scholarly journals Effect of Aqueous Stem Bark Extract ofKhaya senegalensison Some Biochemical, Haematological, and Histopathological Parameters of Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
A. Onu ◽  
Y. Saidu ◽  
M. J. Ladan ◽  
L. S. Bilbis ◽  
A. A. Aliero ◽  
...  
Keyword(s):  
Lymphocytic Infiltration ◽  
Stem Bark ◽  
The Body ◽  
Bark Extract ◽  
Hematological Indices ◽  
Khaya Senegalensis ◽  
Stem Bark Extract ◽  
Cellular Integrity ◽  
Histological Architecture ◽  
Dose Dependent

The subchronic effect of aqueous stem bark extract ofKhaya senegalensison some biochemical, haematological, and histopathological parameters of rats was investigated. The rats were divided into six groups of five rats per group. Groups I to VI were administered graded doses of 0, 400, 800, 1200, 1600, and 2000 mg/kg bw, respectively. The result of study revealed that administration of theKhaya senegalensisfor twenty-eight days at the experimental dose resulted in significant (P<0.05) increase in urea, electrolytes (Na+, K+), and creatinine levels. The extract also significantly (P<0.05) increased serum activity of ALT, AST, and ALP. The levels of protein, albumin, and bilirubin were significantly changed when compared to their control values, but they were not dose dependent. The hematological indices assayed in this study were not significantly affected at the experimental dose when compared to the control values. Histological studies of the liver showed cellular degeneration and necrosis and bile duct hyperplasia and fibrosis with lymphocytic infiltration of the hepatocyte, providing supportive evidence for discussing the biochemical findings, indicative of functional derangement. The histological architecture of the kidney and that of the heart were however preserved. The result of this study indicates that the aqueous stem bark extract ofK. senegalensismay affect the cellular integrity of vital organs of the body.

Combination therapy of vitamin C and phenolics-rich fraction of Khaya senegalensis stem bark extract against Trypanosoma brucei brucei infection

Synergy ◽  
2017 ◽  
Vol 4 ◽  
pp. 19-22
Author(s):  
Mohammed Auwal Ibrahim ◽  
Aliyu Muhammad Musa ◽  
Hassanat Taye Tairu ◽  
Maryam Kassim ◽  
Abubakar Babando Aliyu ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Vitamin C ◽  
Trypanosoma Brucei ◽  
Stem Bark ◽  
Bark Extract ◽  
Trypanosoma Brucei Brucei ◽  
Khaya Senegalensis ◽  
Stem Bark Extract

scholarly journals Assessment of the total aqueous stem bark extract of Sacoglottis gabonensis (Baille) Urban on the anatomo-histology of Wistar rat liver, kidneys and heart

2021 ◽  
Vol 9 (1) ◽  
pp. 35
Author(s):  
Kouassi Kousso Brigitte ◽  
Gnangoran Boua Narcisse ◽  
Kouadio Yao Emile ◽  
Koné Mama ◽  
Yapo Angoué Paul
Keyword(s):  
Rat Liver ◽  
Buruli Ulcer ◽  
Wistar Rat ◽  
Stem Bark ◽  
Bark Extract ◽  
Heart Cells ◽  
Cardiac Tissues ◽  
Stem Bark Extract ◽  
Histological Architecture ◽  
Gross Examination

Sacoglottis gabonensis is a medicinal plant used traditionally for the treatment of Buruli ulcer in Côte d’Ivoire. To ensure its effect over a long period of use, assessment of the total aqueous stem bark extract of S. gabonensis (ETASg) on anatomo-histology of Wistar rat liver, kidneys and heart was evaluated. ETASg was administered to Wistar rats at doses of 3.5; 35 and 350 mg/kg/day for 90 days. The liver of rats treated with ETASg at 35 and 350 mg/kg showed color and appearance changes with whitish nodules. Furthermore, histological architecture revealed micro-vesicular steatosis. In contrast, gross examination did not showed any change color and appearance of the kidneys and heart of the rats tested at all doses of ETASg compared to those of control rats. Histological sections of the kidneys and heart of rats tested at all doses of ETASg showed normal kidney and heart cells. After stopping the administration, the liver abnormalities disappeared at the end of the 120 days. This study revealed that the integrity of the liver tissue is preserved only with ETASg of 3.5 mg/kg. On the other hand, it is guaranteed at all the doses studied for the renal and cardiac tissues. 

scholarly journals Antiplasmodial Effect ofAnthocleista vogeliion Albino Mice Experimentally Infected withPlasmodium berghei berghei(NK 65)

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Lebari Barine Gboeloh ◽  
Okpok Eta Okon ◽  
Samuel Effiong Udoh
Keyword(s):  
Body Weight ◽  
Plasmodium Berghei ◽  
Stem Bark ◽  
Bark Extract ◽  
Stem Bark Extract ◽  
Albino Mice ◽  
Dose Levels ◽  
Group D ◽  
Dose Dependent ◽  
Different Doses

The objective of the present study was to investigate the antiplasmodial effect of the ethanolic stem bark extract ofAnthocleista vogeliiat different doses in albino mice infected withPlasmodium berghei berghei(NK 65). Thirty-six mice were divided into six groups of six mice each. Five groups (B1–B3, D, and G) were infected withPlasmodium berghei bergheiparasitized red blood cells. Groups D, H, and G served as the controls. Six days after infection, mice in groups B1, B2, and B3were treated orally with 100, 200, and 400 mg/kg body weight ofAnthocleista vogelii,respectively, for six executive days. Group D was treated with 5 mg/kg body weight of chloroquine while Group G was given distilled water. Group H was not infected and was not treated. It served as the normal control. The extracts exhibited significant(P<0.05)dose-dependent chemosuppression ofP. berghei. The extract exhibited average chemosuppressive effects of 48.5%, 78.5%, and 86.6% at dose levels of 100, 200, and 400 mg/kg body weight, respectively. Phytochemical screening of the plant extract revealed the presence of saponins, cardiac glycosides, flavonoids, terpenes, alkaloids, and steroid. The acute toxicity (LD50) of the plant was estimated to be 3162 mg/kg body weight. It showed that the stem bark ofA. vogeliipossesses antiplasmodial property.

Anticoccidial effects of Khaya senegalensis aqueous stem bark extract on broiler chickens experimentally infected with Eimeria species

2019 ◽  
Vol 52 (3) ◽  
pp. 1249-1255 ◽  
Author(s):  
Issa A. Muraina ◽  
Jurbe G. Gotep ◽  
James T. Tanko ◽  
ThankGod E. Onyiche ◽  
Oladimeji B. Aladelokun ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Eimeria Species ◽  
Stem Bark ◽  
Bark Extract ◽  
Khaya Senegalensis ◽  
Stem Bark Extract

scholarly journals EFFECTS OF STEM-BARK EXTRACT OF OKOUBAKA AUBREVILLIE ON SOME VISCERAL ORGANS OF WISTAR RATS

2018 ◽  
Vol 15 (3) ◽  
pp. 57
Author(s):  
Achukwu U Peter ◽  
Ufelle A Silas ◽  
Onyekwelu C Kenechukwu ◽  
Amadi N Millicent ◽  
Achukwu O Ngozika ◽  
...  
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Wistar Rats ◽  
Toxicity Testing ◽  
Stem Bark ◽  
The Body ◽  
Bark Extract ◽  
Visceral Organs ◽  
Stem Bark Extract ◽  
Acute Toxicity Testing

Background: Over the past two decades, there has been a tremendous increase in the use of herbal medicine; however, these herbs have not been properly evaluated to ascertain their effect on the body organs. Materials and Methods: Effects of stem bark extract of Okoubaka aubrevillie on some visceral organs were investigated in Wistar rats. For acute toxicity testing, Wistar rats (n=16), grouped into 4, (A-D) orally received graded doses of Okoubaka aubrevillie extract and deaths recorded within 24 hours. For sub-acute study, Wistar rats (n=20) grouped into 5, (A-E) orally received graded doses of Okoubaka aubrevillie extract for 31 days. Blood samples were collected from each rat through retro-orbital puncture for biochemical analysis. The liver, kidney and stomach were excised and processed for light microscopy. For toxin inhibition studies, Wistar rats (n=24) grouped into 6 (A-F), were used. Groups A-C and D-F orally received graded doses of Dichlorvos. Groups A-C further received Okoubaka aubrevillie extract while D-F received water and death records observed. Results: For acute toxicity testing, lethal dose (LD50) of 7500 mg/kg body weight was obtained from the inverse of the log-dose. Sub-acute studies revealed significantly elevated mean body weight in group A (210 ± 4.5 gram) compared to control (178 ± 5.0 gram), (p

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