scholarly journals Predictive Role of ADA in Bronchoalveolar Lavage Fluid in Making the Diagnosis of Pulmonary Tuberculosis

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Fariba Binesh ◽  
Abolhassan Halvani
Keyword(s):  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Study Groups ◽  
Lavage Fluid ◽  
Cross Sectional Study ◽  
Sputum Smear ◽  
Cross Sectional ◽  
Pulmonary Tb ◽  
Diagnostic Usefulness ◽  
Negative Sputum

Current diagnostic tests for tuberculosis (TB) are time-consuming. The aim of this study was to evaluate the diagnostic usefulness of ADA in bronchoalveolar lavage fluid in patients with pulmonary TB. A cross-sectional study was performed in Yazd, Iran, between 2009 and 2010. Patients suspected of pulmonary TB with negative sputum smear for AFB were included in the study. Mean ADA levels in BAL fluids were measured and compared between study groups. Sixty-three patients were enrolled in the study among which 15 cases had pulmonary TB, 33 had pulmonary diseases other than TB, and 15 subjects with normal bronchoscopy results were considered as controls. Mean ADA levels in BAL fluid were4.13±2.55,2.42±1.06, and1.93±0.88, respectively. This rate was significantly higher in the pulmonary TB group compared to the other two groups (P=0.001). Using ROC curve with a cut-off value of 3.5 IU/L, the highest sensitivity (57%) and specificity (84%) were obtained in diagnosis of TB. The results showed that although ADA activity in BAL fluid of pulmonary TB patients was higher than those seen in other diseases, a negative test does not rule out pulmonary TB.

scholarly journals Association of Socio-Demographic Profile with Prevalence of Multi Drug Resistant Tuberculosis among Retreated Pulmonary Tuberculosis Patients in North India

2018 ◽  
Vol 16 (1) ◽  
pp. 1-5
Author(s):  
A. Chaudhary ◽  
T. Mahmood ◽  
A.D. Shukla ◽  
A. Shreenivasa ◽  
Verma Arvind ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
North India ◽  
Sputum Smear ◽  
Cross Sectional ◽  
Pulmonary Tb ◽  
Demographic Profile ◽  
Resistant Tuberculosis ◽  
Multi Drug Resistant Tuberculosis ◽  
Mdr Tb ◽  
Education Status

Methods: An observational cross sectional study, which includes 116 patients of sputum smear positive pulmonary TB of age 18 or above. Further, detailed history taking regarding different demographic profile was done. Also, they were subjected to CB-NAAT and rifampicin resistant cases were considered as MDR-TB. Results: Proportion of MDR-TB was 31.89% among retreatment TB cases. 56.75 % (n=21) of MDR-TB cases were between the age group of 21-40 years. Proportion of MDR-TB was higher among males (75.67%), married (59.45%) and rural dwellers 59.45%. Proportion was 61.76% among patients with BMI <16; 31.57% with BMI 16-16.99, 28.57% with BMI 17-18.49 and 5.7% with BMI 18.50-24.99. MDRTB proportion was less 29.72% (n=11) in patients with history of TB contact in family. Pulmonary TB including MDR-TB was more common among illiterates (37.83% among MDR). Conclusion: Proportion of MDR-TB was high among retreatment cases in north India. Among them low BMI and education status are modifiable factor and this study signifies that MDR-TB burden can be reduced by improving health and education status of patient.

scholarly journals Comparison of Xpert MTB/RIF Assay and the Conventional Sputum Microscopy in DetectingMycobacterium tuberculosisin Northern Thailand

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Kanokwan Pinyopornpanish ◽  
Romanee Chaiwarith ◽  
Chansom Pantip ◽  
Rassamee Keawvichit ◽  
Kanlaya Wongworapat ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Sputum Smear ◽  
Cross Sectional ◽  
Sputum Microscopy ◽  
Lower Specificity ◽  
Negative Sputum ◽  
Low Sensitivity ◽  
Higher Sensitivity

Background.Despite low sensitivity in detection ofMycobacterium tuberculosis, sputum acid-fast smear remains the main diagnostic method. This study aimed to compare the diagnostic performance of Xpert MTB/RIF assay versus conventional sputum acid-fast smear.Materials and Methods.A cross-sectional study was conducted at Chiang Mai University Hospital, Thailand. Patients who were ≥15 years old and had clinically suspected pulmonary tuberculosis were included.Results.109 specimens from 57 patients were included. Using MGIT sputum culture as a reference standard, the sensitivity (SEN) and specificity (SPEC) for Xpert were 95.3% (95% CI, 84.2%, 99.4%) and 86.4% (95% CI, 75.7%, 93.6%). The SEN and SPEC for sputum acid-fast smear were 60.5% (95% CI, 44.4%, 75.0%) and 98.5% (95% CI, 91.8%, 100%). Xpert had significantly higher sensitivity (pvalue < 0.001) and lower specificity (pvalue = 0.022) than sputum acid-fast smear. Among 43 culture-provenM. tuberculosisspecimens, sensitivity of Xpert was 100% (95% CI, 86.7%, 100%) in acid-fast positive smears (n=26) and 88.2% (95% CI, 63.5%, 98.5%) in acid-fast negative smears (n=17).Conclusions.The good sensitivity and specificity of Xpert assay in detectingM. tuberculosisfrom sputum specimens may help in early diagnosis and treatment of pulmonary tuberculosis, particularly among patients who had acid-fast negative sputum smear.

scholarly journals SEROPREVALENCE OF HIV INFECTION IN PULMONARY TUBERCULOSIS PATIENTS.

2020 ◽  
pp. 1-3
Author(s):  
K.G.R. Mallan ◽  
A. Fathahudeen ◽  
Manjula V.D.
Keyword(s):  
Pulmonary Tuberculosis ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Sputum Smear ◽  
Cross Sectional ◽  
Tuberculosis Patients ◽  
Pulmonary Tb ◽  
Medical College ◽  
Elimination Programme ◽  
Kerala State

Aim : To Determine the seroprevalence of Human immunodeficiency virus infection among Pulmonary Tuberculosis patients in a tertiary care teaching institution, in Ernakulam district of Kerala state in India. Methods : Study was conducted in Respiratory medicine department and integrated counselling and testing centre (ICTC) of Government Medical College, Ernakulam With approval of IEC after getting written informed consent , a cross sectional study was conducted among 384 pulmonary TB patients who were registered under the National TB elimination Programme (RNTCP). Result :The prevalence of HIV among study population was 1.3 %. There was no gender difference while the highest age group less than 30 followed by 30-60. The major respiratory pathology among study subjects was consolidation (42.7%) followed by fibrosis(25.3%).Consolidation was a predominant presenting pathology seen in female pulmonary TB patients.The sensitivity of sputum smear against CBNAAT was 60.4% and specificity was 83%. Conclusion : The prevalence is low compared with the national average of 3 to 3.4 % HIV co infection among Tuberculosis patients during the study period.

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