scholarly journals Effects of Electroacupuncture at Auricular Concha Region on the Depressive Status of Unpredictable Chronic Mild Stress Rat Models

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Ru-Peng Liu ◽  
Ji-Liang Fang ◽  
Pei-Jing Rong ◽  
Yufeng Zhao ◽  
Hong Meng ◽  
...  
Keyword(s):  
Open Field Test ◽  
Treatment Options ◽  
Chronic Mild Stress ◽  
Antidepressant Effect ◽  
Mild Stress ◽  
Noninvasive Treatment ◽  
Once Daily ◽  
Rat Models ◽  
Unpredictable Chronic Mild Stress ◽  
Male Wistar Rats

To explore new noninvasive treatment options for depression, this study investigated the effects of electroacupuncture (EA) at the auricular concha region (ACR) of depression rat models. Depression in rats was induced by unpredictable chronic mild stress (UCMS) combined with isolation for 21 days. Eighty male Wistar rats were randomly assigned into four groups: normal, UCMS alone, UCMS with EA-ACR treatment, and UCMS with EA-ear-tip treatment. Rats under inhaled anesthesia were treated once daily for 14 days. The results showed that blood pressure and heart rate were significantly reduced in the EA-ACR group than in the UCMS alone group or the EA-ear-tip group. The open-field test scores significantly decreased in the UCMS alone and EA-ear-tip groups but not in the EA-ACR group. Both EA treatments downregulated levels of plasma cortisol and ACTH in UCMS rats back to normal levels. The present study suggested that EA-ACR can elicit similar cardioinhibitory effects as vagus nerve stimulation (VNS), and EA-ACR significantly antagonized UCMS-induced depressive status in UCMS rats. The antidepressant effect of EA-ACR is possibly mediated via the normalization of the hypothalamic-pituitary-adrenal (HPA) axis hyperactivity.

scholarly journals Alteration of Behavioral Changes and Hippocampus Galanin Expression in Chronic Unpredictable Mild Stress-Induced Depression Rats and Effect of Electroacupuncture Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Yuping Mo ◽  
Haijiang Yao ◽  
Hongtao Song ◽  
Xin Wang ◽  
Wanshun Chen ◽  
...  
Keyword(s):  
Treatment Options ◽  
Chronic Mild Stress ◽  
Antidepressant Effect ◽  
Mild Stress ◽  
Model Group ◽  
Sprague Dawley ◽  
Noninvasive Treatment ◽  
Crossing Numbers ◽  
Sprague Dawley Rats ◽  
Antidepressant Effects

To explore new noninvasive treatment options for depression, this study investigated the effects of electric acupuncture (EA) for depression rat models. Depression in rats was induced by unpredictable chronic mild stress (UCMS) combined with isolation for 21 days. Eighteen male Sprague-Dawley rats were randomly assigned into three groups: control, model, and EA groups. Rats were treated by EA once daily for 21 days. The results showed that body weight and sucrose consumption were significantly increased in EA group than in the model group. The crossing numbers and rearing numbers in the open field test significantly decreased in the model group but not in the EA group. And EA treatments upregulated levels of hippocampus galanin (Gal) in UCMS rats back to relative normal levels. The present study suggested that EA had antidepressant effects on UCMS model rats. The potential antidepressant effect may be related to upregulating Gal expression in hippocampus.

scholarly journals The Effect of Swimming on Anxiety-Like Behaviors and Corticosterone in Stressed and Unstressed Rats

2020 ◽  
Vol 17 (18) ◽  
pp. 6675
Author(s):  
Mohammad Amin Safari ◽  
Maryam Koushkie Jahromi ◽  
Rasoul Rezaei ◽  
Hadi Aligholi ◽  
Serge Brand
Keyword(s):  
Wistar Rats ◽  
Open Field Test ◽  
Recovery Period ◽  
Chronic Mild Stress ◽  
Anxiety Reduction ◽  
Future Research ◽  
Mild Stress ◽  
Swimming Training ◽  
Male Wistar Rats ◽  
Recovery Group

This study assessed the effect of swimming training on anxiety-like behaviors and corticosterone. Thirty adult male Wistar rats were randomly assigned to five study conditions: swimming training (ST); exposure to chronic mild stress (CS); exposure to chronic mild stress followed by swimming training (CS + ST); exposure to chronic mild stress followed by a recovery period (CS + recovery); control. The exercise training consisted of 60 min of swimming exercise per day, for five days a week, and four consecutive weeks. A chronic mild stress program (CMS) was applied for a period of four weeks. Anxiety-like behaviors were measured by open field test (OFT). The number of excrements and blood corticosterone were used as physiological parameters of anxiety. To assess corticosterone, blood samples were taken 48 h after the last session of experiments. Compared to other study conditions, the lowest anxiety-like behaviors and corticosterone concentrations were observed in the ST condition in unstressed rats. In stressed rats, as in the ST + CS group, swimming training probably reduced some anxiety behaviors, but the results showed increased corticosterone compared to control and CS + Recovery. Anxiety parameters and corticosterone concentrations were greatest in the CS condition. In the ST group, anxiety parameters were less than for the ST + CS group. In the CS + Recovery group, anxiety parameters were less than for the CS group. In summary, self-paced swimming training could attenuate some anxiety parameters in both stressed and non-stressed rats. The effect of swimming training in unstressed rats was more prominent than in stressed rats. In stressed rats, a period of recovery was more effective than swimming training in reducing corticosterone. Mechanisms of anxiety reduction other than cortisol should be investigated in future research.

Antidepressant effect of Shudihuang on mice exposed to unpredictable chronic mild stress

2009 ◽  
Vol 123 (1) ◽  
pp. 55-60 ◽  
Author(s):  
Di Zhang ◽  
Xue-sen Wen ◽  
Xue-yan Wang ◽  
Min Shi ◽  
Yu Zhao
Keyword(s):  
Chronic Mild Stress ◽  
Antidepressant Effect ◽  
Mild Stress ◽  
Unpredictable Chronic Mild Stress

scholarly journals Merging the Multi-Target Effects of Kleeb Bua Daeng, a Thai Traditional Herbal Formula in Unpredictable Chronic Mild Stress-Induced Depression

2021 ◽  
Vol 14 (7) ◽  
pp. 659
Author(s):  
Juthamart Maneenet ◽  
Orawan Monthakantirat ◽  
Supawadee Daodee ◽  
Chantana Boonyarat ◽  
Yutthana Chotritthirong ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Chronic Mild Stress ◽  
Antidepressant Activity ◽  
Piper Nigrum ◽  
Psychiatric Disease ◽  
Mild Stress ◽  
Herbal Formula ◽  
Necrosis Factor Alpha ◽  
Unpredictable Chronic Mild Stress

Major depressive disorder (MDD) is a common and debilitating psychiatric disease characterized by persistent low mood, lack of energy, hypoactivity, anhedonia, decreased libido, and impaired cognitive and social functions. However, the multifactorial etiology of MDD remains largely unknown due the complex interaction between genetics and environment involved. Kleeb Bua Daeng (KBD) is a Thai traditional herbal formula that has been used to promote brain health. It consists of a 1:1:1 ratio of the aerial part of Centella asiatica, Piper nigrum fruit, and the petals of Nelumbo nucifera. According to the pharmacological activities of the individual medicinal plants, KBD has good potential as a treatment for MDD. The present study investigated the antidepressant activity of KBD in an unpredictable chronic mild stress (UCMS) mouse model. Daily administration of KBD to UCMS mice ameliorated both anhedonia, by increasing 2% sucrose intake, and hopeless behavior, by reducing immobility times in the forced swimming test (FST) and tail suspension test (TST) without any effect on locomotor activity. The mechanism of KBD activity was multi-modal. KBD promoted neurogenesis by upregulation of brain-derived neurotrophic factor (BDNF) and cyclic AMP-responsive element binding (CREB) mRNA expression in the frontal cortex and hippocampus. Daily treatment with KBD significantly reversed UCMS-induced HPA axis dysregulation by upregulating the glucocorticoid receptor (GR) while downregulating serum- and glucocorticoid-inducible kinase 1 (SGK1) and FK506 binding protein 5 (FKBP5) mRNA expression. KBD treatment also normalized proinflammatory cytokine expression including tumor necrosis factor-alpha (TNF-α), and interleukin (IL)-1β and IL-6. KBD and its component extracts also exhibited an inhibitory effect in vitro on monoamine oxidase (MAO) A and B. The multiple antidepressant actions of KBD emphasize its potential as an effective, novel treatment for MDD.

scholarly journals Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism

2012 ◽  
Vol 4 (4) ◽  
pp. 627-632 ◽  
Author(s):  
JING-MEI ZHONG ◽  
SHAO-YUAN WU ◽  
JIE BAI ◽  
QIANG GUO ◽  
JIAN TAO ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Antidepressant Effect ◽  
Mild Stress ◽  
Stress Model

scholarly journals Social Isolation-Induced Aggression Potentiates Anxiety and Depressive-Like Behavior in Male Mice Subjected to Unpredictable Chronic Mild Stress

PLoS ONE ◽  
2011 ◽  
Vol 6 (6) ◽  
pp. e20955 ◽  
Author(s):  
Xian-cang Ma ◽  
Dong Jiang ◽  
Wen-hui Jiang ◽  
Fen Wang ◽  
Min Jia ◽  
...  
Keyword(s):  
Social Isolation ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Male Mice ◽  
Unpredictable Chronic Mild Stress
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