scholarly journals Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Xiang Wang ◽  
Shunbo Li ◽  
Limu Wang ◽  
Xin Yi ◽  
Yu Sanna Hui ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Iron Nanoparticles ◽  
High Accuracy ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
On Demand ◽  
Chemical Release ◽  
Magnetic Stimulus ◽  
Active Chemical ◽  
Sigmoidal Model

We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involvingEscherichia coliculture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.

A SUBCUTANEOUS INJECTION ASSAY FOR ANTI-ANDROGENS IN THE CHICK

1962 ◽  
Vol 41 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Ralph I. Dorfman
Keyword(s):  
Dose Response ◽  
Subcutaneous Injection ◽  
Response Relationship ◽  
Dose Response Relationship

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.

ACHIEVING HIGH ACCURACY IN AN ATTACK-PATH RECONSTRUCTION IN MARKING ON DEMAND SCHEME

2016 ◽  
Vol 5 (3) ◽  
pp. 24 ◽  
Author(s):  
PRAKASH P. BANU ◽  
KRISHNA E.S. PHALGUNA ◽  
◽  
Keyword(s):  
High Accuracy ◽  
On Demand ◽  
Attack Path

Mathematical Interpretation of the Pharmacodynamics of Homoeopathic Medicines

2021 ◽  
Vol 34 (01) ◽  
pp. 003-016
Author(s):  
John Michel Warner
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Dose Response ◽  
Oral Route ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Force Line ◽  
Administration Routes ◽  
Medicinal Substances ◽  
Medicine Administration

AbstractAccording to Hahnemann, homoeopathic medicines must be great immune responses inducers. In crude states, these medicines pose severe threats to the immune system. So, the immune-system of an organism backfires against the molecules of the medicinal substances. The complex immune response mechanism activated by the medicinal molecules can handle any threats which are similar to the threats posed by the medicinal molecules. The intersectional operation of the two sets, medicine-induced immune responses and immune responses necessary to cure diseases, shows that any effective homoeopathic medicine, which is effective against any disease, can induce immune responses which are necessary to cure the specific disease. In this article, this mechanism has been exemplified by the action of Silicea in human body. Also, a neuroimmunological assessment of the route of medicine administration shows that the oral cavity and the nasal cavity are two administration-routes where the smallest doses (sometimes even few molecules) of a particular homoeopathic medicine induce the most effective and sufficient (in amount) purgatory immune responses. Administering the smallest unitary doses of Silicea in the oral route can make significant changes in the vital force line on the dose–response relationship graph. The dose–response relationship graph further implicates that the most effective dose of a medicine must be below the lethality threshold. If multiple doses of any medicine are administered at same intervals, the immune-system primarily engages with the medicinal molecules; but along the passage of time, the engagement line splits into two: one engages with the medicinal molecules and another engages with diseases. The immune system's engagement with the diseases increases along the passage of time, though the engagement with the medicinal molecules gradually falls with the administration of descending doses. Necessarily, I have shown through mathematical logic that the descending doses, though they seem to be funny, can effectively induce the most effective immune responses.

Optimizing Outcomes in Multiple Sclerosis – A Consensus Initiative

2009 ◽  
Vol 15 (2_suppl) ◽  
pp. 5-35 ◽  
Author(s):  
P Coyle ◽  
B Arnason ◽  
B Hurwitz ◽  
F Lublin
Keyword(s):  
Disease Progression ◽  
Online Survey ◽  
Initial Therapy ◽  
Clinically Isolated Syndrome ◽  
Optimal Management ◽  
Disease Course ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Key Issues ◽  
Delay Progression

Background Initiation of immunomodulators in patients experiencing a clinically isolated syndrome (CIS) may delay progression to clinically definite MS. However, lack of consensus remains on many issues affecting optimal management of MS. Method A panel of 21 MS experts met during 9 meetings to explore key issues in MS and CIS. Meetings addressed 3 phases: 1. CIS definition and diagnosis; 2. initial therapy; and 3. monitoring disease progression and treatment efficacy. Newsletters covering each phase were sent to 5000 U.S.-based neurologists who were invited to participate in an online survey on key issues. Results Most panel members agreed that early treatment may minimize neurodegeneration and most would recommend it for patients; that a dose-response relationship exists for beta-interferon therapy; that more aggressive therapy was most effective early in the disease course; and, that MRI has a role in monitoring disease progression. In face of suboptimal response, most would switch patients to a different therapy; while combination therapy would be reserved for those failing monotherapy regimes. Most online survey respondents agreed with these positions. Conclusions There was uniform consensus from this panel of MS experts that early initiation of immunomodulator therapy was beneficial for CIS patients.

Meta-analytic research of the dose-response relationship between salt intake and risk of heart failure

2021 ◽  
Author(s):  
Satoru Kodama ◽  
Chika Horikawa ◽  
Kazuya Fujihara ◽  
Mariko Hatta ◽  
Yasunaga Takeda ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dose Response ◽  
Salt Intake ◽  
Response Relationship ◽  
Dose Response Relationship
Sign in / Sign up

Export Citation Format

Share Document