scholarly journals Anti-HLA and Anti-MICA Antibodies in Liver Transplant Recipients: Effect on Long-Term Graft Survival

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Michał Ciszek ◽  
Bartosz Foroncewicz ◽  
Krzysztof Mucha ◽  
Dorota Żochowska ◽  
Bogna Ziarkiewicz-Wróblewska ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Graft Survival ◽  
Graft Rejection ◽  
Liver Graft ◽  
Negative Group ◽  
Transplant Recipients ◽  
Blood Samples ◽  
Positive Group ◽  
Liver Transplant Recipients

Objective. Presence of anti-HLA antibodies has a well-known impact on kidney grafts survival; however their role in liver transplantation has not been fully elucidated. We conducted a 7-year prospective study to show correlation between presence of anti-HLA and anti-MICA antibodies and liver graft survival.Methods. Blood samples from 123 liver transplant recipients were collected during patients routine visits. Time from transplantation to blood sample collection was different for each patient. Blood samples were tested for anti-HLA (separately class I and II) and MICA antibodies using Luminex assays.Results. There were 32 (26%) patients with positive anti-HLA and 37 (30%) with positive anti-MICA antibodies. Graft loss occurred in 7 cases (23%) in anti-HLA positive group compared to 20 (22%) in anti-HLA negative group (P=ns) and in 8 cases (22%) in anti-MICA positive group but 19 (23%) in anti-MICA negative group (P=ns). No correlations were detected between presence of antibodies and acute graft rejection (AGR). Presence of any antibodies (anti-HLA or anti-MICA antibodies) correlated with late graft rejection (P=0.04).Conclusion. Presence of anti-HLA or anti-MICA had no impact on long-term liver graft survival; however, detection of any antibodies was correlated with episodes of late graft rejection.

scholarly journals Peritoneal Dialysis After Liver Transplantation: A Systematic Review

2021 ◽  
Vol 8 ◽  
pp. 205435812110297
Author(s):  
Jean Maxime Côté ◽  
Isabelle Ethier ◽  
Héloïse Cardinal ◽  
Marie-Noëlle Pépin
Keyword(s):  
Systematic Review ◽  
Liver Transplantation ◽  
Liver Transplant ◽  
Kidney Failure ◽  
Liver Graft ◽  
Transplant Recipients ◽  
Technique Survival ◽  
Liver Transplant Recipients

Background: Chronic kidney disease following liver transplantation is a major long-term complication. Most liver transplant recipients with kidney failure will be treated with dialysis instead of kidney transplantation due to noneligibility and shortage in organ availability. In this population, the role of peritoneal dialysis (PD) as a modality of kidney replacement therapy (KRT) remains unclear. Objective: To determine the feasibility regarding safety, technique survival, and dialysis efficiency of PD in liver transplant recipients requiring KRT for maintenance dialysis. Design: Systematic review. Setting: Interventional and observational studies reporting the use of PD after liver transplantation. Patients: Adult liver transplant recipients with kidney failure treated with maintenance KRT. Measurements: Extracted data included eligibility criteria, study design, demographics, and PD modality. The following outcomes of interest were extracted: rate of peritonitis and microorganisms involved, noninfectious peritoneal complications, technique survival, and kidney transplantation-censored technique survival. Non-PD complications included overall survival, liver graft dysfunction, and hospitalization rate. Methods: The following databases were searched until July 2020: MedLine/PubMed, EMBASE, CINAHL, and Cochrane Library. Two reviewers independently screening all titles and abstracts of all identified articles. Due to the limited sample size, observational designs and study heterogeneity expected, no meta-analysis was pre-planned. Descriptive statistics were used to report all results. Results: From the 5263 identified studies, 4 were included in the analysis as they reported at least 1 outcome of interest on a total of 21 liver transplant recipients, with an overall follow-up duration on PD of 19.0 (Interquartile range [IQR]: 9.5-29.5) months. Fifteen episodes of peritonitis occurred in a total cumulative PD follow-up of 514 patient-months, representing an incidence rate of 0.35 per year. These episodes did not result in PD technique failure, mortality, or impairment of liver graft function. Limitations: Limitations include the paucity of studies in the field and the small number of patients included in each report, a risk of publication bias and the impossibility to directly compare hemodialysis to PD in this population. These results, therefore, must be interpreted with caution. Conclusions: Based on limited data reporting the feasibility of PD in liver transplant recipients with kidney failure, no signal was associated with an increased risk of infectious complications. Long-term studies evaluating this modality need to be performed. Registration (PROSPERO): CRD42020218374.

The majority of liver transplant recipients with normal liver enzyme tests (LET) exhibit long term liver graft lesions

2000 ◽  
Vol 118 (4) ◽  
pp. A1426
Author(s):  
Michael Bismuth ◽  
Georges-Philippe Pageaux ◽  
Christophe Duvoux ◽  
Val\'erie Costes ◽  
Elie-Serge Zafrani ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Liver Enzyme ◽  
Normal Liver ◽  
Liver Graft ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

scholarly journals The Danish comorbidity in liver transplant recipients study (DACOLT): a non-interventional prospective observational cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Magda Teresa Thomsen ◽  
Julie Høgh ◽  
Andreas Dehlbæk Knudsen ◽  
Anne Marie Reimer Jensen ◽  
Marco Gelpi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplant ◽  
Transplant Recipients ◽  
Short Term ◽  
Term Survival ◽  
Blood Samples ◽  
Liver Transplant Recipients ◽  
Short Term Survival

Abstract Background Liver transplantation is the only curative treatment for patients with end-stage liver disease. Short-term survival has improved due to improved surgical techniques and greater efficacy of immunosuppressive drugs. However, long-term survival has not improved to the same extent as the short-term survival, and the 10-year survival after liver transplantation is 60%. In addition to liver- and transplant-related causes, comorbidities such as cardiovascular, pulmonary, renal, and metabolic diseases have emerged as leading causes of morbidity and mortality in liver transplant recipients. The objective of this study is to assess the burden of comorbidities and identify both liver- and transplant-related risk factors as well as traditional risk factors that contribute to the pathogenesis of comorbidity in liver transplant recipients. Methods/design The Danish Comorbidity in Liver Transplant Recipients (DACOLT) study is an observational, longitudinal study. We aim to include all adult liver transplant recipients in Denmark (n = approx. 600). Participants will be matched by sex and age to controls from the Copenhagen General Population Study (CGPS) and the Copenhagen City Heart Study (CCHS). Physical and biological measures including blood pressure, ankle–brachial index, spirometry, exhaled nitric oxide, electrocardiogram, transthoracic echocardiography, computed tomography (CT) angiography of the heart, unenhanced CT of chest and abdomen and blood samples will be collected using uniform protocols in participants in DACOLT, CGPS, and CCHS. Blood samples will be collected and stored in a research biobank. Follow-up examinations at regular intervals up to 10 years of follow-up are planned. Discussion There is no international consensus standard for optimal clinical care or monitoring of liver transplant recipients. This study will determine prevalence, incidence and risk factors for comorbidity in liver transplant recipients and may be used to provide evidence for guidelines on management, treatment and screening and thereby contribute to improvement of the long-term survival. Trial registration ClinicalTrials.gov: NCT04777032; date of registration: March 02, 2021.

The majority of liver transplant recipients with normal liver enzymetests (LET) exhibit long term liver graft lesions

2000 ◽  
Vol 32 ◽  
pp. 60
Author(s):  
M. Bismuth ◽  
G.P. Pageaux ◽  
C. Duvoux ◽  
V. Costes ◽  
E.S. Zafrani ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Normal Liver ◽  
Liver Graft ◽  
Transplant Recipients ◽  
Liver Transplant Recipients

Endoscopic management of biliary strictures in liver transplant recipients: effect on patient and graft survival

1998 ◽  
Vol 47 (2) ◽  
pp. 128-135 ◽  
Author(s):  
Rafat S. Rizk ◽  
John P. McVicar ◽  
Mary J. Emond ◽  
Charles A. Rohrmann ◽  
Kris V. Kowdley ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Graft Survival ◽  
Endoscopic Management ◽  
Transplant Recipients ◽  
Biliary Strictures ◽  
Liver Transplant Recipients ◽  
Patient And Graft Survival

LONG TERM FOLLOW UP OF 22 OPERATIONAL TOLERANT LIVER TRANSPLANT RECIPIENTS.

2010 ◽  
Vol 90 ◽  
pp. 33
Author(s):  
P. tryphonopoulos ◽  
P. Ruiz ◽  
D. Weppler ◽  
D. Levi ◽  
S. Nishida ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Transplant Recipients ◽  
Long Term Follow Up ◽  
Liver Transplant Recipients

Probability, management, and long-term outcomes of biliary complications after hepatic artery thrombosis in liver transplant recipients

Surgery ◽  
2017 ◽  
Vol 162 (5) ◽  
pp. 1101-1111 ◽  
Author(s):  
Masato Fujiki ◽  
Koji Hashimoto ◽  
Emmanouil Palaios ◽  
Cristiano Quintini ◽  
Federico N. Aucejo ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Hepatic Artery ◽  
Biliary Complications ◽  
Hepatic Artery Thrombosis ◽  
Transplant Recipients ◽  
Long Term Outcomes ◽  
Artery Thrombosis ◽  
Liver Transplant Recipients
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