scholarly journals Exploring Potential Chemical Transformation by Chemical Profiling Approach for Rapidly Evaluating Chemical Consistency between Sun-Dried and Sulfur-Fumigated Radix Paeoniae Alba Using Ultraperformance Liquid Chromatography Coupled with Time-of-Flight Mass Spectrometry

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jida Zhang ◽  
Hao Cai ◽  
Gang Cao ◽  
Xiao Liu ◽  
Chengping Wen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
High Speed ◽  
Quality Evaluation ◽  
Mass Measurement ◽  
Time Of Flight ◽  
Chemical Profiling ◽  
Flight Mass Spectrometry ◽  
Monoterpene Glycoside ◽  
Radix Paeoniae Alba

Ultraperformance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-QTOF/MS) based on a chemical profiling method was applied to rapidly evaluate the chemical consistency between sun-dried and sulfur-fumigated Radix Paeoniae Alba. By virtue of the high resolution, high speed of UPLC, and the accurate mass measurement of TOFMS coupled with reliable MarkerLynx software, five newly assigned monoterpene glycoside sulfonates were found and identified in sulfur-fumigated Radix Paeoniae Alba samples. This method could be applied for rapid quality evaluation of different kinds of sulfur-fumigated Radix Paeoniae Alba among commercial samples.

A new potential biomarker for 1-testosterone misuse in human urine by liquid chromatography quadruple time-of-flight mass spectrometry

2015 ◽  
Vol 7 (11) ◽  
pp. 4486-4492 ◽  
Author(s):  
Yang Liu ◽  
Jianghai Lu ◽  
Sheng Yang ◽  
Youxuan Xu ◽  
Xiaobing Wang
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Human Urine ◽  
Mass Measurement ◽  
Time Of Flight ◽  
Accurate Mass ◽  
Metabolic Profiles ◽  
Flight Mass Spectrometry ◽  
Potential Biomarker ◽  
Full Scan

In this study, 1-testosterone urinary metabolic profiles were investigated by liquid chromatography quadruple time-of-flight mass spectrometry (LC-QTOF-MS) using full scan and targeted MS/MS techniques with accurate mass measurement.

scholarly journals Metabolomics of Ginger Based on Ultra-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry Technology

2020 ◽  
Author(s):  
Hui Yan ◽  
Dongqian Zou ◽  
Guisheng Zhou ◽  
Hanwen Yu ◽  
Penghui Li ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Quality Evaluation ◽  
Time Of Flight ◽  
Ultra Performance Liquid Chromatography ◽  
Partial Least Square ◽  
Least Square ◽  
Related Factors ◽  
Flight Mass Spectrometry ◽  
Mass Spectrometry Technology

Abstract Objectives Dried ginger and ginger are the same type of medicine and food. The differential components of ginger and dried ginger, dried ginger and ginger charcoal were investigated. Materials and Methods The experimental materials were divided into three sample groups: the ginger group, dried ginger group and ginger charcoal group. The ginger group, dried ginger group and ginger charcoal group were qualitatively analyzed by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS). The data were processed by Marker View Software. Principal component analysis (PCA) and orthogonal partial least-square discriminant analysis (OPLS-DA) were performed with SIMCA 13.0 Software. The differential components of the ginger group and dried ginger group as well as the dried ginger group and ginger charcoal group with a VIP>2 (p<0.05), were identified with PeakView 1.2 Software. Results Ten differential components, including 6-gingerol, 8-gingerol and 10-gingerol, were identified between the ginger group and dried ginger group; 13 differential components, including 6-shogaol, 10-gingerol and zingiberone, were identified between the dried ginger group and ginger charcoal group. Conclusions The main differential components between the ginger group and dried ginger group, dried ginger group and ginger charcoal group were gingerols and diphenylheptanes. Based on metabolomics analysis of the chemical composition of ginger medicinal materials, effects and other related factors, it is recommended that 6-gingerol, 6-shogaol and zingiberone should be used as indicative components for the respective quality evaluation of ginger, dried ginger and ginger charcoal. The results of this study may provide a basis for the reasonable quality evaluation of ginger medicinal materials.

scholarly journals Rapid Evaluation of Chemical Consistency of Artificially Induced and Natural Resina Draconis Using Ultra-Performance Liquid Chromatography Quadrupole-Time-of-Flight Mass Spectrometry-Based Chemical Profiling

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1850 ◽  
Author(s):  
Qianping Chen ◽  
Lili He ◽  
Changming Mo ◽  
Zhifeng Zhang ◽  
Hairong Long ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Chemical Constituents ◽  
Time Of Flight ◽  
Ultra Performance Liquid Chromatography ◽  
Market Demand ◽  
Chemical Profiling ◽  
Flight Mass Spectrometry ◽  
Chromatographic Peaks ◽  
Resina Draconis

Resina Draconis is a highly valued traditional medicine widely used in Arabia since ancient times, and it has been commonly used as an antidiarrheic, antimicrobial, antiulcer, blood circulation promoter as well as an anti-inflammatory agent. The tree source from which this medicine orignates grows extremely slowly, producing a very low yield of Resina Draconis. To meet the increasing market demand, artificial methods for stimulating Resina Draconis formation have been developed and applied. However, the chemical differences between artificially induced Resina Draconis (AIRD) and natural Resina Draconis (NRD) have been rarely studied. The aim of this research was to explore and identify the chemical constituents of AIRD and NRD using ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS) based chemical profiling. A total of 56 chromatographic peaks were detected in AIRD, of these, 44 peaks have had their structures tentatively characterized based on high-resolution mass spectra (HRMS) data, fragmentation ions information, reference standards data and literature review. In total, 40 peaks were found both in AIRD and NRD. The potential chemical transformation mechanisms active in Resina Draconis during formation were explored. To the best of our knowledge, this is the first evaluation of the chemical profiles of both AIRD and NRD. Furthermore, these findings are expected to provide a rational basis for the quality assessment of AIRD and the use of AIRD as a substitute for NRD.

Sign in / Sign up

Export Citation Format

Share Document