia accompagned by frequent nocturnal awakenings associated with conscious episodes of compulsive ingestion of food and abnormal circadian rhythms of food and other neuroendocrine factors. Frequently it is associated with obesity and depressed mood.ObjectivesThe purpose of this review is to investigate the state of art concerning the psychopharmacological treatment of NES.MethodsA Medline enquiry of published articles from 2005 to October 2015 was performed using the following keywords: “NES, pharmacological treatment, SSRI, antidepressants, antipsychotic, sertraline, citalopram, escitalopram, duloxetine, venlafaxine, paroxetine, fluoxetine, fluvoxamine, topiramate”. Reviews, single case studies and RCT were also analyzed.ResultsOnly few studies met the selection criteria. A recent 8-week double-blind placebo controlled study, in 34 patients with NES, has confirmed the efficacy of sertraline. Sertraline was associated with significantly greater improvement than placebo in overall symptomatology.ConclusionsSSRIs should be considered the drug of choice for the treatment of NES not only because of evidence in the literature but also since they display the best pharmacological profiles with fewer adverse events. More evidence of efficacy is shown for some SSRIs such us paroxetine, fluvoxamine and especially sertraline. Topiramate should be reserved for cases resistant to treatment with SSRIs.Disclosure of interestThe authors have not supplied their declaration of competing interest.


Author(s):  
Kelly C. Allison ◽  
Jennifer D. Lundgren

The Diagnostic and Statistical Manual (DSM-IV-TR) of the American Psychiatric Association (2000) is currently being revised and new disorders are being considered for inclusion in DSM-V. In this chapter, we evaluate three proposed eating disorders for the DSM-V: binge eating disorder (BED), night eating syndrome (NES), and purging disorder (PD). The history and definition for each is reviewed, relevant theoretical models are presented and compared, and evidence for the usefulness of the models is described. Empirical studies of all three disorders show their independence from other disorders, although comorbid psychopathology is common. Psychological distress is also high, but evidence for negative impact on physical health is less pronounced. Finally, remaining questions for future research are summarized.


2016 ◽  
Vol 33 (S1) ◽  
pp. S426-S426
Author(s):  
F. Coutinho ◽  
I. Brandão

IntroductionNight Eating Syndrome (NES) was described in 1955 in a subset of patients resistant to weight loss. It is characterized by morning anorexia, evening hyperfagia and sleep disturbances. It is also more prevalent among patients with another eating disorder (ED), particularly binge-eating disorder (BED) or bulimia nervosa (BN).ObjectiveReview of the literature about the relationship between NES and another EDs and to present a case report of a patient with a long-standing purgative anorexia nervosa (AN-BP) and comorbid NES.Methodsreview of the literature using the database Medline through Pubmed, with the keywords: “night eating syndrome” and “eating disorder”.ResultsNES is highly prevalent among patients with EDs, with an estimated prevalence of about 5–44%. However, most of the existent literature explores the relationship between NES and BED or BN, and it is not consensual if NES is a subtype of another ED. There is still scarce evidence about NES and AN comorbidity.ConclusionIn this case report, we present a patient with a history of AN-BP, in which the recovery of lost weight and the increase of body mass index (BMI) occurred simultaneously with a period of worsening NES symptoms, which leads the authors to question if the psychopathology of NES has contributed to the recovery of BMI at the expense of maintaining a dysfunctional eating pattern.Disclosure of interestThe authors have not supplied their declaration of competing interest.


2003 ◽  
Vol 33 (3) ◽  
pp. 317-322 ◽  
Author(s):  
Cynthia L. Baxter ◽  
William D. White

Coma is present when the patient appears asleep, is unrousable, and unresponsive. Where no underlying medical condition is found, the role of the psychiatrist may become prominent. We present a clinical case and review the literature on psychogenic coma. According to DSM-IV-TR, psychogenic coma is a dissociative disorder not otherwise specified. Management is largely supportive. Principles include speaking in a reassuring manner and avoiding repeated painful stimuli. Education of family and other professionals that symptoms are real and not consciously feigned may be important. There may be a short-term role for anxiolytic and/or antipsychotic medication to assist return to consciousness.


Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4179
Author(s):  
Kentaro Matsui ◽  
Yoko Komada ◽  
Isa Okajima ◽  
Yoshikazu Takaesu ◽  
Kenichi Kuriyama ◽  
...  

This web-based cross-sectional survey aimed to elucidate the differences between the two core symptoms of night eating syndrome (NES): evening hyperphagia and nocturnal ingestion in the general Japanese population aged 16–79 years. Participants who consumed at least 25% of daily calories after dinner were defined as having evening hyperphagia. Those who consumed food after sleep initiation at least twice a week were determined to have nocturnal ingestion. Of the 8348 participants, 119 (1.5%) were categorized in the evening hyperphagia group, 208 (2.6%) in the nocturnal ingestion group, and 8024 in the non-NES group. Participants with evening hyperphagia and nocturnal ingestion had significantly higher anxiety scores (p < 0.05 and p < 0.001, respectively) and depression (p < 0.001 for both) than those without NES. Multiple logistic regression analysis revealed that evening hyperphagia was significantly and independently associated with higher body mass index, shorter sleep duration, later sleep-wake schedule, and higher insomnia score, while nocturnal ingestion was significantly and independently associated with younger age, smoking habit, living alone, earlier sleep-wake schedule, and higher insomnia score. Sleep duration and sleep-wake schedule characteristics in the two groups were opposite, suggesting differences in the sleep pathophysiology mechanisms.


2008 ◽  
Vol 87 (6) ◽  
pp. 1672-1677 ◽  
Author(s):  
Raymond C Boston ◽  
Peter J Moate ◽  
Kelly C Allison ◽  
Jennifer D Lundgren ◽  
Albert J Stunkard

2017 ◽  
Author(s):  
Senay Topsakal ◽  
Guzin Fidan Yaylalı ◽  
Semin Melahat Fenkci

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