scholarly journals Effectiveness of Fluoride Varnish Application as Cariostatic and Desensitizing Agent in Irradiated Head and Neck Cancer Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Kanchan P. Dholam ◽  
Priyanka Piyush Somani ◽  
Seema D. Prabhu ◽  
Shubhangi R. Ambre
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Fluoride Varnish ◽  
Good Compliance ◽  
Radiation Caries ◽  
Rate Of Increase

Objective. To evaluate the effectiveness of three-month fluoride varnish application on radiation caries and dental sensitivity and to assess compliance to three-month fluoride varnish application.Materials and Methods. 190 irradiated head and neck cancer patients were randomly selected and reviewed retrospectively. Oral prophylaxis, fluoride varnish application, and treatment of dental caries were done prior to radiation therapy. Patients were followed up at every three months for dental evaluation and fluoride varnish application. Decayed-missing-filling-teeth indices, dental sensitivity, and compliance to fluoride varnish application were noted for fifteen months and analyzed statistically.Results. Significant increase in decayed-missing-filling-teeth index was seen at nine(P=0.028), twelve(P=0.003)and fifteen(P=0.002)months follow-up. However, the rate of increase in decayed-missing-filling-teeth indices was 1.64/month which is less than the rate mentioned in the literature (2.5/month). There was no significant effect of sex(P=0.952)and surgery(P=0.672)on radiation caries, but site of disease(P=0.038)and radiation dose(P=0.015)were found to have statistically significant effect. Dental sensitivity decreased from 39% at 3 months to 25% at 15 months followup. 99% compliance to fluoride varnish application was seen till six months followup which decreased to 46% at fifteen months.Conclusion. Three-month fluoride varnish application is effective in decreasing radiation caries and sensitivity and has good compliance.

Radiation Therapy-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients

2014 ◽  
Vol 90 (1) ◽  
pp. S781-S782
Author(s):  
P. Widlak ◽  
K. Jelonek ◽  
M. Ros ◽  
M. Pietrowska ◽  
T. Rutkowski ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Induced Changes

scholarly journals The Incidence of Carotid Stenosis in Head and Neck Cancer Patients After Radiation Therapy

2017 ◽  
Vol 99 (2) ◽  
pp. E326-E327
Author(s):  
D.J. Carpenter ◽  
G. Broadwater ◽  
Y.M. Mowery ◽  
A. Rodrigues ◽  
A.J. Wisdom ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Carotid Stenosis ◽  
Cancer Patients ◽  
Neck Cancer

scholarly journals Reducing Xerostomia by Comprehensive Protection of Salivary Glands in Intensity-Modulated Radiation Therapy with Helical Tomotherapy Technique for Head-and-Neck Cancer Patients: A Prospective Observational Study

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Feng Teng ◽  
Wenjun Fan ◽  
Yanrong Luo ◽  
Zhongjian Ju ◽  
Hanshun Gong ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Salivary Glands ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Helical Tomotherapy ◽  
Clinical Stage ◽  
Flow Rates ◽  
Saliva Flow

Objective. This study aimed to analyze the effects of comprehensive protection of bilateral parotid glands (PG-T), contralateral submandibular gland (cSMG), and accessory salivary glands in the oral cavity (OC) by helical tomotherapy for head-and-neck cancer patients. Methods. Totally 175 patients with histologically confirmed head-and-neck cancer treated with helical tomotherapy were recruited. The doses delivered to PG-T, cSMG, and OC were constrained to be as low as possible in treatment planning. The saliva flow rates and xerostomia questionnaire were evaluated. Correlation between xerostomia and other clinical factors were assessed using univariate and multivariate models. The impact of salivary gland dose on locoregional (LR) recurrence was assessed by Cox analysis. ROC curve was used to determine the threshold of mean dose for each gland. Results. The median follow-up was 25 (19–36) months. The OC mean dose, PG-T mean dose, cSMG mean dose, age, clinical stage (II and III versus IV), and both unstimulated and stimulated saliva flow rates were significantly correlated with xerostomia. The OC mean dose, cSMG mean dose, age, and clinical stage were predictors of xerostomia after adjusting PG-T mean dose, and unstimulated and stimulated saliva flow rates. Xerostomia was significantly decreased when the mean doses of PG-T, cSMG, and OC were kept below 29.12Gy, 29.29Gy, and 31.44Gy, respectively. At 18 months after radiation therapy, early LR recurrence rate was only 4%. Conclusion. Comprehensive protection of salivary glands minimized xerostomia in head-and-neck cancer patients treated by helical tomotherapy, without increasing early LR recurrence risk.

Sign in / Sign up

Export Citation Format

Share Document