scholarly journals Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-βKnockout Mice

2013 ◽  
Vol 2013 ◽  
pp. 1-17 ◽  
Author(s):  
Juanjuan Zhao ◽  
Susumu Urakawa ◽  
Jumpei Matsumoto ◽  
Ruixi Li ◽  
Yoko Ishii ◽  
...  
Keyword(s):  
Growth Factor ◽  
Superior Colliculus ◽  
Visual Information ◽  
Critical Role ◽  
Growth Factor Receptor ◽  
Distribution Patterns ◽  
Platelet Derived Growth Factor ◽  
Functional Development ◽  
Relay Nucleus ◽  
Emotional Deficits

The superior colliculus (SC), a relay nucleus in the subcortical visual pathways, is implicated in socioemotional behaviors. Homeoprotein Otx2 andβsubunit of receptors of platelet-derived growth factor (PDGFR-β) have been suggested to play an important role in development of the visual system and development and maturation of GABAergic neurons. Although PDGFR-β-knockout (KO) mice displayed socio-emotional deficits associated with parvalbumin (PV-)immunoreactive (IR) neurons, their anatomical bases in the SC were unknown. In the present study, Otx2 and PV-immunolabeling in the adult mouse SC were investigated in the PDGFR-βKO mice. Although there were no differences in distribution patterns of Otx2 and PV-IR cells between the wild type and PDGFR-βKO mice, the mean numbers of both of the Otx2- and PV-IR cells were significantly reduced in the PDGFR-βKO mice. Furthermore, average diameters of Otx2- and PV-IR cells were significantly reduced in the PDGFR-βKO mice. These findings suggest that PDGFR-βplays a critical role in the functional development of the SC through its effects on Otx2- and PV-IR cells, provided specific roles of Otx2 protein and PV-IR cells in the development of SC neurons and visual information processing, respectively.

Platelet-derived growth factor receptor-β promotes early endothelial cell differentiation

Blood ◽  
2006 ◽  
Vol 108 (6) ◽  
pp. 1877-1886 ◽  
Author(s):  
Charlotte Rolny ◽  
Ingrid Nilsson ◽  
Peetra Magnusson ◽  
Annika Armulik ◽  
Lars Jakobsson ◽  
...  
Keyword(s):  
Growth Factor ◽  
Critical Role ◽  
Embryonic Stem ◽  
Growth Factor Receptor ◽  
Embryoid Bodies ◽  
Platelet Derived Growth Factor ◽  
Perivascular Cells ◽  
Vascular Stability ◽  
Endothelial Cell Differentiation ◽  
Endothelial Growth Factor

AbstractPlatelet-derived growth factor BB (PDGF-BB) has been assigned a critical role in vascular stability by promoting the recruitment of PDGF receptor-β–expressing perivascular cells. Here we present data indicating that early hematopoietic/endothelial (hemangio) precursors express PDGFR-β based on coexpression with CD31, vascular endothelial growth factor receptor-2, and CD41 in 2 models: mouse yolk sac (embryonic day 8 [E8]) and differentiating mouse embryonic stem cells (embryoid bodies). Expression of PDGFR-β on hemangioprecursor cells in the embryoid bodies gradually disappeared, and, at E14, expression appeared on perivascular cells. Activation of the PDGFR-β on the hemangioprecursors accelerated the differentiation of endothelial cells, whereas differentiation of the hematopoietic lineage was suppressed. In E9.5 yolk sacs derived from recombinant mice expressing kinase-active PDGFR-β with an aspartic acid to asparagine (D894N) replacement in the kinase activating loop and from mice with ubiquitous expression of PDGF-BB driven by the Rosa26 locus, the number of CD41-expressing early hematopoietic cells decreased by 36% and 34%, respectively, compared with staged wild-type littermates. Moreover, enhanced vascular remodeling was evident in the Rosa26–PDGF-BB yolk sacs. We conclude that PDGFR-β is expressed on early hemangioprecursor cells, regulating vascular/hematopoietic development.

scholarly journals Cognitive and Socio-Emotional Deficits in Platelet-Derived Growth Factor Receptor-β Gene Knockout Mice

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e18004 ◽  
Author(s):  
Phuong Thi Hong Nguyen ◽  
Tomoya Nakamura ◽  
Etsuro Hori ◽  
Susumu Urakawa ◽  
Teruko Uwano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Knockout Mice ◽  
Gene Knockout ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Gene Knockout Mice ◽  
Emotional Deficits

Recent Advances on Epidermal Growth Factor Receptor as a Molecular Target for Breast Cancer Therapeutics

2020 ◽  
Vol 21 ◽  
Author(s):  
Swathi R. Shetty ◽  
Ragini Yeeravalli ◽  
Tanya Bera ◽  
Amitava Das
Keyword(s):  
Breast Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tyrosine Kinase ◽  
Critical Role ◽  
Growth Factor Receptor ◽  
Type I ◽  
Egfr Inhibition ◽  
Epidermal Growth

: Epidermal growth factor receptor (EGFR), a type-I transmembrane protein with intrinsic tyrosine kinase activity is activated by peptide growth factors such as EGF, epigen, amphiregulin, etc. EGFR plays a vital role in regulating cell growth, migration, and differentiation in various tissue-specific cancers. It has been reported to be overexpressed in lung, head, and neck, colon, brain, pancreatic, and breast cancer that trigger tumor progression and drug resistance. EGFR overexpression alters the signaling pathway and induces cell division, invasion, and cell survival. Our prior studies demonstrated that EGFR inhibition modulates chemosensitivity in breast cancer stem cells thereby serving as a potential drug target for breast cancer mitigation. Tyrosine kinase inhibitors (Lapatinib, Neratinib) and monoclonal antibodies (Trastuzumab) targeting EGFR have been developed and approved by the US FDA for clinical use against breast cancer. This review highlights the critical role of EGFR in breast cancer progression and enumerates the various approaches being undertaken to inhibit aggressive breast cancers by suppressing the downstream pathways. Further, the mechanisms of action of potential molecules at various stages of drug development as well as clinically approved drugs for breast cancer treatment are illustrated.

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