scholarly journals Similar Connotation in Chronic Hepatitis B and Nonalcoholic Fatty Liver Patients with Dampness-Heat Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Jianye Dai ◽  
Shujun Sun ◽  
Jianmei Cao ◽  
Yu Zhao ◽  
Huijuan Cao ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Fatty Liver ◽  
Chronic Hepatitis B ◽  
Metabolic Profiling ◽  
Intestinal Flora ◽  
Nonalcoholic Fatty Liver ◽  
The World ◽  
Heat Syndrome ◽  
Urine And Serum

The phenomenon that the same syndrome turns up in different diseases appears in the sight of people around the world, which raises the thought for possibility of “Same Treatment for Different Diseases.” Actually, treatment based on ZHENG classification in Traditional Chinese Medicine could bring revelation for the former finding. The dampness-heat syndrome in chronic hepatitis B and nonalcoholic fatty liver is regarded as the breakthrough point. We discussed the molecular mechanism of similar connotation that exists in chronic hepatitis B and nonalcoholic fatty liver by metabonomics to give the modern understanding of dampness-heat syndrome. Both urine and serum metabolic profiling revealed that obvious differences existed between dampness-heat syndrome and non-dampness-heat syndrome but the commonality was proved to appear in chronic hepatitis B and nonalcoholic fatty liver patients with dampness-heat syndrome. Furthermore, disorder of body fluid metabolism, decline in digestive capacity, and imbalance of intestinal flora were found to be the new guiding for treatment, with the hope to provide the basis for Chinese personalized medicine.

scholarly journals The FIB-4 Index Is a Useful Predictor for the Development of Hepatocellular Carcinoma in Patients with Coexisting Nonalcoholic Fatty Liver Disease and Chronic Hepatitis B

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2301
Author(s):  
Minah Kim ◽  
Yeonju Lee ◽  
Jun Sik Yoon ◽  
Minjong Lee ◽  
So Shin Kye ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis B ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Chronic Hepatitis B ◽  
Fatty Liver Disease ◽  
Youden Index ◽  
Nonalcoholic Fatty Liver

Background: The FIB-4 index, a noninvasive tool (FIB-4 index = age × aspartate transaminase (AST)/(platelet count × √alanine aminotransferase (ALT)), is a useful assessment for liver fibrosis. Patients with a high FIB-4 index were reported to have a high risk of developing hepatocellular carcinoma (HCC). This study analyzed the clinical association of the FIB-4 index with HCC development in patients with coexisting nonalcoholic fatty liver disease and chronic hepatitis B (NAFLD–CHB). Methods: This retrospective study analyzed 237 consecutive patients with NAFLD–CHB between January 2006 and December 2010 at the National Police Hospital in Korea. Patients with HCC at baseline and those diagnosed with HCC within 6 months from baseline were excluded. Propensity score matching analysis (PSM) was adopted to balance the baseline characteristics between patients with low and high FIB-4 index values. The cumulative rates of HCC development were compared between the two groups using the Kaplan–Meier method in the matched population. Results: The median follow-up duration was 13 years (interquartile range, 8.2–15.7). The optimal cutoff for the FIB-4 index of 1.77 was calculated based on the maximum Youden index value, with an AUC of 0.70. Among a total of 237 patients with NAFLD–CHB, HCC developed in 20 patients (8.4%) (14 of the 90 patients with a high FIB-4 index vs. 6 of the 147 patients (4.1%) with a low FIB-4 index; log-rank p = 0.003). Patients with a high FIB-4 index had a significantly and independently higher risk of HCC than those with a low FIB-4 index (adjusted hazard ratio, 4.35; 95%; confidence interval, 1.42–13.24; log-rank test, p = 0.006). Conclusion: A high FIB-4 index (≥1.77) might be a useful marker for predicting the development of HCC in patients with NAFLD–CHB.

scholarly journals Nonalcoholic Fatty Liver Disease in Chronic Hepatitis B and C Patients from Western Amazon

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
A. C. M. Nascimento ◽  
D. R. Maia ◽  
S. M. Neto ◽  
E. M. Lima ◽  
M. Twycross ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Chronic Hepatitis B ◽  
Fatty Liver Disease ◽  
Wide Spectrum ◽  
Nonalcoholic Fatty Liver

Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of histological conditions, extending from simple steatosis to end-stage liver failure. The aim of this study was to examine the prevalence of NAFLD and its associations in chronic hepatitis B and C patients.Methods. We included all patients diagnosed with chronic hepatitis B and C who underwent a liver biopsy between January 2010 and October 2011 (n= 104). Parameters studied included hepatitis type, anthropometric data, histologic, hepatic, metabolic and lipid assessments, presence of hypertension and viral load.Results. Hepatitis B was presented in 28.8% (n= 30) of patients, while hepatitis C was presented in 71.2% (n= 74). In addition, hepatic steatosis was present in 25% (n= 26) of the patients. Steatosis was frequently found in hepatitis C patients (31.1%; 25%n= 23), but infrequently in hepatitis B patients (10%;n= 3) (P= 0.024). It was also found that steatosis was frequently present in hepatitis C patients with intense fibrosis (52.94%) (P= 0.025).Discussion. Our results suggest that steatosis is a common feature in patients with viral chronic hepatitis, and that it plays a different role in each type of hepatitis.

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