scholarly journals Synchronous Bilateral Solid Papillary Carcinomas of the Breast

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Noriko Yoshimura ◽  
Shigeru Murakami ◽  
Mayumi Kaneko ◽  
Akio Sakatani ◽  
Naoki Hirabayashi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Ductal Carcinoma ◽  
Preoperative Evaluation ◽  
Bilateral Breast Cancer ◽  
Left Breast ◽  
Partial Mastectomy ◽  
Magnetic Resonance Imaging Examination ◽  
Wide Range ◽  
Synchronous Bilateral Breast Cancer ◽  
The Right

We herein report a case of synchronous bilateral solid papillary carcinoma of the breast. A 73-year-old female had a mass that was detected in the right breast on mammography. An ultrasound examination revealed one intracystic tumor in the right breast and two tumors in the left breast. A fine-needle aspiration biopsy of these three tumors was performed, which revealed a diagnosis of malignancy. A magnetic resonance imaging examination of the breasts showed diffuse small nodules surrounding these tumors bilaterally. Bilateral partial mastectomy and a sentinel lymph node biopsy were performed. Lymph node metastasis was detected in the right axilla, and additional lymph node dissection was performed. The pathological diagnosis was synchronous bilateral breast cancer, invasive ductal carcinoma NOS of the right breast, mucinous carcinomas of the left breast, and bilateral SPCs. A wide range of surgical margins were positive for SPCs, and additional bilateral total mastectomy was then performed. To the best of our knowledge, little is known about synchronous bilateral SPCs. Our case indicates that some SPCs can be widely scattered and make up a variety of invasive carcinomas. It is difficult to make a correct preoperative evaluation in such cases.

scholarly journals Carcinoma en cuirasse associated to zosteriform metastasis from breast adenocarcinoma

2021 ◽  
Vol 5 (4) ◽  
pp. 01-03
Author(s):  
Refka Frioui ◽  
Azza Ghannem ◽  
Mariam Tabka ◽  
Badreddine Sriha ◽  
Colandane Belajouza ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Clinical Manifestations ◽  
Left Breast ◽  
Metastatic Carcinoma ◽  
Breast Adenocarcinoma ◽  
Wide Range ◽  
History Of ◽  
Original Case ◽  
The Right

We report an original case of carcinoma en cuirasse associated with zosteriform metastasis. A 40-year-old woman presented to our department with painful erythematous lesions. She had a history of invasive ductal carcinoma of the left breast. Numerous erythematous, papules and whitish vesicles were present over the right side of the chest in a dermatomal distribution with indurated coalescent plaques. Biopsy revealed metastatic carcinoma of breast origin. Breast mammography showed suspicious right nodule. Controlateral breast carcinoma with CM was diagnosed. CM show a wide range of clinical manifestations. Carcinoma en cuirasse, is a very rare form of metastatic cutaneous breast cancer. It is characterized by diffuse sclerodermatous induration of the skin. Zosteriform metastasis is also rarely seen. It may be distributed along dermatomeres in a variety of clinical patterns, including nodular, papulovesicular, or vesiculobullous. In our case, the zosteriform metastasis occurred in the contralateral site. It announced the developing of contralateral breast cancer.

Synchronous bilateral breast cancer (SBBC): Concordance of receptor status between right and left breast.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 572-572
Author(s):  
Palak Desai ◽  
Eduardo Braun ◽  
Irene Dehghan-Paz ◽  
Paolo Gattuso ◽  
Jeff Canar ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Medical Center ◽  
Bilateral Breast Cancer ◽  
Left Breast ◽  
Kappa Coefficient ◽  
Her2 Status ◽  
Degree Relative ◽  
Her2 Positive ◽  
Receptor Status ◽  
Synchronous Bilateral Breast Cancer

572 Background: This analysis was prompted by a patient who presented with SBBC who had and ER+, HER2- cancer in one breast and an ER-, HER2+ cancer in the other. Since both breasts have the same genetic background and environmental exposures, concordance should be virtually identical unless other factors are at play. Methods: SBBC was defined as bilateral cancer diagnosed concurrently or within 6 months of each other. Cases were identified retrospectively from patients seen at Rush University Medical Center. This analysis was limited to invasive SBCC (ISBBC). Estrogen receptor (ER) and Her2/neu (HER2) status were assessed according current ASCO/CAP guidelines. Correlation between ER and HER2 status was determined using κ statistic. Results: From January 1998 to December 2012, 33 cases of ISBBC were diagnosed. In 65% of cases synchronous disease was diagnosed concurrently. The average age at diagnosis was 56. The majority were multiparous and 79% post menopausal. About half of the patients (55%) had at least one first degree relative with a history of breast or ovarian cancer and 9% of the cohort had a deleterious mutation in BRCA1 or BRCA2. Infiltrating ductal was most common (74%) followed by infiltrating lobular (21%). 53% of breasts specimens also contained ductal carcinoma in situ. 68% of tumors were ER positive and 8% were HER2 positive. Concordance in ER status was seen in 73% of cases (kappa coefficient 0.14) and in HER2 status was 64% (Kappa coefficient 0.35). Conclusions: Despite identical hereditary and environmental exposure, some patients develop ISBBC cancers with discordant receptor status. While this is the exception, it suggests that other factors influence important tumor characteristics. [Table: see text]

scholarly journals Quantitative and dosimetric analysis for treating synchronous bilateral breast cancer using two radiotherapy planning techniques

2021 ◽  
Vol 27 (3) ◽  
pp. 201-206
Author(s):  
Özlem Mermut ◽  
Aysun Ozsoy Ata ◽  
Didem Can Trabulus
Keyword(s):  
Breast Cancer ◽  
Early Stage ◽  
Organs At Risk ◽  
Bilateral Breast Cancer ◽  
Radiotherapy Planning ◽  
Conformity Index ◽  
Treatment Unit ◽  
Significant Difference ◽  
Synchronous Bilateral Breast Cancer ◽  
The Right

Abstract Objective: We compared mono-isocenter and dual-isocenter plans in synchronous bilateral breast cancer (SBBC), which is defined as tumours occurring simultaneously in both breasts, and evaluated the effects of these differences in plans on organs-at-risk (OARs). Materials and methods: We evaluated 10 women with early stage, nod negative (Tis-2N0M0) SBBC. The treatment dose was determined to be 50 Gy. We used mean dose and VXGy to evaluate the OARs. To evaluate the effectiveness of treatment plans, Homogeneity index (HI), conformity index (CI) and sigma index (SI) and monitor units (MU) of monoisocenter (MIT) and dual-isocenter (DIT) plans were compared. During bilateral breast planning, for the single-centre plan, the isocenter was placed at the center of both breasts at a depth of 3-4 cm. For the two-center plan, dual-isocenters were placed on the right and left breasts. Results: No significant difference between the techniques in terms of the scope of the target volume was observed. Statistically significant results were not achieved in MIT and DIT plans for OARs. Upon comparing MIT and DIT, the right-side monitor unit (MU) value in DIT (p = 0.011) was statistically significantly lower than that in MIT. Upon comparing right-left side MIT and DIT, the MU value (p = 0.028) was significantly lower in DIT than MIT. Conclusion: SBBC irradiation is more complex than unilateral breast radiotherapy. No significant difference between both techniques and OARs was observed. However, we recommend MIT as a priority technique due to the ability to protect OARs, ease of administration during treatment, and the fact that the patient stays in the treatment unit for a shorter period of time.

scholarly journals Chyle Leak after Right Axillary Lymph Node Dissection in a Patient with Breast Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Ankita Sarawagi ◽  
Jessica Maxwell
Keyword(s):  
Lymph Node ◽  
Axillary Lymph Node Dissection ◽  
Lymph Node Dissection ◽  
Axillary Lymph Node ◽  
Ductal Carcinoma ◽  
Tissue Expander ◽  
Axillary Lymph ◽  
Node Dissection ◽  
Chyle Leak ◽  
The Right

Background. A female patient was diagnosed with a right-sided chyle leak following right skin sparing mastectomy, axillary lymph node dissection, and immediate tissue expander placement in the setting of invasive ductal carcinoma status post neoadjuvant chemotherapy. Summary. Our patient underwent a level I and II right axillary lymph node dissection followed by an axillary drain placement. On the first postoperative day, a change from serosanguinous to milky fluid in this drain was noted. The patient was diagnosed with a chyle leak based on the milky appearance and elevated triglyceride levels in the fluid. While chyle leaks are rare after an axillary dissection and even rarer to present on the right side, it is a complication of which breast surgeons should be aware. The cause of this complication is thought to be due to injury of the main thoracic duct, its branches, the subclavian duct, or its tributaries. Management is usually conservative; however, awareness of this potential complication even on the right side is of the utmost importance Conclusion. Chyle leaks are an uncommon complication of axillary node dissections and even rarer for them to present on the right side. It can be diagnosed by monitoring the drainage for changes in appearance and volume and by conducting supporting laboratory tests. Conservative management is generally suggested.

A case of extensive ductal carcinoma in situ and sclerosing adenosis with metastasis on sentinel lymph node

2019 ◽  
Vol 105 (6) ◽  
pp. NP63-NP66
Author(s):  
Selin Narter ◽  
Secil Hasdemir ◽  
Sahsine Tolunay ◽  
Sehsuvar Gokgoz
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Left Breast ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Sclerosing Adenosis

Introduction: Sclerosing adenosis is a form of adenosis characterized by lobulocentric architecture, glandular and stromal proliferation in which the stromal component compresses and distorts the glandular structures. Atypical epithelial proliferations such as atypical lobular hyperplasia, lobular carcinoma in situ, and ductal carcinoma in situ may accompany areas of sclerosing adenosis. We present a case of ductal carcinoma in situ and sclerosing adenosis with metastatic carcinoma on sentinel lymph node. Case description: A 40-year-old woman presented with a palpable mass in her left breast. Radiologic studies showed a lesion suggesting malignancy in the left breast and atypical lymph node in the left axillary region. Left lumpectomy and sentinel lymph node biopsy was performed. Histopathologic examination revealed lobulocentric lesions with glandular proliferation and hyalinizing stroma in between. Foci of high-grade cribriform and solid type ductal carcinoma in situ were observed. Sentinel lymph node biopsy showed micrometastasis in one lymph node section. Based on these findings, the patient was diagnosed with high-grade ductal carcinoma in situ with sclerosing adenosis. However, the presence of micrometastasis in the lymph node suggested occult invasion that we were not able to detect. Conclusion: Ductal carcinoma in situ with sclerosing adenosis can mimic invasive carcinoma both radiologically and histologically. It should be kept in mind that there may be occult invasive carcinoma in patients with ductal carcinoma in situ whether the lesion is accompanied by sclerosing adenosis or not. Multiple sections and immunohistochemical studies can be of help.

Is Sentinel Lymph Node Biopsy Reliable After Recent Oncoplastic Breast Reduction?

2021 ◽  
pp. 000313482110234
Author(s):  
Tasha A. Martin ◽  
Salman Choudhry ◽  
Luther H. Holton ◽  
Lorraine Tafra ◽  
Rubie Sue Jackson
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Breast Reduction ◽  
Ductal Carcinoma ◽  
Lymph Node Biopsy ◽  
Partial Mastectomy ◽  
Recurrence Rates ◽  
Identification Rate ◽  
Node Biopsy

An oncoplastic breast reduction may disrupt normal lymphatic drainage and make subsequent identification of the sentinel lymph nodes (SLNs) unreliable. There are little data on the success rate of sentinel lymph node biopsy (SLNB) after recent oncoplastic breast reduction, and there is no agreement on whether SLNB should be done at the time of the partial mastectomy and reduction for ductal carcinoma in situ (DCIS). The primary goals of this study were to evaluate the identification rate of SLNB after recent oncoplastic or functional breast reduction and to examine recurrence rates in this setting. Results reveal SLNB is feasible in this setting. At least one SLN was found in all patients, and there were no recurrences with an average follow-up of 34 months.

Synchronous Bilateral Breast Cancer Diagnosed as Invasive Lobular and Invasive Ductal Carcinoma

2014 ◽  
Vol 3 (4) ◽  
pp. 152
Author(s):  
Emrah Çağlar ◽  
Fatma Tuba Kızıltepe ◽  
Zehra Sumru Çoşar ◽  
Elif Aktaş ◽  
Bilgin Kadri Arıbaş ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Bilateral Breast Cancer ◽  
Synchronous Bilateral Breast Cancer

scholarly journals Pattern of Fine Needle Aspiration Cytology of Superficially Palpable Lesions: One year hospital based study

1970 ◽  
Vol 9 (2) ◽  
pp. 25-29
Author(s):  
E Piya ◽  
R Panth ◽  
S Singh
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Ductal Carcinoma ◽  
Benign Lesion ◽  
Malignant Lesion ◽  
Aspiration Cytology ◽  
Chronic Sialadenitis ◽  
Wide Range ◽  
Malignant Lesions ◽  
One Year

Introduction: This is a retrospective study on fine need aspiration cytology (FNCA) of superficially palpable lesions done in Shree Birendra Hospital, Chhauni, over a period of one year from 14th April 2008 to 13th April 2009. Aim: The aim of this study was to review cytological diagnosis on superficially palpable lesions in various sites. Methods: A total of 323 cytological diagnoses of palpable lumps performed in one year by pathologists were retrieved. Sites of FNA and diagnoses were analyzed and correlated with age and sex of the patients. Results:This study has included 323 FNACs. Lymph node was the most common site for FNAC (32%), followed by breast (29%), thyroid (22%), and salivary gland (2%). Other site comprised 15% of cases. In lymph node, reactive lymphadenitis was the most common benign lesion (42.7%) and metastatic squamous cell carcinoma was the commonest malignant lesion(12.62%). In breast, benign proliferative breast disease was the most common(84.1%) and ductal carcinoma was commonest among malignant lesions(8.5%). Among thyroid lesions, benign proliferative thyroid disease was the commonest one (47.9%)followed by papillary carcinoma among malignant lesions(11.3%).Among salivary gland lesions, Chronic sialadenitis was common inflammatory lesion (37.5%) followed by pleomorphic adenoma among benign lesions(25%) and carcinoma comprised 25%. Lipoma was the commonest lesion ( 63%) from other sites. Conclusion: Wide range of lesions, both benign and malignant, can be diagnosed by FNAC thus restricting surgery to cases only requiring further histopathological evaluation. DOI: http://dx.doi.org/10.3126/mjsbh.v9i2.5022 Medical Journal of Shree Birendra Hospital Vol.9(2) 2010: 25-29  

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